anti-Caspase 8 (CASP8) 抗体产品概述

Full name:
anti-Caspase 8, Apoptosis-Related Cysteine Peptidase 抗体 (CASP8)
在www.antibodies-online.cn可供397 Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) 抗体的36不同的供货商。 再加上,我们可以发Caspase 8 试剂盒 (70)Caspase 8 蛋白 (29)和数多这个蛋白质的别的产品。 总共518 Caspase 8产品已列进来了。
别名:
ALPS2B, CAP4, Casp-8, CASP8, casp8-A, caspase-8, FLICE, MACH, MCH5, xCaspase-8, zgc:92075
列出全部抗体 基因 基因ID UniProt
CASP8 12370 O89110
CASP8 64044  
CASP8 841 Q14790

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引用最多的anti-Caspase 8 抗体

  1. Human Polyclonal Caspase 8 Primary Antibody for IF (cc), IF (p) - ABIN724205 : Wu, Tang, Jiang, Li, Jiang, Liu: PCSK9 siRNA inhibits HUVEC apoptosis induced by ox-LDL via Bcl/Bax-caspase9-caspase3 pathway. in Molecular and cellular biochemistry 2011 (PubMed)
    Show all 10 references for 724205

  2. Human Monoclonal Caspase 8 Primary Antibody for CyTOF, FACS - ABIN252488 : Berges, Fuchs, Opelz, Daniel, Naujokat: Helenalin suppresses essential immune functions of activated CD4+ T cells by multiple mechanisms. in Molecular immunology 2009 (PubMed)
    Show all 6 references for 252488

  3. Cow (Bovine) Polyclonal Caspase 8 Primary Antibody for WB - ABIN222878 : Peluffo, Stouffer, Tesone: Activity and expression of different members of the caspase family in the rat corpus luteum during pregnancy and postpartum. in American journal of physiology. Endocrinology and metabolism 2007 (PubMed)
    Show all 5 references for 222878

  4. Mouse (Murine) Polyclonal Caspase 8 Primary Antibody for WB - ABIN223020 : Woods, Burns, Bradford, Ross, Kosyk, Swenberg, Cunningham, Rusyn: WY-14,643 induced cell proliferation and oxidative stress in mouse liver are independent of NADPH oxidase. in Toxicological sciences : an official journal of the Society of Toxicology 2007 (PubMed)
    Show all 4 references for 223020

  5. Human Polyclonal Caspase 8 Primary Antibody for ELISA, WB - ABIN1532005 : Xu, Xu, Zhou, Zhuang, Wang, Boerner, Wu: Regulation of the Src-PP2A interaction in tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced apoptosis. in The Journal of biological chemistry 2013 (PubMed)
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  6. Human Polyclonal Caspase 8 Primary Antibody for ELISA, WB - ABIN1536108 : Liu, Huang, Liu, Li, Yang, Dou, Liu: Calcium channel blocker verapamil accelerates gambogic acid-induced cytotoxicity via enhancing proteasome inhibition and ROS generation. in Toxicology in vitro : an international journal published in association with BIBRA 2014 (PubMed)
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  7. Human Polyclonal Caspase 8 Primary Antibody for WB - ABIN783312 : Sánchez, Xu, Juo, Kakizaka, Blenis, Yuan: Caspase-8 is required for cell death induced by expanded polyglutamine repeats. in Neuron 1999 (PubMed)
    Show all 2 references for 783312

  8. Human Polyclonal Caspase 8 Primary Antibody for IHC, WB - ABIN222959 : Mahul-Mellier, Strappazzon, Petiot, Chatellard-Causse, Torch, Blot, Freeman, Kuhn, Garin, Verna, Fraboulet, Sadoul: Alix and ALG-2 are involved in tumor necrosis factor receptor 1-induced cell death. in The Journal of biological chemistry 2008 (PubMed)
    Show all 2 references for 222959

  9. Human Polyclonal Caspase 8 Primary Antibody for FACS, IF - ABIN390474 : Ji, Gu, Hu, Wang, Liang, Xia, Lu, Song, Fu, Wang: Polymorphisms in cell death pathway genes are associated with altered sperm apoptosis and poor semen quality. in Human reproduction (Oxford, England) 2009 (PubMed)
    Show all 2 references for 390474

  10. Human Polyclonal Caspase 8 Primary Antibody for IF, WB - ABIN1105679 : Muzio, Chinnaiyan, Kischkel, ORourke, Shevchenko, Ni, Scaffidi, Bretz, Zhang, Gentz, Mann, Krammer, Peter, Dixit: FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex. in Cell 1996 (PubMed)
    Show all 2 references for 1105679

更多抗Caspase 8的相互作用对抗体

Xenopus laevis Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) interaction partners

  1. Furthermore, while activities to process procaspase-8 and procaspase-9 appeared in SAMDC (显示 AMD1 抗体)-overexpressed apoptotic embryos, the activity to process procaspase-8 did not appear in p53 (显示 TP53 抗体)-overexpressed apoptotic embryos.

