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Human WNT1 Protein expressed in Escherichia coli (E. coli) - ABIN413893
Tawk, Makoukji, Belle, Fonte, Trousson, Hawkins, Li, Ghandour, Schumacher, Massaad: Wnt/beta-catenin signaling is an essential and direct driver of myelin gene expression and myelinogenesis. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2011
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maternal Wnt (显示 WNT2 蛋白)/STOP signaling, but not beta-catenin (显示 CTNNB1 蛋白) signaling, has a role in cleavage after fertilization and cell cycle progression
sfrp1 (显示 SFRP1 蛋白) promotes cardiomyocyte differentiation in Xenopus via negative-feedback regulation of Wnt (显示 WNT2 蛋白) signalling.
analysis of differential role of Axin (显示 AXIN1 蛋白) RGS (显示 PITX2 蛋白) domain function in Wnt (显示 WNT2 蛋白) signaling during anteroposterior patterning and maternal axis formation
Data show taht combined Wnt (显示 WNT2 蛋白) and Nodal signaling synergistically activates transcription of Spemann organizer genes.
The authors propose that these dual functions of DP1 (显示 TFDP1 蛋白) can promote and stabilize biphasic Wnt (显示 WNT2 蛋白)-on and Wnt (显示 WNT2 蛋白)-off states in response to a gradual gradient of Wnt (显示 WNT2 蛋白)/beta-catenin (显示 CTNNB1 蛋白) signalling to determine differential cell fates.
Pax9 (显示 PAX9 蛋白)-dependent Wnt (显示 WNT2 蛋白) signaling has a role in palatogenesis and cleft palates
Data show that autocrine Wnt (显示 WNT2 蛋白) secretion is important for the survival, chromosomal stability, differentiation, and tumorigenic potential of embryonic stem cells (ESCs (显示 NR2E3 蛋白)).
Results demonstrated functional differences in the molecular mechanisms downstream of Wnt1 function in the diencephalon, in relation to the spinal cord. Wnt1 signal determines the patterning of the diencephalic dorso-ventral axis
Data show that both transgenic Wnt1-cre and P0-cre are similarly effective in deleting beta-catenin (显示 CTNNB1 蛋白) in the neural crest.
data suggest that WNT1-related osteogenesis imperfecta (显示 COL1A2 蛋白) and osteoporosis are caused in part by decreased mTORC1-dependent osteoblast function resulting from loss of WNT1 signaling in osteocytes.
Administration of EET alters Wnt1, NOV (显示 NOV 蛋白), and HO-1 (显示 HMOX1 蛋白) signaling to prevent obesity-induced cardiomyopathy in obese mice.
Data indicate that Wnt1 proto-oncogene (显示 RAB1A 蛋白) protein (WNT1) is the direct target of microRNA miR (显示 MLXIP 蛋白)-34a in dendritic cell (DC).
In order to evaluate the function of IFT88 (显示 IFT88 蛋白) in regulating craniofacial development, we generated Wnt1-Cre;Ift88fl/fl mice to eliminate Ift88 (显示 IFT88 蛋白) specifically in cranial neural crest (CNC) cells. Wnt1-Cre;Ift88fl/flpups died at birth due to severe craniofacial defects including bilateral cleft lip and palate and tongue agenesis, following the loss of the primary cilia in the CNC-derived palatal mesenchyme
Wnt (显示 WNT2 蛋白), Eda (显示 EDA 蛋白), and Shh (显示 SHH 蛋白) have roles in touch dome Merkel cell development
The data obtained from the 14-3-3epsilon/14-3-3zeta (显示 YWHAZ 蛋白)/Wnt1-Cre mice strongly indicate the importance of 14-3-3 (显示 YWHAQ 蛋白) proteins in the development of melanocyte lineages.
High WNT1 expression in stromal cells is associated with myelodysplastic syndrome.
High WNT1 expression is associated with gastric cancer.
Novel compound heterozygous WNT1 missense mutations, p.Glu123Asp and p.Cys153Gly, identified in a patient with osteogenesis imperfecta (显示 COL1A2 蛋白).
Osteocyte protein expression is altered in patients with osteoporosis caused by WNT1 mutation.
High WNT1 expression is associated with glioma cell invasion.
bone formation is under the control of WNT1 produced by osteocytes, the cells that reside deep in the bone matrix and form dendritic networks.
Knocking down of Wnt-1 by siRNA had the similar effect of miRNA-148a overexpression on cell migration and invasion in lung cancer cells.
High WNT1 expression is associated with Lung Adenocarcinoma Progression.
WNT1 overexpression is associated with Breast Cancer Invasion and Metastasis.
PKA signaling is pivotal in pigmentation process itself in cultured melanoma cells, while the importance of Wnt (显示 WNT2 蛋白)/beta-catenin (显示 CTNNB1 蛋白) signaling should be emphasized in the context of development and differentiation
Data indicate that Wnt-1 protein is present in postdevelopmental endothelial cells where it associates with cytoskeletal elements and may retain function as a tissue polarity gene.
Rspo1-Wnt-VegfC-Vegfr3 signaling plays a crucial role as an endothelial-autonomous permissive cue for developmental angiogenesis.
wnt1 and wnt10b (显示 WNT10B 蛋白) are required to maintain threshold levels of Pax2.1 and Fgf8 (显示 FGF8 蛋白) at the midbrain-hindbrain boundary.
novel role for Wnt (显示 WNT2 蛋白)/beta-catenin (显示 CTNNB1 蛋白) signalling in determining endocardial cell fate
In zebrafish embryos lacking Wnt3a (显示 WNT3A 蛋白), Wnt1 and Wnt10b (显示 WNT10B 蛋白), the expression of engrailed orthologs, pax2a and fgf8 (显示 FGF8 蛋白) is not maintained after mid-somitogenesis
two Dvl (显示 DVL2 蛋白)-associated paralogs, Dpr1 (显示 DACT1 蛋白) and Dpr2 (显示 DACT2 蛋白), participate in distinct Wnt (显示 WNT2 蛋白)-dependent developmental processes
Wnt (显示 WNT2 蛋白)/Axin (显示 AXIN1 蛋白)/beta-catenin (显示 CTNNB1 蛋白) pathway has a role in ventral CNS development
The boundary and roof plate expression of wnt1 each contribute to upregulation of proneural and delta gene expression and neurogenesis in non-boundary regions.
Epistatic analyses suggest a possible genetic interaction between Wnt (显示 WNT2 蛋白)/beta-catenin (显示 CTNNB1 蛋白) and Myostatin (显示 MSTN 蛋白) in regulation of slow and fast twitch muscle myofibrillogenesis
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region.
, protein Wnt-1
, proto-oncogene Int-1
, proto-oncogene Wnt-1
, proto-oncogene protein Wnt-1
, proto-oncogene Int-1 homolog
, wingless-type MMTV integration site family, member 1 (oncogene INT1)
, Wingless-type MMTV integration site 1 homolog
, Wingless-type MMTV integration site 1, homolog
, wingless-related MMTV integration site 1
, murine mammary tumor virus integration site
, wingless-type MMTV integration site family member 1