anti-beta-Site APP-Cleaving Enzyme 1 (BACE) 抗体

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. 再加上,我们可以发beta-Site APP-Cleaving Enzyme 1 试剂盒 (56)beta-Site APP-Cleaving Enzyme 1 蛋白 (34)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
BACE 23821 P56818
BACE 29392 P56819
BACE 23621 P56817

antibodies-online.cn销售最多的anti-beta-Site APP-Cleaving Enzyme 1 抗体

Showing 10 out of 267 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 IF, IHC, WB WB Suggested Anti-BACE1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Human Liver 100 μL Log in to see 24至29个工作日
¥3,074.65
详细
非结合性 EIA, IHC (p), WB 0.4 mL Log in to see 29至35个工作日
¥4,086.26
详细
非结合性 EIA, IHC (p), WB 0.4 mL Log in to see 29至35个工作日
¥4,086.26
详细
非结合性 WB Western blot analysis of anti-BACE Antibody (S498) (ABIN392200) in mouse cerebellum tissue lysates (35 µg/lane). BACE (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 5至8个工作日
¥2,325.14
详细
非结合性 IHC (p), WB Western blot analysis of anti-BACE1 Antibody (N-term) (ABIN392201) in mouse heart tissue lysates (35 µg/lane). BACE1(arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human brain tissue reacted with BACE1 antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 5至8个工作日
¥2,325.14
详细
非结合性 IHC (p), WB The anti-Phospho-BACE-S498 Pab (ABIN389517) is used in Western blot to detect Phospho-BACE-S498 in mouse brain tissue lysate Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 5至8个工作日
¥2,325.14
详细
非结合性 EIA, WB 0.4 mL Log in to see 29至35个工作日
¥4,086.26
详细
非结合性 IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti BACE1/ASP2 Polyclonal Antibody, Unconjugated (ABIN725705) at 1:200 followed by conjugation to the secondary antibody and DAB staining L1 rat brain lysates probed with Anti BACE1/ASP2 Polyclonal Antibody, Unconjugated (ABIN725705) at 1:200 overnight at 4 °C. Followed by conjugation to secondary antibody at 1:3000 for 90 min at 37 °C. Predicted band 51kD. Observed band size:51kD. 100 μL Log in to see 5至7个工作日
¥2,709.56
详细
非结合性 IHC (p), WB 0.1 mg Log in to see 29至35个工作日
¥4,388.90
详细
非结合性 WB 0.1 mg Log in to see 29至35个工作日
¥4,792.50
详细

通过反应活性、应用领域、克隆类型和共轭标记 BACE 抗体

特性 应用范围 宿主 克隆类型 标记
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引用最多的anti-beta-Site APP-Cleaving Enzyme 1 抗体

  1. Human Polyclonal BACE Primary Antibody for EIA, IHC (p) - ABIN358083 : Xie, Guo: PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein. in The Journal of biological chemistry 2005 (PubMed)
    Show all 5 references for 358083

  2. Human Polyclonal BACE Primary Antibody for IHC (p), WB - ABIN392201 : He, Li, Chang, Tang: GGA proteins mediate the recycling pathway of memapsin 2 (BACE). in The Journal of biological chemistry 2005 (PubMed)
    Show all 5 references for 392201

  3. Human Polyclonal BACE Primary Antibody for IHC (p), WB - ABIN401041 : Hussain, Powell, Howlett, Tew, Meek, Chapman, Gloger, Murphy, Southan, Ryan, Smith, Simmons, Walsh, Dingwall, Christie: Identification of a novel aspartic protease (Asp 2) as beta-secretase. in Molecular and cellular neurosciences 2000 (PubMed)
    Show all 4 references for 401041

  4. Human Polyclonal BACE Primary Antibody for WB - ABIN264995 : Yan, Bienkowski, Shuck, Miao, Tory, Pauley, Brashier, Stratman, Mathews, Buhl, Carter, Tomasselli, Parodi, Heinrikson, Gurney: Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity. in Nature 1999 (PubMed)
    Show all 4 references for 264995

  5. Human Polyclonal BACE Primary Antibody for IF (p), IHC (p) - ABIN725705 : Tian, Guo, Wu, Ma, Zhao: Minocycline Alleviates Sevoflurane-Induced Cognitive Impairment in Aged Rats. in Cellular and molecular neurobiology 2015 (PubMed)
    Show all 4 references for 725705

  6. Human Polyclonal BACE Primary Antibody for IHC (p), WB - ABIN389517 : Huang, Chang, Koelsch, Turner, Lupu, Tang: Internalization of exogenously added memapsin 2 (beta-secretase) ectodomain by cells is mediated by amyloid precursor protein. in The Journal of biological chemistry 2004 (PubMed)
    Show all 4 references for 389517

