WNT signaling

Wnts are a class of evolutionarily-conserved, lipid-modified glycoproteins that play a pivotal role in development and homeostasis through a number of different paracrine and autocrine signal-transduction pathways. During early development, Wnt signaling plays a major role in axon guidance, cell polarity, and body axis specification.

Extracellular Wnts bind a variety of different receptors, and initiate signaling in several distinct pathways. Receptors include seven-pass transmembrane Frizzleds and receptor tyrosine kinases ROR and Ryk.

Wnt signaling pathways can result in changes to gene transcription. For example, in the canonical β-catenin signaling pathway Wnt signaling prevents destruction of the transcriptional regulator β-catenin. Wnt signaling can also prompt morphological changes to cellular structure e.g., the non-canonical planar cell polarity pathway induces a kinase cascade that results in reorganization of actin, a core component of the cytoskeleton.

Antagonists

DKK1 (Dickkopf Homolog 1 (Xenopus Laevis)):

The dickkopf protein family interacts with the Wnt signaling pathway and its members are characterized by two conserved cysteine-rich domains. This gene encodes a secreted protein that has low sequence similarity to the dickkopf-3 protein. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2010].   更多...
此分类里的别的抗原:
DKK4 (Dickkopf Homolog 4 (Xenopus Laevis)): DKK4 抗体 DKK4 ELISA试剂盒 DKK4 蛋白
KREMEN1 (Kringle Containing Transmembrane Protein 1): KREMEN1 抗体 KREMEN1 ELISA试剂盒 KREMEN1 蛋白
KREMEN2 (Kringle Containing Transmembrane Protein 2): KREMEN2 抗体 KREMEN2 ELISA试剂盒 KREMEN2 蛋白
DKK2 (Dickkopf 2 Homolog (Xenopus Laevis)): DKK2 抗体 DKK2 ELISA试剂盒 DKK2 蛋白
FRZB (Frizzled-Related Protein): FRZB 抗体 FRZB ELISA试剂盒 FRZB 蛋白
IGFBP4 (Insulin-Like Growth Factor Binding Protein 4): IGFBP4 抗体 IGFBP4 ELISA试剂盒 IGFBP4 蛋白
IGFBP5 (Insulin-Like Growth Factor Binding Protein 5): IGFBP5 抗体 IGFBP5 ELISA试剂盒 IGFBP5 蛋白
IGFBP6 (Insulin-Like Growth Factor Binding Protein 6): IGFBP6 抗体 IGFBP6 ELISA试剂盒 IGFBP6 蛋白
SFRP1 (Secreted Frizzled-Related Protein 1): SFRP1 抗体 SFRP1 ELISA试剂盒 SFRP1 蛋白
SFRP2 (Secreted Frizzled-Related Protein 2): SFRP2 抗体 SFRP2 ELISA试剂盒 SFRP2 蛋白
SFRP4 (Secreted Frizzled-Related Protein 4): SFRP4 抗体 SFRP4 ELISA试剂盒 SFRP4 蛋白
SFRP5 (Secreted Frizzled-Related Protein 5): SFRP5 抗体 SFRP5 ELISA试剂盒 SFRP5 蛋白
WIF1 (WNT Inhibitory Factor 1): WIF1 抗体 WIF1 ELISA试剂盒 WIF1 蛋白
ZNRF3 (Zinc and Ring Finger Protein 3): ZNRF3 抗体   ZNRF3 蛋白

beta-Catenin Pathway

APC - Adenomatous Polyposis Coli

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated...   更多...

CSNK1A1 (Casein Kinase 1, alpha 1):

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member...   更多...

TCF7L1 (Transcription Factor 7-Like 1 (T-Cell Specific, HMG-Box)):

This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell...   更多...

