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anti-Caspase 8 (CASP8) 抗体产品概述

Full name:
anti-Caspase 8, Apoptosis-Related Cysteine Peptidase 抗体 (CASP8)
在www.antibodies-online.cn可供395 Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) 抗体的35不同的供货商。 再加上,我们可以发Caspase 8 试剂盒 (62)Caspase 8 蛋白 (28)和数多这个蛋白质的别的产品。 总共505 Caspase 8产品已列进来了。
别名:
ALPS2B, CAP4, Casp-8, CASP8, casp8-A, caspase-8, FLICE, MACH, MCH5, xCaspase-8, zgc:92075
列出全部抗体 基因 基因ID UniProt
CASP8 12370 O89110
CASP8 64044  
CASP8 841 Q14790

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引用最多的anti-Caspase 8 抗体

  1. Human Polyclonal Caspase 8 Primary Antibody for IF (cc), IF (p) - ABIN724205 : Wu, Tang, Jiang, Li, Jiang, Liu: PCSK9 siRNA inhibits HUVEC apoptosis induced by ox-LDL via Bcl/Bax-caspase9-caspase3 pathway. in Molecular and cellular biochemistry 2011 (PubMed)
    Show all 9 references for ABIN724205

  2. Human Monoclonal Caspase 8 Primary Antibody for CyTOF, FACS - ABIN252488 : Berges, Fuchs, Opelz, Daniel, Naujokat: Helenalin suppresses essential immune functions of activated CD4+ T cells by multiple mechanisms. in Molecular immunology 2009 (PubMed)
    Show all 6 references for ABIN252488

  3. Mouse (Murine) Polyclonal Caspase 8 Primary Antibody for WB - ABIN223020 : Woods, Burns, Bradford, Ross, Kosyk, Swenberg, Cunningham, Rusyn: WY-14,643 induced cell proliferation and oxidative stress in mouse liver are independent of NADPH oxidase. in Toxicological sciences : an official journal of the Society of Toxicology 2007 (PubMed)
    Show all 4 references for ABIN223020

  4. Human Polyclonal Caspase 8 Primary Antibody for ELISA, WB - ABIN1536108 : Liu, Huang, Liu, Li, Yang, Dou, Liu: Calcium channel blocker verapamil accelerates gambogic acid-induced cytotoxicity via enhancing proteasome inhibition and ROS generation. in Toxicology in vitro : an international journal published in association with BIBRA 2014 (PubMed)
    Show all 3 references for ABIN1536108

  5. Human Polyclonal Caspase 8 Primary Antibody for ELISA, WB - ABIN1532005 : Xu, Xu, Zhou, Zhuang, Wang, Boerner, Wu: Regulation of the Src-PP2A interaction in tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced apoptosis. in The Journal of biological chemistry 2013 (PubMed)
    Show all 3 references for ABIN1532005

  6. Human Polyclonal Caspase 8 Primary Antibody for IF, WB - ABIN1105679 : Muzio, Chinnaiyan, Kischkel, ORourke, Shevchenko, Ni, Scaffidi, Bretz, Zhang, Gentz, Mann, Krammer, Peter, Dixit: FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex. in Cell 1996 (PubMed)
    Show all 2 references for ABIN1105679

  7. Human Polyclonal Caspase 8 Primary Antibody for IHC, WB - ABIN222959 : Mahul-Mellier, Strappazzon, Petiot, Chatellard-Causse, Torch, Blot, Freeman, Kuhn, Garin, Verna, Fraboulet, Sadoul: Alix and ALG-2 are involved in tumor necrosis factor receptor 1-induced cell death. in The Journal of biological chemistry 2008 (PubMed)
    Show all 2 references for ABIN222959

  8. Human Polyclonal Caspase 8 Primary Antibody for FACS, IF - ABIN390474 : Ji, Gu, Hu, Wang, Liang, Xia, Lu, Song, Fu, Wang: Polymorphisms in cell death pathway genes are associated with altered sperm apoptosis and poor semen quality. in Human reproduction (Oxford, England) 2009 (PubMed)
    Show all 2 references for ABIN390474

  9. Human Polyclonal Caspase 8 Primary Antibody for WB - ABIN783312 : Sánchez, Xu, Juo, Kakizaka, Blenis, Yuan: Caspase-8 is required for cell death induced by expanded polyglutamine repeats. in Neuron 1999 (PubMed)
    Show all 2 references for ABIN783312

更多抗Caspase 8的相互作用对抗体

Xenopus laevis Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) interaction partners

  1. Furthermore, while activities to process procaspase-8 and procaspase-9 appeared in SAMDC (显示 AMD1 抗体)-overexpressed apoptotic embryos, the activity to process procaspase-8 did not appear in p53 (显示 TP53 抗体)-overexpressed apoptotic embryos.

