IDO1 抗体 (N-Term)
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- 抗原 See all IDO1 抗体
- IDO1 (Indoleamine 2,3-Dioxygenase 1 (IDO1))
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抗原表位
- AA 1-19, AA 155-176, AA 359-376, N-Term
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适用
- 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This IDO1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 特异性
- The antibody recognizes Rat Indoleamine 2,3-dioxygenase 1 (IDO1 or INDO). Does not cross react with IDO2.
- 交叉反应 （详细）
- Species reactivity (tested):Rat, Mouse.
- 纯化方法
- Protein A Chromatography
- 免疫原
- A mixture of three Rat IDO peptides: MPHSQISPAEGSRRILEEY (1-19), LFSFPGGDCDKGFFLVSLMVE (155-176), and VKPSKQKPMGGHKSEEPS (359-376) coupled to keyhole limpet hemocyanin.
- 亚型
- Ig Fraction
- Top Product
- Discover our top product IDO1 Primary Antibody
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anti-Indoleamine 2,3-Dioxygenase 1 (IDO1) (AA 1-403) antibody
IDO1 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 4D2 unconjugated
anti-Indoleamine 2,3-Dioxygenase 1 (IDO1) (Internal Region) antibodyVerified IDO1 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Indoleamine 2,3-Dioxygenase 1 (IDO1) antibodyIDO1 适用: 人 WB, IHC, IHC (p), IF 宿主: 小鼠 Monoclonal 1E11 unconjugated
anti-Indoleamine 2,3-Dioxygenase 1 (IDO1) antibodyIDO1 适用: 小鼠 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 2E2-6 unconjugated
anti-Indoleamine 2,3-Dioxygenase 1 (IDO1) (AA 1-403) antibodyIDO1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Indoleamine 2,3-Dioxygenase 1 (IDO1) (AA 1-100) antibodyIDO1 适用: 人, 小鼠 ELISA, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Indoleamine 2,3-Dioxygenase 1 (IDO1) (AA 304-403) antibodyIDO1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1C5 unconjugated
anti-Indoleamine 2,3-Dioxygenase 1 (IDO1) (Internal Region) antibodyIDO1 适用: 人, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Indoleamine 2,3-Dioxygenase 1 (IDO1) (AA 204-403) antibodyIDO1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Indoleamine 2,3-Dioxygenase 1 (IDO1) antibodyIDO1 适用: 小鼠 WB, ELISA, IHC, ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 浓度
- 0.1 mg/mL
- 缓冲液
- PBS, 0.02 % Sodium Azide, 0.1 % BSA
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Store undiluted at 2-8 °C.
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- 抗原
- IDO1 (Indoleamine 2,3-Dioxygenase 1 (IDO1))
- 别名
- IDO1 / INDO (IDO1 产品)
- 别名
- INDO antibody, ido antibody, indo antibody, IDO antibody, cd107b antibody, IDO1 antibody, IDO-1 antibody, Ido antibody, Indo antibody, indoleamine 2,3-dioxygenase 1 antibody, indoleamine 2,3-dioxygenase 1 L homeolog antibody, indoleamine 2,3-dioxygenase 1-like antibody, IDO1 antibody, ido1.L antibody, ido1 antibody, Ido1 antibody, LOC100050681 antibody
- 背景
- IDO1 is an intracellular heme-containing enzyme of 45 kD that catalyzes the oxidative cleavage of the indole ring of several important regulatory molecules, like tryptophan, serotonin and melatonin. By doing this, IDO1 initiates the production of biologically active metabolites, commonly referred to as kynurenines. IDO1 is widely expressed in a variety of human tissues as well as in macrophages and dendritic cells (DCs). In inflammation, interferons (IFNs) act on specific receptors to trigger IDO1 induction. The production of IFN-gamma and induction of IDO1 represent important antimicrobial mechanisms. Degradation and depletion of tryptophan by IDO1 inhibits the growth of viruses, bacteria and parasites. Furthermore, IDO1 plays a complex and crucial role in immunoregulation during infection, pregnancy, autoimmunity, transplantation, and neoplasia. By local depletion of tryptophan and increasing proapoptotic kynurenines, IDO1 greatly affects T-cell proliferation and survival, both in vitro and in vivo, and also affects B-cell and NK-cell function and survival. There is a central role for IDO1 expression in tolerance involving regulatory cells and DCs. IDO1 acts as an intermediate pathway in LPS-induced production of reactive oxygen species and NF-kappaB activation, two processes that lead to DC maturation. In addition to classic IDO (IDO1) indoleamine 2,3-dioxygenase-2, indoleamine 2,3-dioxygenase-like protein or proto-indoleamine 2,3 dioxygenase (IDO2, IDO-2, INDOL1 or proto-IDO) has been described.Synonyms: 3-dioxygenase, 3-dioxygenase 1, EC=1.13.11.52, IDO, IDO1, INDO, Indoleamine 2, Indoleamine-pyrrole 2
- 基因ID
- 66029
- NCBI登录号
- NP_076463
- UniProt
- Q9ERD9
- 途径
- Activated T Cell Proliferation
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