anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1 (ABCC1) 抗体

The protein encoded by ABCC1 is a member of the superfamily of ATP-binding cassette (ABC) transporters.

列出全部抗体 基因 基因ID UniProt
 ABCC1 ABCC1 4363 P33527
小鼠 ABCC1 ABCC1 17250 O35379
大鼠 ABCC1 ABCC1 24565 Q8CG09
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antibodies-online.cn销售最多的anti-ABCC1 抗体

Showing 10 out of 127 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 WB WB Suggested Anti-ABCC1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  Human Lung 100 μL Log in to see 2至3个工作日
非结合性 IHC (p), WB Anti-MRP1 antibody, Western blotting Lane 1: JURKAT Cell Lysate Lane 2: CEM Cell Lysate Lane 3: A549 Cell Lysate Anti-MRP1 antibody, IHC(P) IHC(P): Human Lung Cancer Tissue 100 μg Log in to see 4至6个工作日
山羊 非结合性 ELISA, WB EB08734 (0.05µg/ml) staining of A549 lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6至7个工作日
Cow 非结合性 WB Western blot analysis of MRP expression in HEK293T (A), Raw264.7 (B), PC12 (C) whole cell lysates. 200 μL Log in to see 13至14个工作日
大鼠 非结合性 IHC (fro), IF, IHC (p), WB   1 mL Log in to see 6至8个工作日
非结合性 FACS, WB Western blot analysis of ABCC1 antibody (C-term) (ABIN390525) in Ramos cell line lysates (35 µg/lane). ABCC1 (arrow) was detected using the purified polyclonal antibody. Flow cytometric analysis of NCI-H292 cells using ABCC1 Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Log in to see 10至11个工作日
小鼠 非结合性 IHC (fro), IF, IHC (p), WB   1 mL Log in to see 6至8个工作日
小鼠 Fluorescein FACS Detection of MRP1 in H69AR Human Cell Line by Flow Cytometry. H69AR human small cell lung cancer cell line was stained with Mouse Anti-Human MRP1 Fluorescein-conjugated Monoclonal Antibody. 100 Tests Log in to see 8至9个工作日
小鼠 PE FACS Detection of MRP1 in H69AR Human Cell Line by Flow Cytometry. H69AR human small cell lung cancer cell line was stained with Mouse Anti-Human MRP1 PE-conjugated Monoclonal Antibody. 100 Tests Log in to see 8至9个工作日
非结合性 EIA, WB 0.4 mL Log in to see 6至8个工作日

引用最多的anti-ABCC1 抗体

  1. Human Polyclonal ABCC1 Primary Antibody for IHC (p), WB - ABIN3044230 : Wang, Zhao, Wu, He, Qu, Zhao, Zhao, Li, Wang: Mechanistic analysis of taxol-induced multidrug resistance in an ovarian cancer cell line. in Asian Pacific journal of cancer prevention : APJCP 2013 (PubMed)
    Show all 2 Pubmed References

  2. Human Monoclonal ABCC1 Primary Antibody for FACS - ABIN4898742 : Keshet, Goldstein, Itzhaki, Cesarkas, Shenhav, Yakirevitch, Treves, Schachter, Amariglio, Rechavi: MDR1 expression identifies human melanoma stem cells. in Biochemical and biophysical research communications 2008 (PubMed)

  3. Human Monoclonal ABCC1 Primary Antibody for CyTOF, FACS - ABIN4900819 : Fiskus, Rao, Fernandez, Herger, Yang, Chen, Kolhe, Mandawat, Wang, Joshi, Eaton, Lee, Atadja, Peiper, Bhalla: Molecular and biologic characterization and drug sensitivity of pan-histone deacetylase inhibitor-resistant acute myeloid leukemia cells. in Blood 2008 (PubMed)

  4. Human Monoclonal ABCC1 Primary Antibody for FACS - ABIN4898743 : Takahashi, Shibata, Oba, Ishikawa, Yoshikawa, Tatsunami, Takahashi, Tampo: Multidrug-resistance-associated protein plays a protective role in menadione-induced oxidative stress in endothelial cells. in Life sciences 2009 (PubMed)

