anti-Casein Kinase 2, alpha 1 Polypeptide (CSNK2A1) 抗体

Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. 再加上,我们可以发Casein Kinase 2, alpha 1 Polypeptide 蛋白 (21)Casein Kinase 2, alpha 1 Polypeptide 试剂盒 (10)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
CSNK2A1 1457 P68400
CSNK2A1 116549 P19139
CSNK2A1 12995 Q60737
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Showing 10 out of 141 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 交付 价格 详细
Cow 非结合性 WB WB Suggested Anti-CSNK2A1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: 721_B cell lysate 100 μL 2至3个工作日
非结合性 WB Western blot of CK2α(Phospho-Thr360/Ser362) antibody and CK2αantibody in vitro kinase assay. Both purified ERK2 and CK2 were used. 50 μg 11至13个工作日
非结合性 WB Western blot of CK2α(Phospho- Thr360/Ser362) antibody and CK2α antibody in vitro kinase assay. Both purified ERK2 and CK2 were used. CK2α (Phospho-Thr360/Ser362) antibody could recognize ERK2 phosphorylated wild type CK2α and CK2α when Ser362 was mutated to alanine. 50 μg 11至13个工作日
非结合性 ELISA, ICC, IF, IHC, WB Western blot analysis of CKII alpha using HepG2 whole cell lysates ABIN6277771 staining HeLa by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibod 100 μL 11至12个工作日
非结合性 EIA, IHC (p), WB   0.4 mL 4至8个工作日
Bat 非结合性 WB 100 μL 11至14个工作日
非结合性 ELISA, WB 100 μL 11至14个工作日
小鼠 非结合性 ELISA, IP, WB 100 μL 14至16个工作日
小鼠 非结合性 IF, PLA, ELISA, WB CSNK2A1 monoclonal antibody (M01), clone 3D9 Western Blot analysis of CSNK2A1 expression in Hela S3 NE . Immunofluorescence of monoclonal antibody to CSNK2A1 on HeLa cell. [antibody concentration 10 ug/ml] 100 μg 11至12个工作日
非结合性 IHC, WB 100 μL 11至13个工作日

引用最多的anti-Casein Kinase 2, alpha 1 Polypeptide 抗体

  1. Human Monoclonal CSNK2A1 Primary Antibody for IF, PLA - ABIN514706 : Lin, Hung, Lin, Li, Lee, Li, Chen, Chen, Yang: CK2 inhibitors enhance the radiosensitivity of human non-small cell lung cancer cells through inhibition of stat3 activation. in Cancer biotherapy & radiopharmaceuticals 2011 (PubMed)

更多抗Casein Kinase 2, alpha 1 Polypeptide的相互作用对抗体

Human Casein Kinase 2, alpha 1 Polypeptide (CSNK2A1) interaction partners

  1. ll variants were predicted to have a delta-delta G value greater than 0, indicating these variants are responsible for stabilizing the CSNK2A1 protein fold

  2. CSNK2A1 plays a role in the nuclear translocation of ERK1/2. Ser246 phosphorylation by CK2 is sufficient for full ERK translocation, while Ser244 phosphorylation accelerates it.

  3. MUS81 is phosphorylated at serine 87 by the protein kinase CK2.CK2-mediated phosphorylation of MUS81 at serine 87 is an early mitotic event stimulated by mild replication stress.

  4. CK2 is a therapeutic target for the prevention of epithelial-mesenchymal transition and metastasis of cancers.

  5. Results show that casein kinase 2 alpha (CK2 )downregulation leads to H3K9me3 and senescence-associated heterochromatic foci (SAHF) formation by increasing H3K9 trimethylase SUV39h1 (SUV39h1) and decreasing H3K9 dimethylase G9a (G9a).

  6. Rad17-S667 in the C-terminal tail is constitutively phosphorylated in vivo in a casein kinase 2-dependent manner, and the phosphorylation is important for 9-1-1 interaction

  7. This and previous studies have found a total of 20 CSNK2A1 variants in 28 individuals with syndromic intellectual disability. The hotspot variant c.593A>G, p.(Lys198Arg) was found in eight of 28 patients. Meanwhile, only five CSNK2B variants were identified in five individuals with neurodevelopmental disorders. We reviewed the previous literature to verify the phenotypic spectrum of CSNK2A1- and CSNK2B-related syndromes

  8. Mutation in CSNK2A1 cause neurodevelopmental abnormalities and dysmorphic features.

  9. Our findings indicate that CD163 contributes to gliomagenesis via CK2 and provides preclinical evidence that CD163 and the CD163 pathway might serve as a therapeutic target for glioma.

