Tumor Necrosis Factor 蛋白 (TNF)产品概述

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Tumor Necrosis Factor 蛋白 (TNF)
在www.antibodies-online.cn可供270 Tumor Necrosis Factor (TNF) 蛋白的26不同的供货商。 再加上,我们可以发Tumor Necrosis Factor 抗体 (1734)Tumor Necrosis Factor 试剂盒 (326)和数多这个蛋白质的别的产品。 总共2367 Tumor Necrosis Factor产品已列进来了。
别名:
Cachectin, cTNF, DIF, RATTNF, tnf, TNF-a, Tnf-alpha, TNFa, tnfa-like, TNFalpha, Tnfsf1a, TNFSF2, xtnf
列出全部蛋白 基因 基因ID UniProt
TNF 7124 P01375
小鼠 TNF TNF 21926 P06804
大鼠 TNF TNF 24835 P16599

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引用最多的Tumor Necrosis Factor 蛋白

  1. Human Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN2003118 : Black, Rauch, Kozlosky, Peschon, Slack, Wolfson, Castner, Stocking, Reddy, Srinivasan, Nelson, Boiani, Schooley, Gerhart, Davis, Fitzner, Johnson, Paxton, March, Cerretti: A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells. in Nature 1997 (PubMed)
    Show all 9 references for 2003118

  2. Mouse (Murine) Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN2007701 : Chen, Goeddel: TNF-R1 signaling: a beautiful pathway. in Science (New York, N.Y.) 2002 (PubMed)
    Show all 6 references for 2007701

  3. Rat (Rattus) Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN413826 : Muehlbauer, Lima, Goldman, Jacobson, Rivera, Goldberg, Palladino, Casadevall, Brojatsch: Proteasome inhibitors prevent caspase-1-mediated disease in rodents challenged with anthrax lethal toxin. in The American journal of pathology 2010 (PubMed)
    Show all 4 references for 413826

  4. Human Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN1047828 : Pennica, Nedwin, Hayflick, Seeburg, Derynck, Palladino, Kohr, Aggarwal, Goeddel: Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin. in Nature 1985 (PubMed)
    Show all 4 references for 1047828

  5. Mouse (Murine) Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN1305135 : Hogan, Vogel: Production of tumor necrosis factor by rIFN-gamma-primed C3H/HeJ (Lpsd) macrophages requires the presence of lipid A-associated proteins. in Journal of immunology (Baltimore, Md. : 1950) 1989 (PubMed)
    Show all 3 references for 1305135

  6. Rat (Rattus) Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN1305133 : Jäättelä: Biologic activities and mechanisms of action of tumor necrosis factor-alpha/cachectin. in Laboratory investigation; a journal of technical methods and pathology 1991 (PubMed)
    Show all 2 references for 1305133

  7. Cow (Bovine) Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN1047829 : Mertens, Muriuki, Gaidulis: Cloning of two members of the TNF-superfamily in cattle: CD40 ligand and tumor necrosis factor alpha. in Immunogenetics 1995 (PubMed)
    Show all 2 references for 1047829

  8. Human Tumor Necrosis Factor Protein expressed in HEK-293 Cells - ABIN2712390 : Adini, Adini, Bazinet, Watnick, Bielenberg, DAmato: Melanocyte pigmentation inversely correlates with MCP-1 production and angiogenesis-inducing potential. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014 (PubMed)

  9. Human Tumor Necrosis Factor Protein expressed in HEK-293 Cells - ABIN2181833 : Dowlati, Herrmann, Swardfager, Liu, Sham, Reim, Lanctôt: A meta-analysis of cytokines in major depression. in Biological psychiatry 2010 (PubMed)

  10. Mouse (Murine) Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN413823 : Srivastava, Qin, Wedhas, Arnush, Linkhart, Chadwick, Kumar: Tumor necrosis factor-alpha augments matrix metalloproteinase-9 production in skeletal muscle cells through the activation of transforming growth factor-beta-activated kinase 1 (TAK1)-dependent signaling pathway. in The Journal of biological chemistry 2007 (PubMed)

更多Tumor Necrosis Factor互动伙伴

Rainbow Trout (Oncorhynchus mykiss) Tumor Necrosis Factor (TNF) interaction partners

  1. Our findings demonstrate that TNF-alpha plays a pivotal role in HF-mediated neuroinflammation and associated alterations of cortical dendritic spine density and has the potential to reveal novel treatment strategies for HF-associated memory deficits.

