SOX4 (N-Term) 抗体

ABIN2780469 产品详细信息, 供应商: Log in to see
抗原
  • EVI16
  • AA682046
  • Sox-4
  • sox4
  • wu:fb82f08
  • wu:fq41g10
  • zgc:65850
  • zgc:77392
  • SRY (sex determining region Y)-box 4
  • SRY-box containing gene 4
  • SRY-box containing gene 4a
  • SOX4
  • Sox4
  • sox4a
抗原表位
N-Term
21
8
5
5
5
4
4
2
1
1
1
1
1
适用
牛, 犬, 山羊, 豚鼠, 马, 人, 小鼠, 兔, 大鼠, 斑马鱼
73
24
21
4
4
2
2
1
1
1
1
宿主

61
12
克隆类型
多克隆
标记
非结合性
1
1
1
1
1
1
1
1
1
1
1
1
1
1
应用范围
Immunohistochemistry (IHC), Western Blotting (WB)
36
23
15
13
12
8
5
3
3
1
选项
Supplier
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免疫原 The immunogen is a synthetic peptide directed towards the N terminal region of human SOX4
Blocking Peptide Blocking peptide for this product available: ABIN984276
序列 STASTGGKAD DPSWCKTPSG HIKRPMNAFM VWSQIERRKI MEQSPDMHNA
特异性 Peptide immunogen shares 93 % with human SOX11.
预测反应 Cow: 100%, Dog: 100%, Goat: 91%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%
产品特性 This is a rabbit polyclonal antibody against SOX4. It was validated on Western Blot using a cell lysate as a positive control.
纯化方法 Affinity Purified
背景 SOX4 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. It may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein.This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: EVI16
Protein Interaction Partner: TAF5, UBE2I, ELAVL1, TP53, MDM2, EP300, tat, SDCBP,
Protein Size: 474
分子量 47 kDa
基因ID 6659
NCBI登录号 NM_003107, NP_003098
UniProt Q06945
研究领域 Stem Cells, Transcription Factors, Neural Stem Cell marker
应用备注 Optimal working dilutions should be determined experimentally by the investigator.
说明

Antigen size: 474 AA

限制 仅限研究用
状态 Liquid
浓度 Lot specific
缓冲液 Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 Avoid repeated freeze-thaw cycles.
储存条件 -20 °C
储存方法 For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
厂商提供的图像
Immunohistochemistry (IHC) image for anti-SOX4 (N-Term) antibody (ABIN2780469) anti-SOX4 (N-Term) antibody
Immunohistochemistry (IHC) image for anti-SOX4 (N-Term) antibody (ABIN2780469) anti-SOX4 (N-Term) antibody (Image 2)
Western Blotting (WB) image for anti-SOX4 (N-Term) antibody (ABIN2780469) Host: Rabbit
Target Name: SOX4
Sample Tissue: Human Fetal Heart
...
Western Blotting (WB) image for anti-SOX4 (N-Term) antibody (ABIN2780469) Host: Rabbit
Target Name: SOX4
Sample Tissue: Human Fetal Liver
...
Immunohistochemistry (IHC) image for anti-SOX4 (N-Term) antibody (ABIN2780469) Human Heart
Immunohistochemistry (IHC) image for anti-SOX4 (N-Term) antibody (ABIN2780469) Human Testis
背景 Hoser, Baader, Bösl, Ihmer, Wegner, Sock: "Prolonged glial expression of Sox4 in the CNS leads to architectural cerebellar defects and ataxia." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 27, Issue 20, pp. 5495-505, 2007 (PubMed).

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