GRIN1/NMDAR1 抗体 (AA 1-564)
(4 references)-
- 抗原 See all GRIN1/NMDAR1 (GRIN1) 抗体
- GRIN1/NMDAR1 (GRIN1) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1))
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抗原表位
- AA 1-564
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适用
- 大鼠
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This GRIN1/NMDAR1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunoprecipitation (IP)
- 特异性
- Specific for the ~120k NR1 subunit of the NMDA receptor. The antibody has been directly tested for reactivity in Western blots in rat and mouse tissues.
- 交叉反应
- 小鼠, 大鼠
- 纯化方法
- Culture supernatant
- 免疫原
- Fusion protein containing amino acids 1-564 of the NR1 subunit
- 克隆位点
- R1JHL
- Top Product
- Discover our top product GRIN1 Primary Antibody
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anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1) (Internal Region) antibody
Verified GRIN1 适用: 人, 小鼠 ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1) (AA 600-700) antibodyGRIN1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1) (C-Term) antibodyGRIN1 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1) antibodyGRIN1 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1) (pSer890) antibodyGRIN1 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1) (AA 42-361) antibodyGRIN1 适用: 大鼠 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S308-48 unconjugated
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1) (AA 42-361) antibody (HRP)GRIN1 适用: 大鼠 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S308-48 HRP
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1) (AA 42-361) antibody (FITC)GRIN1 适用: 大鼠 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S308-48 FITC
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1) (AA 42-361) antibody (Biotin)GRIN1 适用: 大鼠 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S308-48 Biotin
anti-Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1) (AA 42-361) antibody (PE)GRIN1 适用: 大鼠 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal S308-48 PE
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- 应用备注
- Recommended Dilution: WB: 1:1000 IP: 3 µg per 200 µg lysate
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- Lyophilized
- 储存条件
- -20 °C
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: "Region-specific role for GluN2B-containing NMDA receptors in injury to Purkinje cells and CA1 neurons following global cerebral ischemia." in: Neuroscience, Vol. 284, pp. 555-65, (2014) (PubMed).
: "Alcohol inhibition of the NMDA receptor function, long-term potentiation, and fear learning requires striatal-enriched protein tyrosine phosphatase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 16, pp. 6650-5, (2011) (PubMed).
: "Long term synaptic depression that is associated with GluR1 dephosphorylation but not alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor internalization." in: The Journal of biological chemistry, Vol. 283, Issue 48, pp. 33138-46, (2008) (PubMed).
: "Isoflurane-induced caspase-3 activation is dependent on cytosolic calcium and can be attenuated by memantine." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 28, Issue 17, pp. 4551-60, (2008) (PubMed).
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: "Region-specific role for GluN2B-containing NMDA receptors in injury to Purkinje cells and CA1 neurons following global cerebral ischemia." in: Neuroscience, Vol. 284, pp. 555-65, (2014) (PubMed).
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- 抗原
- GRIN1/NMDAR1 (GRIN1) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1))
- 别名
- GRIN1 (GRIN1 产品)
- 别名
- GluN1 antibody, MRD8 antibody, NMDA1 antibody, NMDAR1 antibody, NR1 antibody, nmda1 antibody, nmdar1 antibody, GB19253 antibody, GRIN1 antibody, NMD-R1 antibody, Z16 antibody, GluRdelta1 antibody, GluRzeta1 antibody, M100174 antibody, Nmdar antibody, Rgsc174 antibody, NMDAR1.1 antibody, zgc:152678 antibody, glutamate ionotropic receptor NMDA type subunit 1 antibody, glutamate receptor, ionotropic, N-methyl D-aspartate 1 S homeolog antibody, NMDA receptor 1 antibody, G protein-regulated inducer of neurite outgrowth 1 antibody, glutamate receptor, ionotropic, NMDA1 (zeta 1) antibody, glutamate receptor, ionotropic, N-methyl D-aspartate 1a antibody, GRIN1 antibody, grin1.S antibody, grin1 antibody, Grin1 antibody, Nmdar1 antibody, Gprin1 antibody, grin1a antibody
- 背景
- The ion channels activated by glutamate are typically divided into two classes. Glutamate receptors that are activated by kainate and a-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as kainate/AMPA receptors (K/AMPAR). Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer’s, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002, Wenthold et al., 2003, Carroll and Zukin, 2002). The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS (Lovinger et al., 1989, Alvestad et al., 2003, Snell et al., 1996). The NMDAR is also potentiated by protein phosphorylation (Lu et al., 1999). The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1-subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits. Anti-NMDAR, NR1 Subunit Western blot of 10 ug of rat hippocampal (Hipp) lysate showing specific immunolabeling of the ~120k NR1 subunit of the NMDA receptor.
- 分子量
- '120 kDa
- 基因ID
- 24408
- UniProt
- P35439
- 途径
- Synaptic Membrane, Feeding Behaviour, Regulation of long-term Neuronal Synaptic Plasticity
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