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MYD88 expression in subcutaneous adipose tissue of obese subjects could be associated with the development of components of Metabolic syndrome.
Patients with primary breast and primary female genital tract diffuse large B cell lymphoma have a high frequency of MYD88 mutations.
Mutation in the MYD88 gene is associated with lymphoplasmacytic lymphoma and chronic lymphocytic leukemia.
the polymorphisms in TLR-MyD88-NF-kappaB (显示 NFKB1 ELISA试剂盒) signaling pathway confer genetic susceptibility to Type 2 diabetes mellitus and diabetic nephropathy.
Here the authors show that MAL TIR domains spontaneously and reversibly form filaments in vitro. They also form cofilaments with TLR4 (显示 TLR4 ELISA试剂盒) TIR domains and induce formation of MyD88 assemblies.
data show that in pericytes, MyD88 and IRAK4 (显示 IRAK4 ELISA试剂盒) are key regulators of 2 major injury responses: inflammatory and fibrogenic.
Data indicate that 64 patients (57.1%) carried the myeloid differentiation factor 88 protein (MYD88) L265P mutation and 14 patients (12.5%) carried the chemokine (C-X-C motif) receptor 4 (CXCR4) WHIM (显示 CXCR4 ELISA试剂盒)-like mutation.
HCK (显示 HCK ELISA试剂盒) represents a novel target for therapeutic development in MYD88-mutated Waldenstrom macroglobulinemia and activated-B cell diffuse large B-cell lymphoma, and possibly other diseases driven by mutated MYD88.
We found an that enhanced expression of the TLR4 (显示 TLR4 ELISA试剂盒)-MyD88-NF-kB pathway occurs in GDM placentae, which positively correlates with heightened local IR in placentae and higher maternal hyperglycemia. The TLR4 (显示 TLR4 ELISA试剂盒)/MyD88/NF-kB pathway may play a potential role in the development of IR in placentae of GDM.
We found that over-expression of CRNDE in astrocytes increased the expression of key factors in the toll (显示 TLR4 ELISA试剂盒)-like receptor signaling pathway, especially toll-like receptor-3 (显示 TLR3 ELISA试剂盒)-mediated MyD88-independent pathway.We speculated that CRNDE might trigger inflammation to regulate tumorigenesis and tumor development through the toll (显示 TLR4 ELISA试剂盒)-like receptor pathway
Distinct mechanisms downstream of TLR4 (显示 TLR4 ELISA试剂盒) signaling mediate myelosuppression and hematopoietic stem cell exhaustion during sepsis through unique effects of MyD88 and TRIF (显示 RNF138 ELISA试剂盒).
these data show that both Myd88 and TRIF (显示 RNF138 ELISA试剂盒) are necessary for Th17 differentiation in the lungs in response to immunization with lipopolysaccharide
this study shows that MyD88-dependent myeloid-derived suppressor cells expansion from donor bone marrow is critical for protection against fatal intestinal graft-vs.-host disease
This study reveals that Ehrlichia-induced liver injury and toxic shock are mediated by MyD88-dependent inflammasome activation and autophagy inhibition.
MyD88 signaling in lysozyme (显示 LYZ ELISA试剂盒) M and CD11c (显示 ITGAX ELISA试剂盒)-expressing myeloid cells, as well as in pulmonary epithelial cells, is critical to restore inflammatory cytokine and antimicrobial peptide (显示 cAMP ELISA试剂盒) production, leading to efficient neutrophil recruitment and enhanced bacterial clearance.
These results suggest that S. Typhimurium promotes its systemic growth and dissemination through MyD88 signaling pathways in mesenchymal cells.
data are significant in uncovering a latent, but potent, negative-regulatory role for Myd88 and Fcer1g (显示 FCER1G ELISA试剂盒) in the late stages of B cell responses; such roles could limit acute responses; however, they could be particularly significant in chronic responses, such as autoimmunity and chronic infection
both Myd88(-/-) mouse strains developed some degree of epidermal thickening during the initial stages of IMQ-induced psoriasis, even in the absence of hematopoietic cell activation and infiltration into the skin, suggesting a contribution of MyD88-independent mechanisms in skin-resident stromal cells.
