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抗Human SMAD2 抗体:
抗Mouse (Murine) SMAD2 抗体:
抗Rat (Rattus) SMAD2 抗体:
Human Monoclonal SMAD2 Primary Antibody for IF, IP - ABIN968106
Babu, Jeganathan, Baker, Wu, Kang-Decker, van Deursen: Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation. in The Journal of cell biology 2003
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Human Monoclonal SMAD2 Primary Antibody for IF, IP - ABIN968105
Chen, Waters, Salmon, Murray: Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores. in Science (New York, N.Y.) 1996
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Human Polyclonal SMAD2 Primary Antibody for WB - ABIN2801941
Liu, Pouponnot, Massagué: Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes. in Genes & development 1998
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Human Monoclonal SMAD2 Primary Antibody for ICC, FACS - ABIN969401
Wendt, Smith, Schiemann: p130Cas is required for mammary tumor growth and transforming growth factor-beta-mediated metastasis through regulation of Smad2/3 activity. in The Journal of biological chemistry 2009
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Human Polyclonal SMAD2 Primary Antibody for WB - ABIN1842518
Song, Thalacker, Nilsen-Hamilton: Synergistic and multidimensional regulation of plasminogen activator inhibitor type 1 expression by transforming growth factor type ? and epidermal growth factor. in The Journal of biological chemistry 2012
Human Monoclonal SMAD2 Primary Antibody for FACS, IF - ABIN967045
Hannan, Jamshidi, Pera, Wolvetang: BMP-11 and myostatin support undifferentiated growth of human embryonic stem cells in feeder-free cultures. in Cloning and stem cells 2009
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Human Polyclonal SMAD2 Primary Antibody for WB - ABIN362418
Kim, Jong, Kim, Lee, Kim, Hong, Bang: Transforming growth factor-beta 1 induces apoptosis through Fas ligand-independent activation of the Fas death pathway in human gastric SNU-620 carcinoma cells. in Molecular biology of the cell 2004
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Human Polyclonal SMAD2 Primary Antibody for WB - ABIN362416
Zhang, Shen, Zhang, Wan, Yao, Wu, Wang, Chen, Yan, Jiang: Induction of thoracic aortic remodeling by endothelial-specific deletion of microRNA-21 in mice. in PLoS ONE 2013
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Human Polyclonal SMAD2 Primary Antibody for IHC (p), IHC - ABIN316295
Lee, Lee, Bae, Jung: Abnormal liver differentiation and excessive angiogenesis in mice lacking Runx3. in Histochemistry and cell biology 2013
Human Polyclonal SMAD2 Primary Antibody for ELISA, WB - ABIN257079
Eppert, Scherer, Ozcelik, Pirone, Hoodless, Kim, Tsui, Bapat, Gallinger, Andrulis, Thomsen, Wrana, Attisano: MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma. in Cell 1996
The non-Smad (显示 SMAD1 抗体) JNK (显示 MAPK8 抗体) signaling pathway, which is downstream of Nodal signaling, regulates nuclear movement independently of the Smad (显示 SMAD1 抗体) pathway, and this nuclear movement is associated with Smad (显示 SMAD1 抗体) signal transduction toward the nucleus.
The results of this study found that Bptf (显示 BPTF 抗体) and TGF-beta (显示 TGFB1 抗体)/Smad2 mediate nucleosome remodeling to regulate wnt8a (显示 WNT8A 抗体) expression and hence neural posteriorization.
Smad2 and Eomesodermin (显示 EOMES 抗体) a (Eomesa (显示 EOMES 抗体)) bind common genomic regions proximal to genes involved in mesoderm and endoderm formation, suggesting Eomesa (显示 EOMES 抗体) forms a general component of the Smad2 signalling complex in zebrafish.
