Stathmin 1 (STMN1) (AA 2-149) (Active) protein (His tag)

ABIN2181791 产品详细信息, 供应商: Log in to see
蛋白名称
  • op18
  • stathmin
  • stmn1
  • stmn1a
  • lag
  • lap18
  • pp17
  • pp19
  • pr22
  • smn
  • fj43c10
  • wu:fj38b07
  • wu:fj43c10
  • zgc:110159
  • cb959
  • wu:fb14e04
  • zgc:136942
  • LOC100217988
  • C1orf215
  • LAP18
  • Lag
  • OP18
  • PP17
  • PP19
  • PR22
  • SMN
  • 19k
  • Lap18
  • Op18
  • P18
  • P19
  • Pig
  • Pp17
  • Pp18
  • Pp19
  • Pr22
  • Smn
  • prosolin
  • stathmin 1
  • stathmin 1b
  • stathmin 1a
  • stathmin 1/oncoprotein 18
  • stathmin
  • stmn1-a
  • STMN1
  • stmn1
  • stmn1b
  • stmn1a
  • LOC100217988
  • LOC100229194
  • Stmn1
产品特性
AA 2-149
9
4
2
1
1
1
1
1
1
1
宿主

20
1
1
1
1
1
资源
大肠杆菌(E. Coli)
14
4
3
2
蛋白类型
Recombinant
生物活性
Active
标记
This Stathmin 1 protein is labelled with His tag.
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产品特性 This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 18.1 kDa. The protein migrates as 17-20 kDa under reducing (R) condition (SDS-PAGE).
纯度 >92 % as determined by SDS-PAGE.
过滤 0.22 μm filtered
内毒素水平 Less than 1.0 EU per μg by the LAL method.
背景 Stathmin (STMN1), a member of the stathmin family, is also known as Leukemia-associated phosphoprotein p18, Oncoprotein 18 (Op18), Phosphoprotein p19 (pp19), Protein Pr22 and pp17, which contains one SLD (stathmin-like) domain. The function of STMN1 as an important regulatory protein of microtubule dynamics has been well-characterized. Stathmin (STMN1) interacts with two molecules of dimeric α,β-tubulin to form a tight ternary complex called the T2S complex.One mole of STMN1 binds to two moles of tubulin dimers through the stathmin-like domain (SLD).When STMN1 sequesters tubulin into the T2S complex, tubulin becomes non-polymerizable. Without tubulin polymerization, there is no microtubule assembly.STMN1 also promotes microtubule disassembly by acting directly on the microtubule ends.
分子量 18.1 kDa
NCBI登录号 NP_981946
UniProt P16949
研究领域 Signaling, Cytoskeleton, Alzheimer's Disease
途径 MAPK Pathway, Microtubule Dynamics
限制 仅限研究用
状态 Lyophilized
溶解方式 Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
缓冲液 PBS, pH 7.4
注意事项 Avoid repeated freeze-thaw cycles.
储存条件 -20 °C
储存方法 No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
厂商提供的图像
SDS-PAGE (SDS) image for Stathmin 1 (STMN1) (AA 2-149) (Active) protein (His tag) (ABIN2181791) Human Stathmin 1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stain...
背景 Redeker, Lachkar, Siavoshian, Charbaut, Rossier, Sobel, Curmi: "Probing the native structure of stathmin and its interaction domains with tubulin. Combined use of limited proteolysis, size exclusion chromatography, and mass spectrometry." in: The Journal of biological chemistry, Vol. 275, Issue 10, pp. 6841-9, 2000 (PubMed).

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