(4 references)-
- 抗原 See all SOD1 抗体
- SOD1 (Superoxide Dismutase 1, Soluble (SOD1))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This SOD1 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 品牌
- BD Pharmingen™
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Recombinant Human CuZnSOD GST Fusion Protein
- 克隆位点
- G215-1
- 亚型
- IgG2a
- Top Product
- Discover our top product SOD1 Primary Antibody
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anti-Superoxide Dismutase 1, Soluble (SOD1) (AA 1-154) antibody
SOD1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Superoxide Dismutase 1, Soluble (SOD1) (C-Term) antibodyKO Validated SOD1 适用: 人 WB, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Superoxide Dismutase 1, Soluble (SOD1) antibodyKO Validated SOD1 适用: 人 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Superoxide Dismutase 1, Soluble (SOD1) (AA 2-154) antibodySOD1 适用: 人, 马 WB, IHC, IP, IF/ICC 宿主: 兔 Polyclonal unconjugated
anti-Superoxide Dismutase 1, Soluble (SOD1) (AA 6-100) antibodySOD1 适用: 人, 小鼠, 大鼠 WB, ELISA, ICC, IHC (p), FACS, IHC (fro), IF (p), IF (cc) 宿主: 兔 Polyclonal unconjugated
anti-Superoxide Dismutase 1, Soluble (SOD1) (AA 2-154) antibodySOD1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Superoxide Dismutase 1, Soluble (SOD1) (AA 2-154) antibodySOD1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Superoxide Dismutase 1, Soluble (SOD1) (AA 2-153) antibodySOD1 适用: 兔 WB, IHC, IP, ICC 宿主: 豚鼠 Polyclonal unconjugated
anti-Superoxide Dismutase 1, Soluble (SOD1) (AA 2-154) antibodySOD1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Superoxide Dismutase 1, Soluble (SOD1) (AA 2-153) antibodySOD1 适用: Pig WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Applications include western blot analysis (1-2 µg/ml) of over-expressed human CuZnSOD. CuZnSOD is a homodimeric enzyme with a molecular weight of ~32 kDa. The two subunits associate noncovalently and are also stabilized by an intrachain disulfide bond. The molecular weight of each subunit is ~16 kDa.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.5 mg/mL
- 缓冲液
- Aqueous buffered solution containing ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Store undiluted at 4°C.
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: "Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury." in: Nature genetics, Vol. 13, Issue 1, pp. 43-7, (1996) (PubMed).
: "Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 7, pp. 3024-8, (1995) (PubMed).
: "Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis." in: Nature, Vol. 362, Issue 6415, pp. 59-62, (1993) (PubMed).
: "Superoxide dismutases." in: Advances in enzymology and related areas of molecular biology, Vol. 58, pp. 61-97, (1986) (PubMed).
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: "Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury." in: Nature genetics, Vol. 13, Issue 1, pp. 43-7, (1996) (PubMed).
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- 抗原
- SOD1 (Superoxide Dismutase 1, Soluble (SOD1))
- 别名
- SOD (SOD1 产品)
- 别名
- LOC692639 antibody, ALS antibody, ALS1 antibody, IPOA antibody, SOD antibody, hSod1 antibody, homodimer antibody, CG11793 antibody, Cu antibody, Cu-Zn SOD antibody, Cu/Zn SOD antibody, Cu/Zn sod antibody, Cu/Zn superoxide dismutase antibody, Cu/ZnSOD antibody, CuSOD antibody, CuZn SOD antibody, CuZn-SOD antibody, CuZn-SOD1 antibody, CuZnSOD antibody, Cu[2+]/Zn[2+]SOD antibody, Dmel\\CG11793 antibody, G antibody, Mn SOD antibody, SOD-1 antibody, SOD1 antibody, Sod-1 antibody, Sod1 antibody, To antibody, To-1 antibody, Zn SOD antibody, Zn Sod antibody, Zn-SOD antibody, ZnSod antibody, cSOD antibody, cSod antibody, dSOD1 antibody, l(3)108 antibody, l(3)68Af' antibody, l(3)G antibody, sod antibody, sod1 antibody, CU/ZN-SOD antibody, SODC antibody, DKFZP469M1833 antibody, B430204E11Rik antibody, Cu/Zn-SOD antibody, Ipo-1 antibody, Ipo1 antibody, SOD1L1 antibody, XSODB antibody, als antibody, als1 antibody, ipoa antibody, sod1-a antibody, ZSOD antibody, cuzn antibody, Cu/Zn superoxide dismutase antibody, superoxide dismutase 1 antibody, Superoxide dismutase 1 antibody, superoxide dismutase 1, soluble antibody, superoxide dismutase 1 S homeolog antibody, Superoxide dismutase [Cu-Zn] antibody, superoxide dismutase 1 L homeolog antibody, superoxide dismutase [Cu-Zn]-like antibody, superoxide dismutase [Cu-Zn] antibody, superoxide dismutase Sod1 antibody, SOD antibody, SOD1 antibody, Sod1 antibody, sod1 antibody, sod1.S antibody, sod-1 antibody, sod1.L antibody, LOC101451855 antibody, LOC101115136 antibody
- 背景
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The superoxide free radical O2.- is an intermediate form of molecular oxygen that is produced as a natural by-product of respiration and other biological processes Free radicals like O2.- can lead to the formation of additional reactive oxygen species that, in turn, can cause oxidative damage to DNA, protein, and lipid. The superoxide dismutases provide a defense against the damaging effects of O2.- by converting it to O2 + H2O2 (hydrogen peroxide). Hydrogen peroxide is then normally converted to water by either glutathione peroxidase or catalase. SODs are divided up into three types, and thought to evolve from two independent evolutionary lines: The copper- and zinc-containing SOD, CuZnSOD, is expressed in the cytosol of eukaryotic cells, the manganese-containing SOD, MnSOD, is present in bacteria, in the matrix of bacteria, and in mitochondria, and the iron-containing SOD, FeSOD, is found primarily in bacteria and is also expressed in some plants. All of the SODs catalyze the dismutation of O2.- at approximately the same rates. CuZnSOD lacks amino acid sequence homology with MnSOD and FeSOD, suggesting that it evolved independently from the FeSOD/MnSOD family of enzymes. Mutations have been described in the gene encoding CuZnSOD (SOD1) which reduce the activity and halflife of the enzyme. However, the role of these mutations in pathogenesis remains to be elucidated. Clone G215-1 recognizes human CuZnSOD. The antibody was originally characterized by western blot analysis of cells from transgenic mice expressing human CuZnSOD. Recombinant full-length human CuZnSOD GST fusion protein was used as immunogen.
Synonyms: CuZnSOD Copper/Zinc-Binding Superoxide Dismutase - 分子量
- 32 kDa
- 途径
- Sensory Perception of Sound, Transition Metal Ion Homeostasis
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