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Human Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN2003118
Black, Rauch, Kozlosky, Peschon, Slack, Wolfson, Castner, Stocking, Reddy, Srinivasan, Nelson, Boiani, Schooley, Gerhart, Davis, Fitzner, Johnson, Paxton, March, Cerretti: A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells. in Nature 1997
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Human Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN1305134
Hogan, Vogel: Production of tumor necrosis factor by rIFN-gamma-primed C3H/HeJ (Lpsd) macrophages requires the presence of lipid A-associated proteins. in Journal of immunology (Baltimore, Md. : 1950) 1989
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Human Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN413820
Bhola, Simon: Determinism and divergence of apoptosis susceptibility in mammalian cells. in Journal of cell science 2009
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Rat (Rattus) Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN413826
Muehlbauer, Lima, Goldman, Jacobson, Rivera, Goldberg, Palladino, Casadevall, Brojatsch: Proteasome inhibitors prevent caspase-1-mediated disease in rodents challenged with anthrax lethal toxin. in The American journal of pathology 2010
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Mouse (Murine) Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN1305135
Jäättelä: Biologic activities and mechanisms of action of tumor necrosis factor-alpha/cachectin. in Laboratory investigation; a journal of technical methods and pathology 1991
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Human Tumor Necrosis Factor Protein expressed in Wheat germ - ABIN1323120
Ku, Kim, Bae: Piperlonguminine downregulates endothelial protein C receptor shedding in vitro and in vivo. in Inflammation 2014
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Human Tumor Necrosis Factor Protein expressed in Pichia - ABIN988275
Fritz, Radziwill: CNK1 promotes invasion of cancer cells through NF-kappaB-dependent signaling. in Molecular cancer research : MCR 2010
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Human Tumor Necrosis Factor Protein expressed in Escherichia coli (E. coli) - ABIN935816
Spatz, Eibl, Hink, Wolf, Fischer, Mayr, Schernthaner, Eibl: Impaired primary immune response in type-1 diabetes. Functional impairment at the level of APCs and T-cells. in Cellular immunology 2003
Our findings demonstrate that TNF-alpha plays a pivotal role in HF-mediated neuroinflammation and associated alterations of cortical dendritic spine density and has the potential to reveal novel treatment strategies for HF-associated memory deficits.
the present study assessed the combined impacts of estrogens and bacterial infection on the insulin (显示 INS 蛋白)-like growth factors (IGF) and tumor-necrosis factor (TNF)-alpha.
The expression of miR (显示 MYLIP 蛋白)-125b-1 regulated by NF-kappaB (显示 NFKB1 蛋白) has been reported in diverse cell types under various stimuli, this study found that its expression was also significantly regulated by NF-kappaB (显示 NFKB1 蛋白) in TNFalpha-stimulated HeLa and HepG2 cells
In the Han Chinese population, the allele 'A' of TNF-alpha -308 may increase the risk for osteoarthritis (OA), whereas TNF-alpha -238 polymorphisms do not play a role in OA patients.
Letter: serum TNF-alpha was not elevated in chronic spontaneous urticaria.
Metastatic cells can escape the proapoptotic effects of TNF-alpha through increased autocrine IL-6 (显示 IL6 蛋白)/STAT3 (显示 STAT3 蛋白) signaling
The predicted 3D structures of IL-1beta (显示 IL1B 蛋白), TNF-alpha, and IL-8 (显示 IL8 蛋白) from Oncorhynchus mykiss, Dicentrarchus labrax, and Chionodraco hamatus are reported and the differences between them and their mammalian counterparts investigated.
The mitochondrial dysfunction may be caused by increased brain levels of TNFalpha without physiological stress but will be exacerbated after middle cerebral artery occlusion.
TNF-alpha is released rapidly in trout macrophages after stimulation with lipopolysaccharide and zymosan, and its secretion is dependent on TACE (显示 ADAM17 蛋白)-like activity that is regulated by ERK (显示 MAPK1 蛋白), JNK (显示 MAPK8 蛋白) and p38MAPK (显示 MAPK14 蛋白) signaling pathways.
Recombinant, as well as native trout TNF-alpha, directly stimulates glucose uptake in trout muscle cells and provide evidence, for the first time in nonmammalian vertebrates, for a potential regulatory role of TNF-alpha in skeletal muscle metabolism.
In intestinal cells, TNF activates NF-kappaB (显示 NFKB1 蛋白), which reduces expression of the Cl(-) / HCO3(-) exchanger SLC26A3 (显示 SLC26A3 蛋白), via direct binding to the promoter region.