TCF7L2 (Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box)):

This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq,...   更多...
此分类里的别的抗原:
AES (Amino-terminal Enhancer of Split): AES 抗体 AES ELISA试剂盒 AES 蛋白
AXIN1 (Axin 1): AXIN1 抗体 AXIN1 ELISA试剂盒 AXIN1 蛋白
CTNNB1 (Catenin (Cadherin-Associated Protein), beta 1, 88kDa): CTNNB1 抗体 CTNNB1 ELISA试剂盒 CTNNB1 蛋白
DVL1 (Dishevelled, Dsh Homolog 1 (Drosophila)): DVL1 抗体 DVL1 ELISA试剂盒 DVL1 蛋白
GSK3a - GSK3 alpha: GSK3a 抗体 GSK3a ELISA试剂盒 GSK3a 蛋白
GSK3b - GSK3 beta: GSK3b 抗体 GSK3b ELISA试剂盒  
LLGL1 (Lethal Giant Larvae Homolog 1 (Drosophila)): LLGL1 抗体 LLGL1 ELISA试剂盒 LLGL1 蛋白
LLGL2 (Lethal Giant Larvae Homolog 2 (Drosophila)): LLGL2 抗体 LLGL2 ELISA试剂盒 LLGL2 蛋白
LEF1 (Lymphoid Enhancer-Binding Factor 1): LEF1 抗体 LEF1 ELISA试剂盒 LEF1 蛋白
PYGO1 (Pygopus Homolog 1 (Drosophila)): PYGO1 抗体   PYGO1 蛋白
PYGO2 (Pygopus Homolog 2 (Drosophila)): PYGO2 抗体   PYGO2 蛋白
TCF3 (Transcription Factor 3): TCF3 抗体    
TCF4 (Transcription Factor 4): TCF4 抗体 TCF4 ELISA试剂盒 TCF4 蛋白
TCF7 (Transcription Factor 7 (T-Cell Specific, HMG-Box)): TCF7 抗体 TCF7 ELISA试剂盒 TCF7 蛋白
TLE1 (Transducin-Like Enhancer of Split 1 (E(sp1) Homolog, Drosophila)): TLE1 抗体   TLE1 蛋白
TLE2 (Transducin-Like Enhancer of Split 2 (E(sp1) Homolog, Drosophila)): TLE2 抗体 TLE2 ELISA试剂盒 TLE2 蛋白
TLE4 (Transducin-Like Enhancer of Split 4 (E(sp1) Homolog, Drosophila)): TLE4 抗体    
TLE6 (Transducin-Like Enhancer of Split 6 (E(sp1) Homolog, Drosophila)): TLE6 抗体   TLE6 蛋白

Calcium Pathway

CAMK2B (Calcium/calmodulin-Dependent Protein Kinase (CaM Kinase) II beta):

The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that...   更多...

CAMK2A (Calcium/calmodulin-Dependent Protein Kinase II alpha):

The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is...   更多...

CDC42 (Cell Division Cycle 42 (GTP Binding Protein, 25kDa)):

The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to...   更多...

PPP3CA (Protein Phosphatase 3, Catalytic Subunit, alpha Isoform):

catalytic subunit of Calcineurin (CaN), ubiquitously expressed Ca2+/CaM-dependent protein phosphatase\; mediates activities of transcription factors and ion channels\; involved in regulation of T-cell activation [RGD, Feb 2006].   更多...
此分类里的别的抗原:
CAMK2D (Calcium/calmodulin-Dependent Protein Kinase II delta): CAMK2D 抗体 CAMK2D ELISA试剂盒 CAMK2D 蛋白
CAMK2G (Calcium/calmodulin-Dependent Protein Kinase II gamma): CAMK2G 抗体 CAMK2G ELISA试剂盒 CAMK2G 蛋白
CALM1 - Calmodulin 1 (Phosphorylase Kinase, Delta): CALM1 抗体 CALM1 ELISA试剂盒 CALM1 蛋白
PLCb2 - Phospholipase C beta 2: PLCb2 抗体 PLCb2 ELISA试剂盒 PLCb2 蛋白
PLCb4 - Phospholipase C beta 4: PLCb4 抗体 PLCb4 ELISA试剂盒  
PLCd3 - Phospholipase C delta 3: PLCd3 抗体 PLCd3 ELISA试剂盒 PLCd3 蛋白
PLCG2 - Phospholipase C gamma 2: PLCG2 抗体 PLCG2 ELISA试剂盒 PLCG2 蛋白
PLCB1 - Phospholipase C beta 1: PLCB1 抗体 PLCB1 ELISA试剂盒 PLCB1 蛋白
PLCB3 (phospholipase C, beta 3 (Phosphatidylinositol-Specific)): PLCB3 抗体 PLCB3 ELISA试剂盒 PLCB3 蛋白
PLCD1 (phospholipase C, delta 1): PLCD1 抗体 PLCD1 ELISA试剂盒 PLCD1 蛋白
PLCG1 - Phospholipase C gamma 1: PLCG1 抗体 PLCG1 ELISA试剂盒 PLCG1 蛋白
PKCa - PKC alpha: PKCa 抗体 PKCa ELISA试剂盒 PKCa 蛋白
PRKCB - PKC beta: PRKCB 抗体 PRKCB ELISA试剂盒 PRKCB 蛋白
PRKCG - PKC gamma: PRKCG 抗体 PRKCG ELISA试剂盒 PRKCG 蛋白
PPP3CB (Protein Phosphatase 3, Catalytic Subunit, beta Isozyme): PPP3CB 抗体 PPP3CB ELISA试剂盒 PPP3CB 蛋白
PPP3CC (Protein Phosphatase 3, Catalytic Subunit, gamma Isozyme): PPP3CC 抗体 PPP3CC ELISA试剂盒 PPP3CC 蛋白
PPP3R1 (Protein Phosphatase 3, Regulatory Subunit B, alpha): PPP3R1 抗体 PPP3R1 ELISA试剂盒 PPP3R1 蛋白

