anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1 (ABCC1) 抗体

The protein encoded by ABCC1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. 再加上,我们可以发ABCC1 试剂盒 (30)ABCC1 蛋白 (11)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
ABCC1 4363 P33527
ABCC1 17250 O35379
ABCC1 24565 Q8CG09
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antibodies-online.cn销售最多的anti-ABCC1 抗体

Showing 10 out of 71 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 WB 100 μL Log in to see 2至3个工作日
非结合性 FACS, WB Western blot analysis of ABCC1 antibody (C-term) (ABIN390525) in Ramos cell line lysates (35 µg/lane). ABCC1 (arrow) was detected using the purified polyclonal antibody. Flow cytometric analysis of NCI-H292 cells using ABCC1 Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Log in to see 10至11个工作日
非结合性 EIA, WB 0.4 mL Log in to see 6至8个工作日
非结合性 IHC (p), WB Anti-MRP1 antibody, Western blotting Lane 1: JURKAT Cell Lysate Lane 2: CEM Cell Lysate Lane 3: A549 Cell Lysate Anti-MRP1 antibody, IHC(P) IHC(P): Human Lung Cancer Tissue 100 μg Log in to see 4至6个工作日
山羊 非结合性 ELISA, WB EB08734 (0.05µg/ml) staining of A549 lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6至7个工作日
Cow 非结合性 WB Western blot analysis of MRP expression in HEK293T (A), Raw264.7 (B), PC12 (C) whole cell lysates. 200 μL Log in to see 13至14个工作日
大鼠 非结合性 IHC (fro), IF, IHC (p), WB   1 mL Log in to see 6至8个工作日
小鼠 非结合性 IHC (fro), IF, IHC (p), WB   1 mL Log in to see 6至8个工作日
小鼠 Fluorescein FACS Detection of MRP1 in H69AR Human Cell Line by Flow Cytometry. H69AR human small cell lung cancer cell line was stained with Mouse Anti-Human MRP1 Fluorescein-conjugated Monoclonal Antibody. 100 Tests Log in to see 8至9个工作日
小鼠 PE FACS Detection of MRP1 in H69AR Human Cell Line by Flow Cytometry. H69AR human small cell lung cancer cell line was stained with Mouse Anti-Human MRP1 PE-conjugated Monoclonal Antibody. 100 Tests Log in to see 8至9个工作日

通过反应活性、应用领域、克隆类型和共轭标记 ABCC1 抗体

特性 应用范围 宿主 克隆类型 标记
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引用最多的anti-ABCC1 抗体

  1. Human Polyclonal ABCC1 Primary Antibody for IHC (p), WB - ABIN3044230 : Wang, Zhao, Wu, He, Qu, Zhao, Zhao, Li, Wang: Mechanistic analysis of taxol-induced multidrug resistance in an ovarian cancer cell line. in Asian Pacific journal of cancer prevention : APJCP 2013 (PubMed)
    Show all 2 Pubmed References

  2. Monoclonal ABCC1 Primary Antibody for IF, WB - ABIN534097 : Chen, Yang, Li, Zhang: The amino terminus of the human multidrug resistance transporter ABCC1 has a U-shaped folding with a gating function. in The Journal of biological chemistry 2006 (PubMed)

  3. Human Monoclonal ABCC1 Primary Antibody for FACS - ABIN4898743 : Takahashi, Shibata, Oba, Ishikawa, Yoshikawa, Tatsunami, Takahashi, Tampo: Multidrug-resistance-associated protein plays a protective role in menadione-induced oxidative stress in endothelial cells. in Life sciences 2009 (PubMed)

  4. Human Monoclonal ABCC1 Primary Antibody for FACS - ABIN4898742 : Keshet, Goldstein, Itzhaki, Cesarkas, Shenhav, Yakirevitch, Treves, Schachter, Amariglio, Rechavi: MDR1 expression identifies human melanoma stem cells. in Biochemical and biophysical research communications 2008 (PubMed)

