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SUV39H1 抗体 (N-Term)

SUV39H1 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN356686
发货至: 中国
  • 抗原 See all SUV39H1 抗体
    SUV39H1 (Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1))
    抗原表位
    • 17
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    N-Term
    适用
    • 61
    • 17
    • 7
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    • 1
    人, 小鼠
    宿主
    • 53
    • 8
    克隆类型
    • 53
    • 8
    多克隆
    标记
    • 23
    • 7
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    • 4
    • 1
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    This SUV39H1 antibody is un-conjugated
    应用范围
    • 39
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    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    特异性
    This antibody is specific to SUV39H1.
    纯化方法
    Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
    免疫原
    Purified recombinant GST fusion protein encoding N-terminal of human SUV39H1.
    亚型
    Ig Fraction
    Top Product
    Discover our top product SUV39H1 Primary Antibody
  • 应用备注
    ELISA: 1/1,000. Western Blot: 1/100-1/500. Immunohistochemistry.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.25 mg/mL
    缓冲液
    PBS containing 0.09 % (W/V) Sodium Azide as preservative.
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • 抗原
    SUV39H1 (Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1))
    别名
    SUV39H1 / KMT1A (SUV39H1 产品)
    别名
    H3-K9-HMTase 1 antibody, KMT1A antibody, MG44 antibody, SUV39H antibody, AI852103 antibody, AL022883 antibody, DXHXS7466e antibody, mIS6 antibody, RGD1565028 antibody, kmt1a antibody, suv39h antibody, fe02c04 antibody, suv39h1 antibody, wu:fe02c04 antibody, zgc:101027 antibody, fe47h06 antibody, wu:fb18a10 antibody, wu:fe47h06 antibody, zgc:136593 antibody, suppressor of variegation 3-9 homolog 1 antibody, suppressor of variegation 3-9 homolog 1 (Drosophila) antibody, suppressor of variegation 3-9 homolog 1 L homeolog antibody, suppressor of variegation 3-9 homolog 1a antibody, suppressor of variegation 3-9 homolog 1b antibody, SUV39H1 antibody, Suv39h1 antibody, suv39h1.L antibody, suv39h1a antibody, suv39h1b antibody
    背景
    Similar to acetylation and phosphorylation, histone methylation at the N-terminal tail has emerged as an important role in regulating chromatin dynamics and gene activity. Histone methylation occurs on arginine and lysine residues and is catalyzed by two families of proteins, the protein arginine methyltransferase family and the SET-domain-containing methyltransferase family. Five members have been identified in the arginine methyltransferase family. About 27 are grouped into the SET-domain family, and another 17 make up the PR domain family that is related to the SET domain family. The retinoblastoma protein-interacting zinc finger geneRIZ1 is a tumor suppressor gene and a FOUNDING member of the PR domain family. RIZ1 inactivation is commonly found in many types of human cancers and occurs through loss of mRNA expression, frame shift mutation, chromosomal deletion, and missense mutation. RIZ1 is also a tumor susceptibility gene in mice. The loss of RIZ1 mRNA in human cancers was shown to associate with DNA methylation of its promoter CpG island. Methylation of the RIZ1 promoter strongly correlated with lost or decreased RIZ1 mRNA expression in breast, liver, colon, and lung cancer cell lines as well as in liver cancer tissues.Synonyms: Histone H3-K9 methyltransferase 1, Histone-lysine N-methyltransferase SUV39H1, Lysine N-methyltransferase 1A, Position-effect variegation 3-9 homolog, SUV39H, Suppressor of variegation 3-9 homolog 1
    基因ID
    6839, 9606
    UniProt
    O43463
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