  2. the present study assessed the combined impacts of estrogens and bacterial infection on the insulin (显示 INS 蛋白)-like growth factors (IGF) and tumor-necrosis factor (TNF)-alpha.

  3. The expression of miR (显示 MYLIP 蛋白)-125b-1 regulated by NF-kappaB (显示 NFKB1 蛋白) has been reported in diverse cell types under various stimuli, this study found that its expression was also significantly regulated by NF-kappaB (显示 NFKB1 蛋白) in TNFalpha-stimulated HeLa and HepG2 cells

  4. In the Han Chinese population, the allele 'A' of TNF-alpha -308 may increase the risk for osteoarthritis (OA), whereas TNF-alpha -238 polymorphisms do not play a role in OA patients.

  5. Letter: serum TNF-alpha was not elevated in chronic spontaneous urticaria.

  6. Metastatic cells can escape the proapoptotic effects of TNF-alpha through increased autocrine IL-6 (显示 IL6 蛋白)/STAT3 (显示 STAT3 蛋白) signaling

  7. The predicted 3D structures of IL-1beta (显示 IL1B 蛋白), TNF-alpha, and IL-8 (显示 IL8 蛋白) from Oncorhynchus mykiss, Dicentrarchus labrax, and Chionodraco hamatus are reported and the differences between them and their mammalian counterparts investigated.

  8. The mitochondrial dysfunction may be caused by increased brain levels of TNFalpha without physiological stress but will be exacerbated after middle cerebral artery occlusion.

  9. TNF-alpha is released rapidly in trout macrophages after stimulation with lipopolysaccharide and zymosan, and its secretion is dependent on TACE (显示 ADAM17 蛋白)-like activity that is regulated by ERK (显示 MAPK1 蛋白), JNK (显示 MAPK8 蛋白) and p38MAPK (显示 MAPK14 蛋白) signaling pathways.

  10. Recombinant, as well as native trout TNF-alpha, directly stimulates glucose uptake in trout muscle cells and provide evidence, for the first time in nonmammalian vertebrates, for a potential regulatory role of TNF-alpha in skeletal muscle metabolism.

Human Tumor Necrosis Factor (TNF) interaction partners

  1. GW1929 abolishes the TNFalpha-mediated decrease of ApoA-I (显示 APOA1 蛋白) mRNA expression in both HepG2 and Caco-2 cells but does not block TNFalpha-mediated inhibition of ApoA-I (显示 APOA1 蛋白) protein secretion by HepG2 cells.

  2. Our results indicate that TNFalpha gene -238G/A polymorphism increases the risk of developing psoriasis vulgaris among Indians.

  3. These results suggested that TNF-alpha -308 A allele was significantly associated with distant tumor metastasis in rectal cancer patients.

  4. This study provides the evidence to support that TNF-alpha involves in thoracic ossification of the ligamentum flavum probably through regulating cell proliferation via cyclin D1 (显示 CCND1 蛋白) and c-Myc (显示 MYC 蛋白), and promoting osteoblast differentiation via Osx (显示 MID1 蛋白).

  5. results therefore demonstrate cancer epigenetics induces a loop of cancer-stroma-cancer interaction in omental microenvironment that promotes peritoneal metastasis of ovarian cancer cells via TNFalpha-TGFalpha-EGFR (显示 EGFR 蛋白).

  6. Cystatin C (显示 CST3 蛋白) significantly decreased the lipopolysaccharide-stimulated release and expression of tumor necrosis factor-alpha in monocyte and peripheral blood mononuclear cultures from healthy donors and Crohn's patients.

