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ACCN3 encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. 再加上，我们可以发Amiloride-Sensitive Cation Channel 3 蛋白 (4)和数多这个蛋白质的别的产品。
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Muscles from horses submitted to strenuous exercises produce lactic acid, which may induce variable pain through ACCN (显示 ACCN1 抗体) differential properties; ACCN1 (显示 ACCN2 抗体) and ACCN3 genes have an ubiquitous expression but ACCN1 (显示 ACCN2 抗体) is more highly expressed in the spinal cord.
Acidic pH resulted in an increase in ASIC-3 expressionin the discs of paitents with intervertebral disc degeneration.
the data demonstrate a functional link between ASICs and [Ca(2 (显示 CA2 抗体)+)]i/RhoA (显示 RHOA 抗体) pathway, which contributes to the acidity-induced epithelial-mesenchymal transition.
The results show that acid-sensing ion channel 1 (显示 ACCN2 抗体), acid-sensing ion channel 2 (显示 ACCN1 抗体), and acid-sensing ion channel 3 are expressed in A549 cells at the messenger RNA and protein levels, and acid-sensing ion channel (显示 ACCN2 抗体)-like currents were elicited by extracellular acid stimuli.
Blocking ASIC3 in interneurons from temporal lobe epilepsy patients decreased the frequency of action potential firing.
These findings open new perspectives on the roles of ASIC3 in the absence of tissue pH variation, as well as on the contribution of those channels to lipid-mediated signaling.
Sea (显示 Slc25a1 抗体) anemone peptide with uncommon beta-hairpin structure inhibits acid-sensing ion channel 3 (ASIC3) and reveals analgesic activity.
Experiments with Asic3 inhibitors show that Asic3 inhibition leads to loss of pressure-induced vasodilation due to pressure detection failure rather than endothelial mechanisms.
The highly proton sensitive ASIC3 channels are predominantly distributed in peripheral sensory neurons, correlating with their roles in multimodal sensory perception, including nociception, mechanosensation, and chemosensation.
CAR and ASIC3 co-immunoprecipitate only when co-expressed with PSD-95 (显示 DLG4 抗体).
Lignan from thyme possesses inhibitory effect on ASIC3 channel current.
Targeted knockout of Asic3 disrupts spindle afferent sensitivity to dynamic stimuli and impairs mechanotransduction in dorsal root ganglion neurons because of substrate deformation-induced neurite stretching, but not to direct neurite indentation.
acid-sensing ion channel 3, activated by concomitant acid and certain pruritogens, constitute a novel signaling pathway that counteracts itch tachyphylaxis to successive pruritogenic stimulation.
a small conopeptide of only four amino acids from the venom of Conus textile that strongly potentiated currents of ASIC3, which has a specific role in the pain pathway. This peptide, RPRFamide, belongs to the subgroup of cono-RFamides.
High ASIC3 expression is associated with Bone Pain Induced by Multiple Myeloma.
This study suggested that the macrophage- and neutrophil-produced IL1beta (显示 IL1B 抗体) in the muscles during I/R activates enhanced IL1r1 (显示 IL1RN 抗体) in muscle afferents increase expression of ASIC3 possibly via JNK (显示 MAPK8 抗体) activation.
segmental analgesia of electroacupuncture-induced analgesia (EA) with lower intensity is partially mediated by ASIC3 receptor on Abeta (显示 APP 抗体)-fiber, whereas systemic analgesia induced by EA with higher intensity is more likely induced by TRPV1 (显示 TRPV1 抗体) receptor on Adelta- and C-fibers
the potentiation of ASICs by quinine depends on the presence of the ASIC1a (显示 ACCN2 抗体), ASIC2a (显示 ACCN1 抗体) subunits, but not ASIC1b, ASIC3 subunits. Furthermore, we have determined the amino acids in ASIC1a (显示 ACCN2 抗体) that are involved in the modulation of ASICs by pHi.
fatigue reduces pH in muscle that subsequently activates ASIC3 on macrophages to enhance hyperalgesia to muscle insult.
ASIC3 is critical for scratching behavior and pathological changes in chronic itch.
Data suggest that activation of acid-sensing ion channel 3 (ASIC3) on fibroblast-like synoviocytes (FLS) by acidic pH from an inflamed joint could limit synovial proliferation resulting in reduced inflammatory mediators and subsequent joint damage.
This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 2 has been observed as proton-gated channels sensitive to gadolinium. Alternatively spliced transcript variants have been described.
amiloride-sensitive cation channel 3
, amiloride-sensitive cation channel 3-like
, acid sensing ion channel 3
, acid-sensing ion channel 3
, dorsal root ASIC
, proton gated cation channel DRASIC
, amiloride-sensitive cation channel 3, testis
, modulatory subunit of ASIC2a
, neuronal amiloride-sensitive cation channel 3
, proton-gated cation channel subunit
, testis sodium channel 1