anti-SMAD2 (SMAD2) 抗体产品概述

Full name:
anti-SMAD, Mothers Against DPP Homolog 2 抗体 (SMAD2)
在www.antibodies-online.cn可供424 SMAD, Mothers Against DPP Homolog 2 (SMAD2) 抗体的30不同的供货商。 再加上,我们可以发SMAD2 试剂盒 (43)SMAD2 蛋白 (29)和数多这个蛋白质的别的产品。 总共516 SMAD2产品已列进来了。
7120426M23Rik, fj43c06, hMAD-2, hSMAD2, JV18, JV18-1, Madh2, Madr2, mMad2, Smad-2, wu:fj43c06, Xmad2, XSmad2

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所有可销售的anti-SMAD2 抗体


引用最多的anti-SMAD2 抗体

  1. Human Polyclonal SMAD2 Primary Antibody for IF, IHC - ABIN1532651 : Zhang, Feng, We, Derynck: Receptor-associated Mad homologues synergize as effectors of the TGF-beta response. in Nature 1996 (PubMed)
    Show all 2 references for 1532651

  2. Human Polyclonal SMAD2 Primary Antibody for ELISA, WB - ABIN1532650 : Eppert, Scherer, Ozcelik, Pirone, Hoodless, Kim, Tsui, Bapat, Gallinger, Andrulis, Thomsen, Wrana, Attisano: MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma. in Cell 1996 (PubMed)
    Show all 2 references for 1532650

  3. Human Polyclonal SMAD2 Primary Antibody for IHC (p), IHC - ABIN316295 : Lee, Lee, Bae, Jung: Abnormal liver differentiation and excessive angiogenesis in mice lacking Runx3. in Histochemistry and cell biology 2013 (PubMed)

  4. Cow (Bovine) Polyclonal SMAD2 Primary Antibody for WB - ABIN2780721 : Zheng, Zugates, Lu, Shi, Bai, Lee: Baboon/dSmad2 TGF-beta signaling is required during late larval stage for development of adult-specific neurons. in The EMBO journal 2006 (PubMed)

  5. Human Polyclonal SMAD2 Primary Antibody for IF, WB - ABIN391546 : Funaba, Zimmerman, Mathews: Modulation of Smad2-mediated signaling by extracellular signal-regulated kinase. in The Journal of biological chemistry 2002 (PubMed)

  6. Cow (Bovine) Polyclonal SMAD2 Primary Antibody for IHC, WB - ABIN2779412 : Antonson, Jakobsson, Almlöf, Guldevall, Steffensen, Gustafsson: RAP250 is a coactivator in the transforming growth factor beta signaling pathway that interacts with Smad2 and Smad3. in The Journal of biological chemistry 2008 (PubMed)


Zebrafish SMAD, Mothers Against DPP Homolog 2 (SMAD2) interaction partners

  1. The results of this study found that Bptf (显示 BPTF 抗体) and TGF-beta (显示 TGFB1 抗体)/Smad2 mediate nucleosome remodeling to regulate wnt8a (显示 WNT8A 抗体) expression and hence neural posteriorization.

  2. Smad2 and Eomesodermin (显示 EOMES 抗体) a (Eomesa (显示 EOMES 抗体)) bind common genomic regions proximal to genes involved in mesoderm and endoderm formation, suggesting Eomesa (显示 EOMES 抗体) forms a general component of the Smad2 signalling complex in zebrafish.

  3. These results reveal that kinesin-mediated transport of Smad2 along microtubules to the receptors is an essential step in ligand-induced Smad2 activation.

  4. study systemically uncovers a large number of Smad2 targets in early gastrulas and suggests cooperative roles of Smad2 and other transcription factors in controlling target gene transcription

  5. Nodal signaling and mesendoderm induction depend on Smad2/3 and suggest that transforming growth factor-beta signals other than Nodal also contribute to Smad2/3 signaling and embryonic patterning.

  6. Smad2/3 activities play important roles not only in mesendodermal development but also in neural development during early vertebrate embryogenesis

Human SMAD, Mothers Against DPP Homolog 2 (SMAD2) interaction partners

  1. selective inhibition of SMAD3 (显示 SMAD3 抗体) or CCT6A (显示 CCT6A 抗体) efficiently suppresses TGF-beta (显示 TGFB1 抗体)-mediated metastasis. Findings provide a mechanism that directs TGF-beta (显示 TGFB1 抗体) signaling toward its prometastatic arm and may contribute to the development of therapeutic strategies targeting TGF-beta (显示 TGFB1 抗体) for non-small-cell lung carcinoma.