  5. Human Monoclonal ABCC1 Primary Antibody for CyTOF, FACS - ABIN4900819 : Fiskus, Rao, Fernandez, Herger, Yang, Chen, Kolhe, Mandawat, Wang, Joshi, Eaton, Lee, Atadja, Peiper, Bhalla: Molecular and biologic characterization and drug sensitivity of pan-histone deacetylase inhibitor-resistant acute myeloid leukemia cells. in Blood 2008 (PubMed)


Human ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1 (ABCC1) interaction partners

  1. Data show that miR (显示 MLXIP 抗体)-145 level decreased in breast cancer tissues, breast cancer cell lines and doxorubicin resistant MCF-7 cells, and inversely correlated with multidrug resistance-associated protein 1 (MRP1) expression level.

  2. PG accumulation assay is a new, unique tool for the parallel determination of the function of the ABCG2 (显示 ABCG2 抗体), ABCB1 (显示 ABCB1 抗体), and ABCC1 multidrug transporters

  3. Authors make a strong correlation between induced SLAMF3 (显示 LY9 抗体) overexpression and the specific loss of MRP-1 (显示 MDM4 抗体) expression and its functionalities as a drugs resistance transporter.

  4. ABCC1 exports corticosterone but not cortisol. We show that ABCC1 is expressed in adipose tissue and that ABCC1 inhibition increases intracellular corticosterone, but not cortisol, and induces glucocorticoid-responsive gene transcription in adipocytes.

  5. GSK1904529A did not alter the expression level of MRP1 (显示 MDM4 抗体), induced a G0/G1 phase cell cycle arrest. Our results indicated that GSK1904529A significantly increased the sensitivity of MRP1 (显示 MDM4 抗体) overexpressing cells to chemotherapeutic agents.

  6. High MRP1 (显示 MDM4 抗体) expression is associated with ovarian cancer.

  7. These results show that multidrug resistant leukemia cell microparticle regulation of ABCC1 in recipient cells is governed by the transfer of both miR (显示 MLXIP 抗体)-326 and ABCB1 (显示 ABCB1 抗体) from donor cells

  8. Higher expression of ABCG2 (显示 ABCG2 抗体) and MRP1 (显示 MDM4 抗体), and lower expression of CK19 (显示 KRT19 抗体) in papillary thyroid carcinomas with a solid component were associated with higher tumor recurrence rate and shorter disease-free survival.

  9. Visfatin (显示 NAMPT 抗体) increases the nuclear translocation of Akt (显示 AKT1 抗体) and its binding with ABCC1. These data showed that visfatin (显示 NAMPT 抗体) can decrease doxorubicin sensitivity of Non-small-cell lung cancer cells via activation of Akt (显示 AKT1 抗体)/MRP1 (显示 MDM4 抗体).

  10. Studied hedgehog (显示 SHH 抗体) signaling effect thru ATP-binding cassette (ABC (显示 ABCB6 抗体)) transporters in hepatoma drug sensitivity. Results suggest Hedgehog (显示 SHH 抗体) signaling transcription factor Gli-2 (显示 GLI2 抗体) to be the primary regulator for drug sensitivity of hepatoma through the ABCC1 transporter.

Cow (Bovine) ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1 (ABCC1) interaction partners

  1. Using electron cryomicroscopy, authors determined the molecular structures of bovine MRP1 in two conformations: an apo (显示 C9orf3 抗体) form at 3.5 A without any added substrate and a complex form at 3.3 A with one of its physiological substrates, leukotriene C4; structures show that by forming a single bipartite binding site, MRP1 can recognize a of substrates with different chemical structures.

  2. P-gp (显示 ABCB4 抗体), Bcrp (显示 ABCG2 抗体) and Mrp1 are functionally expressed in bovine/rat co-culture model and model is suitable for investigations of small molecule transport.

Mouse (Murine) ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1 (ABCC1) interaction partners

  1. Mrp1 protects cardiac myocytes and fibroblasts against doxorubicin-induced toxicity, potentially by regulating extracellular redox states.

