anti-Lysyl Oxidase-Like 2 (LOXL2) 抗体产品概述

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anti-Lysyl Oxidase-Like 2 抗体 (LOXL2)
在www.antibodies-online.cn可供108 Lysyl Oxidase-Like 2 (LOXL2) 抗体的19不同的供货商。 再加上,我们可以发Lysyl Oxidase-Like 2 蛋白 (29)Lysyl Oxidase-Like 2 试剂盒 (27)和数多这个蛋白质的别的产品。 总共173 Lysyl Oxidase-Like 2产品已列进来了。
别名:
1110004B06Rik, 4930526G11Rik, 9430067E15Rik, CG4402, Dmel\\CG4402, dmlox-2, Dmloxl-2, GB13360, LOR2, lox2-like, loxl-2, LOXL2, WS9-14

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  1. Human Monoclonal LOXL2 Primary Antibody for ELISA, WB - ABIN396576 : Rodriguez, Vaysberg, Mikels, McCauley, Velayo, Garcia, Smith: Modulation of lysyl oxidase-like 2 enzymatic activity by an allosteric antibody inhibitor. in The Journal of biological chemistry 2010 (PubMed)
    Show all 5 references for 396576

  2. Human Polyclonal LOXL2 Primary Antibody for EIA, WB - ABIN953202 : Rückert, Joensson, Saeger, Grützmann, Pilarsky: Functional analysis of LOXL2 in pancreatic carcinoma. in International journal of colorectal disease 2010 (PubMed)
    Show all 4 references for 953202

  3. Human Monoclonal LOXL2 Primary Antibody for ELISA, WB - ABIN561690 : Fujimoto, Tajima: Reciprocal regulation of LOX and LOXL2 expression during cell adhesion and terminal differentiation in epidermal keratinocytes. in Journal of dermatological science 2009 (PubMed)
    Show all 3 references for 561690

  4. Human Polyclonal LOXL2 Primary Antibody for ELISA, WB - ABIN561689 : Ghiggeri, Gigante, Di Donato et al.: Constitutional Nephrin Deficiency in Conditionally Immortalized Human Podocytes Induced Epithelial-Mesenchymal Transition, Supported by β-Catenin/NF-kappa B Activation: A Consequence of Cell Junction ... in International journal of nephrology 2014 (PubMed)

  5. Human Polyclonal LOXL2 Primary Antibody for ICC, IF - ABIN442901 : Wong, Zhang, Gilkes, Chen, Wei, Chaturvedi, Hubbi, Semenza: Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis. in Journal of molecular medicine (Berlin, Germany) 2012 (PubMed)

更多抗Lysyl Oxidase-Like 2的相互作用对抗体

Fruit Fly (Drosophila melanogaster) Lysyl Oxidase-Like 2 (LOXL2) interaction partners

  1. Dmloxl-1 and Dmloxl-2 are differentially expressed; active DmLOXL-1 influences gene expression and development

Human Lysyl Oxidase-Like 2 (LOXL2) interaction partners

  1. new LOXL2 splice variant contributes to tumor progression by novel molecular mechanisms different from LOXL2WT

  2. LOXL2 is a potential therapeutic target against tumor progression.

  3. Insulin (显示 INS 抗体) resistance promotes lysyl oxidase like 2 induction and fibrosis accumulation in non-alcoholic fatty liver disease.

  4. SMYD3 (显示 SMYD3 抗体) enhances tumorigenicity in esophageal squamous cell carcinoma by enhancing transcription of ezrin (显示 EZR 抗体) and LOXL2, which are involved in proliferation, migration, and invasion.

  5. Data show that lysyl oxidase-like 2 (LOXL2) is a histone modifier enzyme that removes trimethylated lysine 4 (K4) in histone H3 (显示 HIST3H3 抗体) (H3K4me3) through an amino-oxidase reaction.

  6. LOXL2 was determined to promote proliferation of hepatocellular carcinoma (HCC (显示 FAM126A 抗体)) and demonstrated to be highly expressed in HCC (显示 FAM126A 抗体) adjacent non-tumor tissue samples compared with tumor tissue samples.

  7. LOXL2 messenger RNA levels were increased in intrahepatic cholangiocarcinoma. These results were confirmed at a protein level, with a significantly higher LOXL2 immunostaining tumoral stroma. Univariate analysis revealed that LOXL2 expression was correlated with a poor overall survival and disease-free survival.

  8. glomerular extracellular matrix. Altogether, we demonstrate that LOXL2 is a novel component of the molecular machinery that forms cross-linked collagen IV (显示 COL4 抗体) networks, which are essential for glomerular basement membrane stability and molecular ultrafiltration function.

  9. The expression levels of lysyl oxidase-like 2 (LOXL2) mRNA and protein were markedly suppressed in transfected prostate cancer cells with microRNAs miR (显示 MLXIP 抗体)-26a, miR (显示 MLXIP 抗体)-26b, miR (显示 MLXIP 抗体)-29a, miR (显示 MLXIP 抗体)-29b, miR (显示 MLXIP 抗体)-29c and miR (显示 MLXIP 抗体)-218.