  2. tail regression at metamorphosis implicates an apoptotic pathway inducible by T(3) hormone in an organ autonomous manner and involving the cell death executioners BH3 interacting domain death agonist (显示 BID 抗体) and Caspases-2 and -8

Mouse (Murine) Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) interaction partners

  1. Statistically significant increases in the expression of Fas (显示 FAS 抗体) and caspase-8 were observed, along with other molecules involved in the extrinsic apoptotic pathway such as Dapk1 (显示 DAPK1 抗体), Traf3 (显示 TRAF3 抗体), Tnsf12, Tnfrsf1A (显示 TNFRSF1A 抗体) and Ripk1 (显示 RIPK1 抗体).

  2. Results suggest that caspase-8 could regulate receptor-interacting protein 3 (RIP3 (显示 RIPK3 抗体))-mediated necroptosis.

  3. we show that caspase-8 activity promotes cell-intrinsic cytokine expression, independent of its role in cell death in response to Yersinia infection

  4. Data indicate that NLRC4 (显示 NLRC4 抗体) activation in Intestinal epithelial cells (IECs) leads to cell expulsion and IL-18 (显示 IL18 抗体) release, and implicate Caspase-8 in NLRC4 (显示 NLRC4 抗体) inflammasome responses in vivo by generation of doubly deficient in Caspase-1 (显示 CASP1 抗体) and Caspase-8.

  5. ING4 (显示 ING4 抗体) might suppress proliferation and enhance apoptosis in human malignant melanoma cells by activating Fas (显示 FAS 抗体)-induced apoptosis in a caspase-8-dependent pathway.

  6. studies have uncovered the combined actions of the NLRP3 (显示 NLRP3 抗体) inflammasome and caspase 8 leading to IL-1beta (显示 IL1B 抗体) maturation and the directionality of IL-1beta (显示 IL1B 抗体) in driving disease inPstpip2(cmo (显示 PSTPIP2 抗体))mice.

  7. Chronic TLR Stimulation Controls NLRP3 (显示 NLRP3 抗体) Inflammasome Activation through IL-10 (显示 IL10 抗体) Mediated Regulation of NLRP3 (显示 NLRP3 抗体) Expression and Caspase-8 Activation

  8. A20 targets caspase-8 and FADD to protect HTLV-I-infected cells.

  9. Data indicate that receptor-interacting serine-threonine kinase 3 (RIPK3 (显示 RIPK3 抗体)) deletion prevents inflammatory phenotypes in CreLysM (lysozyme (显示 LYZ 抗体) M) Casp8fl/fl (caspase 8) mice.

  10. CASP8 deletion did not affect the overall number of microglia expressing the pan (显示 SUPT6H 抗体) specific microglia marker, Iba1 (显示 AIF1 抗体)

Human Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) interaction partners

  1. Insertion genotype of CASP8 rs3834129 polymorphisms showed risk in CAD (显示 CAD 抗体). CASP8 rs3769818 activates intronic cryptic donor.

  2. Caspase-8 controls the secretion of inflammatory lysyl-tRNA synthetase (显示 KARS 抗体) in exosomes from colorectal cancer cells.

  3. Fisetin inhibited Triple-Negative Breast Cancer Cells cell division and induced apoptosis, which was associated with mitochondrial membrane permeabilization and the activation of caspase-9 (显示 CASP9 抗体) and caspase-8, as well as the cleavage of poly(ADP-ribose) polymerase-1 (显示 PARP1 抗体).

  4. Caspase-8 can serve in two distinct roles in response to TRAIL receptor engagement, as a scaffold for assembly of a Caspase-8-FADD-RIPK1 "FADDosome" complex, leading to NFkappaB-dependent inflammation, or as a protease that promotes apoptosis.

  5. Using the tDED filament structure as a template, structural analyses reveal the interaction surfaces between FADD (显示 FADD 抗体) and caspase-8 and the distinct mechanisms of regulation by cFLIP (显示 CFLAR 抗体) and MC159 through comingling and capping, respectively.

  6. our novel findings expand our understanding of the key mechanisms underlying the anti-apoptotic functions of caspase-8 which may act as a critical block to existing antitumour therapies.

  7. Proteases caspase-1 (显示 CASP1 抗体) and caspase-8 have redundant roles in cleaving IL-1beta (显示 IL1B 抗体) and promoting osteomyelitis. [review]

  8. Dasatinib, a c-Src (显示 SRC 抗体) inhibitor, dephosphorylated caspase-8 to facilitate necroptosis, rather than apoptosis, in paclitaxel-treated p-Casp8-expressing lung adenocarcinoma cells.

