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CHEK2 抗体 (AA 31-234)

Name: CHEK2 抗体 (AA 31-234)
SKU: ABIN968596
Availability: OutOfStock

CHEK2 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 小鼠 Monoclonal 19-Chk2 unconjugated

Western blot anakysis of Chk2 on RSV-3T3 lysate. (CHEK2 抗体 (AA 31-234))

1 image

(1 reference)

产品编号 ABIN968596

发货至: 中国

Datasheet as PDF

抗原 See all CHEK2 抗体

CHEK2 (Checkpoint Kinase 2 (CHEK2))
抗原表位
30

28

21

17

16

15

15

15

9

8

8

8

8

7

7

6

4

3

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 31-234
适用
261

96

82

16

14

7

6

5

2

2

2

1

1
人, 小鼠, 大鼠
宿主
242

20

1

1
小鼠
Compatible Secondaries
克隆类型
228

36
单克隆
标记
116

14

12

12

12

12

12

12

10

9

7

7

7

7

7

2

2

2

1

1
This CHEK2 antibody is un-conjugated
应用范围
206

80

79

72

37

36

33

28

28

19

18

5

1

1

1

1

1
Western Blotting (WB), Immunofluorescence (IF)

交叉反应

人, 大鼠

产品特性

1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

纯化方法

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

免疫原

Mouse Chk2 aa. 31-234

克隆位点

19-Chk2

亚型

IgG1

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CHEK2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated

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CHEK2 适用: 人, 猴, 犬 WB, IHC, IF, IHC (p), FACS 宿主: 小鼠 Monoclonal 10G7 unconjugated

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CHEK2 适用: 人, 犬 WB, IHC, IF, IHC (p), IP, FACS 宿主: 小鼠 Monoclonal 5C4 unconjugated

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anti-Checkpoint Kinase 2 (CHEK2) (AA 1-220) antibody
CHEK2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

说明

Related Products: ABIN967389

限制

仅限研究用
状态

Liquid

浓度

250 μg/mL

缓冲液

Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store undiluted at -20° C.
Tominaga, Morisaki, Kaneko, Fujimoto, Tanaka, Ohtsubo, Hirai, Okayama, Ikeda, Nakanishi: "Role of human Cds1 (Chk2) kinase in DNA damage checkpoint and its regulation by p53." in: The Journal of biological chemistry, Vol. 274, Issue 44, pp. 31463-7, (1999) (PubMed).
抗原

CHEK2 (Checkpoint Kinase 2 (CHEK2))

别名

Chk2 (CHEK2 产品)

别名

CDS1 antibody, CHK2 antibody, HuCds1 antibody, LFS2 antibody, PP1425 antibody, RAD53 antibody, hCds1 antibody, fa66f08 antibody, wu:fa66f08 antibody, zgc:55865 antibody, Cds1 antibody, HUCDS1 antibody, Rad53 antibody, Chk2 antibody, cds1 antibody, chek2 antibody, chk2 antibody, hucds1 antibody, lfs2 antibody, pp1425 antibody, rad53 antibody, checkpoint kinase 2 antibody, serine/threonine-protein kinase chk2 antibody, checkpoint kinase 2 L homeolog antibody, CHEK2 antibody, chek2 antibody, Chek2 antibody, MCYG_07308 antibody, chek2.L antibody

背景

The cell cycle is regulated by multiple checkpoints that determine cell fate. Such checkpoints ensure that DNA replication and chromosomal segregation are completed with high fidelity. When DNA is damaged, specific kinases and phosphatases, key components of cell cycle checkpoints, function to arrest the cell cycle and provide the necessary time for DNA repair. For example, DNA damage induces arrest of the cell cycle at the G2 checkpoint via Wee1-mediated inhibitory phosphorylation of the kinase Cdc2. Inhibition is relieved by the Cdc25C phosphatase via Cdc2 dephosphorylation. In turn, the Chk1 and Chk2 protein kinases phosphorylate and inhibit Cdc25C, thus preventing activation of the Cdc2-cyclin B complex and entry into mitosis. Chk2, the human homolog of S. cerevisiae Rad53 and S. pombe Cds1, contains a C-terminal kinase domain, an N-terminal regulatory region that is rich in TQ and SQ pairs, and a forked head-associated domain (FHA) which is found in other cell cycle kinases. Chk2 is expressed during late G1 to M phase and is found in the nucleoplasm. Thus, Chk1 and Chk2 activity may be an important checkpoint that inhibits entry into mitosis in response to DNA damage. This antibody is routinely tested by western blot analysis.

分子量

60 kDa

途径

p53 Pathway, Apoptosis, Cell Division Cycle