anti-GRIN1 (GRIN1) 抗体产品概述

Full name:
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 抗体 (GRIN1)
在www.antibodies-online.cn可供258 Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1) 抗体的26不同的供货商。 再加上,我们可以发GRIN1 试剂盒 (25)GRIN1 蛋白 (10)和数多这个蛋白质的别的产品。 总共305 GRIN1产品已列进来了。
别名:
4930447P04Rik, GB19253, GluN1, GluRdelta1, GluRzeta1, GRIN1, M100174, MRD8, Ndor, NMD-R1, NMDA1, Nmdar, NMDAR1, NR1, Rgsc174

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引用最多的anti-GRIN1 抗体

  1. Human Monoclonal GRIN1 Primary Antibody for ICC, IF - ABIN152467 : Nagy, Kolok, Dezso, Boros, Szombathelyi: Differential alterations in the expression of NMDA receptor subunits following chronic ethanol treatment in primary cultures of rat cortical and hippocampal neurones. in Neurochemistry international 2002 (PubMed)
    Show all 10 references for 152467

  2. Human Monoclonal GRIN1 Primary Antibody for BI, IHC - ABIN967491 : Brose, Huntley, Stern-Bach, Sharma, Morrison, Heinemann: Differential assembly of coexpressed glutamate receptor subunits in neurons of rat cerebral cortex. in The Journal of biological chemistry 1994 (PubMed)
    Show all 4 references for 967491

  3. Rat (Rattus) Polyclonal GRIN1 Primary Antibody for ICC, IF - ABIN251579 : González-González, Henley: Postsynaptic kainate receptor recycling and surface expression are regulated by metabotropic autoreceptor signalling. in Traffic (Copenhagen, Denmark) 2013 (PubMed)
    Show all 2 references for 251579

  4. Rat (Rattus) Polyclonal GRIN1 Primary Antibody for ELISA, WB - ABIN185678 : Rajji, Chapman, Eichenbaum, Greene: The role of CA3 hippocampal NMDA receptors in paired associate learning. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 (PubMed)

  5. Human Polyclonal GRIN1 Primary Antibody for IHC, ELISA - ABIN1532960 : Foldes, Rampersad, Kamboj: Cloning and sequence analysis of cDNAs encoding human hippocampus N-methyl-D-aspartate receptor subunits: evidence for alternative RNA splicing. in Gene 1993 (PubMed)

更多抗GRIN1的相互作用对抗体

Human Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1) interaction partners

  1. Two novel Grin1 mutations were identified in 2 cases of severe early infantile encephalopathy. Se688Tyr mutation results in disruption of NMDA ligand binding and the p.Gly827Arg mutation results in disrupted gating of the ion channel.

  2. A homozygous missense variant of GRIN1 was identified in two consanguineous sibs affected with severe intellectual disability and autistic features.

  3. NMDA receptor-dependent signaling is involved in melanosome transfer, which is associated with calcium influx, cytoskeleton protein (显示 SPTBN1 抗体) redistribution, dendrites and filopodia formation

  4. Findings show that N-methyl-d-aspartic acid receptor subunit GluN1 is expressed on oligodendrocytes and myelin in humans.

  5. De novo GRIN1 mutations are associated with severe intellectual disability with cortical visual impairment as well as oculomotor and movement disorders being discriminating phenotypic features. Loss of NMDA receptor function appears to be the underlying disease mechanism. The identification of both heterozygous and homozygous mutations blurs the borders of dominant and recessive inheritance of GRIN1-associated disorders.

  6. The differences in cortical NMDAR expression and post-synaptic density protein 95 (显示 DLG4 抗体) are present in psychiatric disorders and suicide completion and may contribute to different responses to ketamine.

  7. GRIN1 (rs4880213) was significantly associated with depression and disruptive behavior in adolescents.

  8. Knockdown of PKD1 (显示 PKD1 抗体) did not affect NMDAR internalization but prevented the phosphorylation and inhibition of remaining surface NMDARs and NMDAR-mediated synaptic functions.

  9. Study found GluN receptor subunit-specific changes in mixed subcortical ischemic vascular dementia(SIVD)/Alzheimer's disease(AD) (decreased GluN1) and SIVD (increased GluN2A (显示 GRIN2A 抗体) and 2B), likely reflecting interaction of ischemic neurovascular and AD processes

  10. The results of this study suggested that GRIN1 mutations cause encephalopathy resulting in seizures and movement disorders.

Xenopus laevis Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1) interaction partners

  1. Establishment of late-phase long-term potentiation (L-LTP (显示 SCP2 抗体)) in vivo requires NMDAR activation in the postsynaptic tectal cells within a critical time window after LTP (显示 SCP2 抗体) induction.