  10. Overexpression of LOXL2 and SERPINH1 (显示 SERPINH1 抗体) was observed in clinical specimens of lung cancer and fibrotic lesions. Downregulation of miR (显示 MLXIP 抗体)-29a caused overexpression of LOXL2 and SERPINH1 (显示 SERPINH1 抗体) in lung cancer and IPF, suggesting that these genes are involved in the pathogenesis of these two diseases.

Mouse (Murine) Lysyl Oxidase-Like 2 (LOXL2) interaction partners

  1. Insulin (显示 INS 抗体) resistance promotes lysyl oxidase like 2 (显示 LOXL3 抗体) induction and fibrosis accumulation in non-alcoholic fatty liver disease.

  2. glomerular extracellular matrix. Altogether, we demonstrate that LOXL2 (显示 LOXL3 抗体) is a novel component of the molecular machinery that forms cross-linked collagen IV (显示 COL4 抗体) networks, which are essential for glomerular basement membrane stability and molecular ultrafiltration function.

  3. LOX (显示 LOX 抗体) and LOXL2 (显示 LOXL3 抗体) may play an important role in the pathogenesis of AMD (显示 AMD1 抗体). Targeting LOXL2 (显示 LOXL3 抗体) could have a broader efficacy than targeting LOX (显示 LOX 抗体), by reducing angiogenesis and inflammation, as well as fibrosis.

  4. Loss and gain of function analyses combined with in vivo studies in syngeneic breast cancer models demonstrate the participation of LOXL2 (显示 LOXL3 抗体) and E47 (显示 TCF3 抗体) in tumor growth and their requirement for lung metastasis.

  5. Findings reveal new insight into the mechanisms of fibroblast activation, a novel function of LOXL2 (显示 LOXL3 抗体), and further highlight the importance of generating LOXL2 (显示 LOXL3 抗体)-targeted therapies for the prevention of tumor progression and metastasis.

  6. The Snail1 (显示 SNAI1 抗体) transcription factor represses mouse pericentromeric transcription, acting through the H3K4 deaminase LOXL2 (显示 LOXL3 抗体).

  7. The enzymatic activity of lysyl oxidas-like-2 (LOXL2 (显示 LOXL3 抗体)) is not required for LOXL2 (显示 LOXL3 抗体)-induced inhibition of keratinocyte differentiation.

  8. This study provides the first evidence for the role of LOXL2 (显示 LOXL3 抗体) in regulating angiogenesis through collagen IV (显示 COL4 抗体) scaffolding.

  9. LOXL2 (显示 LOXL3 抗体) promotes chondrocyte differentiation by mechanisms that are likely to include roles as both a regulator and an effector of chondrocyte differentiation

  10. The efficacy and safety of LOXL2 (显示 LOXL3 抗体)-specific monoclonal antibody represents a new therapeutic approach with broad applicability in oncologic and fibrotic diseases.

Lysyl Oxidase-Like 2 (LOXL2) 抗原简介

Antigen Summary

This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.

Alternative names and synonyms associated with Lysyl Oxidase-Like 2 (LOXL2)

  • lysyl oxidase-like 2 (lox2) 抗体
  • lysyl oxidase-like 2 (LOXL2) 抗体
  • lysyl oxidase-like 2 (loxl2) 抗体
  • lysyl oxidase-like 2 (Loxl2) 抗体
  • 1110004B06Rik 抗体
  • 4930526G11Rik 抗体
  • 9430067E15Rik 抗体
  • CG4402 抗体
  • Dmel\\CG4402 抗体
  • dmlox-2 抗体
  • Dmloxl-2 抗体
  • GB13360 抗体
  • LOR2 抗体
  • lox2-like 抗体
  • loxl-2 抗体
  • LOXL2 抗体
  • WS9-14 抗体

Protein level used designations for LOXL2

CG4402-PA , lox2-PA , lysyl oxidase-like 2 , Lysyl oxidase-like protein 2 , lysyl oxidase homolog 2 , lysyl oxidase homolog 2-like , lysyl oxidase related 2 , lysyl oxidase-like protein 2 , lysyl oxidase-related protein 2 , lysyl oxidase-related protein WS9-14 , Lysyl oxidase homolog 2

GENE ID SPECIES
37485 Drosophila melanogaster
408544 Apis mellifera
585092 Strongylocentrotus purpuratus
100158339 Xenopus laevis
100216062 Xenopus (Silurana) tropicalis
100413360 Callithrix jacchus
464053 Pan troglodytes
710151 Macaca mulatta
100543026 Meleagris gallopavo
4017 Homo sapiens
419533 Gallus gallus
486118 Canis lupus familiaris
532684 Bos taurus
94352 Mus musculus
290350 Rattus norvegicus
100171427 Pongo abelii
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