These results reveal that kinesin-mediated transport of Smad2 along microtubules to the receptors is an essential step in ligand-induced Smad2 activation.
study systemically uncovers a large number of Smad2 targets in early gastrulas and suggests cooperative roles of Smad2 and other transcription factors in controlling target gene transcription
Nodal signaling and mesendoderm induction depend on Smad2/3 and suggest that transforming growth factor-beta signals other than Nodal also contribute to Smad2/3 signaling and embryonic patterning.
Smad2/3 activities play important roles not only in mesendodermal development but also in neural development during early vertebrate embryogenesis
CRT (显示 SLC6A8 抗体) regulates TGF-beta1 (显示 TGFB1 抗体)-induced-EMT (显示 ITK 抗体) through modulating Smad (显示 SMAD1 抗体) signaling
P311 (显示 C5orf13 抗体) is a novel TGFbeta1 (显示 TGFB1 抗体)/Smad (显示 SMAD1 抗体) signaling-mediated regulator of transdifferentiation in epidermal stem cells during cutaneous wound healing.
human epidermal growth factor receptor (显示 EGFR 抗体) 2 (HER-2 (显示 ERBB2 抗体)) levels, were correlated well with TSP50 (显示 PRSS50 抗体)/p-Samd2 (显示 SARM1 抗体)/3 and TSP50 (显示 PRSS50 抗体)/p27 (显示 PAK2 抗体) expression status. Thus, our studies revealed a novel regulatory mechanism underlying TSP50 (显示 PRSS50 抗体)-induced cell proliferation and provided a new favorable intervention target for the treatment of breast cancer
IL-17 (显示 IL17A 抗体) can induce A549 alveolar epithelial cells to undergo epithelial-mesenchymal transition via the TGF-beta1 (显示 TGFB1 抗体) mediated Smad2/3 and ERK1/2 (显示 MAPK1/3 抗体) activation
a critical role for miR (显示 MLXIP 抗体)-503-3p in induction of breast cancer EMT (显示 ITK 抗体)
Nuclear localization of Smad2 was reduced in TGFbeta (显示 TGFB1 抗体)-1-stimulated primary tubular epithelial cells. Changes in nuclear Smad2 correlated with a reduced expression of the pro-fibrotic factor CTGF (显示 CTGF 抗体). Transient downregulation of Smad2 interfered with TGFbeta (显示 TGFB1 抗体)-1-induced CTGF (显示 CTGF 抗体) synthesis.
Low SMAD2 expression is associated with progression of hepatic fibrosis.
In order to study the translation between mouse model and patients, we evaluated the signature of phosphorylated Sma- and Mad-related protein 2 (pSmad2), as molecular marker of TGF-beta/activin activity, in the kidneys of streptozotocin (STZ)-treated mice compared to that of type 1 diabetes (T1D) patients.
SMAD2/SMAD3 (显示 SMAD3 抗体) signaling by bone morphogenetic proteins causes disproportionate induction of HAS2 (显示 HAS2 抗体) expression and hyaluronan production in immortalized human granulosa cells.
miR (显示 MLXIP 抗体)-27a contributed to cell proliferation and invasion by inhibiting TGF-beta (显示 TGFB1 抗体)-induced cell cycle arrest. These results suggest that miR (显示 MLXIP 抗体)-27a may function as an oncogene (显示 RAB1A 抗体) by regulating SMAD2 and SMAD4 (显示 SMAD4 抗体) in lung cancer.
Grg4 (显示 TLE4 抗体) occupancy at the Xnr1 (显示 NODAL 抗体) enhancer significantly decreases with Smad2 overexpression.Nodal-activated Smad2 physically displaces Grg4 (显示 TLE4 抗体) from FoxH1 (显示 FOXH1 抗体) at the Xnr1 (显示 NODAL 抗体) enhancer, an essential feature of the transcriptional switch mechanism.
E2a (显示 TCF3 抗体) is necessary to drive transcription of Smad2/3 target genes, including critical regulators of dorsal cell fate and morphogenesis
GDF11 (显示 GDF11 抗体) has a central role in the activation of Smad2 phosphorylation in tailbud stage Xenopus embryos.
