Use your antibodies-online credentials, if available.
抗Human Angiopoietin 1 抗体:
抗Mouse (Murine) Angiopoietin 1 抗体:
抗Rat (Rattus) Angiopoietin 1 抗体:
Human Polyclonal Angiopoietin 1 Primary Antibody for IF (p), IHC (p) - ABIN728323
Lv, Fan, Su: Is a swine model of arteriovenous malformation suitable for human extracranial arteriovenous malformation? A preliminary study. in Cardiovascular and interventional radiology 2013
Show all 4 Pubmed References
Human Polyclonal Angiopoietin 1 Primary Antibody for IHC (p), WB - ABIN965551
Suri, Jones, Patan, Bartunkova, Maisonpierre, Davis, Sato, Yancopoulos: Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. in Cell 1997
Show all 3 Pubmed References
Mouse (Murine) Polyclonal Angiopoietin 1 Primary Antibody for IHC, WB - ABIN95109
Dallabrida, Ismail, Pravda, Parodi, Dickie, Durand, Lai, Cassiola, Rogers, Rupnick: Integrin binding angiopoietin-1 monomers reduce cardiac hypertrophy. in The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008
Show all 2 Pubmed References
Human Polyclonal Angiopoietin 1 Primary Antibody for IHC, IHC (p) - ABIN4280606
Zibert, Wallbrecht, Schön, Mir, Jacobsen, Trochon-Joseph, Bouquet, Villadsen, Cadossi, Skov, Schön: Halting angiogenesis by non-viral somatic gene therapy alleviates psoriasis and murine psoriasiform skin lesions. in The Journal of clinical investigation 2011
Chicken Monoclonal Angiopoietin 1 Primary Antibody for IHC (fro), IHC (p) - ABIN259879
Regula, Lundh von Leithner, Foxton, Barathi, Cheung, Bo Tun, Wey, Iwata, Dostalek, Moelleken, Stubenrauch, Nogoceke, Widmer, Strassburger, Koss, Klein, Shima, Hartmann: Targeting key angiogenic pathways with a bispecific CrossMAb optimized for neovascular eye diseases. in EMBO molecular medicine 2016
These results indicate that the Angpt-Tie2 (显示 TEK 抗体) system is essential for SC integrity. The impairment of this system underlies POAG-associated pathogenesis, supporting the possibility that Tie2 (显示 TEK 抗体) agonists could be a therapeutic option for glaucoma.
Ang-1 specifically increases circulating Gr1(+ )inflammatory monocytes and increases monocyte/macrophage retention in atherosclerotic plaques, thereby contributing to development of atherosclerosis.
NOX2 (显示 CYBB 抗体), NOX4 (显示 NOX4 抗体), and mitochondrial-derived reactive oxygen species contribute to angiopoietin-1 signaling and angiogenic responses in endothelial cells.
ANG-1, ANG-2 (显示 ANGPT2 抗体) and TIE-2 (显示 TEK 抗体) levels were significantly increased in placenta of non-complicated ART pregnancies compared to placentas from spontaneous conception.
study is the first one to report Ang1 capacity to induce MIP-1beta (显示 CCL4 抗体) gene expression, protein synthesis and release from neutrophils, and that these effects are mediated by PI3K (显示 PIK3CA 抗体), p38 MAPK (显示 MAPK14 抗体) and MEK (显示 MAP2K1 抗体) activation and downstream NF-kappaB (显示 NFKB1 抗体) activation
In this study, we found that angiopoietins and Tie receptors were highly expressed in cervical cancer cells. Tie-2 (显示 TEK 抗体) expression in tumor cells predicted poorer prognosis.Our data support that dual inhibition of Ang-1 and Ang-2 (显示 ANGPT2 抗体) may be an alternative target for anti-angiogenic adjuvant therapy in advanced or recurrent cervical squamous cell cancer.
Data show that fibulin-5 (显示 FBLN5 抗体) strongly binds to the endothelial cell surface reducing endothelial cell viability and interfering with the signaling pathways of the Ang-1/TIE-2 (显示 TEK 抗体) receptor axis.