  2. PIP2 supports the open state of NMDA receptors via the adaptor protein alpha-actinin (显示 ACTN1 抗体). PIP2 and alpha-actinin (显示 ACTN1 抗体) act like a two-component hinge keeping the channel gate in its open state.

Mouse (Murine) Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1) interaction partners

  1. GluN1 deletions in D1- and A2A-expressing cell types reveal distinct modes of behavioral regulation. The data supports the hypothesis that cell type-specific NMDAR signaling regulates separable behavioral outcomes related to locomotion, despair, and relapse.

  2. In diabetic mice, knockdown of NR1 using lentivirus carrying NR1-shRNA ameliorated the pathological features associated with diabetic kidney disease. NR1 knockdown decreased the cell shape remodelling, cell collapse, bovine serum albumin (显示 ALB 抗体) permeability, and migration induced by high glucose.

  3. In a model of depressive disorder, the oxidation of NR1 by NOX1 (显示 NOX1 抗体)-derived reactive oxygen species was demonstrated in prefrontal cortex.

  4. the present study demonstrates that nNOS-derived NO signaling modulated by spinal Sig-1R activation increases Nox2 activity and concomitant ROS production, which leads to a ROS-induced increase in PKC-dependent pGluN1 expression in the spinal cord dorsal horn and the development of pain hypersensitivity

  5. NMDAR1 plays a pivotal role in hemin-induced NLRP3 (显示 NLRP3 抗体)-mediated inflammatory damage through synergistic activation.

  6. Nbea (显示 NBEA 抗体) targets glutamate and GABA receptors to the synapse via distinct molecular pathways by interacting with specific effector proteins.

  7. Study demonstrated that NMDAR functions are regulated by ghrelin (显示 GHRL 抗体) in a GHSR1a-dependent manner: NMDAR-mediated synaptic currents are increased as a result of GluN1 subunit phosphorylation in the hippocampal pyramidal neurons and synapses

  8. Lysosomal iron modulates NMDA receptor-mediated excitation via small GTPase (显示 RACGAP1 抗体), Dexras1 (显示 RASD1 抗体)

  9. Deletion of the gene encoding the essential NR1 subunit of the NMDA receptor (NMDAR), restricted to the CA1 (显示 CA1 抗体) region of the hippocampus results in abnormal fear response in mice.

  10. Heterozygous NR1 (+/-) mice with reduced glutamate function are more sensitive to the disruptive effects of social isolation.

GRIN1 抗原简介

Antigen Summary

The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described.

Alternative names and synonyms associated with GRIN1

  • glutamate receptor, ionotropic, N-methyl D-aspartate 1 (grin1) 抗体
  • glutamate receptor, ionotropic, N-methyl D-aspartate 1 (GRIN1) 抗体
  • NMDA receptor 1 (Nmdar1) 抗体
  • glutamate receptor, ionotropic, N-methyl D-aspartate 1 (Grin1) 抗体
  • glutamate receptor, ionotropic, NMDA1 (zeta 1) (Grin1) 抗体
  • NADPH dependent diflavin oxidoreductase 1 (Ndor1) 抗体
  • 4930447P04Rik 抗体
  • GB19253 抗体
  • GluN1 抗体
  • GluRdelta1 抗体
  • GluRzeta1 抗体
  • GRIN1 抗体
  • M100174 抗体
  • MRD8 抗体
  • Ndor 抗体
  • NMD-R1 抗体
  • NMDA1 抗体
  • Nmdar 抗体
  • NMDAR1 抗体
  • NR1 抗体
  • Rgsc174 抗体

Protein level used designations for GRIN1

glutamate receptor, ionotropic, N-methyl D-aspartate 1 , NMDA-type glutamate receptor 1 , NMDA-type glutamate receptor subunit 1 , N-methyl-D-aspartate receptor 1 , glutamate [NMDA] receptor subunit zeta-1 , N-methyl-D-aspartate receptor channel, subunit zeta-1 , N-methyl-D-aspartate receptor subunit NR1 , NMD-R1 , glutamate [NMDA] receptor subunit zeta 1 , glutamate receptor ionotropic, NMDA 1 , N-methyl-D-aspartate glutamate receptor , NMDA R1 receptor C1 cassette , neurotransmitter receptor , Glutamate [NMDA] receptor subunit zeta-1 , glutamate receptor subunit zeta 1 , N-methyl-D-aspartate receptor , NMDA glutamate receptor , N-methyl-D-aspartate receptor type 1 , NADPH-dependent diflavin oxidoreductase 1

GENE ID SPECIES
780048 Xenopus (Silurana) tropicalis
100023485 Monodelphis domestica
406079 Apis mellifera
443281 Ovis aries
751779 Taeniopygia guttata
2902 Homo sapiens
24408 Rattus norvegicus
494007 Canis lupus familiaris
397953 Xenopus laevis
404296 Gallus gallus
14810 Mus musculus
78797 Mus musculus
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