  7. Data show that pan-caspase (显示 CASP3 蛋白) inhibitors facilitated 5-fluorouracil (5-FU)-induced necroptosis mediated by secretion of tumor necrosis factor alpha (TNF-alpha) driven by nuclear factor kappaB (NF-kappaB (显示 NFKB1 蛋白)) and required RIP1 (显示 UQCRFS1 蛋白) kinase.

  8. The enhanced survival properties and decreased TNF signaling of rheumatoid arthritis (RA) low-density granulocytes, are likely to have important consequences for disease pathology and response to therapy.

  9. PRDX6 (显示 PRDX6 蛋白) inhibited the carcinogenesis of hepatocellular carcinoma, and the calcium-independent phospholipase A2 (显示 PNPLA8 蛋白) activity of PRDX6 (显示 PRDX6 蛋白) promoted cancer cell death induced by TNF-alpha.

  10. The progression of pregnancy is accompanied by the concerted increase in TNFalpha and VEGF secretion and decrease in the production of their soluble receptors, but the expression of cell surface receptors does not depend on gestational age. The observed patterns of basal and stimulated expression of TNFalpha and VEGF may reflect the dual immune and morphogenetic roles of placental macrophages in gestation.

Mouse (Murine) Tumor Necrosis Factor (TNF) interaction partners

  1. MK2 (显示 KCNA2 蛋白)-mediated phosphorylation of RIPK1 (显示 RIPK1 蛋白) serves as a checkpoint within the TNF signaling pathway that integrates cell survival and cytokine production.

  2. TLR4 (显示 TLR4 蛋白) activates CASPASE-8 (显示 CASP8 蛋白) to cleave and remove the deubiquitinase cylindromatosis (CYLD (显示 CYLD 蛋白)) in a TRIF (显示 RNF138 蛋白)- and RIPK1 (显示 RIPK1 蛋白)-dependent manner to disable necroptosis in macrophages.

  3. impaired TNF/TNFR2 (显示 TNFRSF1B 蛋白) signaling enhances Th2 and Th17 polarization and aggravates allergic airway inflammation.

  4. The elevated cytotoxicity achieved by suppressing mTOR (显示 FRAP1 蛋白) was a result of up-regulation of NKG2D (显示 KLRK1 蛋白) and TNF-alpha. The inhibition of STAT5 (显示 STAT5A 蛋白) pathways via siRNA interference or a specific inhibitor eliminated the up-regulation of NKG2D (显示 KLRK1 蛋白) and TNF-alpha in rapamycin-treated Vgamma4 gammadelta T cells.

  5. this study shows that tumor produced TNF-alpha causes an upregulation of PD-L1 (显示 CD274 蛋白) expression by tumor-associated monocytes

  6. differential regulation of exocytosis by TNF-alpha involves the actin cytoskeleton and is a necessary component for priming of the 2 major neutrophil antimicrobial defense mechanisms: oxygen radical generation and release of toxic granule contents.

  7. this study shows that vagotomy can increase tumor growth and worsen survival in a murine pancreatic cancer model mediated through tumor-associated macrophages and TNFalpha

  8. Adiponectin (显示 ADIPOQ 蛋白), TNF-alpha, and LOX-1 (显示 OLR1 蛋白) exert complex regulatory effects on the coronary microvascular endothelial function in atherosclerotic ApoE (显示 APOE 蛋白) knockout mice.

  9. PRDX6 (显示 PRDX6 蛋白) inhibited the carcinogenesis of hepatocellular carcinoma, and the calcium-independent phospholipase A2 (显示 LYPLA1 蛋白) activity of PRDX6 (显示 PRDX6 蛋白) promoted cancer cell death induced by TNF-alpha.

  10. Activation of CX3CR1 (显示 CX3CR1 蛋白)(high)Ly6C(low) monocytes impaired motor learning and learning-related dendritic spine plasticity through tumor necrosis factor (TNF)-alpha-dependent mechanisms.