The levels of IL-1 (显示 IL1A 蛋白), IL-6 (显示 IL6 蛋白) and TNF-alpha in GCF (显示 GUCY2F 蛋白) were higher in patients with ischemic stroke but the difference was not significant. In conclusion, ischemic stroke was found to be associated with higher levels of IL-1beta (显示 IL1B 蛋白) and IL-6 (显示 IL6 蛋白) in serum
A hypo-fucosylated form of anti-TNF binds FcgammaRIIIa with higher affinity and induces development o (显示 MRC1 蛋白)f CD206(+) macrophages in human PBMCs, especially PBMCs that express low-affinity FcgammaRIIIa.
High TNF-alpha levels are associated with B12 (显示 NDUFB3 蛋白) deficiency and anemia.
A higher intake of fruits was related to lower insulin (显示 INS 蛋白), HOMA-IR, and TNF-alpha promoter methylation. A healthy dietary pattern and higher fruit intake (particularly apples and citrus fruits) were related to better glucose tolerance in healthy subjects, which could be mediated by lower TNF-alpha methylation.
The TNF-alpha-308A polymorphism is unlikely to play a major role in the risk for ocular C. Trachomatis in the Chinese population.
Calcipotriol increases the immunosuppressive power of betamethasone by suppressing the inflammatory TNF-alpha - IL-23 (显示 IL23A 蛋白) - IL-17 (显示 IL17A 蛋白) axis in psoriasis.
study reports that plasmacytoid dendritic cells (pDCs) incubated with IFNlambda3 plus IL-3 (显示 IL-3 蛋白) synergize in triggering the production of large amounts of both IFNalpha and TNFalphaTNFalpha; production of IFNalpha by IFNlambda3 plus IL-3 (显示 IL-3 蛋白)-treated pDCs is mostly dependent on endogenously produced TNFalpha
Our findings suggest that tumor necrosis factor-alpha promoter polymorphism may be an important candidate for body mass index, fasting glucose and postprandial triacylglycerol response.
High TNF-alpha expression is associated with breast cancer.
FcgammaR engagement by anti-TNF is required for reduction of colitis in mice and development of CD206 (显示 MRC1 蛋白)(+) macrophages.
long-term PM2.5 exposure caused hepatic steatosis and dyslipidemia through triggering inflammation, which was, at least partly, dependent on iRhom2 (显示 RHBDF2 蛋白)/TNF-alpha pathway in liver-resident macrophages
Pretreating mice with carrageenan once a day before injecting LPS (显示 TLR4 蛋白) increased the levels of IL-10 (显示 IL10 蛋白) by 2.5-fold and reduced TNF-alpha production by 2-fold compared with control. So, kappa/beta-carrageenan alone and in combination with LPS (显示 TLR4 蛋白) enhanced the cellular activity and mobility of peritoneal macrophages by increasing cell adhesion and migration compared with control.
TNF/Lymphotoxin alpha/beta deficiency influences PM2.5 exposure-induced response of energy metabolism through alterations in both food intake and energy expenditure.
TNF has an essential role in TLR ligand-mediated but not protease-mediated allergic airway inflammation
TonEBP (显示 NFAT5 蛋白) expression correlated with canonical osmoregulatory targets TauT/SLC6A6 (显示 TAUT 蛋白), SMIT/SLC5A3 (显示 SLC5A3 蛋白), and AR/AKR1B1 (显示 AKR1B1 蛋白), supporting in vitro findings that the inflammatory milieu during IDD (显示 DGS2 蛋白) does not interfere with TonEBP (显示 NFAT5 蛋白) osmoregulation. In summary, whereas TonEBP (显示 NFAT5 蛋白) participates in the proinflammatory response to TNF-alpha
Increased basal transmission and plasticity of glutamate (显示 GRIN1 蛋白) synapses that was related to increased levels of tumor necrosis factor alpha (TNFalpha).
Results showed that lncRNA SeT and miR (显示 MLXIP 蛋白)-155 mediate Tnfalpha gene dosage control by regulating the homologous pairing of the two gene alleles and ultimately regulating its biallelic pattern.
Internalized CpG oligodeoxynucleotide (ODN)-conjugated PPMs (PPM-CpG) greatly enhance the induction of selected cytokines (TNF-alpha and IL-6 (显示 IL6 蛋白)) in RAW 264.7 cells compared to that by the soluble CpG ODN and ionic complexes.
TMZ pretreatment effectively reduced the myocardial damage caused by CME via inhibiting the PDCD4 (显示 PDCD4 蛋白)/NF-kappaB (显示 NFKB1 蛋白)/ TNF-alpha pathway in cardiomyocytes.
