anti-APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2) 抗体

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. 再加上,我们可以发APEX2 试剂盒 (4)APEX2 蛋白 (3)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
APEX2 27301 Q9UBZ4
APEX2 77622 Q68G58
APEX2 317628  
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antibodies-online.cn销售最多的anti-APEX2 抗体

Showing 10 out of 55 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 交付 价格 详细
大鼠 非结合性 WB Western blot analysis of APEX2 expression in rat kidney extract ( Lane 1). APEX2 at 57KD was detected using rabbit anti- APEX2 Antigen Affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL. The blot was developed using chemiluminescence (ECL) method (Catalog # EK1002). 100 μg 4至6个工作日
Cow 非结合性 IHC, IHC (p), WB Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-APEX2 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. 50 μL 11至14个工作日
非结合性 IHC (p), WB 50 μL 6至8个工作日
非结合性 FACS, IF, IHC (p), WB Western Blot at 1:1000 dilution + MCF-7 whole cell lysate Lysates/proteins at 20 ug per lane. Immunofluorescent analysis of U251 cells, using APEX2 Antibody . Antibody was diluted at 1:25 dilution. Alexa Fluor 488-conjugated goat anti-rabbit lgG at 1:400 dilution was used as the secondary antibody (green). Cytoplasmic actin was counterstained with Dylight Fluor 554 (red) conjugated Phalloidin (red). 400 μL 2至3个工作日
非结合性 IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain labeled with Anti-APEX2 Polyclonal Antibody, Unconjugated (ABIN718481) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL 3至7个工作日
Cow 非结合性 IHC, IHC (p), WB   100 μg 11至14个工作日
Alexa Fluor 594 IF (p)   100 μL 14至21个工作日
非结合性 IHC, ELISA   100 μL 11至14个工作日
小鼠 非结合性 IF, WB Western Blot analysis of APEX2 expression in transfected 293T cell line by APEX2 MaxPab polyclonal antibody.Lane 1: APEX2 transfected lysate(56.98 KDa).Lane 2: Non-transfected lysate. Immunofluorescence of purified MaxPab antibody to APEX2 on HeLa cell. [antibody concentration 10 ug/ml] 50 μg 11至12个工作日
非结合性 WB APEXL2 pAb tested by Western blot. APEXL2 detection by Western blot. The analysis of APEXL2 was performed using HeLa whole-cell extract and APEXL2 pAb at a 1:500 dilution. 200 μL 1至2个工作日

引用最多的anti-APEX2 抗体

  1. Human Polyclonal APEX2 Primary Antibody for WB - ABIN4281061 : Karkhanis, Wang, Tae, Hu, Imbalzano, Sif: Protein arginine methyltransferase 7 regulates cellular response to DNA damage by methylating promoter histones H2A and H4 of the polymerase δ catalytic subunit gene, POLD1. in The Journal of biological chemistry 2012 (PubMed)

  2. Human Polyclonal APEX2 Primary Antibody for ICC, IF - ABIN5075036 : Mengwasser, Adeyemi, Leng, Choi, Clairmont, DAndrea, Elledge: Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets. in Molecular cell 2019 (PubMed)


Human APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2) interaction partners

  1. Identified APEX2 and FEN1 as synthetic lethal genes with both BRCA1 and BRCA2 loss of function in tumor cell lines.

  2. Single-Strand Break End Resection in Genome Integrity: Mechanism and Regulation by APE2.

  3. Determinants in nuclease specificity of Ape1 and Ape2, human homologues of Escherichia coli exonuclease III

  4. Ape2 exhibits strong 3'-5' exonuclease and 3'-phosphodiesterase activities and has only a very weak AP-endonuclease activity.

  5. Ape2 may be involved in repair of oxidative DNA damage and PCNA-dependent repair synthesis.

  6. Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia.

Xenopus laevis APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2) interaction partners

  1. APE2 promotes ATR-Chk1 DNA damage response pathway from a single-strand break.

  2. APE2 associates with Chk1; a serine residue (S86) in the Chk1-binding motif of APE2 is essential for Chk1 phosphorylation, indicating a Claspin-like but distinct role for APE2 in ATR-Chk1 signaling.

Mouse (Murine) APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2) interaction partners

  1. expression of Apex 2 in chondrocytes appears to be associated with the degeneration of articular cartilage in osteoarthritis.

  2. Results indicate a role for apurinic/apyrimidinic endonuclease (APE) 2 (Apex2) in the protection of germinal center (GC) cells from activation-induced cytidine deaminase (AID)-independent damage.

  3. data provide new insight into error-prone repair of AID-induced lesions, which we propose is facilitated by down-regulation of APE1 and up-regulation of APE2 expression in germinal center B cells.

  4. Extensive analysis of bone marrow hematopoiesis in APE2-deficient mice finds inhibition of the pro-B to pre-B lymphocyte transition, due to a p53-dependent DNA damage response, independent from its ubiquitous and essential homolog APE1.

  5. may participate in postreplicative base excision repair

  6. APEX2 is required for proper cell cycle progression of proliferating lymphocytes.

  7. Both APE1 and APE2 function in antibody switch recomibination, resulting in double stranded breaks necesary for this recombination.

  8. The present study clearly demonstrates that APEX2-null lymphocytes have a higher frequency of DNA breaks, indicating that APEX2 may play an important role(s) during their generation and/or repair.

  9. Apex2 is required for efficient somatic hypermutation of immunoglobulin genes.

APEX2 抗原简介


Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with APEX2

  • apurinic/apyrimidinic endodeoxyribonuclease 2 (APEX2) 抗体
  • apurinic/apyrimidinic endodeoxyribonuclease 2 (apex2) 抗体
  • APEX nuclease (apurinic/apyrimidinic endonuclease) 2 (apex2) 抗体
  • apurinic/apyrimidinic endodeoxyribonuclease 2 L homeolog (apex2.L) 抗体
  • APEX nuclease (apurinic/apyrimidinic endonuclease) 2 (APEX2) 抗体
  • apurinic/apyrimidinic endonuclease 2 (Apex2) 抗体
  • apurinic/apyrimidinic endodeoxyribonuclease 2 (Apex2) 抗体
  • ape2 抗体
  • apexl2 抗体
  • C430040P13Rik 抗体
  • xth2 抗体
  • zgc:55889 抗体

Protein level used designations for APEX2

AP endonuclease 2 , AP endonuclease XTH2 , DNA-(apurinic or apyrimidinic site) lyase 2 , apurinic/apyrimidinic endonuclease-like 2 , APEX nuclease 2 , apurinic-apyrimidinic endonuclease 2 , APEX nuclease (apurinic/apyrimidinic endonuclease) 2 , DNA-(apurinic or apyrimidinic site) lyase 2-like

27301 Homo sapiens
448512 Xenopus (Silurana) tropicalis
393115 Danio rerio
446614 Xenopus laevis
491499 Canis lupus familiaris
511790 Bos taurus
702084 Macaca mulatta
100410557 Callithrix jacchus
100434759 Pongo abelii
77622 Mus musculus
317628 Rattus norvegicus
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