Pig (Porcine) Tumor Necrosis Factor (TNF) interaction partners

  1. TMZ pretreatment effectively reduced the myocardial damage caused by CME via inhibiting the PDCD4 (显示 PDCD4 蛋白)/NF-kappaB (显示 NFKB1 蛋白)/ TNF-alpha pathway in cardiomyocytes.

  2. TNF-alpha, secreted from activated Monocytes, mediates the downregulation of OTX2 (显示 OTX2 蛋白) and essential retinal pigment epithelium genes.

  3. TNF-alpha induced MMP-13 (显示 MMP13 蛋白) expression by condylar cells might be involved in the degradation of the juvenile condyle.

  4. TNF-alpha was able to promote theca interna cell proliferation. Our results suggest that TNF-alpha might play a role in hyperandrogenism, cortex thickness, and the increased ovary volume observed in polycystic ovaries.

  5. This study showed that the -791(C-->T) mutation of the TNF-alpha gene could be considered an important potential genetic marker of enterotoxigenic Escherichia coli F18 (显示 MAMLD1 蛋白) resistance.

  6. Both Nsp1beta and Nsp11 of porcine reproductive and respiratory syndrome virus were demonstrated to be responsible for the inhibitory effect on TNF-alpha production in pulmonary alveolar macrophages.

  7. Study presents evidence demonstrating a single species of exotoxin ApxI, derived from A. pleuropneumoniae serotype 10, induces the expression and production of proinflammatory cytokines IL-1beta (显示 IL1B 蛋白), IL-8 (显示 IL8 蛋白) and TNF-alpha in porcine alveolar macrophages.

  8. the role of miR (显示 MYLIP 蛋白)-181a in adipocyte differentiation by regulation of TNF-alpha

  9. The NOS inhibitor, L-NMMA, significantly suppressed the combined effects of HT and CORM-2 on TNFalpha-triggered NFkappaBp65 phosphorylation as well as decreased cell viability.

  10. High-volume hemofiltration improves hemodynamics and heart dysfunction in septic shock pigs, which may be attributed to reduction of TNF-alpha in myocardium but not in circulation.

Cow (Bovine) Tumor Necrosis Factor (TNF) interaction partners

  1. Data suggest that luteolytic factors (such as TNFa, interferon gamma (显示 IFNG 蛋白), and PGF2a) control expression of MMP1 (显示 MMP1 蛋白), other matrix metalloproteinases, and tissue inhibitors of metalloproteinase in cultured luteal cells.

  2. These results suggest that polymorphism of the TNFalpha-824 A>G gene and mTNFalpha protein expression play an important role in the pathogenesis of enzootic bovine leukosis.

  3. These results suggest that the endometrium might lower the TNF concentration in the blastocyst by (1) regulating TNF secretion into the uterine fluid and (2) inducing decreased TNF and TNFR2 (显示 TNFRSF1B 蛋白) mRNA transcription in the embryo.

  4. There was a significant association between the proviral load and a low frequency of the G/G genotype of TNF-alpha at position -824.

  5. SNP in the TNF-alpha gene affects immune function and reproductive performance in dairy cows.

  6. Studied genotypic and expression profiling of partial TNF-alpha gene and its association with mastitis susceptibility in 129 crossbred cattle.

  7. Messenger RNA and protein levels of prostaglandin (PG) E synthase (PGES (显示 PTGES 蛋白)), PGF2alpha receptor (PGFR), tumor necrosis factor-alpha (TNF) and Fas (显示 FAS 蛋白) were found to be higher in the corpus luteum of pregnancy than in corpus luteum of the cycle.

  8. TNF-alpha up-regulates NaV1.7 (显示 SCN9A 蛋白) mRNA in both adrenal chromaffin cells and dorsal root ganglia (DRG) neurons, highlighting the peripheral nociceptive mechanism of TNF-alpha

  9. These results provide evidence for a high prevalence of subclinical endometritis in repeat breeding cows as well as the involvement of TNFalpha and iNOS (显示 NOS2 蛋白) pathways in the regulation of this pathological condition.