  7. Human Polyclonal BACE Primary Antibody for WB - ABIN392200 : Chiocco, Kulnane, Younkin, Younkin, Evin, Lamb: Altered amyloid-beta metabolism and deposition in genomic-based beta-secretase transgenic mice. in The Journal of biological chemistry 2004 (PubMed)
    Show all 4 references for 392200

  8. Cow (Bovine) Polyclonal BACE Primary Antibody for IF, IHC - ABIN2782766 : Shimizu, Tosaki, Kaneko, Hisano, Sakurai, Nukina: Crystal structure of an active form of BACE1, an enzyme responsible for amyloid beta protein production. in Molecular and cellular biology 2008 (PubMed)

更多抗beta-Site APP-Cleaving Enzyme 1的相互作用对抗体

Mouse (Murine) beta-Site APP-Cleaving Enzyme 1 (BACE) interaction partners

  1. In conclusion, glucocorticoid couples mGR (显示 GRHL1 抗体) with Galphas (显示 GNAS 抗体) and triggers cAMP-PKA-CREB (显示 CREB1 抗体) axis dependent on the lipid raft to stimulate BACE1 upregulation and Abeta (显示 APP 抗体) generation.SIGNIFICANCE STATEMENT Patients with Alzheimer's disease (AD) have been growing sharply and stress is considered as the major environment factor of AD.

  2. study supports the hypothesis that Abeta (显示 APP 抗体) induces microtubule disruption in presynaptic dystrophic neurites that surround plaques, thus impairing axonal transport and leading to accumulation of BACE1 and exacerbation of amyloid pathology in Alzheimer's disease

  3. Here, we demonstrate that Snapin (显示 SNAPIN 抗体)-mediated retrograde transport plays a critical role in removing BACE1 from presynaptic terminals toward the soma, thus reducing synaptic Abeta (显示 APP 抗体) production. Adeno (显示 ADORA2A 抗体)-associated virus-mediated Snapin (显示 SNAPIN 抗体) overexpression in the hippocampus of mutant hAPP mice significantly decreases synaptic Abeta (显示 APP 抗体) levels, attenuates synapse loss, and thus rescues cognitive deficits. Our study uncovers a new pathway...

  4. beta-site APP cleaving enzyme 1 (BACE1) is essential for amyloid beta protein production. We discovered that A673V mutation shifted the BACE1 cleavage site from the Glu (显示 GCG 抗体)(11) to the Asp(1 (显示 BACE2 抗体)) site, resulting in much higher C99 level and C99/C89 ratio.

  5. SEPT8 (显示 SEPT8 抗体) modulates beta-amyloidogenic processing of APP (显示 APP 抗体) through a mechanism affecting the intracellular sorting and accumulation of BACE1.

  6. the depletion of BIN1 (显示 BIN1 抗体) increases cellular BACE1 levels through impaired endosomal trafficking and reduces BACE1 lysosomal degradation, resulting in increased Ab production. Our findings provide a mechanistic role of BIN1 (显示 BIN1 抗体) in the pathogenesis of Alzheimer disease (AD), as a novel genetic regulator of BACE1 levels and Ab production

  7. In an Alzheimer's disease mouse model we show that BACE-1 is upregulated at the blood-brain barrier compared to healthy controls.

  8. study provides new insights into autophagy-mediated regulation of BACE1 turnover and APP (显示 APP 抗体) processing, thus building a foundation for future development of potential Alzheimer's disease therapeutic strategies.

  9. analysis suggests that some familial Alzheimer's disease mutations in APP (显示 APP 抗体) are amyloidogenic and/or amyloidolytic via selection of alternative BACE1 cleavage sites

  10. data indicate that Egr-1 (显示 EGR1 抗体) promotes Abeta (显示 APP 抗体) synthesis via transcriptional activation of BACE-1 and suggest that Egr-1 (显示 EGR1 抗体) plays role in activation of BACE-1 and acceleration of Abeta (显示 APP 抗体) synthesis in AD brain.

Human beta-Site APP-Cleaving Enzyme 1 (BACE) interaction partners

  1. Study showed that serum deprivation enhances ADAM10 (显示 ADAM10 抗体)/17-mediated cleavage and secretion of enzymatically active BACE1. This could be the result of alterations in the lipid composition of the membrane that lead in disruption of membrane compartmentalization in lipid rafts and non-lipid rafts. At present the significance of BACE1 shedding in the development of Alzheimer's disease is unclear.

  2. Data suggest that trimerization of BACE1 requires transmembrane sequences (TMSs) and cytoplasmic domains, with residues Ala463 and Cys466 buried within trimer interface of the sulfur-rich core of TMSs; BACE1 appears to play role in compartmentalization of intracellular copper by transferring cytosolic copper to intracellular compartments.

  3. SEPT8 (显示 SEPT8 抗体) modulates beta-amyloidogenic processing of APP (显示 APP 抗体) through a mechanism affecting the intracellular sorting and accumulation of BACE1.