TNF-alpha, secreted from activated Monocytes, mediates the downregulation of OTX2 (显示 OTX2 蛋白) and essential retinal pigment epithelium genes.
TNF-alpha induced MMP-13 (显示 MMP13 蛋白) expression by condylar cells might be involved in the degradation of the juvenile condyle.
TNF-alpha was able to promote theca interna cell proliferation. Our results suggest that TNF-alpha might play a role in hyperandrogenism, cortex thickness, and the increased ovary volume observed in polycystic ovaries.
This study showed that the -791(C-->T) mutation of the TNF-alpha gene could be considered an important potential genetic marker of enterotoxigenic Escherichia coli F18 (显示 MAMLD1 蛋白) resistance.
Both Nsp1beta and Nsp11 of porcine reproductive and respiratory syndrome virus were demonstrated to be responsible for the inhibitory effect on TNF-alpha production in pulmonary alveolar macrophages.
Study presents evidence demonstrating a single species of exotoxin ApxI, derived from A. pleuropneumoniae serotype 10, induces the expression and production of proinflammatory cytokines IL-1beta (显示 IL1B 蛋白), IL-8 (显示 IL8 蛋白) and TNF-alpha in porcine alveolar macrophages.
the role of miR (显示 MYLIP 蛋白)-181a in adipocyte differentiation by regulation of TNF-alpha
The NOS inhibitor, L-NMMA, significantly suppressed the combined effects of HT and CORM-2 on TNFalpha-triggered NFkappaBp65 phosphorylation as well as decreased cell viability.
High-volume hemofiltration improves hemodynamics and heart dysfunction in septic shock pigs, which may be attributed to reduction of TNF-alpha in myocardium but not in circulation.
Data suggest that luteolytic factors (such as TNFa, interferon gamma (显示 IFNG 蛋白), and PGF2a) control expression of MMP1 (显示 MMP1 蛋白), other matrix metalloproteinases, and tissue inhibitors of metalloproteinase in cultured luteal cells.
These results suggest that polymorphism of the TNFalpha-824 A>G gene and mTNFalpha protein expression play an important role in the pathogenesis of enzootic bovine leukosis.
These results suggest that the endometrium might lower the TNF concentration in the blastocyst by (1) regulating TNF secretion into the uterine fluid and (2) inducing decreased TNF and TNFR2 (显示 TNFRSF1B 蛋白) mRNA transcription in the embryo.
There was a significant association between the proviral load and a low frequency of the G/G genotype of TNF-alpha at position -824.
SNP in the TNF-alpha gene affects immune function and reproductive performance in dairy cows.
Studied genotypic and expression profiling of partial TNF-alpha gene and its association with mastitis susceptibility in 129 crossbred cattle.
Messenger RNA and protein levels of prostaglandin (PG) E synthase (PGES (显示 PTGES 蛋白)), PGF2alpha receptor (PGFR), tumor necrosis factor-alpha (TNF) and Fas (显示 FAS 蛋白) were found to be higher in the corpus luteum of pregnancy than in corpus luteum of the cycle.
TNF-alpha up-regulates NaV1.7 (显示 SCN9A 蛋白) mRNA in both adrenal chromaffin cells and dorsal root ganglia (DRG) neurons, highlighting the peripheral nociceptive mechanism of TNF-alpha
These results provide evidence for a high prevalence of subclinical endometritis in repeat breeding cows as well as the involvement of TNFalpha and iNOS (显示 NOS2 蛋白) pathways in the regulation of this pathological condition.
Exposure to follicular fluid transiently increased the transcript levels of IL8 (显示 IL8 蛋白) and PTGS2 (显示 PTGS2 蛋白), and decreased the expression of SOD2 (显示 SOD2 蛋白), GPX3 (显示 GPX3 蛋白), DAB2 (显示 DAB2 蛋白), and NR3C1 (显示 NR3C1 蛋白). TNF and IL6 (显示 IL6 蛋白) levels were also decreased while those of NAMPT (显示 NAMPT 蛋白) were unaffected.
The results obtained showed that IL-6 (显示 IL6 蛋白) expression in adipose tissue biopsies derived from animals with equine metabolic syndrome was enhanced while TNF-alpha levels of both groups were comparable.
Data indicate that tumor necrosis factor-alpha production is closely related to ovarian steroid actions.
