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- 抗原 See all LEFTY2 抗体
- LEFTY2 (Left-Right Determination Factor 2 (LEFTY2))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This LEFTY2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA
- 特异性
- A BALB/c mouse was immunized with a recombinant form of 6X HIS tagged human LEFTY.
- 纯化方法
- Protein A Column
- 免疫原
- LEFTY2 monoclonal antibody was raised against recombinant LEFTY2 (Human). Hybridoma: Produced by the fusion between BALB/c mouse splenocytes and mouse Sp2/0 myeloma cells using conventional hybridoma technology.
- 克隆位点
- 7C5G1H6H10
- 亚型
- IgG2a kappa
- Top Product
- Discover our top product LEFTY2 Primary Antibody
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anti-Left-Right Determination Factor 2 (LEFTY2) (AA 57-366) antibody
LEFTY2 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Left-Right Determination Factor 2 (LEFTY2) (C-Term) antibodyLEFTY2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Left-Right Determination Factor 2 (LEFTY2) antibodyLEFTY2 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB52667 unconjugated
anti-Left-Right Determination Factor 2 (LEFTY2) (N-Term) antibodyLEFTY2 适用: 人, 大鼠, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Left-Right Determination Factor 2 (LEFTY2) (AA 1-366) antibodyLEFTY2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Left-Right Determination Factor 2 (LEFTY2) (Internal Region) antibodyLEFTY2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Left-Right Determination Factor 2 (LEFTY2) antibodyLEFTY2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Left-Right Determination Factor 2 (LEFTY2) (N-Term) antibodyLEFTY2 适用: 人, 小鼠, 大鼠, Pig, Cow, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Left-Right Determination Factor 2 (LEFTY2) (AA 1-366) antibodyLEFTY2 适用: 人 WB 宿主: 兔 Polyclonal RB52397 unconjugated
anti-Left-Right Determination Factor 2 (LEFTY2) (AA 77-180) antibodyLEFTY2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1H6 unconjugated
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- 应用备注
- LEFTY2 antibody can be used in immunohistochemistry starting at 2.5 μg/mL.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- 0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- As with all antibodies avoid freeze/thaw cycles.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store LEFTY2 antibody at 4 °C or -20 °C.
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- 抗原
- LEFTY2 (Left-Right Determination Factor 2 (LEFTY2))
- 别名
- LEFTY2 (LEFTY2 产品)
- 别名
- EBAF antibody, LEFTA antibody, LEFTYA antibody, TGFB4 antibody, AI450052 antibody, Ebaf antibody, Leftb antibody, Stra3 antibody, Tgfb4 antibody, lefty antibody, lefty-1 antibody, atv2 antibody, cb720 antibody, fe38b03 antibody, wu:fe38b03 antibody, 6030463A22Rik antibody, AV214969 antibody, Lefta antibody, Ebaf2 antibody, left-right determination factor 2 antibody, left right determination factor 1 antibody, lefty2 antibody, Left-right determination factor 2 antibody, left-right determination factor 2-like antibody, LEFTY2 antibody, Lefty1 antibody, lft2 antibody, Lefty2 antibody, LOC699676 antibody, LOC100232580 antibody
- 背景
- During vertebrate embryogenesis, a left-right axis is established. Secreted growth factors of the TGF-beta family, including gene products derived from nodal, lefty-1 and lefty-2, play crucial roles in establishing left-right asymmetries. TGF-beta (Transforming growth factor-beta) is a pleiotropic cytokine that regulates growth and differentiation of diverse types of cells. TGF-beta actions are directed by ligand-induced activation of TGF-beta receptors. Complexes formed move into the nucleus, where they act as components of a transcriptional complex. Lefty, a novel member of the TGF-beta superfamily, inhibits TGF-beta signaling. Lefty acts to inhibit phosphorylation of Smad2 following activation of the TGF-beta receptor. Lefty also inhibits events downstream from R-Smad phosphorylation. Lefty provides a repressed state of TGF-beta-responsive genes. The Lefty family is comprised of Lefty 1 and Lefty 2 in mouse, and Lefty A and Lefty B in humans. Members of the TGF-beta superfamily require processing for their activation. Cleavage is therefore an essential step for Lefty activation. Lefty is synthesized as a large inactive precursor (42 kDa) that must be endoproteolytically processed to release the bioactive polypeptide (28 kDa and 34 kDa forms). The 28 kDa form induces MAPK activity.
- 基因ID
- 7044
- UniProt
- O00292
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