TRKA 抗体 (Neurotrophic Tyrosine Kinase, Receptor, Type 1)

Details for Product anti-NTRK1 Antibody No. ABIN127050, 供应商: Log in to see
抗原
  • trk
  • trka
  • TRKA
  • MTC
  • TRK
  • TRK1
  • Trk-A
  • p140-TrkA
  • C80751
  • Tkr
  • TrkA
  • Trk
  • CTRKA
  • trkA
  • CAPM1
  • CFTD
  • NEM1
  • OK/SW-cl.5
  • TM-5
  • TM3
  • TM30
  • TM30nm
  • TM5
  • TPMsk3
  • hscp30
  • neurotrophic tyrosine kinase, receptor, type 1
  • tropomyosin 3
  • ntrk1
  • NTRK1
  • LOC100354292
  • Ntrk1
  • TPM3
适用
人, 小鼠, 大鼠
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宿主

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克隆类型
多克隆
标记
This TRKA antibody is un-conjugated
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应用范围
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
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42
19
10
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1
选项
Supplier
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Supplier Product No.
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免疫原 Synthetic peptide surrounding amino acid 494 of human TrkA
特异性 The antibody detects 140 kDa TrkA. It does not cross-react with TrkB or TrkC.
纯化方法 Affinity Chromatography
别名 TrkA (NTRK1 Antibody 摘要)
背景 TrkA, the high affinity Nerve Growth Factor (NGF) receptor, autophosphorylates on tyrosine to activate multiple effectors. Phosphorylation at Tyr490 is required for Shc association and activation of the Ras-MAP kinase cascade. Residues Tyr674/675 lie within the catalytic domain, and phosphorylation at these sites reflects Trk kinase activity.Synonyms: High affinity nerve growth factor receptor, NTRK1, Neurotrophic tyrosine kinase receptor type 1, TRK, TRK1-transforming tyrosine kinase protein, Trk-A, p140-TrkA
基因ID 4914
NCBI登录号 NP_001007793
UniProt P04629
研究领域 Cancer
途径 RTK signaling, Neurotrophin Signaling Pathway, cAMP Metabolic Process
应用备注 Western blotting (0.5-4 μg/mL). Immunoprecipitation. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
限制 仅限研究用
浓度 0.5 mg/mL
缓冲液 PBS, pH 7.2, containing 30 % Glycerol, 0.5 % BSA, 0.01 % Thimerosal.
储存液 Thimerosal (Merthiolate)
注意事项 This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 Avoid repeated freezing and thawing.
储存条件 -20 °C
储存方法 Store the antibody at -20 °C. For long-term storage, aliquot and freeze at -20 °C to -70 °C.
厂商提供的图像
 image for anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) antibody (ABIN127050) anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) antibody
背景 Segal, Greenberg: "Intracellular signaling pathways activated by neurotrophic factors." in: Annual review of neuroscience, Vol. 19, pp. 463-89, 1997 (PubMed).

Stephens, Loeb, Copeland, Pawson, Greene, Kaplan: "Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses." in: Neuron, Vol. 12, Issue 3, pp. 691-705, 1994 (PubMed).

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