SPARC 蛋白 (SPARC)产品概述

Full name:
Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) 蛋白 (SPARC)
在www.antibodies-online.cn可供43 Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) (SPARC) 蛋白的14不同的供货商。 再加上,我们可以发SPARC 抗体 (271)SPARC 试剂盒 (61)和数多这个蛋白质的别的产品。 总共384 SPARC产品已列进来了。
别名:
AA517111, BM-40, hm:zeh0062, ON, SPARC
列出全部蛋白 基因 基因ID UniProt
SPARC 20692 P07214
SPARC 6678 P09486
SPARC 24791 P16975

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引用最多的SPARC 蛋白

  1. Human SPARC Protein expressed in Escherichia coli (E. coli) - ABIN1047668 : Lankat-Buttgereit, Mann, Deutzmann, Timpl, Krieg: Cloning and complete amino acid sequences of human and murine basement membrane protein BM-40 (SPARC, osteonectin). in FEBS letters 1988 (PubMed)

  2. Mouse (Murine) SPARC Protein expressed in Human Cells - ABIN2007893 : Sussman, Sun, Krofft, Durvasula: SPARC accelerates disease progression in experimental crescentic glomerulonephritis. in The American journal of pathology 2009 (PubMed)

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Zebrafish Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) (SPARC) interaction partners

  1. these data identify a contributory role for DNA methylation (显示 HELLS 蛋白) in regulating sparc expression in zebrafish embryogenesis.

  2. Results establish a role for an ECM (显示 MMRN1 蛋白) protein (Sparc) as an important regulator of embryonic haematopoiesis during early development in zebrafish.

  3. Data show that Sparc (Osteonectin) functions in morphogenesis of the pharyngeal skeleton and inner ear in zebrafish.

  4. Sparc is directly required for normal otolith growth

Mouse (Murine) Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) (SPARC) interaction partners

  1. The results demonstrate for the first time a functional role of the N-propeptide in regulating collagen fiber assembly and cell behavior and suggest that SPARC and the N-propeptide of collagen I have distinct activities in regulating collagen fiber assembly and fibroblast function.

  2. SPARC plays a key role in influencing the spatial organization of the anterior segment, potentially via modulation of collagen properties, while Hevin is not likely to be involved.

  3. An ADAMTS1 (显示 ADAMTS1 蛋白) blocking antibody suppressed the SPARC-induced collagen I secretion, indicating that SPARC promoted collagen production directly through ADAMTS1 (显示 ADAMTS1 蛋白) interaction. In conclusion, ADAMTS1 (显示 ADAMTS1 蛋白) is an important mediator of SPARC-regulated cardiac aging.

  4. SPARC appears to be an important modulator of the actin cytoskeleton, implicating maintenance of muscular function

  5. resistivity measurements were taken on 22 mice, 11 wild-type and 11 sparc-/- (knock out for the protein SPARC: secreted protein acidic and rich in cysteine), bearing mammary carcinomas.

  6. SPARC isoforms, acting on Adipose stromal cells through distinct mechanisms, have an additive effect in inducing ASC (显示 STS 蛋白) migration.

  7. SPARC levels were not associated with efficacy in patients with MPC. This exploratory analysis does not support making treatment decisions regarding nab-paclitaxel plus gemcitabine or gemcitabine alone in MPC based on SPARC expression.

  8. SPARC is proposed to act as a critical regulator of transglutaminase activity on collagen I with implications for mechanical strength of tissues.

  9. Tumor-produced SPARC and VCAM1 (显示 VCAM1 蛋白) are regulators of cancer extravasation.

  10. The results of this study indicated that the loss of p53 (显示 TP53 蛋白) by deletion/mutation in the early stages of glioma formation may cooperate with the induction of SPARC to potentiate cancer cell survival and escape from immune surveillance.

Human Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) (SPARC) interaction partners

  1. The mRNA and protein levels of SPARC were 5.78-fold higher in cancer tissues compared with the case-matched normal epithelium. High expression levels of SPARC in esophageal squamous cell carcinoma parenchyma were related to lymph node metastasis and poor prognosis (p = 0.049 and p = 0.04).

  2. SPARC can serve a dual function role as both predictor for prognosis and potentially biomarker for lymph node metastasis in resected pancreatic cancer patients.

  3. SPARC appears to be an important modulator of the actin cytoskeleton, implicating maintenance of muscular function

  4. that SPARC-mediated degradation of the extracellular matrix, and its possible association with MMPs, might contribute to progression of phyllodes tumors

  5. WIN-dependent increase in the level of SPARC plays a critical role in sensitizing osteosarcoma cells to TRAIL action

  6. high SPARC-expression was a significant predictor of poor OS in HPV-negative OPSCC patients using Kaplan-Meier analysis and the log-rank test

  7. We identified five new biomarkers: GDF15 (显示 GDF15 蛋白), osteonectin, TRAP5, TWEAK (显示 TNFSF12 蛋白), and YKL40 (显示 CHI3L1 蛋白) as being promising markers for monitoring bone metastases.

  8. SPARC levels were not associated with efficacy in patients with MPC. This exploratory analysis does not support making treatment decisions regarding nab-paclitaxel plus gemcitabine or gemcitabine alone in MPC based on SPARC expression.

  9. CD90 (显示 THY1 蛋白) is upregulated in gastric cancer and inhibits gastric cancer cell apoptosis by modulating the expression level of SPARC protein.

  10. SPARC might be an unfavorable indicator in patients with pancreatic cancer, especially in the stroma.[Review]

Cow (Bovine) Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) (SPARC) interaction partners

  1. findings indicate that secreted protein acidic cysteine-rich (SPARC) is intricately regulated by pro-angiogenic and other growth factors together with components of the extracellular matrix during the follicle-luteal transition

  2. This study reports the temporal changes in vascular endothelial growth factor A (VEGFA (显示 VEGFA 蛋白)), fibroblast growth factor 2 (FGF2 (显示 FGF2 蛋白)) and osteonectin during the follicular-luteal transition and corpus luteum development in the cow.

Horse (Equine) Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) (SPARC) interaction partners

  1. data suggest that SPARC might modulate angiogenesis during wound healing in the horse, which could protect against the disproportionate fibroplasia commonly afflicting limb wounds and leading to the development of exuberant granulation tissue

蛋白简介SPARC

蛋白简介

This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion.

Alternative names and synonyms associated with SPARC

  • secreted acidic cysteine rich glycoprotein (sparc)
  • secreted acidic cysteine rich glycoprotein (Sparc)
  • secreted protein, acidic, cysteine-rich (osteonectin) (SPARC)
  • secreted protein, acidic, cysteine-rich (osteonectin) (Sparc)
  • SPARC protein (MGC64258)
  • SPARC-like (LOC100855736)
  • AA517111 蛋白
  • BM-40 蛋白
  • hm:zeh0062 蛋白
  • ON 蛋白
  • SPARC 蛋白

Protein level used designations for SPARC

SPARC , osn , osteonectin , ON , basement-membrane protein 40 , secreted protein acidic and rich in cysteine , BM-40 , cysteine-rich protein , Secreted acidic cystein-rich glycoprotein (osteonectin) , secreted acidic cysteine rich glycoprotein

GENE ID SPECIES
321357 Danio rerio
20692 Mus musculus
6678 Homo sapiens
282077 Bos taurus
24791 Rattus norvegicus
595124 Sus scrofa
100009355 Oryctolagus cuniculus
386571 Gallus gallus
100860800 Capra hircus
595143 Canis lupus familiaris
100060119 Equus caballus
100174069 Pongo abelii
379441 Xenopus laevis
100855736 Canis lupus familiaris
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