  2. tail regression at metamorphosis implicates an apoptotic pathway inducible by T(3) hormone in an organ autonomous manner and involving the cell death executioners BH3 interacting domain death agonist (显示 BID 抗体) and Caspases-2 and -8

Mouse (Murine) Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) interaction partners

  1. ING4 (显示 ING4 抗体) might suppress proliferation and enhance apoptosis in human malignant melanoma cells by activating Fas (显示 FAS 抗体)-induced apoptosis in a caspase-8-dependent pathway.

  2. studies have uncovered the combined actions of the NLRP3 (显示 NLRP3 抗体) inflammasome and caspase 8 leading to IL-1beta (显示 IL1B 抗体) maturation and the directionality of IL-1beta (显示 IL1B 抗体) in driving disease inPstpip2(cmo (显示 PSTPIP2 抗体))mice.

  3. Chronic TLR Stimulation Controls NLRP3 (显示 NLRP3 抗体) Inflammasome Activation through IL-10 (显示 IL10 抗体) Mediated Regulation of NLRP3 (显示 NLRP3 抗体) Expression and Caspase-8 Activation

  4. A20 targets caspase-8 and FADD to protect HTLV-I-infected cells.

  5. Data indicate that receptor-interacting serine-threonine kinase 3 (RIPK3 (显示 RIPK3 抗体)) deletion prevents inflammatory phenotypes in CreLysM (lysozyme (显示 LYZ 抗体) M) Casp8fl/fl (caspase 8) mice.

  6. CASP8 deletion did not affect the overall number of microglia expressing the pan (显示 SUPT6H 抗体) specific microglia marker, Iba1 (显示 AIF1 抗体)

  7. We observed that NDMP generation was dependent on the extrinsic caspase (显示 CASP3 抗体) apoptotic pathway (caspase 3 (显示 CASP3 抗体) and caspase 8), cAMP activation of PKA but not of Epac (显示 RAPGEF3 抗体), and on activation of MLCK (显示 MYLK 抗体).

  8. Internalized Cryptococcus neoformans Activates the Canonical Caspase-1 (显示 CASP1 抗体) and the Noncanonical Caspase-8 Inflammasomes.

  9. Casp8-dependent migration of enterocytes is likely involved in intestinal physiology and inflammation-related pathophysiology.

  10. NLRP3 (显示 NLRP3 抗体) inflammasomes directly utilize caspase-8 as both a pro-apoptotic initiator and major IL-1beta (显示 IL1B 抗体)-converting protease

Human Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) interaction partners

  1. Our results revealed that caspase-8 gene silencing may result from the methylation of its gene promoter in human glioma tissues. The expression of caspase-8 at the mRNA level was significantly associated with the grade of human glioma.

  2. Suggest that caspase 8 SNPs were not associated with rheumatoid arthritis.

  3. novel dynamic interplay between Src (显示 SRC 抗体) and caspase-8 likely acts as a potent signal-integrating switch directing the cell towards apoptosis or survival

  4. Findings showed that, in MDA-MB-231 cells, casp-8 might play some unusual roles which should be better explored, in order to understand whether it might be identified as a molecular therapeutic target.

  5. Study showed that TRAIL and caspase-8 expression decreased in human osteosarcoma, resulting in increased cell proliferation, and reduced cell apoptosis suggesting they play important roles in the occurrence, development, and prognosis of osteosarcoma.

  6. evidence that Articulatin-D efficiently activates caspase-8 involved in extrinsic pathway of apoptosis induction, which ultimately results in caspase-3 (显示 CASP3 抗体)-dependent DNA fragmentation of Jurkat cells.

  7. Copper induces the activation of apoptosis through casp3 (显示 CASP3 抗体)/casp8/casp9 (显示 CASP9 抗体)/AIF (显示 AIFM1 抗体)/TP53 (显示 TP53 抗体) signaling pathways. Suggest that apoptosis activation mechanism is dependent on the concentration, time of exposure to Cu and cell type.

  8. our findings indicate that the expression levels of P-GP (显示 ABCB4 抗体), MYC (显示 MYC 抗体), caspase-8, and AKT3 (显示 AKT3 抗体) are candidate biomarkers of cell sensitivity to PLKis.

