IDO1 抗体
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北京 101111
Quick Overview for IDO1 抗体 (ABIN1169195)
抗原
See all IDO1 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- anti-IDO (mouse), pAb
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特异性
- Recognizes mouse IDO1. Detects a band of ~45 kDa by Western blot.
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产品特性
- Polyclonal Antibody. Recognizes mouse IDO. Detects a band of ~45 kDa by Western blot. Source: Rabbit. Applications: ELISA, ICC, IHC, WB. Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives. IDO catalyzes the first and rate-limiting step in the main pathway of human tryptophan catabolism, the kynurenine pathway. Proinflammatory mediators, such as endotoxin and IFN-gamma induce the expression of IDO in several tissues. IDO-dependent suppression of T-cell responses might function as natural immunoregulatory mechanism. Physiological IDO activity has been implicated in T-cell tolerance to tumors, dysfunctional selftolerance in non-obese diabetic (NOD) mice, and as a protective negative regulator in autoimmune disorders.
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过滤
- 0.2 μm filtered
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免疫原
- Recombinant mouse IDO1.
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anti-Indoleamine 2,3-Dioxygenase 1 (IDO1) (Internal Region) antibody
Verified IDO1 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Indoleamine 2,3-Dioxygenase 1 (IDO1) (AA 1-403) antibodyIDO1 适用: 人 WB, IHC, ICC, IF (p) 宿主: 兔 Monoclonal BLR031F unconjugated Recombinant Antibody
anti-Indoleamine 2,3-Dioxygenase 1 (IDO1) antibodyIDO1 适用: 人 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 1E11 unconjugated
anti-Indoleamine 2,3-Dioxygenase 1 (IDO1) (AA 1-403) antibodyIDO1 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 4D2 unconjugated
anti-Indoleamine 2,3-Dioxygenase 1 (IDO1) (N-Term) antibodyIDO1 适用: 人 WB, IHC, FACS, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Indoleamine 2,3-Dioxygenase 1 (IDO1) (AA 1-403) antibodyIDO1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Indoleamine 2,3-Dioxygenase 1 (IDO1) antibodyIDO1 适用: 小鼠 WB, ELISA, IHC, FACS, IF, IP, FM, MA 宿主: 小鼠 Monoclonal 2E2-6 unconjugated
anti-Indoleamine 2,3-Dioxygenase 1 (IDO1) (AA 1-100) antibodyIDO1 适用: 人 IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Indoleamine 2,3-Dioxygenase 1 (IDO1) (AA 374-403), (C-Term) antibodyIDO1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB15061 unconjugated
anti-Indoleamine 2,3-Dioxygenase 1 (IDO1) (AA 79-105) antibodyIDO1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB15060 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 0.2μm-filtered solution in PBS, pH 7.4.
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储存液
- Without preservative
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注意事项
- After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.
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储存条件
- 4 °C,-20 °C
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储存方法
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+4°C
-20°C
Stable for at least 6 months after receipt when stored at -20°C.
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有效期
- 6 months
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: "Blockade of indoleamine 2,3-dioxygenase protects mice against lipopolysaccharide-induced endotoxin shock." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 5, pp. 3146-54, (2009) (PubMed).
: "A novel cancer therapy by skin delivery of indoleamine 2,3-dioxygenase siRNA." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 15, Issue 2, pp. 641-9, (2009) (PubMed).
: "Spontaneous renal allograft acceptance associated with "regulatory" dendritic cells and IDO." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 180, Issue 5, pp. 3103-12, (2008) (PubMed).
: "IFN-gamma-induced IDO and WRS expression in microglia is differentially regulated by IL-4." in: Glia, Vol. 55, Issue 13, pp. 1385-96, (2007) (PubMed).
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- IDO1 (Indoleamine 2,3-Dioxygenase 1 (IDO1))
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别名
- IDO
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背景
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Alternate Names/Synonyms: Indoleamine 2,3-dioxygenase 1, IDO, INDO
Product Description: IDO1 is a heme enzyme that catalyzes the first and rate-limiting step in the main pathway of human tryptophan catabolism, the kynurenine pathway, causing depletion of tryptophan which can lead to halted growth of microbes as well as T cells. IDO1 is an immune checkpoint protein, thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation and antioxidant activity. Cancer cells are able to evade the immune system is by hijacking the checkpoint proteins. Increased IDO1 protein levels drive growth arrest and apoptosis of the effector T cells, a group of immune cells that mediate the immune system's ability to destroy pathogens. By reducing the number of effector T cells, IDO1 overexpression prevents the immune system from effectively destroying cancer cells. IDO1 overexpression has been observed in a wide range of human cancers such as prostatic, colorectal, pancreatic, cervical, gastric, ovarian, head or lung cancer. Physiological IDO1 activity has been implicated in T cell tolerance to tumors, dysfunctional selftolerance in non-obese diabetic (NOD) mice, and as a protective negative regulator in autoimmune disorders.
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UniProt
- P28776
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途径
- Activated T Cell Proliferation
抗原
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