APEX2 抗体 (APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2)

Details for Product anti-APEX2 Antibody No. ABIN718481, 供应商: Log in to see
抗原
  • ape2
  • apexl2
  • xth2
  • zgc:55889
  • APE2
  • APEXL2
  • XTH2
  • C430040P13Rik
  • apurinic/apyrimidinic endodeoxyribonuclease 2
  • APEX nuclease (apurinic/apyrimidinic endonuclease) 2
  • apurinic/apyrimidinic endodeoxyribonuclease 2 L homeolog
  • APEX nuclease (apurinic/apyrimidinic endonuclease) 2-like 1
  • apurinic/apyrimidinic endonuclease 2
  • apex2
  • apex2.L
  • APEX2
  • Apex2l1
  • Apex2
适用
人, 小鼠, 大鼠
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16
2
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2
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1
宿主

56
3
克隆类型
多克隆
标记
This APEX2 antibody is un-conjugated
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3
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2
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2
1
1
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1
1
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1
应用范围
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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21
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7
4
1
选项
Supplier
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Supplier Product No.
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免疫原 KLH conjugated synthetic peptide derived from human APEX2
亚型 IgG
纯化方法 Purified by Protein A.
别名 APEX2 (APEX2 Antibody 摘要)
背景

Function as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Displays also double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities. Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially. Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents. In the nucleus functions in the PCNA-dependent BER pathway. Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes. Required for proper cell cycle progression during proliferation of peripheral lymphocytes.

Subcellular location: Cytoplasm, Nucleus, Mitochondrion

Synonyms: APE2, XTH2, ZGRF2, APEXL2, DNA-(apurinic or apyrimidinic site) lyase 2, AP endonuclease XTH2, APEX nuclease 2, APEX nuclease-like 2, Apurinic-apyrimidinic endonuclease 2, AP endonuclease 2, APEX2

基因ID 27301
UniProt Q9UBZ4
研究领域 Chromatin and Nuclear Signaling, DNA/RNA
应用备注 WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
限制 仅限研究用
状态 Liquid
浓度 1 μg/μL
缓冲液 Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
储存条件 -20 °C
储存方法 Store at -20°C
有效期 12 months
厂商提供的图像
Immunohistochemistry (IHC) image for anti-APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2) antibody (ABIN718481) Formalin-fixed and paraffin embedded rat brain labeled with Anti-APEX2 Polyclonal Ant...
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