Perforin 1 抗体 (Perforin 1 (Pore Forming Protein)) (Alexa Fluor 488)

Details for Product anti-PRF1 Antibody No. ABIN2657572, 供应商: Log in to see
抗原
  • PRF1
  • LOC443187
  • perforin
  • prf1
  • FLH2
  • HPLH2
  • P1
  • PFN1
  • PFP
  • Pfn
  • Pfp
  • Prf-1
  • Cyta
  • RATCYTA
  • perforin 1 (pore forming protein)
  • perforin
  • perforin 1-like
  • PRF1
  • LOC443187
  • prf1
  • Prf1
  • LOC100342396
适用

158
46
24
22
2
2
1
1
1
宿主
小鼠
100
75
20
克隆类型 (克隆位点)
单克隆 ()
标记
This Perforin 1 antibody is conjugated to Alexa Fluor 488
16
12
10
5
4
3
3
2
2
2
2
2
2
2
2
2
2
2
应用范围
Flow Cytometry (FACS)
98
81
46
41
38
37
35
34
31
6
6
6
3
2
2
1
1
1
1
1
选项
Supplier
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Supplier Product No.
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克隆位点 DG9
亚型 IgG2b kappa
交叉反应
无交叉反应 小鼠
纯化方法 The antibody was purified by affinity chromatography, and conjugated with Alexa Fluor® 488 under optimal conditions.
别名 Perforin (PRF1 Antibody 摘要)
背景 Perforin is a 70 kD cytolytic protein that is expressed in the cytoplasmic granules of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. Perforin is one of the major effector molecules used by cytotoxic T cells and NK cells to mediate targeted cell lysis.
研究领域 Immunology, Innate Immunity, Adaptive Immunity, Inflammation
途径 Apoptosis, Caspase Cascade in Apoptosis
应用备注 Optimal working dilution should be determined by the investigator.
限制 仅限研究用
缓冲液 Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 Protect from prolonged exposure to light. Do not freeze.
储存条件 4 °C
储存方法 The antibody solution should be stored undiluted between 2°C and 8°C
厂商提供的图像
Flow Cytometry (FACS) image for anti-Perforin 1 (Pore Forming Protein) (PRF1) antibody (Alexa Fluor 488) (ABIN2657572) anti-Perforin 1 (Pore Forming Protein) (PRF1) antibody (Alexa Fluor 488)
背景 Mace, Orange: "Lytic immune synapse function requires filamentous actin deconstruction by Coronin 1A." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 18, pp. 6708-13, 2014 (PubMed).

Makedonas, Hutnick, Haney, Amick, Gardner, Cosma, Hersperger, Dolfi, Wherry, Ferrari, Betts: "Perforin and IL-2 upregulation define qualitative differences among highly functional virus-specific human CD8 T cells." in: PLoS pathogens, Vol. 6, Issue 3, pp. e1000798, 2010 (PubMed).

Wood, Meeths, Chiang, Bechensteen, Boelens, Heilmann, Horiuchi, Rosthøj, Rutynowska, Winiarski, Stow, Nordenskjöld, Henter, Ljunggren, Bryceson: "Different NK cell-activating receptors preferentially recruit Rab27a or Munc13-4 to perforin-containing granules for cytotoxicity." in: Blood, Vol. 114, Issue 19, pp. 4117-27, 2009 (PubMed).

Chen, Hou, Jiang, Ma, Meng, Wang, Zhang, Zhang, Tang, Zhang, Wan, Li, Yu, Hu, Yang, He, Wang, Cao: "Response of memory CD8+ T cells to severe acute respiratory syndrome (SARS) coronavirus in recovered SARS patients and healthy individuals." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 175, Issue 1, pp. 591-8, 2005 (PubMed).

Mauad, van Schadewijk, Schrumpf, Hack, Fernezlian, Garippo, Ejzenberg, Hiemstra, Rabe, Dolhnikoff: "Lymphocytic inflammation in childhood bronchiolitis obliterans." in: Pediatric pulmonology, Vol. 38, Issue 3, pp. 233-9, 2004 (PubMed).

Schaerli, Ebert, Willimann, Blaser, Roos, Loetscher, Moser: "A skin-selective homing mechanism for human immune surveillance T cells." in: The Journal of experimental medicine, Vol. 199, Issue 9, pp. 1265-75, 2004 (PubMed).

Lieberman: "The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal." in: Nature reviews. Immunology, Vol. 3, Issue 5, pp. 361-70, 2003 (PubMed).

Trapani, Smyth: "Functional significance of the perforin/granzyme cell death pathway." in: Nature reviews. Immunology, Vol. 2, Issue 10, pp. 735-47, 2002 (PubMed).

Barrat, Le Deist, Benkerrou, Bousso, Feldmann, Fischer, de Saint Basile: "Defective CTLA-4 cycling pathway in Chediak-Higashi syndrome: a possible mechanism for deregulation of T lymphocyte activation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 15, pp. 8645-50, 1999 (PubMed).

Watanabe, De Rosa, Cmelak, Hoppe, Herzenberg, Roederer: "Long-term depletion of naive T cells in patients treated for Hodgkin's disease." in: Blood, Vol. 90, Issue 9, pp. 3662-72, 1997 (PubMed).

Hameed, Olsen, Cheng, Fox, Hruban, Podack: "Immunohistochemical identification of cytotoxic lymphocytes using human perforin monoclonal antibody." in: The American journal of pathology, Vol. 140, Issue 5, pp. 1025-30, 1992 (PubMed).

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