  2. Loss of ABCC1 expression is associated with neonatal hyperbilirubinemia.

  3. Data, including data from studies in knockout mice, suggest that Mrp1 is involved in development of vascular endothelial dysfunction in diabetic angiopathy; Mrp1 appears to be required for oxidative stress in endothelial cells due to hyperglycemia.

  4. Oxidant-enriched Tumorigenic Endothelial Cells (EOMA) cells survive a heavy oxidant burden by rapid efflux of GSSG, which is lethal if trapped within the cell. A hyperactive MRP-1 system for GSSG efflux acts as a critical survival factor for these cells, making it a potential target for EOMA therapeutics.

  5. P-gp, Bcrp, Mrp1 and Mrp4 are differentially expressed at the outer and inner blood retinal barrier, resulting in an altered ability to limit substrate distribution at the retina as compared with the blood brain barrier

  6. Lentivirus-based RNAi stably knocks down the expression of the Mrp1 gene in the established TM4 (显示 TPM4 抗体) sertoli cell line.

  7. neprilysin (显示 MME 抗体) x ABCC1 double-deficient mice present a new model for early effects of amyloid-beta-related mild cognitive impairment that allows investigations without artificial overexpression of inherited Alzheimer's disease genes

  8. Expression of apoA-I (显示 APOA1 抗体) or ABCA1 (显示 ABCA1 抗体) can reduce steatosis by decreasing lipid storage in hepatocytes through lipid transport and may also reduce endoplasmic reticulum stress, further lessening hepatic steatosis

  9. Loss of Mrp1 coupled with reductions in steroid hormone levels leads to alterations in extrahepatic phase I, phase II and phase III metabolizing enzymes in a tissue-specific manner.

  10. Cd or H(2)O(2) exposure increased the expression of key transport genes, Mrp1 and Mrp2 (显示 ABCC2 抗体), in WT cells but not in metallothionein (显示 MT 抗体)-null cells.

Rabbit ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1 (ABCC1) interaction partners

  1. MRP1 appears to be primarily localized in the basolateral membrane of conjunctival epithelial cells and functions in the efflux of certain organic anions and inflammatory factors

ABCC1 抗原简介


The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown.

Gene names and symbols associated with ABCC1

  • ATP binding cassette subfamily C member 1 (ABCC1) 抗体
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 1 (Abcc1) 抗体
  • ATP binding cassette subfamily C member 1 (Abcc1) 抗体
  • ABC29 抗体
  • ABCC 抗体
  • Abcc1a 抗体
  • Abcc1b 抗体
  • Avcc1a 抗体
  • GS-X 抗体
  • Mdrap 抗体
  • Mrp 抗体
  • Mrp1 抗体

Protein level used designations for ABCC1

ATP-binding cassette transporter variant ABCC1delta-ex13 , ATP-binding cassette transporter variant ABCC1delta-ex13&14 , ATP-binding cassette transporter variant ABCC1delta-ex25 , ATP-binding cassette transporter variant ABCC1delta-ex25&26 , LTC4 transporter , leukotriene C(4) transporter , multidrug resistance-associated protein 1 , ATP-binding cassette sub-family C member 1 , multidrug resistance protein 1 , ATP-binding cassette, sub-family C (CFTR/MRP), member 1a , ATP-binding cassette, sub-family C (CFTR/MRP), member 1b , multiple drug resistance-associated protein , ATP-binding cassette sub-family C ( CFTR/MRP) member 1a , ATP-binding cassette, sub-family C (CFTR/MRP), member 1 , ATP-binding cassette superfamily member C1 , ATP-binding cassette transporter sub-family C member 1 , ATP-binding cassette, sub-family C, member 1 , multiple drug resistance protein 1

4363 Homo sapiens
281588 Bos taurus
395416 Gallus gallus
403453 Canis lupus familiaris
17250 Mus musculus
24565 Rattus norvegicus
100734674 Cavia porcellus
733619 Sus scrofa
791240 Equus caballus
100345841 Oryctolagus cuniculus
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