The data suggest that MyD88 signaling in dendritic cells (DC) and intestinal epithelial cells (IEC) is both essential and sufficient to induce a full spectrum of host responses upon intestinal infection with Citrobacter rodentium.
Downregulation of adaptor protein MyD88 compromises the angiogenic potential of B16 murine melanoma\
a novel function of MyD88 in the regulation of metabolism that appears to be independent of its known roles in immunity and development.
propose that dMyD88 is the functional homolog of TIRAP (显示 TIRAP ELISA试剂盒) and that both proteins function as sorting adaptors to recruit downstream signaling adaptors to activated receptors
DmMyD88 encodes an essential component of the Toll (显示 TLR4 ELISA试剂盒) pathway in dorsoventral pattern formation.
We show that there is a direct interaction between Kra and Tube presumably mediated by the death domains present in both proteins.
both the heterodimeric and heterotrimeric complexes form kidney-shaped structures and that Tube is bivalent and has separate high affinity binding sites for dMyD88 and Pelle (显示 IRAK1 ELISA试剂盒).
These results suggest that porcine circovirus 2 induces IL-8 (显示 IL8 ELISA试剂盒) secretion via the TLR2 (显示 TLR2 ELISA试剂盒)/MyD88/NF-kappaB (显示 NFKB1 ELISA试剂盒) signalling pathway.
At 30 days after autotransplantation of a pig kidney, mRNA expression increases for MyD88.
These results suggest that an MyD88-dependent signaling pathway is present in newborn as well as in adult swine and that it is involved in the innate immune system of these animals.
Fish IRF6 (显示 IRF6 ELISA试剂盒) is distinguished from the homolog of mammals by being a positive regulator of IFN transcription and phosphorylated by MyD88 and TBK1 (显示 TBK1 ELISA试剂盒), suggesting that differences in the IRF6 (显示 IRF6 ELISA试剂盒) regulation pattern exist between lower and higher vertebrates.
DrIRF1 works in concert with MyD88 to activate zebrafish IFNvarphi3 but not IFNvarphi1. These results provide insights into the evolving function of IRF1 (显示 IRF1 ELISA试剂盒) as a positive IFN regulator.
MyD88 signaling has an important protective role during early pathogenesis.
MyD88-dependent signaling is involved in the innate immune response of the developing zebrafish embryo, a model for the study of vertebrate innate immunity.
L. rhamnosus GR-1 ameliorates the E. coli-induced disruption of cellular ultrastructure, subsequently reducing the percentage of bovine endometrial epithelial cells apoptosis and limiting inflammatory responses, partly via attenuation of MyD88-dependent and MyD88-independent pathway activation
Modulated cytokine expression in Bovine viral diarrhea virus type 2 infected macrophages was associated with decreased MyD88 expression.
The study demonstrates that in cattle, animals heterozygous at the MyD88 A625C polymorphic marker have a 5-fold reduced risk for active pulmonary tuberculosis.
MyD88 plays a functional role in transducing LPS (显示 IRF6 ELISA试剂盒) signaling from TLR-4 (显示 TLR4 ELISA试剂盒) to downstream effector molecules involved in NF-kappaB (显示 NFKB1 ELISA试剂盒) activation
MyD88 interacts with interferon (显示 IFNA ELISA试剂盒) regulatory factor (IRF) 3 (显示 IRF3 ELISA试剂盒) and IRF7 (显示 IRF7 ELISA试剂盒) in Atlantic salmon (Salmo salar)
the salmon MyD88 was cloned and its expression was analysed.
This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants.
myeloid differentiation primary response gene (88)
, myeloid differentiation primary response protein MyD88
, myeloid differentiation primary response protein MyD88-B
, Toll/IL-1 receptor binding protein MyD88-B
, myeloid differentiation primary response gene 88
, myeloid differentiation primary response factor 88
, myeloid differentiation factor 88
, myeloid differentiation primary response protein 88
, myeloid differentiation response protein 88