  2. In response to TGF-beta (显示 TGFB1 抗体), RASSF1A (显示 RASSF1 抗体) is recruited to TGF-beta (显示 TGFB1 抗体) receptor I and targeted for degradation by the co-recruited E3 ubiquitin ligase (显示 MUL1 抗体) ITCH. RASSF1A (显示 RASSF1 抗体) degradation is necessary to permit Hippo pathway effector YAP1 (显示 YAP1 抗体) association with SMADs and subsequent nuclear translocation of receptor-activated SMAD2.

  3. Smad2 is a key scaffold, allowing RIN1 (显示 RIN1 抗体) to act as a GTP (显示 AK3 抗体) exchange factor for MFN2 (显示 MFN2 抗体)-GTPase (显示 RACGAP1 抗体) activation to promote mitochondrial ATP synthesis and suppress superoxide production during mitochondrial fusion.

  4. Ang (显示 ANG 抗体) down-regulate the expression of Col (显示 HDAC1 抗体)-I, alpha-SMA (显示 SMN1 抗体) and TGF-beta1 (显示 TGFB1 抗体)/Smad2/3 and subsequently inhibits fibroblast-myofibroblast transition.

  5. The nuclear importin (显示 KPNA4 抗体) IPO5 (显示 IPO5 抗体) was identified as a novel interacting protein of SMAD1 (显示 GARS 抗体). Overexpression of IPO5 (显示 IPO5 抗体) in various cell lines specifically increases nuclear localization of BMP receptor (显示 BMPR1A 抗体)-activated SMADs (R-SMADs) confirming a functional relationship between IPO5 (显示 IPO5 抗体) and BMP but not TGF-beta (显示 TGFB1 抗体) R-SMADs.

  6. Our findings suggest a stronger chondrogenic potential of CD105(+) SMSCs in comparison to that of CD105(-) SMSCs and that CD105 enhances chondrogenesis of SMSCs by regulating TGF-beta (显示 TGFB1 抗体)/Smad2 signaling pathway, but not Smad1 (显示 GARS 抗体)/5. Our study provides a better understanding of CD105 with respect to chondrogenic differentiation.

  7. the findings show that TIEG1 (显示 KLF10 抗体) is highly expressed in human keloids and that it directly binds and represses Smad7 (显示 SMAD7 抗体) promoter-mediated activation of TGF-beta (显示 TGFB1 抗体)/Smad2 signaling

  8. A significant association was found between the low expression of inhibitory protein SMAD-7 (显示 SMAD7 抗体) and both zeta-chain-associated protein kinase (显示 CDK7 抗体) 70-negative cells (p = 0.04) and lower apoptotic index (p = 0.004). No differences were observed in SMAD-2/3 expression. In conclusion, our results demonstrate a significant correlation between greater SMAD-1 (显示 GARS 抗体)/8 and lower SMAD-4 (显示 SMAD4 抗体) expression in chronic lymphocytic leukemia cells

  9. High expression of SMAD2 is associated with colorectal carcinoma.

  10. this study shows that tolfenamic acid inhibits growth of colon cancer cells through downregulation of Smad2

Xenopus laevis SMAD, Mothers Against DPP Homolog 2 (SMAD2) interaction partners

  1. Grg4 (显示 TLE4 抗体) occupancy at the Xnr1 (显示 NODAL 抗体) enhancer significantly decreases with Smad2 overexpression.Nodal-activated Smad2 physically displaces Grg4 (显示 TLE4 抗体) from FoxH1 (显示 FOXH1 抗体) at the Xnr1 (显示 NODAL 抗体) enhancer, an essential feature of the transcriptional switch mechanism.

  2. E2a (显示 TCF3 抗体) is necessary to drive transcription of Smad2/3 target genes, including critical regulators of dorsal cell fate and morphogenesis

  3. GDF11 (显示 GDF11 抗体) has a central role in the activation of Smad2 phosphorylation in tailbud stage Xenopus embryos.

  4. XPIASy functions as an essential negative regulator of the XSmad2 pathway to ensure proper mesoderm induction at the appropriate time and in the appropriate region.

Pig (Porcine) SMAD, Mothers Against DPP Homolog 2 (SMAD2) interaction partners

  1. Activin A (显示 INHBA 抗体) and overexpression of SMAD2/3 significantly promoted expressions of porcine NANOG (显示 NANOG 抗体) and OCT4 (显示 POU5F1 抗体),maintaining induced pluripotent stem cell self-renewal through up-regulation of Nanog (显示 NANOG 抗体)/OCT4 (显示 POU5F1 抗体) expression.

Cow (Bovine) SMAD, Mothers Against DPP Homolog 2 (SMAD2) interaction partners

  1. the present work provides evidence supporting a functional role of SMAD2/3 in bovine early embryogenesis

  2. Mechanical compression not only with physiological but also with excessive stress can activate Smad2/3P signaling, which is known to be protective for articular cartilage and to block chondrocyte terminal differentiation.