  10. Multiple conformations of kinase II subunit alpha (CK2alpha) hinge region, located near the active site, were observed during the dynamics.

  11. New crystal forms were exploited and one provided a crystal structure of CK2alpha2 at 1.89A resolution.

  12. Casein kinase II, glycogen synthase kinase-3, and Ikaros mediated regulation of leukemia has been summarized. (Review)

  13. Our results showcase the potentially valuable functional impact of microRNAs in regulating GG related epilepsy. As CK-2alpha inhibition enhances miR-217 expression, disrupting the miR-217-CK-2alpha interplay through CK-2alpha inhibitors might represent a novel therapeutic strategies aimed at LEAT.

  14. The results suggest that CK2alpha promotes migration and invasion of clear cell renal cell carcinoma and therefore could serve as a novel prognostic biomarker and molecular therapeutic target in this type of cancer.

  15. The newly designed casein kinase 2 (CK2) Inhibitors were screened on one lung cancer cell line A549, showing low micromolar anti-proliferative activity.

  16. CK2 governs the molecular decision between encephalitogenic TH17 cells and protective Treg cells development.

  17. Data suggest that casein kinase 2 (CK2) inhibition is a promising approach to blocking beta-catenin in MPNST cells, although combinatorial therapies may be required for maximal efficacy.

  18. Results provide evidence that CK2A is critical fro RSV virus replication in human cells.

  19. Vascular smooth muscle protein kinase CK2 inhibition suppresses neointima formation via a proline-rich homeodomain-dependent mechanism.

  20. we have identified kinases, particularly CK2, associated with the autocrine malignant cell network that may play a central role in sustaining the cytokine network and/or mediating its effects in ovarian cancer.

Silk Worm Casein Kinase 2, alpha 1 Polypeptide (CSNK2A1) interaction partners

  1. To clarify the control mechanism of the catalytic activity of casein kinase 2 (CK2) during early embryonic development in the silkworm, Bombyx mori, attempted an in-vitro functional analysis by using the recombinant alpha and beta subunits of B. mori CK2

Maize/Corn (Zea mays) Casein Kinase 2, alpha 1 Polypeptide (CSNK2A1) interaction partners

  1. identify the the ZmeIF5A serine residues phosphorylated by CK2

  2. analysis of free energy differences of binding of adenosine triphosphate (ATP) and guanine triphosphate (GTP) to the protein kinase CK2

  3. The complex structure between a C-terminal deletion mutant of human CK2alpha and the ATP-competitive inhibitor emodin is studies in comparison with with a previously published complex structure of emodin and maize CK2alpha.

  4. The regulatory subunit of protein kinase CK2 is identified as a novel intracellular partner of AdipoR1 and CK2 is shown to be an effector molecule in adiponectin signaling.

  5. CK2alpha-4 is a splicing variant of maize protein kinase CK2, and may function as a negative regulator of other CK2s.

Mouse (Murine) Casein Kinase 2, alpha 1 Polypeptide (CSNK2A1) interaction partners

  1. these data suggest that Fcgamma receptor/reactive oxygen species/CK2alpha is a key inducer of NF-kappaB activation in airway epithelial cells in a murine model of asthma

  2. Data (including data from studies using knockout mice) suggest that Brg1 is phosphorylated by casein kinase 2 (Ck2; Ck2alpha1 and Ck2alpha-prime are catalytic subunits) in proliferating skeletal myoblasts; Brg1 is catalytic subunit of SWI/SNF chromatin-remodeling enzymes; Ck2-mediated phosphorylation of Brg1 appears to regulate myoblast proliferation. (Brg1 = Brahma-related gene 1 protein)

  3. Casein kinase 2 plays a central role in striatal physiology and in severity of l-DOPA-induced dyskinesia.

  4. Casein kinase 1 (alpha, delta and epsilon) localize at the spindle poles, but may not be essential for mammalian oocyte meiotic progression.

  5. These data support a model in which activated Akt enhances rRNA synthesis both by preventing TIF-IA degradation and phosphorylating CK2alpha, which in turn phosphorylates TIF-IA.

  6. An essential role of CK2alpha in the mammalian circadian clock.

  7. receptor beta and its domains interact with casein kinase 2, phosphokinase C, and N-myristoylation sites of mitochondrial and nuclear proteins in mouse brain

  8. CK2alpha levels are predominant in comparison to CK2alpha' levels throughout the mammalian brain.

  9. The overall phenotype found in CK2alpha (-/- ) mice, is described.

  10. These experiments demonstrate that combined loss of one CK2alpha allele and both CK2alpha' alleles leads to unique abnormalities of growth and development.