  5. Monoclonal ABCC1 Primary Antibody for IF, WB - ABIN534097 : Chen, Yang, Li, Zhang: The amino terminus of the human multidrug resistance transporter ABCC1 has a U-shaped folding with a gating function. in The Journal of biological chemistry 2006 (PubMed)


Human ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1 (ABCC1) interaction partners

  1. Enhanced BRAF (显示 BRAF 抗体)-mediated NRF2 (显示 GABPA 抗体) gene transcription and Histone Acetyltransferases-mediated NRF2 (显示 GABPA 抗体) protein acetylation contributes to ABCC1-mediated chemoresistance and glutathione-mediated survival in acquired topoisomerase II (显示 TOP2 抗体) poison-resistant cancer cells.

  2. Pomolic acid also down-modulated the activity of the multidrug resistance associated protein 1 (MRP1) and inhibited migration of Glioblastoma (GBM) cells. These results show that PA acts on several pathways of GBM drug resistance and therefore may be of potential interest for the treatment of this tumor

  3. Our data present for the very first time the high negative correlation between MRP1 (显示 MDM4 抗体) protein expression in LSC (显示 ARHGEF1 抗体) and AML (显示 RUNX1 抗体) patients' remission. It does strongly suggest that MRP1 (显示 MDM4 抗体) expression in LSC (显示 ARHGEF1 抗体) is an adverse prognostic marker in patients with de novo AML (显示 RUNX1 抗体).

  4. These data showed that Wls (显示 WLS 抗体) was differentially expressed in HCC (显示 FAM126A 抗体). Statistical analysis results suggest that Wls (显示 WLS 抗体) expression might increase as HCC (显示 FAM126A 抗体) progresses.

  5. No significant correlation was observed between rs504348 genotypes and cystic fibrosis (显示 S100A8 抗体) severity. A significantly higher expression of ABCC1 mRNA was induced by CF plasma compared to healthy control plasma.

  6. MRP1 (显示 MDM4 抗体) is regulated by CLIC1 (显示 CLIC1 抗体), leading to CLIC1 (显示 CLIC1 抗体)-mediated development of chemoresistance in choriocarcinoma cells.

  7. Wls (显示 WLS 抗体)-SEC12 (显示 PREB 抗体) binding is stable, with the interacting interface biochemically mapped to cytosolic segments of individual proteins. Mutant Wls (显示 WLS 抗体) that fails to communicate with the COPII machinery cannot effectively support Wnt (显示 WNT2 抗体) secretion. These data suggest that formation of early Wnt (显示 WNT2 抗体) secretory vesicles is carefully regulated to ensure proper export of functional ligands

  8. High MRP1 (显示 MDM4 抗体) expression is associated with resistance to doxorubicin in breast cancer.

  9. Our data indicates that hypomethylation of the ABCC1 promoter is not cancer type-specific but occurs in cancer cell lines of different origins.

  10. Our work demonstrates for the first time that the adaptation to endoplasmic reticulum(ER) stress in cancer cells produces a MDR phenotype. The PERK (显示 EIF2AK3 抗体)/Nrf2 (显示 GABPA 抗体)/MRP1 (显示 MDM4 抗体) axis is responsible for the resistance to ER stress and chemotherapy, and may represent a good therapeutic target in aggressive and resistant tumors.

Cow (Bovine) ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1 (ABCC1) interaction partners

  1. Using electron cryomicroscopy, authors determined the molecular structures of bovine MRP1 in two conformations: an apo (显示 C9orf3 抗体) form at 3.5 A without any added substrate and a complex form at 3.3 A with one of its physiological substrates, leukotriene C4; structures show that by forming a single bipartite binding site, MRP1 can recognize a of substrates with different chemical structures.

  2. P-gp (显示 ABCB4 抗体), Bcrp and Mrp1 are functionally expressed in bovine/rat co-culture model and model is suitable for investigations of small molecule transport.

Mouse (Murine) ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1 (ABCC1) interaction partners

  1. Mrp1 protects cardiac myocytes and fibroblasts against doxorubicin-induced toxicity, potentially by regulating extracellular redox states.

  2. Loss of ABCC1 expression is associated with neonatal hyperbilirubinemia.

  3. Data, including data from studies in knockout mice, suggest that Mrp1 is involved in development of vascular endothelial dysfunction in diabetic angiopathy; Mrp1 appears to be required for oxidative stress in endothelial cells due to hyperglycemia.

