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NOTCH1 inhibits activation of ATM (显示 ATM ELISA试剂盒) by impairing the formation of an ATM (显示 ATM ELISA试剂盒)-FOXO3a (显示 FOXO3 ELISA试剂盒)-KAT5 (显示 KAT5 ELISA试剂盒) complex.
Data demonstrate the possible involvement of Notch1 signaling in the pathogenesis and development of endometriosis, via regulating proliferation and migration of endometrial epithelial and stromal stem cells.
Studies suggest that embryonic signaling pathways, the likes of Notch, Wnt (显示 WNT2 ELISA试剂盒), and Hedgehog (显示 SHH ELISA试剂盒) and tumor marker Oct-4 (显示 POU5F1 ELISA试剂盒) offer targets for cascade-specific molecular inhibition as they are fundamental to (cancer and normal) stem cell maintenance and growth.
Findings illuminated a novel STRAP-NOTCH1-HES1 molecular axis as a CSC regulator in colorectal cancer.
RBPJ (显示 RBPJ ELISA试剂盒) interacts with L3MBTL3 to promote repression of Notch signaling via histone demethylase (显示 MBD2 ELISA试剂盒) KDM1A (显示 KDM1A ELISA试剂盒).
Notch1/Snail1 (显示 SNAI1 ELISA试剂盒)/E-cadherin (显示 CDH1 ELISA试剂盒) pathway facilitates the EMT (显示 ITK ELISA试剂盒) through HIF-1alpha (显示 HIF1A ELISA试剂盒) in SRA01/04 cells during hypoxia and promotes LEC motility.
Data suggest that activation of Notch1 signaling inhibits apoptosis of dental follicle stem cells via both canonical mitochondrial pathway and non-canonical Akt (显示 AKT1 ELISA试剂盒) signaling pathway (which is dependent on intracellular domain of Notch1), together with regulation of nuclear gene expression (repression of p53 (显示 TP53 ELISA试剂盒) gene expression).
Data indicate that jagged 1 (显示 JAG1 ELISA试剂盒) protein (JAG1 (显示 JAG1 ELISA试剂盒))-mediated Notch signaling regulates differentiation of basal cells (BC) into secretory cells.
Results indicate that Notch1 is significantly displaced and accumulated in fibrillary structures in the susceptible hippocampal and cortical regions of sporadic Alzheimer's disease (AD) patients. The dominant deposition of Notch1 in the brain parenchyma and its general signal reduction in neurons is consistent in all the AD patients analyzed and suggests that Notch1 may potentially be considered a novel hallmark of AD.
Diffuse NICD1 positivity in adenoid cystic carcinomas correlates with solid growth pattern, the presence of NOTCH1 gain-of-function mutations, and unfavorable outcome.
Induction of autophagy required ligand-dependent, Notch intracellular domain (NIC (显示 NCSTN ELISA试剂盒)) activity, which controlled mitochondrial organization and survival of activated Tregs.
Our data demonstrate the role of endothelial Notch1 in the proper development of the semilunar valves and cardiac outflow tract.
BLOS2 (显示 BLOC1S2 ELISA试剂盒) physically interacted with Notch1 in endo-lysosomal trafficking of Notch1. The findings suggest that BLOS2 (显示 BLOC1S2 ELISA试剂盒) is a novel negative player in regulating Notch signaling through lysosomal trafficking to control multiple stem and progenitor cell homeostasis in vertebrates.
Notch signaling and Id2/3 regulate neurogenesis in a complementary manner and ID factors can induce neural stem cell maintenance and quiescence in the absence of Notch.
pre-coated Notch1 protein promotes Notch1-knocked down B cells to produce antibody in LPS (显示 TLR4 ELISA试剂盒)-stimulated B cells suggesting that Notch1 in other cells may promote antibody production by binding its ligands Dll1 (显示 DLL1 ELISA试剂盒) and Jag1 (显示 JAG1 ELISA试剂盒) in B cells.
behavioral and functional studies demonstrated that POMC (显示 POMC ELISA试剂盒)-Notch1(-/-) mutant mice showed anxiety and depressive-like behavior with impaired synaptic transmission properties in the dentate gyrus
Notch1-Hes-1 signaling controls TLR7-induced autophagic death of macrophage via regulation of P62 in mice with lupus.
Notch1 haploinsufficiency decreased the expression of Ctgf (显示 CTGF ELISA试剂盒) in the aorta and in vitro cell culture system. In vitro studies on SMCs using the Notch1 intracellular domain (NICD) plasmid, dominant negative mastermind-like (dnMAML), or specific siRNA suggest that Notch1, not Notch3 (显示 NOTCH3 ELISA试剂盒), directly modulates the expression of CTGF (显示 CTGF ELISA试剂盒)
Notch signaling has roles in distinct aspects of prostate cancer biology, promoting metastasis in a prostate-specific Pten-null mouse model
Dll4 (显示 DLL4 ELISA试剂盒)-Notch1 signalling couples sprouting angiogenesis and artery formation.
Notch initially destabilises beta-catenin (显示 CTNNB1 ELISA试剂盒) in a process that does not depend on its phosphorylation by GSK3 (显示 GSK3b ELISA试剂盒)
Notch signaling promotes floor plate and hypochord fates over notochord, but has variable effects on Shh (显示 SHH ELISA试剂盒) expression in the midline.
Transgenic tadpoles were prepared with an elastase promoter driving either the stromelysin-3 (显示 MMP11 ELISA试剂盒) gene or the constitutively active form of Notch (IC).
ZFP423 (显示 104125 ELISA试剂盒) coordinates Notch1 and bone morphogenetic protein signaling, selectively up-regulating Hes5 (显示 HES5 ELISA试剂盒) gene expression.
results suggest that a cell-to-cell interaction via the Notch/Su(H (显示 RBPJ ELISA试剂盒)) pathway has a significant role in the PGC (显示 PGC ELISA试剂盒) migration by regulating cell motility
the process of delimiting the three germ layers requires Notch signaling.
BCL6 (显示 BCL6 ELISA试剂盒) inhibits transcription by competing for the Notch1 intracellular domain, preventing the coactivator Mastermind-like1 (MAM1 (显示 MAML1 ELISA试剂盒)) from binding.
the combination of XSICD-mediated intracellular signaling and the extracellular domain of Notch ligands-mediated activation of Notch receptor is involved in the primary neurogenesis
Notch signaling is activated when activin (显示 Actbeta ELISA试剂盒)-like signaling induces various tissues from homogenous undifferentiated cells.
Notch controls smad2 (显示 SMAD2 ELISA试剂盒) nuclear localization and the competence of ectodermal cells for activin A (显示 INHBA ELISA试剂盒) in Xenopus embryos
the NOTCH1 polymorphism g.A48250G was significantly associated with body height, body weight, and height at hip cross, and that g.A49239C only showed significant associations with body height
bovine herpesvirus 1 ORF2 protein reduced the trans-activation potential of Notch1 and Notch3 (显示 NOTCH3 ELISA试剂盒), suggesting that ORF2 interfered with the trans-activation potential of Notch.
Cellular size or Notch1 expression is not per se a specific marker for mesenchymal progenitor cells in adult articular cartilage.
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development.
, Notch homolog 1, translocation-associated (Drosophila)
, Notch homolog 1, translocation-associated
, neurogenic locus notch homolog protein 1
, translocation-associated notch protein TAN-1
, Motch A
, Notch gene homolog 1
, major type A protein
, transmembrane receptor Notch1
, Drosophila Notch homolog 1 (controlling the the ectodermal and neural cell fate in Drosophila)
, neurogenic locus notch protein homolog