  3. a detailed computational model for TGF-beta (显示 TGFB1 抗体) signalling that incorporates elements of previous models together with crosstalking between Smad1 (显示 SMAD1 抗体)/5/8 and Smad2/3 channels through a negative feedback loop dependent on Smad7 (显示 SMAD7 抗体).

Mouse (Murine) SMAD, Mothers Against DPP Homolog 2 (SMAD2) interaction partners

  1. selective inhibition of SMAD3 (显示 SMAD3 抗体) or CCT6A (显示 CCT6A 抗体) efficiently suppresses TGF-beta (显示 TGFB1 抗体)-mediated metastasis. Findings provide a mechanism that directs TGF-beta (显示 TGFB1 抗体) signaling toward its prometastatic arm and may contribute to the development of therapeutic strategies targeting TGF-beta (显示 TGFB1 抗体) for non-small-cell lung carcinoma.

  2. results demonstrate that TGF-beta1 (显示 TGFB1 抗体)-induced autophagy links beta-catenin (显示 CTNNB1 抗体) and Smad (显示 SMAD1 抗体) signaling to promote epithelial-mesenchymal transition in C1.1 cells through a novel pY654-beta-catenin (显示 CTNNB1 抗体)/p-Smad2/ILK (显示 ILK 抗体) pathway.

  3. These results suggest that Nedd9 (显示 NEDD9 抗体) is a Smad2/3 target gene implicated in RANKL (显示 TNFSF11 抗体)-induced osteoclastogenesis.

  4. In conclusion, TGF-beta (显示 TGFB1 抗体) signaling pathway may influence liver fibrosis by incorporating with YB-1 (显示 YBX1 抗体), indicating that YB-1 (显示 YBX1 抗体) could be a potential target for therapies against liver fibrosis.

  5. miR (显示 MLXIP 抗体)-27b is an anti-fibrotic microRNA that inhibits fibroblast activation by targeting TGFbeta (显示 TGFB1 抗体) receptor 1 and SMAD2.

  6. hese studies revealed that Smad2 plays an essential role in the development of the growth plate, that both Smads 2 and 3 inhibit Ihh (显示 IHH 抗体) expression in the neonatal growth plate, and suggested they accomplish this by binding to distinct SBEs, mediating assembly of distinct repressive complexes.

  7. This study found evidence of increased leukocyte phosphorylated-Smad2/3 staining in both single leukocytes and platelet-leukocyte aggregates in mice that developed aortic valve stenosis, suggesting the presence of increased circulating active TGF-beta1 (显示 TGFB1 抗体).

  8. Data show that muscle-specific (显示 EIF3K 抗体) Smad (显示 SMAD1 抗体) proteins Smad2/3-deficient mice exhibited significant resistance to denervation-induced muscle atrophy.

  9. these data demonstrate that the SMI drives ES cells to skeletal muscle via concerted activation of the Wnt (显示 WNT2 抗体) pathway, and inhibition of Smad2/3 signaling and Shh (显示 SHH 抗体) pathways.

  10. Arsenite disrupts zinc-dependent TGFbeta2-SMAD2/3 activity during murine cardiac progenitor cell differentiation.

SMAD2 抗原简介

Antigen Summary

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene.

Alternative names and synonyms associated with SMAD2

  • SMAD family member 2 (SMAD2) 抗体
  • SMAD family member 2 (smad2) 抗体
  • MAD homolog 2 (Drosophila) (smad2) 抗体
  • SMAD family member 2 (Smad2) 抗体
  • 7120426M23Rik 抗体
  • fj43c06 抗体
  • hMAD-2 抗体
  • hSMAD2 抗体
  • JV18 抗体
  • JV18-1 抗体
  • Madh2 抗体
  • Madr2 抗体
  • mMad2 抗体
  • Smad-2 抗体
  • wu:fj43c06 抗体
  • Xmad2 抗体
  • XSmad2 抗体

Protein level used designations for SMAD2

SMAD, mothers against DPP homolog 2 , MAD (mothers against decapentaplegic, Drosophila) homolog 2 , SMA- and MAD-related protein 2 , SMAD 2 , SMAD family member 2 , mothers against DPP homolog 2 , mothers against decapentaplegic homolog 2 , MAD homolog 2 , Sma- and Mad-related protein 2 , mother against DPP homolog 2 , mothers against decapentaplegic-like 2 , Smad 2 , mad-related protein 2

100033843 Equus caballus
496586 Xenopus (Silurana) tropicalis
30639 Danio rerio
4087 Homo sapiens
432023 Xenopus laevis
395247 Gallus gallus
480144 Canis lupus familiaris
100155304 Sus scrofa
516010 Bos taurus
17126 Mus musculus
29357 Rattus norvegicus
455407 Pan troglodytes
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