  9. Overexpression of CASP8 is associated with lung cancer.

  10. Thymoquinone inhibitory effects were associated with inhibition of NF-kappaB (显示 NFKB1 抗体) and altered expression of its downstream effectors IL-8 (显示 IL8 抗体) and its receptors, the anti-apoptotic Bcl-2 (显示 BCL2 抗体), Bcl-xL (显示 BCL2L1 抗体), X-IAP (显示 ALPI 抗体), and FLIP, as well as the pro-apoptotic TRAIL-R1, caspase-8, caspase-9 (显示 CASP9 抗体), Bcl-xS (显示 BCL2L1 抗体), and cytochrome c (显示 CYCS 抗体).

Cow (Bovine) Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) interaction partners

  1. S. aureus-induced apoptosis in bovine mammary epithelial cells apoptosis was mitigated by caspase-3 (显示 CASP3 抗体) and caspase-8 inhibitors, suggesting that apoptosis is initiated via caspase-8 activation.

  2. Endothelial cell apoptosis by H. somnus-activated platelets required activation of both caspase-8 and caspase-9 (显示 CASP9 抗体).

Pig (Porcine) Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) interaction partners

  1. Nitric oxide-dependent increase in caspase-8 mRNA levels is associated with phosphorylation of STAT-1 (显示 STAT1 抗体) at Ser (显示 SIGLEC1 抗体)-727 and STAT1 (显示 STAT1 抗体) binding to the caspase-8 promoter in cultured lung endothelial cells.

  2. Data show that cysteine significantly reduced the expression of pro-inflammatory cytokines, including TNF-alpha (显示 TNF 抗体), IL-6 (显示 IL6 抗体), IL-12p40, IL-1beta (显示 IL1B 抗体), and resulted in increased expression of the apoptosis initiator caspase-8 and bcl2L1 (显示 BCL2L1 抗体).

Zebrafish Caspase 8, Apoptosis-Related Cysteine Peptidase (CASP8) interaction partners

  1. Targeted gene knockdown of TNFRSF1B (显示 TNFRSF1B 抗体) in zebrafish embryos results in the induction of a caspase-8, caspase-2 (显示 CASP2 抗体) and P53 (显示 TP53 抗体)-dependent apoptotic program in endothelial cells that bypasses caspase-3 (显示 CASP3 抗体).

  2. These results show that zebrafish casp8 has a structure and function similar to mammalian CASP8 orthologs and the role of caspase-8 in the apoptotic signal pathway has been conserved over at least 450 million years of vertebrate evolution.

Caspase 8 (CASP8) 抗原简介

Antigen Summary

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.

Alternative names and synonyms associated with Caspase 8 (CASP8)

  • caspase 8, apoptosis-related cysteine peptidase (casp8) 抗体
  • death related ced-3/Nedd2-like protein (Dredd) 抗体
  • caspase 8, apoptosis-related cysteine peptidase (CASP8) 抗体
  • caspase-8 (AaeL_AAEL014148) 抗体
  • caspase-8 (casp8) 抗体
  • caspase 8 (LOC100222284) 抗体
  • caspase 8 (Casp8) 抗体
  • caspase 8 (LOC100348477) 抗体
  • ALPS2B 抗体
  • CAP4 抗体
  • Casp-8 抗体
  • CASP8 抗体
  • casp8-A 抗体
  • caspase-8 抗体
  • FLICE 抗体
  • MACH 抗体
  • MCH5 抗体
  • xCaspase-8 抗体
  • zgc:92075 抗体

Protein level used designations for CASP8

caspase-8 , xcaspase 8 , death related ced-3/Nedd2-like protein , GLEAN_14026 , caspase 8, apoptosis-related cysteine peptidase , caspase 8 , caspase-8-like , DEATH effector domain caspase , Fas-linked ICE-like protease , FADD-homologous ICE/CED-3-like protease , FADD-like ICE , ICE-like apoptotic protease 5 , MACH-alpha-1/2/3 protein , MACH-beta-1/2/3/4 protein , MORT1-associated ced-3 homolog , apoptotic cysteine protease , apoptotic protease Mch-5 , caspase 8, apoptosis-related cysteine protease , caspase-8a , cysteine protease

GENE ID SPECIES
373559 Xenopus laevis
661095 Tribolium castaneum
702781 Macaca mulatta
5563818 Aedes aegypti
100049400 Oryzias latipes
100066502 Equus caballus
100142684 Felis catus
100172115 Pongo abelii
100222284 Taeniopygia guttata
100472842 Ailuropoda melanoleuca
100579132 Hydra magnipapillata
100586183 Nomascus leucogenys
12370 Mus musculus
64044 Rattus norvegicus
100348477 Oryctolagus cuniculus
841 Homo sapiens
746477 Pan troglodytes
507481 Bos taurus
395284 Gallus gallus
488473 Canis lupus familiaris
595105 Sus scrofa
101107334 Ovis aries
58022 Danio rerio
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