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- 抗原 See all Notch1 (NOTCH1) ELISA试剂盒
- Notch1 (NOTCH1) (Notch 1 (NOTCH1))
- 抗原表位
- AA 19-526
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适用
- 人
- 检测方法
- Colorimetric
- 实验类型
- Sandwich ELISA
- 应用范围
- ELISA
- 原理
- Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human NOTCH1
- 品牌
- PicoKine™
- Analytical Method
- Quantitative
- 特异性
- Expression system for standard: NSO, Immunogen sequence: A19-Q526
- 交叉反应 （详细）
- There is no detectable cross-reactivity with other relevant proteins.
- 产品特性
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Tissue Specificity: In fetal tissues most abundant in spleen, brain stem and lung. Also present in most adult tissues where it is found mainly in lymphoid tissues.
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Notch 1 (NOTCH1) ELISA Kit
NOTCH1 适用: 人 Colorimetric Sandwich ELISA 0.15 ng/mL - 10 ng/mL Cell Culture Supernatant, Cell Lysate, Plasma, Serum, Tissue Homogenate
Notch 1 (NOTCH1) ELISA KitNOTCH1 适用: 小鼠 Colorimetric Sandwich ELISA 0.15 ng/mL - 10 ng/mL Cell Culture Supernatant, Cell Lysate, Plasma, Serum, Tissue Homogenate
Notch 1 (NOTCH1) ELISA KitNOTCH1 适用: 大鼠 Colorimetric Sandwich ELISA 0.15 ng/mL - 10 ng/mL Cell Culture Supernatant, Cell Lysate, Plasma, Serum, Tissue Homogenate
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- 板类型
- Pre-coated
- 限制
- 仅限研究用
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- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
- 有效期
- 12 months
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- 抗原 See all Notch1 (NOTCH1) ELISA试剂盒
- Notch1 (NOTCH1) (Notch 1 (NOTCH1))
- 别名
- NOTCH1 (NOTCH1 产品)
- 别名
- notch1 ELISA Kit, NOTCH1 ELISA Kit, hn1 ELISA Kit, tan1 ELISA Kit, notch ELISA Kit, xotch ELISA Kit, xnotch ELISA Kit, notch-1 ELISA Kit, xnotch1 ELISA Kit, TAN1 ELISA Kit, hN1 ELISA Kit, 9930111A19Rik ELISA Kit, Mis6 ELISA Kit, N1 ELISA Kit, Tan1 ELISA Kit, lin-12 ELISA Kit, NOTCH ELISA Kit, Xotch ELISA Kit, notch1-a ELISA Kit, notch 1 ELISA Kit, fibropellin-1 ELISA Kit, Notch homolog 1, translocation-associated (Drosophila) ELISA Kit, Notch homolog 1, translocation-associated ELISA Kit, notch 1 S homeolog ELISA Kit, notch1 ELISA Kit, LOC100631526 ELISA Kit, NOTCH1 ELISA Kit, Notch1 ELISA Kit, notch1.S ELISA Kit
- 背景
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Protein Function: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis, negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO).
Background: Notch proteins are single-pass transmembrane receptors that regulate cell fate decisions during development. The Notch family includes 4 receptors, NOTCH1, NOTCH2, NOTCH3, and NOTCH4, whose ligands include JAG1, JAG2, DLL1), DLL3, and DLL4. Notch homolog 1, translocation-associated (NOTCH1), is a human gene encoding a single-pass transmembrane receptor. It functions as a receptor for membrane bound ligands, and may play multiple roles during development. NOTCH1 may normally coordinates the process of somitogenesis, and the activated Notch 1 and Notch 3 promote differentiation of progenitor cells into astroglia.
Synonyms: Neurogenic locus notch homolog protein 1, Notch 1, hN1, Translocation-associated notch protein TAN-1, Notch 1 extracellular truncation, NEXT, Notch 1 intracellular domain, NICD, NOTCH1, TAN1,
Full Gene Name: notch 1
Cellular Localisation: Cell membrane, Single-pass type I membrane protein. - UniProt
- P46531
- 途径
- Notch Signaling, Stem Cell Maintenance, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development
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