Co-Receptors

LRP5 (Low Density Lipoprotein Receptor-Related Protein 5):

This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role...   更多...

LRP6 (Low Density Lipoprotein Receptor-Related Protein 6):

This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through...   更多...

Frizzleds

Fzd1 - FZD1

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if...   更多...

FZD2 (Frizzled Family Receptor 2):

This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. This gene encodes a protein that is coupled to the beta-catenin canonical signaling pathway. Competition between the wingless-type MMTV integration site family, member 3A and...   更多...
此分类里的别的抗原:
LOC100313610 - Frizzled 5/8 Protein Receptor: LOC100313610 抗体    
FZD10 (Frizzled Family Receptor 10): FZD10 抗体 FZD10 ELISA试剂盒 FZD10 蛋白
FZD3 (Frizzled Family Receptor 3): FZD3 抗体 FZD3 ELISA试剂盒 FZD3 蛋白
FZD4 (Frizzled Family Receptor 4): FZD4 抗体 FZD4 ELISA试剂盒 FZD4 蛋白
FZD6 (Frizzled Family Receptor 6): FZD6 抗体 FZD6 ELISA试剂盒 FZD6 蛋白
FZD7 (Frizzled Family Receptor 7): FZD7 抗体    
FZD8 (Frizzled Family Receptor 8): FZD8 抗体 FZD8 ELISA试剂盒 FZD8 蛋白
GPBAR1 (G Protein-Coupled Bile Acid Receptor 1): GPBAR1 抗体 GPBAR1 ELISA试剂盒 GPBAR1 蛋白

PCP Pathway

DAAM1 (Dishevelled Associated Activator of Morphogenesis 1):

Cell motility, adhesion, cytokinesis, and other functions of the cell cortex are mediated by reorganization of the actin cytoskeleton and several formin homology (FH) proteins have been associated with these processes. The protein encoded by this gene contains two FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. A key regulator of cytoskeletal architecture,...   更多...

JUN - C-JUN

This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul...   更多...