  10. Exposure to follicular fluid transiently increased the transcript levels of IL8 (显示 IL8 蛋白) and PTGS2 (显示 PTGS2 蛋白), and decreased the expression of SOD2 (显示 SOD2 蛋白), GPX3 (显示 GPX3 蛋白), DAB2 (显示 DAB2 蛋白), and NR3C1 (显示 NR3C1 蛋白). TNF and IL6 (显示 IL6 蛋白) levels were also decreased while those of NAMPT (显示 NAMPT 蛋白) were unaffected.

Horse (Equine) Tumor Necrosis Factor (TNF) interaction partners

  1. The results obtained showed that IL-6 (显示 IL6 蛋白) expression in adipose tissue biopsies derived from animals with equine metabolic syndrome was enhanced while TNF-alpha levels of both groups were comparable.

  2. Data indicate that tumor necrosis factor-alpha production is closely related to ovarian steroid actions.

  3. These results indicate that in equine corpus luteum, cytokines TNF, IFNG (显示 IFNG 蛋白) and FASL (显示 FASL 蛋白) regulate nitric oxide activity, via eNOS (显示 NOS3 蛋白) expression modulation.

  4. These data show the presence of cytokines TNF and IFNG (显示 IFNG 蛋白), and their receptors, in the equine corpus luteum and indicate their potential involvement in regulation of luteal function.

  5. The contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of IL-6 (显示 IL6 蛋白), IL-10 (显示 IL10 蛋白) and TNF-alpha, in horses with recurrent airway obstruction during exacerbation and in remission is reported.

Rabbit Tumor Necrosis Factor (TNF) interaction partners

  1. TUNEL staining was positively correlated with TNF-a protein expression. Our findings suggest that apoptosis can be induced in the vocal fold epithelium after 120min of modal intensity phonation. In contrast, shorter durations of vibration exposure do not result in apoptosis signaling.

  2. Inflammatory factors such as TNF-alpha can stimulate MMP-2 (显示 MMP2 蛋白)/9 activity in corneal epithelium cells. This may be a potential manipulating mechanism of MMP expression in the pathogenesis of corneal diseases.

  3. The JNK (显示 MAPK8 蛋白) pathway plays an important role in mechanical ventilation-stimulated TNF-alpha expression in alveolar macrophages, but the injury-stimulated IL-8 (显示 IL8 蛋白) expression may be regulated by other signaling pathways.

  4. The TNFalpha-evoked Cl- current.

  5. IL-1beta (显示 IL1B 蛋白) and TNF-alpha expression increases significantly during acute lung injury. Ambroxol combined with low-dose heparin inhibits teh release of IL-1beta (显示 IL1B 蛋白) and TNF-alpha.

  6. Hypercapnia increased expression of TNFa and decreased expression of NFKB in acute lung injury models.

  7. In the early stages of myocardial ischemia, bone marrow stem cells are mobilized and home to ischemic myocardium with a concomitant increase in expression of cytokines VEGF (显示 VEGFA 蛋白) and TNFalpha.

  8. Ammonium perchlorate can increase gene expressions of types I, III collagens, TGF-beta(1 (显示 TGFB1 蛋白)) and TNF-alpha in lung of rabbits.

  9. TNFalpha may either be directly or indirectly involved in vascular damage following an embolic stroke. Moreover, TNFalpha may mediate some of the detrimental effects of tPA (显示 PLAT 蛋白) on the vascular compartment

Rhesus Monkey Tumor Necrosis Factor (TNF) interaction partners

  1. These interactions result in the induction of the TNF signaling pathway, activation of apoptosis, and DNA-damage stress response.

  2. Findings showed that both mucosal compartments harbor similar percentages of memory CD4 (显示 CD4 蛋白)(+) T cells and displayed comparable cytokine TNF-alpha responses to mitogenic stimulations prior to infection.

  3. Primary role for IL-1beta (显示 IL1B 蛋白) and TNF-alpha in the triggering of preterm labor associated with inflammation or infection.