  11. TNP1 is a newly identified binding partner of the alpha-subunit of casein kinase 2.

  12. Casein kinase II has a role in phosphorylation of NF-kappaB p65 subunit enhancement of inducible nitric-oxide synthase gene transcription

  13. CK2 selectively phosphorylates MKP3, suggesting cross-regulation between CK2alpha and MKP3, as well as a modulation of ERK2-MAPK signaling by CK2alpha via MKP3

  14. In cultured hippocampal neurons, the capacity of Nerve Growth Factor to promote axon elongation is mostly mediated by p75NTR, and the activation of this pathway leads to the inactivation of GSK-3beta.

  15. CK2 involvement in the phenomenon of the drug resistance was investigated.

  16. CK2alpha has an essential role in embryogenesis, as mice lacking CK2alpha die in mid-embryogenesis, with cardiac and neural tube defects.

  17. These results suggest that Ikaros acts as a negative regulator on iNOS expression.

  18. The balance between beta-arr and CK1/2 determines whether WNT/RAC-1 or other non-canonical WNT pathways are activated.

  19. reversible phosphorylation of CK2alpha requires precise regulation to allow proper mitotic progression

  20. CAPS activity in priming vesicle exocytosis requires CK2 phosphorylation

Cow (Bovine) Casein Kinase 2, alpha 1 Polypeptide (CSNK2A1) interaction partners

  1. Involvement of ubiquitous protein kinase CK2 in angiogenesis. Naturally derived CK2 inhibitors may be useful for treatment of proliferative retinopathies. (Protein kinase CK2)

Casein Kinase 2, alpha 1 Polypeptide (CSNK2A1) 抗原简介


Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene.

Gene names and symbols associated with CSNK2A1

  • casein kinase 2 alpha 1 (CSNK2A1) 抗体
  • casein kinase 2 alpha subunit (ck2a) 抗体
  • casein kinase 2 alpha subunit (Ck2a) 抗体
  • casein kinase 2, alpha 1 polypeptide (csnk2a1) 抗体
  • CK2 protein kinase alpha 2 (cka2) 抗体
  • casein kinase II alpha subunit (Ckiialpha) 抗体
  • Casein kinase II alpha subunit (CK2A1) 抗体
  • casein kinase 2 alpha 1 (Csnk2a1) 抗体
  • casein kinase 2, alpha 1 polypeptide (Csnk2a1) 抗体
  • casein kinase 2, alpha 1 polypeptide S homeolog (csnk2a1.S) 抗体
  • BmCK2a 抗体
  • CK-II 抗体
  • CK2 抗体
  • Ck2a 抗体
  • ck2a1 抗体
  • CKII 抗体
  • Ckiialpha 抗体
  • csnk2a1 抗体
  • Csnk2a1-rs4 抗体
  • CSNK2A3 抗体
  • wu:fi38e04 抗体
  • wu:fi38h03 抗体

Protein level used designations for CSNK2A1

CK II alpha 3 , CK2 catalytic subunit alpha , casein kinase II alpha 1 polypeptide pseudogene , casein kinase II alpha 1 subunit , casein kinase II subunit alpha , protein kinase CK2 , casein kinase 2 alpha subunit , ck2 alpha , casein kinase 2, alpha 1 polypeptide , casein kinase 2 protein catalytic subunit , casein kinase II subunit alpha-like , CK II alpha , casein kinase 2, alpha subunit , CK II , casein kinase II alpha subunit , CK2 alpha subunit , PCO082342 , PCO082342_ov , casein kinase2 subunit alpha , casein protein kinase subunit alpha , ck2a2 , Casein kinase II alpha subunit , casein kinase II, alpha 1 polypeptide , casein kinase II, alpha 1 related sequence 4 , Casein kinase II subunit alpha' , alpha subunit of casein kinase II

1457 Homo sapiens
445749 Ciona intestinalis
692502 Bombyx mori
30502 Danio rerio
477185 Canis lupus familiaris
100173187 Pongo abelii
100303588 Saccoglossus kowalevskii
100414021 Callithrix jacchus
100301533 Oryctolagus cuniculus
432370 Gallus gallus
542460 Zea mays
100121624 Nasonia vitripennis
100602220 Nomascus leucogenys
2898437 Paramecium tetraurelia strain d4-2
116549 Rattus norvegicus
12995 Mus musculus
399319 Xenopus laevis
282419 Bos taurus
100714882 Cavia porcellus
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