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c-MYC 抗体 (N-Term)

MYC 适用: 人, 小鼠, 大鼠, 犬, Cow, 绵羊, 兔, 豚鼠, 斑马鱼, 马 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN486791
发货至: 中国
  • 抗原 See all c-MYC (MYC) 抗体
    c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))
    抗原表位
    • 55
    • 45
    • 44
    • 40
    • 24
    • 21
    • 19
    • 16
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    • 11
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    N-Term
    适用
    • 374
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    人, 小鼠, 大鼠, 犬, Cow, 绵羊, 兔, 豚鼠, 斑马鱼, 马
    宿主
    • 297
    • 97
    • 7
    • 3
    • 2
    • 1
    克隆类型
    • 288
    • 118
    多克隆
    标记
    • 196
    • 32
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    • 1
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    This c-MYC antibody is un-conjugated
    应用范围
    • 306
    • 142
    • 96
    • 83
    • 80
    • 64
    • 58
    • 28
    • 26
    • 17
    • 14
    • 13
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    Western Blotting (WB)
    序列
    QPYFYCDEEE NFYQQQQQSE LQPPAPSEDI WKKFELLPTP PLSPSRRSGL
    预测反应
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 100%
    产品特性
    This is a rabbit polyclonal antibody against MYC. It was validated on Western Blot using a cell lysate as a positive control.
    纯化方法
    Affinity Purified
    免疫原
    The immunogen is a synthetic peptide directed towards the N terminal region of human MYC
    Top Product
    Discover our top product MYC Primary Antibody
  • 应用备注
    Optimal working dilutions should be determined experimentally by the investigator.
    说明

    Antigen size: 454 AA

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Mallampalli, Kaercher, Snavely, Pulijala, Chen, Coon, Zhao, Agassandian: "Fbxl12 triggers G1 arrest by mediating degradation of calmodulin kinase I." in: Cellular signalling, Vol. 25, Issue 10, pp. 2047-59, (2013) (PubMed).

  • 抗原
    c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))
    别名
    Myc Proto-Oncogene protein (MYC 产品)
    别名
    MRTL antibody, MYCC antibody, bHLHe39 antibody, c-Myc antibody, CMYC antibody, c-myc antibody, C-MYC antibody, LOC100136746 antibody, ARC antibody, B430311C09Rik antibody, MYC antibody, NOP antibody, Nop30 antibody, RNCMYC antibody, mMyc antibody, AU016757 antibody, Myc2 antibody, Niard antibody, Nird antibody, cmyc antibody, zc-myc antibody, c-myc II antibody, myc-B antibody, myc2 antibody, myc1 antibody, CMyc antibody, zgc:55680 antibody, CG10798 antibody, D-Myc antibody, DM antibody, DMYc antibody, Dm antibody, Dmel\CG10798 antibody, Dmyc antibody, EG:BACN5I9.1 antibody, anon-WO03040301.171 antibody, bHLHe57 antibody, c-MYC antibody, d-myc antibody, dMYC antibody, dMyc antibody, dMyc1 antibody, da antibody, dm antibody, dm/dMyc antibody, dm/myc antibody, dmyc antibody, dmyc1 antibody, l(1)G0139 antibody, l(1)G0354 antibody, l(1)G0359 antibody, myc antibody, MYC proto-oncogene, bHLH transcription factor antibody, v-myc myelocytomatosis viral oncogene homolog antibody, nucleolar protein 3 (apoptosis repressor with CARD domain) antibody, myelocytomatosis oncogene antibody, MYC proto-oncogene, bHLH transcription factor a antibody, MYC proto-oncogene, bHLH transcription factor L homeolog antibody, MYC proto-oncogene, bHLH transcription factor S homeolog antibody, v-myc myelocytomatosis viral oncogene homolog (avian) antibody, MYC proto-oncogene, bHLH transcription factor b antibody, CG10798 gene product from transcript CG10798-RB antibody, MYC antibody, LOC100136746 antibody, Nol3 antibody, Myc antibody, myca antibody, myc.L antibody, myc.S antibody, mycb antibody
    背景
    MYC is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this MYC gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma.The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: c-Myc, MRTL, bHLHe39
    Protein Interaction Partner: UBC, USP37, USP22, KDM1A, SKP2, SMAD7, SNRNP70, CEP57, LDOC1, BRD3, KIDINS220, MAX, CSNK2B, CSNK2A1, USP28, NMI, PFDN5, TP73, EP400, SP1, PIAS2, ZBTB17, IGF2BP3, PTRF, SDK1, MRPL53, PRKCDBP, PHLDB2, KNDC1, MZT2B, RIN3, NEK11, MICALL2, NLRX1, NABP2, MYC, M
    Protein Size: 454
    分子量
    50 kDa
    基因ID
    4609
    NCBI登录号
    NM_002467, NP_002458
    途径
    p53 Pathway, Cell Division Cycle, Sensory Perception of Sound, Transition Metal Ion Homeostasis, Mitotic G1-G1/S Phases, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus, Warburg Effect
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