Ang-1 is not a predictive and clinically relevant biomarker in pulmonary hypertension
We could therefore conclude that angiogenesis is an important event in the development of common skin warts, and the upregulation of both Ang1 and -2 and their binding receptor Tie2 (显示 TEK 抗体) may play a role in the angiogenesis associated with the development of these lesions.
In vitro binding assays with purified components reveal that Tie-integrin recognition is direct, and further demonstrate that the receptor binding domain of the Tie2 ligand (显示 ANGPT2 抗体) Ang-1, but not the receptor binding domain of Ang-2 (显示 ANGPT2 抗体), can independently associate with a5b1 or aVb3. cooperative Tie/integrin interactions selectively stimulate ERK/MAPK (显示 MAPK1 抗体) signaling in the presence of both Ang-1 and fibronectin (显示 FN1 抗体)
we demonstrate that targeted Ang-1 overexpression attenuates myofibroblast activation and interstitial collagen I accumulation, inhibits the upregulation of transforming growth factor beta1 and subsequent phosphorylation of Smad 2 (显示 SMAD2 抗体)/3, dampens renal inflammation, and stimulates the growth of peritubular capillaries in the obstructed kidney.
Hydroxysafflor yellow A promotes angiogenesis in ischemic hindlimb via the angiopoietin 1/ Tie-2 (显示 TEK 抗体) signaling pathway.
COMP (显示 COMP 抗体)-Ang1 can enhance BMP2 (显示 BMP2 抗体)-induced cranial bone regeneration with increased pericyte recruitment. Combined delivery of the proteins might be a therapeutic strategy to repair cranial bone damage.
Hematopoietic stem cells regulate the regeneration of their niche by secreting Angpt1.
Myocardium-derived angiopoietin-1 is essential for coronary vein formation in the developing heart.
Ang-1 strongly enhances skeletal muscle regeneration in response to fiber injury and that this effect is mediated through induction of the myogenesis program in muscle progenitor cells and the angiogenesis program in endothelial cells.
These results suggest that PRP extract prevents endotoxin-induced pulmonary edema mainly through Ang (显示 ANG 抗体)-Tie2 (显示 TEK 抗体) signaling, and PRP extract could be a potential therapeutic strategy for sepsis-induced pulmonary edema
E2 increases Ang-1 and enhances capillary density in brain under basal conditions through estrogen receptor-alpha (显示 ESR1 抗体), priming the middle cerebral artery territory for survival after experimental focal ischemia
The important role of Ang-1 in the activation of mast cells, and a potential therapeutic effect of Ang-1 on anaphylaxis diseases.
Zebra fish (Danio rerio) morphants showed that mild knock down of Ang-1 produces a small-brained phenotype that could be rescued with Ang-1 mRNA.
Angiopoietin-1 receptor Tie2 (显示 TEK 抗体) distinguishes multipotent differentiation capability in bovine coccygeal nucleus pulposus cells.
inhibition of NO production by Ang-1, via phosphorylation of eNOS (显示 NOS3 抗体) on Thr (显示 TRH 抗体)(497) by PKC zeta (显示 PRKCZ 抗体), is responsible, at least in part, for inhibition of VEGF (显示 VEGFA 抗体)-stimulated endothelial permeability by Ang-1.
Angiopoietin 1 was predominantly present in the maturing glomeruli.
The expression of ANGPT1 has already been studied during metanephric glomerulogenesis, but it remains to be elucidated during the development of the embryonic mesonephros.
Attenuates H2O2-induced stress-activated protein kinase (显示 CDK7 抗体) (SEK)1 (显示 MAP2K4 抗体)/JNK (显示 MAPK8 抗体) phosphorylation through the PI 3 (显示 PI3 抗体)-kinase/Akt (显示 AKT1 抗体) pathway and inhibits the apoptosis of vascular endothelial cells induced by oxidative stress.
Estrogen-dependent control of Ang-1 expression plays an important role in stabilizing meningeal microvessel and maintaining healthy microvascular networks.
forward mandibular positioning enhance the expression of Ang1 and Ang2 (显示 ANGPT2 抗体) in condylar cartilage.
Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
, angiopoietin 1