XPIASy functions as an essential negative regulator of the XSmad2 pathway to ensure proper mesoderm induction at the appropriate time and in the appropriate region.
Activin A (显示 INHBA 抗体) and overexpression of SMAD2/3 significantly promoted expressions of porcine NANOG (显示 NANOG 抗体) and OCT4 (显示 POU5F1 抗体),maintaining induced pluripotent stem cell self-renewal through up-regulation of Nanog (显示 NANOG 抗体)/OCT4 (显示 POU5F1 抗体) expression.
the present work provides evidence supporting a functional role of SMAD2/3 in bovine early embryogenesis
Mechanical compression not only with physiological but also with excessive stress can activate Smad2/3P signaling, which is known to be protective for articular cartilage and to block chondrocyte terminal differentiation.
a detailed computational model for TGF-beta (显示 TGFB1 抗体) signalling that incorporates elements of previous models together with crosstalking between Smad1 (显示 SMAD1 抗体)/5/8 and Smad2/3 channels through a negative feedback loop dependent on Smad7 (显示 SMAD7 抗体).
This study tested the hypothesis that inhibins act in an autocrine manner on Leydig cells using a pre-pubertal Leydig cell line, TM3 (显示 TPM1 抗体), as a model of immature Leydig cells.
Lnc-LFAR1 binds directly to Smad2/3 and promotes transcription of TGFbeta (显示 TGFB1 抗体), Smad2, Smad3 (显示 SMAD3 抗体), Notch2 (显示 NOTCH2 抗体) and Notch3 (显示 NOTCH3 抗体) which, in turn, results in TGFbeta (显示 TGFB1 抗体) and Notch (显示 NOTCH1 抗体) pathway activation.
the levels of Smad2/3, P-Smad2/3 expressions were decreased, while the level of Smad7 (显示 SMAD7 抗体) expression was increased after treatment with osthole.
These findings implicate TGF-beta (显示 TGFB1 抗体)-Smad2/3 signaling in activated tissue-resident cardiac fibroblasts as principal mediators of the fibrotic response.
selective inhibition of SMAD3 (显示 SMAD3 抗体) or CCT6A (显示 CCT6A 抗体) efficiently suppresses TGF-beta (显示 TGFB1 抗体)-mediated metastasis. Findings provide a mechanism that directs TGF-beta (显示 TGFB1 抗体) signaling toward its prometastatic arm and may contribute to the development of therapeutic strategies targeting TGF-beta (显示 TGFB1 抗体) for non-small-cell lung carcinoma.
results demonstrate that TGF-beta1 (显示 TGFB1 抗体)-induced autophagy links beta-catenin (显示 CTNNB1 抗体) and Smad (显示 SMAD1 抗体) signaling to promote epithelial-mesenchymal transition in C1.1 cells through a novel pY654-beta-catenin (显示 CTNNB1 抗体)/p-Smad2/ILK (显示 ILK 抗体) pathway.
These results suggest that Nedd9 (显示 NEDD9 抗体) is a Smad2/3 target gene implicated in RANKL (显示 TNFSF11 抗体)-induced osteoclastogenesis.
In conclusion, TGF-beta (显示 TGFB1 抗体) signaling pathway may influence liver fibrosis by incorporating with YB-1 (显示 YBX1 抗体), indicating that YB-1 (显示 YBX1 抗体) could be a potential target for therapies against liver fibrosis.
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene.
SMAD, mothers against DPP homolog 2
, MAD (mothers against decapentaplegic, Drosophila) homolog 2
, SMA- and MAD-related protein 2
, SMAD 2
, SMAD family member 2
, mothers against DPP homolog 2
, mothers against decapentaplegic homolog 2
, MAD homolog 2
, Sma- and Mad-related protein 2
, mother against DPP homolog 2
, mothers against decapentaplegic-like 2
, Smad 2
, mad-related protein 2