These results indicate that in equine corpus luteum, cytokines TNF, IFNG (显示 IFNG 蛋白) and FASL (显示 FASL 蛋白) regulate nitric oxide activity, via eNOS (显示 NOS3 蛋白) expression modulation.
These data show the presence of cytokines TNF and IFNG (显示 IFNG 蛋白), and their receptors, in the equine corpus luteum and indicate their potential involvement in regulation of luteal function.
The contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of IL-6 (显示 IL6 蛋白), IL-10 (显示 IL10 蛋白) and TNF-alpha, in horses with recurrent airway obstruction during exacerbation and in remission is reported.
TUNEL staining was positively correlated with TNF-a protein expression. Our findings suggest that apoptosis can be induced in the vocal fold epithelium after 120min of modal intensity phonation. In contrast, shorter durations of vibration exposure do not result in apoptosis signaling.
Inflammatory factors such as TNF-alpha can stimulate MMP-2 (显示 MMP2 蛋白)/9 activity in corneal epithelium cells. This may be a potential manipulating mechanism of MMP expression in the pathogenesis of corneal diseases.
The JNK (显示 MAPK8 蛋白) pathway plays an important role in mechanical ventilation-stimulated TNF-alpha expression in alveolar macrophages, but the injury-stimulated IL-8 (显示 IL8 蛋白) expression may be regulated by other signaling pathways.
The TNFalpha-evoked Cl- current.
IL-1beta (显示 IL1B 蛋白) and TNF-alpha expression increases significantly during acute lung injury. Ambroxol combined with low-dose heparin inhibits teh release of IL-1beta (显示 IL1B 蛋白) and TNF-alpha.
Hypercapnia increased expression of TNFa and decreased expression of NFKB in acute lung injury models.
In the early stages of myocardial ischemia, bone marrow stem cells are mobilized and home to ischemic myocardium with a concomitant increase in expression of cytokines VEGF (显示 VEGFA 蛋白) and TNFalpha.
Ammonium perchlorate can increase gene expressions of types I, III collagens, TGF-beta(1 (显示 TGFB1 蛋白)) and TNF-alpha in lung of rabbits.
TNFalpha may either be directly or indirectly involved in vascular damage following an embolic stroke. Moreover, TNFalpha may mediate some of the detrimental effects of tPA (显示 PLAT 蛋白) on the vascular compartment
These interactions result in the induction of the TNF signaling pathway, activation of apoptosis, and DNA-damage stress response.
Findings showed that both mucosal compartments harbor similar percentages of memory CD4 (显示 CD4 蛋白)(+) T cells and displayed comparable cytokine TNF-alpha responses to mitogenic stimulations prior to infection.
Primary role for IL-1beta (显示 IL1B 蛋白) and TNF-alpha in the triggering of preterm labor associated with inflammation or infection.
Data indicate that three single-nucleotide polymorphisms were identified in tumor necrosis factor-alpha (TNF-alpha) gene.
The results reveal a crucial role for TNFalpha/TNFR2 (显示 TNFRSF1B 蛋白) axis in the protection of the skin against DUOX1 (显示 DUOX1 蛋白)-mediated oxidative stress.
TNF alpha is the first molecule identified that is produced by dying retinal neurons and is necessary to induce Muller glia to proliferate in the zebrafish retinal regeneration response.
The data suggest that Mycobacterium marinum SecA2 modulates adaptive immunity to promote granuloma stability, perhaps through induction of tumor necrosis factor alpha.
TNF is not required for tuberculous granuloma formation, but maintains granuloma integrity indirectly by restricting mycobacterial growth within macrophages and preventing their necrosis.
The main proinflammatory effects of fish TNF-alpha are mediated through the activation of endothelial cells and point to the complexity of the evolution that has taken place in the regulation of innate immunity by cytokines.
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
, TNF, macrophage-derived
, TNF, monocyte-derived
, tumor necrosis factor ligand superfamily member 2
, tumor necrosis factor-alpha
, tumor necrosis factor (TNF superfamily, member 2)
, tumor necrosis factor alpha
, tumor necrosis factor
, tumor-necrosis factor
, tumour necrosis factor
, TNF alpha
, ATP-binding cassette, sub-family F (GCN20), member 1
, tumour necrosis factor alpha
, putative tumour necrosis factor alpha
, LPS-induced TNF-alpha factor homolog
, TNF-alpha factor
, lipid-induced TNF-alpha factor
, lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog
, small integral membrane protein of lysosome/late endosome
, tissue necrosis factor-alpha
, tumor necrosis factor, alpha
, Tumor necrosis factor ligand superfamily member 2
, TNF-alpha 1