  4. Oxidant-enriched Tumorigenic Endothelial Cells (EOMA) cells survive a heavy oxidant burden by rapid efflux of GSSG, which is lethal if trapped within the cell. A hyperactive MRP-1 system for GSSG efflux acts as a critical survival factor for these cells, making it a potential target for EOMA therapeutics.

  5. P-gp, Bcrp, Mrp1 and Mrp4 are differentially expressed at the outer and inner blood retinal barrier, resulting in an altered ability to limit substrate distribution at the retina as compared with the blood brain barrier

  6. Lentivirus-based RNAi stably knocks down the expression of the Mrp1 gene in the established TM4 (显示 TPM4 抗体) sertoli cell line.

  7. neprilysin (显示 MME 抗体) x ABCC1 double-deficient mice present a new model for early effects of amyloid-beta-related mild cognitive impairment that allows investigations without artificial overexpression of inherited Alzheimer's disease genes

  8. Expression of apoA-I (显示 APOA1 抗体) or ABCA1 (显示 ABCA1 抗体) can reduce steatosis by decreasing lipid storage in hepatocytes through lipid transport and may also reduce endoplasmic reticulum stress, further lessening hepatic steatosis

  9. Loss of Mrp1 coupled with reductions in steroid hormone levels leads to alterations in extrahepatic phase I, phase II and phase III metabolizing enzymes in a tissue-specific manner.

  10. Cd or H(2)O(2) exposure increased the expression of key transport genes, Mrp1 and Mrp2 (显示 ABCC2 抗体), in WT cells but not in metallothionein (显示 MT 抗体)-null cells.

Rabbit ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1 (ABCC1) interaction partners

  1. MRP1 appears to be primarily localized in the basolateral membrane of conjunctival epithelial cells and functions in the efflux of certain organic anions and inflammatory factors

ABCC1 抗原简介


Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity).

Gene names and symbols associated with ABCC1

  • ATP binding cassette subfamily C member 1 (ABCC1) 抗体
  • wntless Wnt ligand secretion mediator (WLS) 抗体
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 1 (Abcc1) 抗体
  • ATP binding cassette subfamily C member 1 (Abcc1) 抗体
  • ABC29 抗体
  • ABCC 抗体
  • Abcc1a 抗体
  • Abcc1b 抗体
  • Avcc1a 抗体
  • C1orf139 抗体
  • EVI 抗体
  • GPR177 抗体
  • GS-X 抗体
  • Mdrap 抗体
  • mig-14 抗体
  • Mrp 抗体
  • Mrp1 抗体

Protein level used designations for ABCC1

ATP-binding cassette transporter variant ABCC1delta-ex13 , ATP-binding cassette transporter variant ABCC1delta-ex13&14 , ATP-binding cassette transporter variant ABCC1delta-ex25 , ATP-binding cassette transporter variant ABCC1delta-ex25&26 , LTC4 transporter , leukotriene C(4) transporter , multidrug resistance-associated protein 1 , G protein-coupled receptor 177 , integral membrane protein GPR177 , protein evenness interrupted homolog , protein wntless homolog , putative NF-kappa-B-activating protein 373 , putative NFkB activating protein 373 , ATP-binding cassette sub-family C member 1 , multidrug resistance protein 1 , ATP-binding cassette, sub-family C (CFTR/MRP), member 1a , ATP-binding cassette, sub-family C (CFTR/MRP), member 1b , multiple drug resistance-associated protein , ATP-binding cassette sub-family C ( CFTR/MRP) member 1a , ATP-binding cassette, sub-family C (CFTR/MRP), member 1 , ATP-binding cassette superfamily member C1 , ATP-binding cassette transporter sub-family C member 1 , ATP-binding cassette, sub-family C, member 1 , multiple drug resistance protein 1

4363 Homo sapiens
79971 Homo sapiens
281588 Bos taurus
395416 Gallus gallus
403453 Canis lupus familiaris
17250 Mus musculus
24565 Rattus norvegicus
100734674 Cavia porcellus
733619 Sus scrofa
791240 Equus caballus
100345841 Oryctolagus cuniculus