  4. the depletion of BIN1 (显示 BIN1 抗体) increases cellular BACE1 levels through impaired endosomal trafficking and reduces BACE1 lysosomal degradation, resulting in increased Ab production. Our findings provide a mechanistic role of BIN1 (显示 BIN1 抗体) in the pathogenesis of Alzheimer disease (AD), as a novel genetic regulator of BACE1 levels and Ab production

  5. in vitro BACE1-activity assays demonstrate that palmitoylation-dependent dimerization of APP (显示 APP 抗体) promotes beta-cleavage of APP (显示 APP 抗体) in lipid-rich detergent resistant cell membranes (DRMs), when compared to total APP (显示 APP 抗体).

  6. The circular RNA ciRS-7 promotes APP (显示 APP 抗体) and BACE1 degradation in an NF-kappaB (显示 NFKB1 抗体)-dependent manner.

  7. rs638405 in BACE1 was not associated with the risk of Alzheimer's disease (AD), rs638405 decreased the risk of apolipoprotein-E (显示 APOE 抗体) epsilon4 (APOE4) positive AD patients, rs638405 also decreased the risk of Asian AD patients. Data of meta-analysis suggested rs638405 in BACE1 was a protective factor of AD.

  8. analysis suggests that some familial Alzheimer's disease mutations in APP (显示 APP 抗体) are amyloidogenic and/or amyloidolytic via selection of alternative BACE1 cleavage sites

  9. In this study, we aimed to investigate the association of BACE1 rs490460 with the risk of Schizophrenia in an Iranian population. A significant association was observed between the rs490460 T allele and Schizophrenia ( p = 0.0002, odds ratio 0.69, 95% confidence interval 0.57-0.84).

  10. findings demonstrate that USP8 (显示 USP8 抗体) plays a key role in the trafficking and degradation of BACE1 by deubiquitinating lysine 501.

Zebrafish beta-Site APP-Cleaving Enzyme 1 (BACE) interaction partners

  1. bace1 mutants display hypomyelination in the peripheral nervous system and supernumerary neuromasts while in bace2 (显示 BACE2 抗体) mutants the shape and migration of melanocytes is affected.

beta-Site APP-Cleaving Enzyme 1 (BACE) 抗原简介

蛋白简介

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with BACE

  • beta-site APP-cleaving enzyme 1 (BACE1) 抗体
  • beta-site APP-cleaving enzyme 1 (MGC145931) 抗体
  • beta-site APP-cleaving enzyme 1 (LOC100232107) 抗体
  • beta-site APP-cleaving enzyme 2 (bace2) 抗体
  • beta-site APP-cleaving enzyme 2 (BACE2) 抗体
  • beta-site APP-cleaving enzyme 2 (LOC100224177) 抗体
  • beta-site APP cleaving enzyme 1 (Bace1) 抗体
  • beta-site APP-cleaving enzyme 1 (bace1) 抗体
  • ASP2 抗体
  • BACE 抗体
  • BACE1 抗体
  • BACE2 抗体
  • C76936 抗体
  • HSPC104 抗体
  • MGC68482 抗体
  • MGC68881 抗体
  • MGC145931 抗体
  • zgc:77409 抗体

Protein level used designations for BACE

beta-site APP-cleaving enzyme 1 , beta-secretase 1 , beta-secretase 1 isoform A preproprotein , beta-secretase 1 isoform B preproprotein , beta-secretase 1 isoform C preproprotein , beta-secretase 1-like , beta-site APP-cleaving enzyme 2 , beta-secretase 2-like , APP beta-secretase , ASP2 , asp 2 , aspartyl protease 2 , beta-site amyloid precursor protein cleaving enzyme 1 , memapsin-2 , membrane-associated aspartic protease 2 , beta-secretase 1 precursor variant 1 , beta-site APP cleaving enzyme 1 , beta-site amyloid beta A4 precursor protein-cleaving enzyme , transmembrane aspartic proteinase Asp2 , beta-site APP cleaving enzyme , beta secretase 1

GENE ID SPECIES
100071137 Equus caballus
451573 Pan troglodytes
697694 Macaca mulatta
779940 Xenopus (Silurana) tropicalis
100025518 Monodelphis domestica
100232107 Taeniopygia guttata
100459804 Pongo abelii
380307 Xenopus laevis
398806 Xenopus laevis
747819 Pan troglodytes
100016587 Monodelphis domestica
100216145 Xenopus (Silurana) tropicalis
100224177 Taeniopygia guttata
100406072 Callithrix jacchus
100602656 Nomascus leucogenys
23821 Mus musculus
29392 Rattus norvegicus
100135485 Cavia porcellus
23621 Homo sapiens
614333 Bos taurus
403005 Danio rerio
419768 Gallus gallus
489390 Canis lupus familiaris
100511707 Sus scrofa
100343442 Oryctolagus cuniculus
101119667 Ovis aries
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