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CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. 再加上，我们可以发CDC20 蛋白 (7) 和 和数多这个蛋白质的别的产品。
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Human Polyclonal CDC20 Primary Antibody for ICC, IF - ABIN252981
Di Fiore, Pines: How cyclin A destruction escapes the spindle assembly checkpoint. in The Journal of cell biology 2010
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Human Polyclonal CDC20 Primary Antibody for ICC, IF - ABIN252980
Ahlskog, Björk, Elsing, Aspelin, Kallio, Roos-Mattjus, Sistonen: Anaphase-promoting complex/cyclosome participates in the acute response to protein-damaging stress. in Molecular and cellular biology 2010
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Xenopus laevis Monoclonal CDC20 Primary Antibody for CyTOF, ELISA - ABIN251088
Sackton, Dimova, Zeng, Tian, Zhang, Sackton, Meaders, Pfaff, Sigoillot, Yu, Luo, King: Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C. in Nature 2014
Human Polyclonal CDC20 Primary Antibody for IP, WB - ABIN233786
Yamamuro, Kano, Naito: Functions of FZR1 and CDC20, activators of the anaphase-promoting complex, during meiotic maturation of swine oocytes. in Biology of reproduction 2008
we demonstrate that the CDC20-MAD2 (显示 MAD2L1 抗体) complex could also be formed independently of the SAC (显示 ADCY10 抗体). Moreover, in prolonged arrest caused by nocodazole treatment, the overall levels of the CDC20-MAD2 (显示 MAD2L1 抗体) complex are gradually, but significantly, reduced and this is associated with lower levels of cyclin B1 (显示 CCNB1 抗体), which brings a new insight into the mechanism of mitotic "slippage" of the arrested cells.
Cdc20 may be a promising molecular target for chemotherapy.
Long non-coding RNA SPRY4 (显示 SPRY4 抗体)-IT1 (显示 HAUS3 抗体) promotes cell proliferation and invasion by regulation of Cdc20 in pancreatic cancer cells
Cdc20 functions as an important negative regulator of SMAR1 (显示 BANP 抗体) in higher grades of cancer
Data provide support for the recent structure-based models and functionally dissect three elements of Cdc20 inhibition: sequestration of Cdc20 in the core mitotic checkpoint (显示 BUB3 抗体) complex, sufficient at low Cdc20 concentrations; inhibition of a second Cdc20 through the Mad3 (显示 SMAD3 抗体) C terminus, independent of Mad2 (显示 MAD2L1 抗体) binding to this Cdc20 molecule; and occupancy of the APC (显示 APC 抗体)/C with full MCC (显示 MCC 抗体), where Mad3 (显示 SMAD3 抗体) and Apc15 (显示 ANAPC15 抗体) are involved.
CDC20 gene, related to cell proliferation in protein complex A, might play momentous roles in the initiation and development of consecutive Trauma-Induced Sepsis.
A mitotic phosphorylation site on Cdc20, known to be a substrate of PP2A (显示 PPP2R4 抗体)(B56), modulates APC (显示 APC 抗体)/C(Cdc20) assembly.
c-Myc (显示 MYC 抗体) is a driver when combined with kRas/Akt3 (显示 AKT3 抗体) oncogenic signals in gliomagenesis, whereas Cdc20 overexpression is a passenger
The ABBA (显示 MTSS1L 抗体)-KEN (显示 PCNT 抗体)-ABBA (显示 MTSS1L 抗体) amino acid motif cassette holds the Mitotic Checkpoint (显示 BUB3 抗体) Complex (MCC (显示 MCC 抗体)) onto the Anaphase-Promoting Complex-Cyclosome (APC (显示 APC 抗体)/C) by binding the two Cdc20 molecules in the MCC (显示 MCC 抗体)-APC (显示 APC 抗体)/C complex.
It discuses the roles of Cdc20 in SAC (显示 ADCY10 抗体) signalling and mitotic exit, describe how the integration of traditional approaches with emerging technologies has revealed new details of Cdc20 functions, comment about the potential of Cdc20 as a therapeutic target for the treatment of human malignancies.
Cdc20 auto-ubiquitylation does not play a major role in terminating Cdc20 activation.
Dephosphorylation of Cdc20 is required for its loading and activation of the APC/C ubiquitin ligase.
A role for the fizzy/cdc20 family of proteins in activation of the APC (显示 APC 抗体)/C distinct from substrate recruitment is reported.
Cdc20 hypomorphism causes chromatin bridging and chromosome misalignment, revealing a requirement for Cdc20 in efficient sister chromosome separation and chromosome-microtubule attachment.
The physiologically effective threshold level of Cdc20 is high for female meiosis I.
Results indicate that Cdc20 also contributes to post-anaphase activation of the APC (显示 APC 抗体)/C.
The seven tandem WD motifs of Cdc20 they are required for speriolin binding and for localization of Cdc20 to the centrosomes and nucleus, suggesting that speriolin might regulate or stabilize the folding of Cdc20 during meiosis in spermatogenic cells
Data suggest that Mad2 (显示 MXI1 抗体) and BubR1 (显示 BUB1B 抗体) must cooperate to inhibit Cdc20 activity.
Cdc20 is degraded through two independent degradation signals (degrons), the KEN (显示 PCNT 抗体) box and a newly described CRY (显示 CRY2 抗体) box.
Cdc20 and securin (显示 PTTG1 抗体) double mutant embryos could not maintain the metaphase arrest, suggesting a role of securin (显示 PTTG1 抗体) in preventing mitotic exit
Expression of the cdc20 gene is down-regulated by zif268 (显示 EGR1 抗体) in neuronal cells; altered expression of proteasome-regulatory genes following zif268 (显示 EGR1 抗体) induction may be a key component of long-lasting CNS plasticity.
Cdc20 is required for the anaphase onset of the first meiosis but not the second meiosis in mouse oocytes
findings suggest a novel function of HSF1 (显示 HSF1 抗体) frequently overexpressed in cancer cells, to inhibit APC (显示 APC 抗体)/C activity by interacting with Cdc20, and to result in aneuploidy development and genomic instability
porcine FZR1 (显示 FZR1 抗体) and CDC20 work on the maintenance of meiotic arrest at the first meiotic prophase and on the exit from M1
CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separation.
cell division cycle 20 homolog
, CDC20 cell division cycle 20 homolog
, cell division cycle protein 20 homolog
, cell cycle protein p55CDC