RHO - Rhodopsin

Retinitis pigmentosa is an inherited progressive disease which is a major cause of blindness in western communities. It can be inherited as an autosomal dominant, autosomal recessive, or X-linked recessive disorder. In the autosomal dominant form,which comprises about 25% of total cases, approximately 30% of families have mutations in the gene encoding the rod photoreceptor-specific protein...   更多...
此分类里的别的抗原:
MAPK10 (Mitogen-Activated Protein Kinase 10): MAPK10 抗体 MAPK10 ELISA试剂盒 MAPK10 蛋白
MAPK8 - JNK: MAPK8 抗体 MAPK8 ELISA试剂盒 MAPK8 蛋白
MAPK9 (Mitogen-Activated Protein Kinase 9): MAPK9 抗体 MAPK9 ELISA试剂盒 MAPK9 蛋白
NFAT5 (Nuclear Factor of Activated T-Cells 5, Tonicity-Responsive): NFAT5 抗体 NFAT5 ELISA试剂盒 NFAT5 蛋白
NFATC1 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 1): NFATC1 抗体 NFATC1 ELISA试剂盒 NFATC1 蛋白
NFAT1 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2): NFAT1 抗体 NFAT1 ELISA试剂盒 NFAT1 蛋白
NFATC3 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 3): NFATC3 抗体 NFATC3 ELISA试剂盒 NFATC3 蛋白
NFATC4 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 4): NFATC4 抗体 NFATC4 ELISA试剂盒 NFATC4 蛋白
RHOA (Ras Homolog Gene Family, Member A): RHOA 抗体 RHOA ELISA试剂盒 RHOA 蛋白
RHOC (Ras Homolog Gene Family, Member C): RHOC 抗体 RHOC ELISA试剂盒 RHOC 蛋白
RHO (rho): RHO 抗体 RHO ELISA试剂盒 RHO 蛋白
ROCK1 (rho-Associated, Coiled-Coil Containing Protein Kinase 1): ROCK1 抗体 ROCK1 ELISA试剂盒 ROCK1 蛋白
ROCK2 (rho-Associated, Coiled-Coil Containing Protein Kinase 2): ROCK2 抗体 ROCK2 ELISA试剂盒 ROCK2 蛋白

Receptor Tyrosine Kinases

ROR1 (Receptor Tyrosine Kinase-Like Orphan Receptor 1):

This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed...   更多...

ROR2 (Receptor Tyrosine Kinase-Like Orphan Receptor 2):

The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by...   更多...

RYK (RYK Receptor-Like Tyrosine Kinase):

The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that...   更多...

WNTs

WNT2 (Wingless-Type MMTV Integration Site Family Member 2):

This gene is a member of the WNT gene family. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Alternatively spliced transcript variants have been identified for this gene. [provided...   更多...

WNT1 (Wingless-Type MMTV Integration Site Family, Member 1):

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be...   更多...
此分类里的别的抗原:
WNT3A (Wingless-Type MMTV Integration Site Family, Member 3A): WNT3A 抗体 WNT3A ELISA试剂盒 WNT3A 蛋白
WNT10A (Wingless-Type MMTV Integration Site Family, Member 10A): WNT10A 抗体 WNT10A ELISA试剂盒 WNT10A 蛋白
WNT10B (Wingless-Type MMTV Integration Site Family, Member 10B): WNT10B 抗体 WNT10B ELISA试剂盒 WNT10B 蛋白
WNT16 (Wingless-Type MMTV Integration Site Family, Member 16): WNT16 抗体 WNT16 ELISA试剂盒 WNT16 蛋白
WNT2B (Wingless-Type MMTV Integration Site Family, Member 2B): WNT2B 抗体 WNT2B ELISA试剂盒 WNT2B 蛋白
WNT3 (Wingless-Type MMTV Integration Site Family, Member 3): WNT3 抗体 WNT3 ELISA试剂盒 WNT3 蛋白
WNT4 (Wingless-Type MMTV Integration Site Family, Member 4): WNT4 抗体 WNT4 ELISA试剂盒 WNT4 蛋白
WNT5A (Wingless-Type MMTV Integration Site Family, Member 5A): WNT5A 抗体 WNT5A ELISA试剂盒 WNT5A 蛋白
WNT6 (Wingless-Type MMTV Integration Site Family, Member 6): WNT6 抗体 WNT6 ELISA试剂盒 WNT6 蛋白
WNT7A (Wingless-Type MMTV Integration Site Family, Member 7A): WNT7A 抗体 WNT7A ELISA试剂盒 WNT7A 蛋白
WNT7B (Wingless-Type MMTV Integration Site Family, Member 7B): WNT7B 抗体 WNT7B ELISA试剂盒 WNT7B 蛋白
WNT8A (Wingless-Type MMTV Integration Site Family, Member 8A): WNT8A 抗体 WNT8A ELISA试剂盒 WNT8A 蛋白
WNT8B (Wingless-Type MMTV Integration Site Family, Member 8B): WNT8B 抗体    
WNT9A (Wingless-Type MMTV Integration Site Family, Member 9A): WNT9A 抗体 WNT9A ELISA试剂盒 WNT9A 蛋白
WNT9B (Wingless-Type MMTV Integration Site Family, Member 9B): WNT9B 抗体 WNT9B ELISA试剂盒 WNT9B 蛋白