Botulinum Neurotoxin Type B (BoNT/B) 抗体
This 小鼠 单克隆 antibody specifically detects Botulinum Neurotoxin Type B in cELISA 和 FACS. It exhibits reactivity toward Clostridium botulinum.
产品编号 ABIN179725
发货至:
中国
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Quick Overview for Botulinum Neurotoxin Type B (BoNT/B) 抗体 (ABIN179725)
抗原
See all Botulinum Neurotoxin Type B (BoNT/B) 抗体
Botulinum Neurotoxin Type B (BoNT/B)
适用
Clostridium botulinum
宿主
小鼠
克隆类型
单克隆
标记
非结合性
应用范围
Cell-ELISA (cELISA), Flow Cytometry (FACS)
克隆位点
GR-3G7
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特异性
- Anti-BoNT/B
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纯化方法
- Protein G
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免疫原
- genetic immunisation with cDNA encoding BoNT/B
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亚型
- IgG1
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anti-Botulinum Neurotoxin Type B (BoNT/B) antibody
BoNT/B 适用: Clostridium botulinum ELISA, WB 宿主: Chicken egg unconjugated
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应用备注
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Flow cytometry: 1.2 µg/10^6 cells
CELISA: 1:200 - 1:400
For each application a titration should be performed to determine the optimal concentration. -
限制
- 仅限研究用
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浓度
- 2 mg/mL
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缓冲液
- PBS, pH 7.2
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C
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储存方法
- short term: 2 °C - 8 °C, long term: -20 °C
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- Botulinum Neurotoxin Type B (BoNT/B)
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别名
- BoNT B, Lightchain
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物质类
- Bacteria
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背景
- Botulinum neurotoxin type B (BoNT/B) is produced by Clostridium botulinum, a genetically diverse class of anaerobic, spore-forming, gram-positive bacilli. Seven different botulinum toxin groups have been identified serologically and are called botulinum toxin type A,B,C,D,E,F, and G. BoNT/B is a two-chain polypeptide with a 100-kDa heavy chain, which is responsible for neurospecific binding joined by a disulphide bond to a 50-kDa light chain, a zinc-endopeptidase which blocks neurotransmitter release. BoNT/B is one of the most poisonous naturally occurring substances. It inhibits acetylcholine release from neuromuscular junctions while it is used as an important therapeutic mainstay in the treatment of spasticity disorders and as a cosmetic treatment.
抗原
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