anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE) 抗体产品概述

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anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon 抗体 (IKBKE)
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别名:
AW558201, IKBKE, IKK-E, IKK-i, IKKE, IKKepsilon, Ikki, MGC130907, zgc:100844
列出全部抗体 基因 基因ID UniProt
IKBKE 9641 Q14164
IKBKE 363984  
IKBKE 56489 Q9R0T8

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引用最多的anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon 抗体

  1. Human Polyclonal IKBKE Primary Antibody for EIA, WB - ABIN116937 : Peters, Liao, Maniatis: IKKepsilon is part of a novel PMA-inducible IkappaB kinase complex. in Molecular cell 2000 (PubMed)
    Show all 2 references for 116937

  2. Human Monoclonal IKBKE Primary Antibody for ELISA, WB - ABIN2869280 : Boehm, Zhao, Yao, Kim, Firestein, Dunn, Sjostrom, Garraway, Weremowicz, Richardson, Greulich, Stewart, Mulvey, Shen, Ambrogio, Hirozane-Kishikawa, Hill, Vidal, Meyerson, Grenier, Hinkle, Root et al.: Integrative genomic approaches identify IKBKE as a breast cancer oncogene. ... in Cell 2007 (PubMed)
    Show all 2 references for 2869280

  3. Human Polyclonal IKBKE Primary Antibody for ICC, IF - ABIN4324307 : Sun, Sammut, Wang, Kurihara, Windle, Roodman, Galson: TBK1 mediates critical effects of measles virus nucleocapsid protein (MVNP) on pagetic osteoclast formation. in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2013 (PubMed)

  4. Human Polyclonal IKBKE Primary Antibody for IHC (p), WB - ABIN392751 : Blume-Jensen, Hunter: Oncogenic kinase signalling. in Nature 2001 (PubMed)

  5. Human Polyclonal IKBKE Primary Antibody for EIA, IHC (p) - ABIN360635 : Cantrell: Phosphoinositide 3-kinase signalling pathways. in Journal of cell science 2001 (PubMed)

  6. Human Polyclonal IKBKE Primary Antibody for ELISA, IHC - ABIN4324306 : Péant, Diallo, Lessard, Delvoye, Le Page, Saad, Mes-Masson: Regulation of IkappaB kinase epsilon expression by the androgen receptor and the nuclear factor-kappaB transcription factor in prostate cancer. in Molecular cancer research : MCR 2007 (PubMed)

更多抗Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon的相互作用对抗体

Human Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE) interaction partners

  1. Virus-activated kinase IKKepsilon phosphorylated YAP (显示 YAP1 抗体) at Ser403 and thereby triggered degradation of YAP (显示 YAP1 抗体) in lysosomes and, consequently, relief of YAP (显示 YAP1 抗体)-mediated inhibition of the cellular antiviral response.

  2. We then determined that YAP1 (显示 YAP1 抗体) negatively regulates miR (显示 MLXIP 抗体)-let-7b/i by overexpressing and silencing YAP1 (显示 YAP1 抗体) expression. In addition, miR (显示 MLXIP 抗体)-let-7b/i feedback decreases the expression of IKBKE and YAP1 (显示 YAP1 抗体) and suppresses the transportation of YAP1 (显示 YAP1 抗体) located in the nucleus. Therefore, the regulatory feedback circuit of IKBKE upward arrow-->YAP1 (显示 YAP1 抗体) upward arrow-->miR (显示 MLXIP 抗体)-let-7b/i downward arrow-->IKBKE upward arrow dictates glioblastoma progress...

  3. our findings highlight the functional importance of IKBKE in pancreatic cancer

  4. we define a pathobiologic function for IKKepsilon in reprogramming glucose metabolism and driving progression in pancreatic ductal adenocarcinoma

  5. demonstrate a key role of TBK1 (显示 TBK1 抗体)/IKKepsilon in the survival and proliferation of HTLV-1-transformed T cells

  6. Data suggest that changes in inhibitor of nuclear factor kappa B kinase subunit epsilon (IKKepsilon) and TANK-binding kinase 1 (TBK1 (显示 TBK1 抗体)) expression may be involved in the development of intestinal-type gastric cancer.

  7. Live NiV infection, but not a recombinant NiV lacking the M protein (显示 MYOM2 抗体), reduced the levels of endogenous TRIM6 (显示 TRIM6 抗体) protein expression. To our knowledge, matrix proteins of paramyxoviruses have never been reported to be involved in innate immune antagonism. We report here a novel mechanism of viral innate immune evasion by targeting TRIM6 (显示 TRIM6 抗体), IKKepsilon and unanchored polyubiquitin (显示 UBB 抗体) chains.

