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Aurora A 抗体 (C-Term)

Name: Aurora A 抗体 (C-Term)
SKU: ABIN1882163
Availability: OutOfStock

AURKA 适用: 人 WB, IF, FACS 宿主: 兔 Polyclonal RB6834 unconjugated

Western blot analysis of anti-Aurora-A Pab (ABIN1882163 and ABIN2841166) in cell line lysate. (Aurora A 抗体 (C-Term))

Aurora-A Antibody (C-term) (ABIN1882163 and ABIN2841166) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram). (Aurora A 抗体 (C-Term))

FACS

Confocal immunofluorescent analysis of Aurora-A Antibody (C-term) (ABIN1882163 and ABIN2841166) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). (Aurora A 抗体 (C-Term))

Western blot analysis of Aurora-A (arrow) using rabbit polyclonal Aurora-A Antibody (C-term) (ABIN1882163 and ABIN2841166). (Aurora A 抗体 (C-Term))

4 images

(6 references)

产品编号 ABIN1882163

发货至: 中国

Datasheet as PDF

抗原 See all Aurora A (AURKA) 抗体

Aurora A (AURKA) (Aurora Kinase A (AURKA))
抗原表位
28

17

8

8

7

7

7

6

6

3

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 364-392, C-Term
适用
119

72

40

20

18

14

6

3

2

2

2

2
人
宿主
117

19

1
兔
Compatible Secondaries
克隆类型
104

32
多克隆
标记
80

9

7

6

4

4

4

4

4

4

3

3

1

1

1

1

1
This Aurora A antibody is un-conjugated
应用范围
98

54

32

23

19

14

12

11

6

3

2

1

1
Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

纯化方法

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

免疫原

This Aurora-A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 364-392 amino acids from the C-terminal region of human Aurora-A.

克隆位点

RB6834

亚型

Ig Fraction

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anti-Aurora Kinase A (AURKA) (C-Term) antibody
AURKA 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated

anti-Aurora Kinase A (AURKA) (AA 268-404) antibody
AURKA 适用: 人 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 2D8A4 unconjugated

anti-Aurora Kinase A (AURKA) antibody
AURKA 适用: 人, 大鼠, 猴 WB, ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 1F8 unconjugated

anti-Aurora Kinase A (AURKA) (pThr288) antibody
AURKA 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Aurora Kinase A (AURKA) (AA 268-404) antibody
AURKA 适用: 人, 小鼠 WB, ELISA, IHC, FACS, ICC, Neut 宿主: 小鼠 Monoclonal 4H5A8 unconjugated

anti-Aurora Kinase A (AURKA) antibody
AURKA 适用: 人, 大鼠, 猴 WB, ELISA, IHC 宿主: 小鼠 Monoclonal 4G10 unconjugated

anti-Aurora Kinase A (AURKA) (AA 364-392) antibody
AURKA 适用: 人 WB, ELISA, IF, FACS 宿主: 兔 Polyclonal unconjugated

anti-Aurora Kinase A (AURKA) (AA 1-131) antibody
AURKA 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Aurora Kinase A (AURKA) (AA 1-100) antibody
AURKA 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

应用备注

IF: 1:10~50. WB: 1:1000. WB: 1:1000. FC: 1:10~50

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

有效期

6 months
Nakamura, Hirano, Okinaka, Takemura, Yokota, Ono, Shigeno, Shibata, Fujisawa, Ohnishi: "The FOXM1 transcriptional factor promotes the proliferation of leukemia cells through modulation of cell cycle progression in acute myeloid leukemia." in: Carcinogenesis, Vol. 31, Issue 11, pp. 2012-21, (2010) (PubMed).

Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, (2002) (PubMed).

Tanaka, Ueda, Kanamori, Ideguchi, Yang, Kitajima, Ishigatsubo: "Cell-cycle-dependent regulation of human aurora A transcription is mediated by periodic repression of E4TF1." in: The Journal of biological chemistry, Vol. 277, Issue 12, pp. 10719-26, (2002) (PubMed).

Deloukas, Matthews, Ashurst, Burton, Gilbert, Jones, Stavrides, Almeida, Babbage, Bagguley, Bailey, Barlow, Bates, Beard, Beare, Beasley, Bird, Blakey, Bridgeman, Brown, Buck, Burrill, Butler, Carder et al.: "The DNA sequence and comparative analysis of human chromosome 20. ..." in: Nature, Vol. 414, Issue 6866, pp. 865-71, (2002) (PubMed).

Nigg: "Mitotic kinases as regulators of cell division and its checkpoints." in: Nature reviews. Molecular cell biology, Vol. 2, Issue 1, pp. 21-32, (2001) (PubMed).

Shindo, Nakano, Kuroyanagi, Shirasawa, Mihara, Gilbert, Jenkins, Copeland, Yagita, Okumura: "cDNA cloning, expression, subcellular localization, and chromosomal assignment of mammalian aurora homologues, aurora-related kinase (ARK) 1 and 2." in: Biochemical and biophysical research communications, Vol. 244, Issue 1, pp. 285-92, (1998) (PubMed).
抗原

Aurora A (AURKA) (Aurora Kinase A (AURKA))

别名

Aurora-A (AURKA 产品)

别名

AIK antibody, ARK1 antibody, AURA antibody, AURORA2 antibody, BTAK antibody, PPP1R47 antibody, STK15 antibody, STK6 antibody, STK7 antibody, AIRK1 antibody, AU019385 antibody, AW539821 antibody, Ark1 antibody, Aurora-A antibody, Ayk1 antibody, IAK antibody, IAK1 antibody, Stk6 antibody, 87A7-9/2 antibody, Aur-A antibody, AurA antibody, CG3068 antibody, Dmel\\CG3068 antibody, aur-A antibody, aurA antibody, ck10 antibody, ck[10] antibody, l(3)87Ac antibody, l(3)ck10 antibody, ARK-1 antibody, Eg2 antibody, aik antibody, ark1 antibody, aur-a antibody, aura antibody, aurka-a antibody, aurora2 antibody, btak antibody, stk15 antibody, stk6 antibody, stk7 antibody, pEg2 antibody, wu:fb37c10 antibody, wu:fc02c02 antibody, zgc:100912 antibody, AURKA antibody, aurka antibody, aurora kinase A antibody, aurora A antibody, aurora kinase A L homeolog antibody, hypothetical protein antibody, aurora kinase A S homeolog antibody, AURKA antibody, Aurka antibody, aurA antibody, aurka.L antibody, aurka antibody, Aurora-A antibody, aurka.S antibody

背景

Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases, members of the Ser/Thr protein kinase family, associate with microtubules during chromosome movement and segregation. Auroria kinase A may play a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. It may be involved in microtubule formation and/or stabilization. This protein has also been postulated to play a key role during tumor development and progression. Aurora kinase A localizes on centrosomes in interphase cells and at each spindle pole in mitosis. It is highly expressed in testis, weakly in skeletal muscle, thymus and spleen, and also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines. Expression is cell-cycle regulated, low in G1/S, accumulates during G2/M, and decreases rapidly afterward. Defects in Aurora kinase A are responsible for numerical centrosome aberrations including aneuploidy.

分子量

45809

NCBI登录号

NP_003591, NP_940835, NP_940836, NP_940837, NP_940838, NP_940839

UniProt

O14965

途径

Cell Division Cycle, Asymmetric Protein Localization