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CIT 抗体 (AA 1420-1612)

CIT 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 小鼠 Monoclonal 6-CRIK unconjugated
产品编号 ABIN968502
发货至: 中国
  • 抗原 See all CIT 抗体
    CIT (Citron (Rho-Interacting, serine/threonine Kinase 21) (CIT))
    抗原表位
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 1420-1612
    适用
    • 23
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 22
    • 1
    小鼠
    克隆类型
    • 23
    单克隆
    标记
    • 11
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CIT antibody is un-conjugated
    应用范围
    • 13
    • 9
    • 6
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    交叉反应
    人, 大鼠
    产品特性
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    5. For fluorochrome spectra and suitable instrument settings, please refer to us.
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    免疫原
    Mouse CRIK aa. 1420-1612
    克隆位点
    6-CRIK
    亚型
    IgG1 kappa
    Top Product
    Discover our top product CIT Primary Antibody
  • 说明

    Related Products: ABIN968539, ABIN967389, ABIN968537

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    250 μg/mL
    缓冲液
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store undiluted at -20°C.
  • Furuyashiki, Fujisawa, Fujita, Madaule, Uchino, Mishina, Bito, Narumiya: "Citron, a Rho-target, interacts with PSD-95/SAP-90 at glutamatergic synapses in the thalamus." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 19, Issue 1, pp. 109-18, (1999) (PubMed).

    Zhang, Vazquez, Apperson, Kennedy: "Citron binds to PSD-95 at glutamatergic synapses on inhibitory neurons in the hippocampus." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 19, Issue 1, pp. 96-108, (1999) (PubMed).

    Di Cunto, Calautti, Hsiao, Ong, Topley, Turco, Dotto: "Citron rho-interacting kinase, a novel tissue-specific ser/thr kinase encompassing the Rho-Rac-binding protein Citron." in: The Journal of biological chemistry, Vol. 273, Issue 45, pp. 29706-11, (1998) (PubMed).

    Madaule, Eda, Watanabe, Fujisawa, Matsuoka, Bito, Ishizaki, Narumiya: "Role of citron kinase as a target of the small GTPase Rho in cytokinesis." in: Nature, Vol. 394, Issue 6692, pp. 491-4, (1998) (PubMed).

  • 抗原
    CIT (Citron (Rho-Interacting, serine/threonine Kinase 21) (CIT))
    别名
    CRIK (CIT 产品)
    别名
    CIT antibody, crik antibody, xcit antibody, stk21 antibody, C030025P15Rik antibody, CRIK antibody, CRIK-SK antibody, Cit-k antibody, STK21 antibody, citron rho-interacting serine/threonine kinase antibody, citron (rho-interacting, serine/threonine kinase 21) antibody, citron Rho-interacting kinase antibody, citron antibody, Cit antibody, CIT antibody, LOC100083347 antibody, cit antibody
    背景
    Citron was identified by its interactions with activated Rho and Rac. It contains a zinc finger (ZF) region, a pleckstrin homology (PH) domain, a citron/MRCK/Gek (CMG) domain, and a coiled-coil domain with a Rho-Rac binding region (RRB). Citron binds to PSD-95 via its C-terminal tSXV motif and the PDZ domain on PSD-95. This association occurs at post synaptic densities where citron-PSD-95 may provide a specific link between the Rho signaling cascade and the synaptic NMDA receptor complex. Citron Rho-interacting kinase (CRIK) and CRIK short kinase (CRIK-SK) are Ser/Thr kinase isoforms of the myotonic dystrophy kinase family. CRIK contains full-length citron, with an N-terminal kinase domain. CRIK-SK is a splice variant that contains only the kinase domain. CRIK co-localizes with actin in keratinocytes and co-expression of CRIK and Rho increases CRIK kinase activity two-fold. In addition, CRIK mutants cause abnormal contraction during cytokinesis. CRIK is expressed highest in testis, but is also present in brain, spleen, lung, and kidney. Thus, CRIK is a Ser/Thr kinase that functions downstream of Rho during events such as cytokinesis and synaptic transmission.
    Synonyms: Serine/Threonine Protein Kinase 21
    分子量
    240 kDa
    途径
    SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection
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