MAP4 抗体 (AA 583-702)
(3 references)-
- 抗原 See all MAP4 抗体
- MAP4 (Microtubule-Associated Protein 4 (MAP4))
-
抗原表位
- AA 583-702
-
适用
- 人
-
宿主
- 小鼠
-
克隆类型
- 单克隆
-
标记
- This MAP4 antibody is un-conjugated
-
应用范围
- Western Blotting (WB), Immunofluorescence (IF)
- 产品特性
-
1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Human MAP4 aa. 583-702
- 克隆位点
- 18-MAP4
- 亚型
- IgG1
- Top Product
- Discover our top product MAP4 Primary Antibody
-
anti-Microtubule-Associated Protein 4 (MAP4) (AA 2-250) antibody
MAP4 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Microtubule-Associated Protein 4 (MAP4) (AA 243-549) antibodyMAP4 适用: 人 WB, ELISA, IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Microtubule-Associated Protein 4 (MAP4) (AA 575-818) antibodyMAP4 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Microtubule-Associated Protein 4 (MAP4) (AA 1-99) antibodyMAP4 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 7C9 unconjugated
anti-Microtubule-Associated Protein 4 (MAP4) (AA 942-1152) antibodyMAP4 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Microtubule-Associated Protein 4 (MAP4) (pSer941) antibodyMAP4 适用: 人, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Microtubule-Associated Protein 4 (MAP4) (AA 701-800) antibodyMAP4 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Microtubule-Associated Protein 4 (MAP4) (AA 882-1062) antibodyMAP4 适用: 小鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Microtubule-Associated Protein 4 (MAP4) (AA 351-400) antibodyMAP4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Microtubule-Associated Protein 4 (MAP4) (AA 1102-1152) antibodyMAP4 适用: 人 IHC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
-
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- 250 μg/mL
- 缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store undiluted at -20°C.
-
-
: "MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption." in: Cell, Vol. 89, Issue 2, pp. 297-308, (1997) (PubMed).
: "Mapmodulin: a possible modulator of the interaction of microtubule-associated proteins with microtubules." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 10, pp. 5084-9, (1997) (PubMed).
: "Differential expression of alternatively spliced forms of MAP4: a repertoire of structurally different microtubule-binding domains." in: Biochemistry, Vol. 34, Issue 7, pp. 2289-301, (1995) (PubMed).
-
: "MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption." in: Cell, Vol. 89, Issue 2, pp. 297-308, (1997) (PubMed).
-
- 抗原
- MAP4 (Microtubule-Associated Protein 4 (MAP4))
- 别名
- MAP4 (MAP4 产品)
- 别名
- XMAP4 antibody, mtap4 antibody, AA407148 antibody, MAP-4 antibody, Mtap-4 antibody, Mtap4 antibody, microtubule associated protein 4 antibody, microtubule associated protein 4 L homeolog antibody, microtubule-associated protein 4 antibody, MAP4 antibody, map4.L antibody, Map4 antibody
- 背景
- The microtubule (MT) cytoskeleton functions in cytoplasmic organization, cellular movement, determination of cell polarity, intracellular transport, and chromosome segregation. Dynamic instability, continuous cycles of MT assembly (stabilization) and disassembly, mediates MT participation in these events. The function of MTs, particularly stabilization, is regulated by MT-associated proteins (MAPs). A subfamily of MAPs, called AP-MAPs (assembly promoting MAPs), includes tau, MAP2, and MAP4. These proteins are classified as type II MAPs and contain a C-terminal MT binding domain with 3 to 5 imperfect repeats of an 18 amino acid motif. While tau and MAP2 are specifically expressed in neuronal cells, MAP4 is the major MAP of nonneuronal mammalian cells. MAP activity and interaction with MTs are regulated by MARK (MAP/MT affinity-regulating kinase) and mapmodulin. MARK-mediated phosphorylation of MAPs on their homologous KXGS motifs results in detachment of MAPs from MTs and MT disruption. In addition, mapmodulin tightly interacts with the MT-binding domains of MAPs and hinders MAP binding to MTs. Thus, MAP4 is a highly regulated type II MAP that controls MT assembly and disassembly.
- 分子量
- 200-220 kDa
- 途径
- p53 Pathway, Microtubule Dynamics
-