Goat Tumor Necrosis Factor (TNF) interaction partners

  1. Data indicate that three single-nucleotide polymorphisms were identified in tumor necrosis factor-alpha (TNF-alpha) gene.

Zebrafish Tumor Necrosis Factor (TNF) interaction partners

  1. The results reveal a crucial role for TNFalpha/TNFR2 (显示 TNFRSF1B 蛋白) axis in the protection of the skin against DUOX1 (显示 DUOX1 蛋白)-mediated oxidative stress.

  2. TNF alpha is the first molecule identified that is produced by dying retinal neurons and is necessary to induce Muller glia to proliferate in the zebrafish retinal regeneration response.

  3. The data suggest that Mycobacterium marinum SecA2 modulates adaptive immunity to promote granuloma stability, perhaps through induction of tumor necrosis factor alpha.

  4. TNF is not required for tuberculous granuloma formation, but maintains granuloma integrity indirectly by restricting mycobacterial growth within macrophages and preventing their necrosis.

  5. The main proinflammatory effects of fish TNF-alpha are mediated through the activation of endothelial cells and point to the complexity of the evolution that has taken place in the regulation of innate immunity by cytokines.

蛋白简介Tumor Necrosis Factor (TNF)

蛋白简介

This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.

Alternative names and synonyms associated with Tumor Necrosis Factor (TNF)

  • tumor necrosis factor (TNF superfamily, member 2) (TNF)
  • tumor necrosis factor (tnf)
  • tumour necrosis factor alpha-like (tnf-alpha)
  • tumor necrosis factor alpha (tnf-alpha)
  • lipopolysaccharide-induced TNF factor (LITAF)
  • tumor necrosis factor (TNF)
  • tumor necrosis factor (Tnf)
  • tumor necrosis factor alpha (TNF)
  • tumor necrosis factor b (TNF superfamily, member 2) (tnfb)
  • Cachectin 蛋白
  • cTNF 蛋白
  • DIF 蛋白
  • RATTNF 蛋白
  • tnf 蛋白
  • TNF-a 蛋白
  • Tnf-alpha 蛋白
  • TNFa 蛋白
  • tnfa-like 蛋白
  • TNFalpha 蛋白
  • Tnfsf1a 蛋白
  • TNFSF2 蛋白
  • xtnf 蛋白

Protein level used designations for Tumor Necrosis Factor 蛋白 (TNF)

tumor necrosis factor (TNF superfamily, member 2) , tumor necrosis factor alpha , tumor necrosis factor , tumour necrosis factor alpha , putative tumour necrosis factor alpha , LPS-induced TNF-alpha factor homolog , TNF-alpha factor , lipid-induced TNF-alpha factor , lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog , small integral membrane protein of lysosome/late endosome , tissue necrosis factor-alpha , APC1 protein , TNF, macrophage-derived , TNF, monocyte-derived , TNF-a , cachectin , tumor necrosis factor ligand superfamily member 2 , tumor necrosis factor-alpha , TNF-alpha , tumor-necrosis factor , tumour necrosis factor , ATP-binding cassette, sub-family F (GCN20), member 1 , TNF alpha , tumor necrosis factor, alpha , TNF2 , lta

GENE ID SPECIES
744399 Pan troglodytes
100136064 Oncorhynchus mykiss
100304592 Ictalurus punctatus
100134991 Xenopus (Silurana) tropicalis
100136034 Oncorhynchus mykiss
100137091 Salmo salar
374125 Gallus gallus
7124 Homo sapiens
21926 Mus musculus
24835 Rattus norvegicus
397086 Sus scrofa
280943 Bos taurus
443540 Ovis aries
100033834 Equus caballus
403922 Canis lupus familiaris
100135630 Cavia porcellus
100009088 Oryctolagus cuniculus
493755 Felis catus
715467 Macaca mulatta
100397484 Callithrix jacchus
101420445 Dasypus novemcinctus
494186 Pan troglodytes
101318178 Tursiops truncatus
100861232 Capra hircus
554167 Danio rerio
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