  8. The adaptor molecule RAIDD (显示 CRADD 抗体) coordinates IKKepsilon and IRF7 (显示 IRF7 抗体) interaction to ensure efficient expression of type I interferon (显示 IFNA 抗体).

  9. These findings collectively support the conclusion that IKK (显示 CHUK 抗体) modulates innate immune signaling cascades via phosphorylating the RIG-I (显示 DDX58 抗体) cytosolic sensor, providing a feedback regulatory mechanism.

  10. Blunting of NOX2 (显示 CYBB 抗体)-dependent IKKepsilon oncogenic kinase expression reduces proliferation and viability of human breast cancer cells.

Mouse (Murine) Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE) interaction partners

  1. Virus-activated kinase IKKepsilon phosphorylated YAP (显示 YAP1 抗体) at Ser403 and thereby triggered degradation of YAP (显示 YAP1 抗体) in lysosomes and, consequently, relief of YAP (显示 YAP1 抗体)-mediated inhibition of the cellular antiviral response.

  2. REGgamma-mediated control of IkappaBvarepsilon contributes to NFkappaB activation and promotes bowel inflammation and associated tumour formation in response to chronic injury

  3. Suggest that by reducing production of cAMP in adipocytes, PDE3B (显示 PDE3B 抗体), IKKepsilon and TBK1 (显示 TBK1 抗体) may contribute to the repression of energy expenditure during obesity.

  4. A role for APPL1 (显示 APPL1 抗体) in TLR3 (显示 TLR3 抗体)/4-dependent TBK1 (显示 TBK1 抗体) and IKKepsilon activation in macrophages.

  5. The results highlight the importance of the C-terminal region in the functional activity of IKKepsilon in innate immune response

  6. tic (显示 ARNTL 抗体) ablation of IKBKE resulted in enhanced and prolonged priming of the NLRP3 (显示 NLRP3 抗体) inflammasome in cultured macrophages, in hypertrophic adipose tissue, and in livers of hypercholesterolemic mice.

  7. novel insight into IKKepsilon, which is involved in adipose tissue inflammation during the development of obesity

  8. miR (显示 MLXIP 抗体)-339-5p inhibits expression of the pro-inflammatory factors in alcohol-induced brain inflammation through the NF-kappaB (显示 NFKB1 抗体) pathway by abolishing IKK-beta (显示 IKBKB 抗体) and IKK-epsilon activity.

  9. IKKepsilon deficiency inhibits inflammation and induces cardiac protection in high-fat diet-induced obesity in mice.

  10. IKKepsilon is expressed in neurons and is upregulated in the hypothalamus of obese mice, contributing to insulin (显示 INS 抗体) and leptin (显示 LEP 抗体) resistance.

Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE) 抗原简介

Antigen Summary

IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009

Alternative names and synonyms associated with Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE)

  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon (IKBKE) 抗体
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon (ikbke) 抗体
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon (Ikbke) 抗体
  • inhibitor of kappaB kinase epsilon (Ikbke) 抗体
  • AW558201 抗体
  • IKBKE 抗体
  • IKK-E 抗体
  • IKK-i 抗体
  • IKKE 抗体
  • IKKepsilon 抗体
  • Ikki 抗体
  • MGC130907 抗体
  • zgc:100844 抗体

Protein level used designations for IKBKE

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon , IKKe , inhibitor of nuclear factor kappa-B kinase subunit epsilon , inhibitor of nuclear factor kappa-B kinase subunit epsilon-like , I-kappa-B kinase epsilon , IKK-epsilon , IKK-related kinase epsilon , inducible I kappa-B kinase , inducible IkappaB kinase , inhibitor of kappaB kinase epsilon , IKK-E , inducible IKappaB kinase

GENE ID SPECIES
430480 Gallus gallus
437024 Danio rerio
478950 Canis lupus familiaris
695607 Macaca mulatta
734896 Xenopus laevis
742813 Pan troglodytes
100019578 Monodelphis domestica
100055384 Equus caballus
100077063 Ornithorhynchus anatinus
100448480 Pongo abelii
100519508 Sus scrofa
100548215 Meleagris gallopavo
100562496 Anolis carolinensis
9641 Homo sapiens
533216 Bos taurus
363984 Rattus norvegicus
56489 Mus musculus
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