  9. Loss of function mutations in FAT1 (显示 FAT1 抗体) and CASP8 prevent cell adhesion and promote cell migration and proliferation in oral squamous cell carcinoma cell lines.

  10. Dysregulation of a potassium channel (显示 KCNAB2 抗体), THIK-1 (显示 KCNK13 抗体), targeted by caspase-8, accelerates cell shrinkage.

Cow (Bovine) Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) interaction partners

  1. S. aureus-induced apoptosis in bovine mammary epithelial cells apoptosis was mitigated by caspase-3 (显示 CASP3 抗体) and caspase-8 inhibitors, suggesting that apoptosis is initiated via caspase-8 activation.

  2. Endothelial cell apoptosis by H. somnus-activated platelets required activation of both caspase-8 and caspase-9 (显示 CASP9 抗体).

Pig (Porcine) Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) interaction partners

  1. Nitric oxide-dependent increase in caspase-8 mRNA levels is associated with phosphorylation of STAT-1 (显示 STAT1 抗体) at Ser (显示 SIGLEC1 抗体)-727 and STAT1 (显示 STAT1 抗体) binding to the caspase-8 promoter in cultured lung endothelial cells.

  2. Data show that cysteine significantly reduced the expression of pro-inflammatory cytokines, including TNF-alpha (显示 TNF 抗体), IL-6 (显示 IL6 抗体), IL-12p40, IL-1beta (显示 IL1B 抗体), and resulted in increased expression of the apoptosis initiator caspase-8 and bcl2L1 (显示 BCL2L1 抗体).

Zebrafish Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) interaction partners

  1. Induction of apoptosis through targeted activation of caspase (显示 CASP3 抗体) by tamoxifen (ATTAC(TM)) further expands the repertoire of genetic tools for conditional interrogation of cellular functions.

  2. Targeted gene knockdown of TNFRSF1B (显示 TNFRSF1B 抗体) in zebrafish embryos results in the induction of a caspase-8, caspase-2 (显示 CASP2 抗体) and P53 (显示 TP53 抗体)-dependent apoptotic program in endothelial cells that bypasses caspase-3 (显示 CASP3 抗体).

  3. These results show that zebrafish casp8 has a structure and function similar to mammalian CASP8 orthologs and the role of caspase-8 in the apoptotic signal pathway has been conserved over at least 450 million years of vertebrate evolution.

Caspase 8 (CASP8) 抗原简介

Antigen Summary

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.

Alternative names and synonyms associated with Caspase 8 (CASP8)

  • caspase 8, apoptosis-related cysteine peptidase (casp8) 抗体
  • death related ced-3/Nedd2-like protein (Dredd) 抗体
  • caspase 8, apoptosis-related cysteine peptidase (CASP8) 抗体
  • caspase-8 (AaeL_AAEL014148) 抗体
  • caspase-8 (casp8) 抗体
  • caspase 8 (LOC100222284) 抗体
  • caspase 8 (Casp8) 抗体
  • caspase 8 (LOC100348477) 抗体
  • ALPS2B 抗体
  • CAP4 抗体
  • Casp-8 抗体
  • CASP8 抗体
  • casp8-A 抗体
  • caspase-8 抗体
  • FLICE 抗体
  • MACH 抗体
  • MCH5 抗体
  • xCaspase-8 抗体
  • zgc:92075 抗体

Protein level used designations for CASP8

caspase-8 , xcaspase 8 , death related ced-3/Nedd2-like protein , GLEAN_14026 , caspase 8, apoptosis-related cysteine peptidase , caspase 8 , caspase-8-like , DEATH effector domain caspase , Fas-linked ICE-like protease , FADD-homologous ICE/CED-3-like protease , FADD-like ICE , ICE-like apoptotic protease 5 , MACH-alpha-1/2/3 protein , MACH-beta-1/2/3/4 protein , MORT1-associated ced-3 homolog , apoptotic cysteine protease , apoptotic protease Mch-5 , caspase 8, apoptosis-related cysteine protease , caspase-8a , cysteine protease

GENE ID SPECIES
373559 Xenopus laevis
661095 Tribolium castaneum
702781 Macaca mulatta
5563818 Aedes aegypti
100049400 Oryzias latipes
100066502 Equus caballus
100142684 Felis catus
100172115 Pongo abelii
100222284 Taeniopygia guttata
100472842 Ailuropoda melanoleuca
100579132 Hydra magnipapillata
100586183 Nomascus leucogenys
12370 Mus musculus
64044 Rattus norvegicus
100348477 Oryctolagus cuniculus
841 Homo sapiens
746477 Pan troglodytes
507481 Bos taurus
395284 Gallus gallus
488473 Canis lupus familiaris
595105 Sus scrofa
101107334 Ovis aries
58022 Danio rerio
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