anti-Feline Leukemia Virus Subgroup C Cellular Receptor 1 (FLVCR1) 抗体产品概述

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anti-Feline Leukemia Virus Subgroup C Cellular Receptor 1 抗体 (FLVCR1)
在www.antibodies-online.cn可供50 Feline Leukemia Virus Subgroup C Cellular Receptor 1 (FLVCR1) 抗体的12不同的供货商。 再加上,我们可以发Feline Leukemia Virus Subgroup C Cellular Receptor 1 蛋白 (5)和数多这个蛋白质的别的产品。 总共60 Feline Leukemia Virus Subgroup C Cellular Receptor 1产品已列进来了。
别名:
9630055N22Rik, AXPC1, FLVCR, Flvcr1, MFSD7B, PCA, PCARP, si:ch211-147d7.6
列出全部抗体 基因 基因ID UniProt
FLVCR1 28982 Q9Y5Y0
FLVCR1 226844  
FLVCR1    

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引用最多的anti-Feline Leukemia Virus Subgroup C Cellular Receptor 1 抗体

  1. Human Polyclonal FLVCR1 Primary Antibody for ELISA, WB - ABIN185315 : Quigley, Yang, Worthington, Phillips, Sabo, Sabath, Berg, Sassa, Wood, Abkowitz: Identification of a human heme exporter that is essential for erythropoiesis. in Cell 2004 (PubMed)

  2. Human Monoclonal FLVCR1 Primary Antibody for RNAi, ELISA - ABIN565398 : Alves, Costa, Sorgine, Nascimento-Silva, Teodosio, Bárcena, Castro-Faria-Neto, Bozza, Orfao, Oliveira, Maya-Monteiro: Heme-oxygenases during erythropoiesis in K562 and human bone marrow cells. in PLoS ONE 2011 (PubMed)

更多抗Feline Leukemia Virus Subgroup C Cellular Receptor 1的相互作用对抗体

Human Feline Leukemia Virus Subgroup C Cellular Receptor 1 (FLVCR1) interaction partners

  1. Using fibroblasts and lymphoblastoid cell lines from patients with sensory neurodegeneration, we here show that the FLVCR1-mutations reduce heme export activity, enhance oxidative stress and increase sensitivity to programmed cell death. Our data link heme metabolism to sensory neuron maintenance and suggest that intracellular heme overload causes early-onset degeneration of pain-sensing neurons in humans

  2. RPS19 (显示 RPS19 抗体)-downregulated erythroleukemia cells show reduced FLVCR1a and FLVCR1b mRNA levels associated with heme overload.

  3. Flvcr1 regulates differentiation of erythroid progenitors by controlling intracellular heme accumulation.

  4. both HIF2alpha (显示 EPAS1 抗体) and ETS1 (显示 ETS1 抗体) are involved in the transcriptional regulation of Flvcr1a and that HIF2alpha (显示 EPAS1 抗体) is absolutely required for Flvcr1a induction upon hypoxia

  5. FLVCR1 mutants failed to fold properly in the ER, were rapidly degraded in the lysosomes, and therefore, could not export heme out of cells. Thus, accumulation of heme in FLVCR1-mutant cells could cause cellular toxicity.

  6. Study identified sequence variants in the known disease-causing genes SLC6A3 (显示 SLC6A3 抗体) and FLVCR1, and present evidence to strongly support the pathogenicity of variants identified in TUBGCP6 (显示 TUBGCP6 抗体), BRAT1 (显示 C7orf27 抗体), SNIP1 (显示 SNIP1 抗体), CRADD (显示 CRADD 抗体), and HARS (显示 HARS 抗体).

  7. Posterior column ataxia (显示 USP14 PLURAL_@14456@) with retinitis pigmentosa is caused by mutations in FLVCR1.

  8. relative protein expression of 2 heme transporters, Feline Leukemia Virus, Subgroup C, Receptor 1 (FLVCR1) and Breast Cancer Resistance Protein (显示 ABCG2 抗体), was assessed in placental tissue in relation to maternal/neonatal iron status and placental iron concentration

  9. These results suggest that aberrant FLVCR1 causes a selective degeneration of a subpopulation of neurons in the retina and the posterior columns of the spinal cord via dysregulation of heme or iron homeostasis.

  10. hemopexin (显示 HPX 抗体) directly interacts with FLVCR

Mouse (Murine) Feline Leukemia Virus Subgroup C Cellular Receptor 1 (FLVCR1) interaction partners

  1. study found that primary and immortalized murine macrophages downregulate Flvcr mRNA levels upon LPS (显示 TLR4 抗体) stimulation; findings point to a new role for FLVCR and heme export in macrophages responses to infection and inflammation

  2. These studies identify a novel and unexpected role for FLVCR, a major facilitator superfamily metabolite transporter, in T cell development

  3. Flvcr1a maintains a free heme pool that regulates heme synthesis and degradation as well as cytochromes P450 (显示 POR 抗体) expression and activity.

  4. FLVCR is redundant in stem cells but has critical and contrasting stage-specific roles in discrete hematopoietic lineages

  5. Hemochromatosis (显示 HFE 抗体) is associated not only with excessive accumulation of free iron in the retina and retinal pigment epithelium but also with excessive accumulation of heme.

  6. data show that FLVCR exports heme & is required by erythroid progenitors to complete terminal differentiation; data show that FLVCR functions in macrophage heme-iron recycling and that systemic iron balance involves heme-iron trafficking via FLVCR

Feline Leukemia Virus Subgroup C Cellular Receptor 1 (FLVCR1) 抗原简介

Antigen Summary

This gene encodes a member of the major facilitator superfamily of transporter proteins. The encoded protein is a heme transporter that may play a critical role in erythropoiesis by protecting developing erythroid cells from heme toxicity. This gene may play a role in posterior column ataxia with retinitis pigmentosa and the hematological disorder Diamond-Blackfan syndrome.

Alternative names and synonyms associated with Feline Leukemia Virus Subgroup C Cellular Receptor 1 (FLVCR1)

  • feline leukemia virus subgroup C cellular receptor 1 (FLVCR1) 抗体
  • feline leukemia virus subgroup C cellular receptor 1 (flvcr1) 抗体
  • feline leukemia virus subgroup C cellular receptor (FLVCR) 抗体
  • major facilitator superfamily domain containing 7B (Mfsd7b) 抗体
  • 9630055N22Rik 抗体
  • AXPC1 抗体
  • FLVCR 抗体
  • Flvcr1 抗体
  • MFSD7B 抗体
  • PCA 抗体
  • PCARP 抗体
  • si:ch211-147d7.6 抗体

Protein level used designations for FLVCR1

feline leukemia virus subgroup C cellular receptor 1 , feline leukemia virus subgroup C receptor-related protein 1 , feline leukemia virus subgroup C receptor-related protein 1-like , feline leukemia virus subgroup C cellular receptor , eline leukemia virus subgroup C cellular receptor 1

GENE ID SPECIES
421365 Gallus gallus
490285 Canis lupus familiaris
533317 Bos taurus
562595 Danio rerio
100022877 Monodelphis domestica
100050536 Equus caballus
100217398 Sus scrofa
100358453 Oryctolagus cuniculus
100407159 Callithrix jacchus
100442230 Pongo abelii
100492275 Xenopus (Silurana) tropicalis
100606448 Nomascus leucogenys
710008 Macaca mulatta
28982 Homo sapiens
457724 Pan troglodytes
493854 Felis catus
226844 Mus musculus
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