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Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. 再加上，我们可以发beta-Site APP-Cleaving Enzyme 1 试剂盒 (56) 和 beta-Site APP-Cleaving Enzyme 1 蛋白 (34)和数多这个蛋白质的别的产品。
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Human Polyclonal BACE Primary Antibody for EIA, IHC (p) - ABIN358083
Xie, Guo: PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein. in The Journal of biological chemistry 2005
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Human Polyclonal BACE Primary Antibody for IHC (p), WB - ABIN392201
He, Li, Chang, Tang: GGA proteins mediate the recycling pathway of memapsin 2 (BACE). in The Journal of biological chemistry 2005
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Human Polyclonal BACE Primary Antibody for IHC (p), WB - ABIN401041
Hussain, Powell, Howlett, Tew, Meek, Chapman, Gloger, Murphy, Southan, Ryan, Smith, Simmons, Walsh, Dingwall, Christie: Identification of a novel aspartic protease (Asp 2) as beta-secretase. in Molecular and cellular neurosciences 2000
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Human Polyclonal BACE Primary Antibody for WB - ABIN264995
Yan, Bienkowski, Shuck, Miao, Tory, Pauley, Brashier, Stratman, Mathews, Buhl, Carter, Tomasselli, Parodi, Heinrikson, Gurney: Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity. in Nature 1999
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Human Polyclonal BACE Primary Antibody for IF (p), IHC (p) - ABIN725705
Tian, Guo, Wu, Ma, Zhao: Minocycline Alleviates Sevoflurane-Induced Cognitive Impairment in Aged Rats. in Cellular and molecular neurobiology 2015
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Human Polyclonal BACE Primary Antibody for IHC (p), WB - ABIN389517
Huang, Chang, Koelsch, Turner, Lupu, Tang: Internalization of exogenously added memapsin 2 (beta-secretase) ectodomain by cells is mediated by amyloid precursor protein. in The Journal of biological chemistry 2004
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Human Polyclonal BACE Primary Antibody for WB - ABIN392200
Chiocco, Kulnane, Younkin, Younkin, Evin, Lamb: Altered amyloid-beta metabolism and deposition in genomic-based beta-secretase transgenic mice. in The Journal of biological chemistry 2004
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Cow (Bovine) Polyclonal BACE Primary Antibody for IF, IHC - ABIN2782766
Shimizu, Tosaki, Kaneko, Hisano, Sakurai, Nukina: Crystal structure of an active form of BACE1, an enzyme responsible for amyloid beta protein production. in Molecular and cellular biology 2008
In conclusion, glucocorticoid couples mGR (显示 GRHL1 抗体) with Galphas (显示 GNAS 抗体) and triggers cAMP-PKA-CREB (显示 CREB1 抗体) axis dependent on the lipid raft to stimulate BACE1 upregulation and Abeta (显示 APP 抗体) generation.SIGNIFICANCE STATEMENT Patients with Alzheimer's disease (AD) have been growing sharply and stress is considered as the major environment factor of AD.
study supports the hypothesis that Abeta (显示 APP 抗体) induces microtubule disruption in presynaptic dystrophic neurites that surround plaques, thus impairing axonal transport and leading to accumulation of BACE1 and exacerbation of amyloid pathology in Alzheimer's disease
Here, we demonstrate that Snapin (显示 SNAPIN 抗体)-mediated retrograde transport plays a critical role in removing BACE1 from presynaptic terminals toward the soma, thus reducing synaptic Abeta (显示 APP 抗体) production. Adeno (显示 ADORA2A 抗体)-associated virus-mediated Snapin (显示 SNAPIN 抗体) overexpression in the hippocampus of mutant hAPP mice significantly decreases synaptic Abeta (显示 APP 抗体) levels, attenuates synapse loss, and thus rescues cognitive deficits. Our study uncovers a new pathway...
beta-site APP cleaving enzyme 1 (BACE1) is essential for amyloid beta protein production. We discovered that A673V mutation shifted the BACE1 cleavage site from the Glu (显示 GCG 抗体)(11) to the Asp(1 (显示 BACE2 抗体)) site, resulting in much higher C99 level and C99/C89 ratio.
SEPT8 (显示 SEPT8 抗体) modulates beta-amyloidogenic processing of APP (显示 APP 抗体) through a mechanism affecting the intracellular sorting and accumulation of BACE1.
the depletion of BIN1 (显示 BIN1 抗体) increases cellular BACE1 levels through impaired endosomal trafficking and reduces BACE1 lysosomal degradation, resulting in increased Ab production. Our findings provide a mechanistic role of BIN1 (显示 BIN1 抗体) in the pathogenesis of Alzheimer disease (AD), as a novel genetic regulator of BACE1 levels and Ab production
In an Alzheimer's disease mouse model we show that BACE-1 is upregulated at the blood-brain barrier compared to healthy controls.
study provides new insights into autophagy-mediated regulation of BACE1 turnover and APP (显示 APP 抗体) processing, thus building a foundation for future development of potential Alzheimer's disease therapeutic strategies.
analysis suggests that some familial Alzheimer's disease mutations in APP (显示 APP 抗体) are amyloidogenic and/or amyloidolytic via selection of alternative BACE1 cleavage sites
data indicate that Egr-1 (显示 EGR1 抗体) promotes Abeta (显示 APP 抗体) synthesis via transcriptional activation of BACE-1 and suggest that Egr-1 (显示 EGR1 抗体) plays role in activation of BACE-1 and acceleration of Abeta (显示 APP 抗体) synthesis in AD brain.
Study showed that serum deprivation enhances ADAM10 (显示 ADAM10 抗体)/17-mediated cleavage and secretion of enzymatically active BACE1. This could be the result of alterations in the lipid composition of the membrane that lead in disruption of membrane compartmentalization in lipid rafts and non-lipid rafts. At present the significance of BACE1 shedding in the development of Alzheimer's disease is unclear.
Data suggest that trimerization of BACE1 requires transmembrane sequences (TMSs) and cytoplasmic domains, with residues Ala463 and Cys466 buried within trimer interface of the sulfur-rich core of TMSs; BACE1 appears to play role in compartmentalization of intracellular copper by transferring cytosolic copper to intracellular compartments.
in vitro BACE1-activity assays demonstrate that palmitoylation-dependent dimerization of APP (显示 APP 抗体) promotes beta-cleavage of APP (显示 APP 抗体) in lipid-rich detergent resistant cell membranes (DRMs), when compared to total APP (显示 APP 抗体).
The circular RNA ciRS-7 promotes APP (显示 APP 抗体) and BACE1 degradation in an NF-kappaB (显示 NFKB1 抗体)-dependent manner.
rs638405 in BACE1 was not associated with the risk of Alzheimer's disease (AD), rs638405 decreased the risk of apolipoprotein-E (显示 APOE 抗体) epsilon4 (APOE4) positive AD patients, rs638405 also decreased the risk of Asian AD patients. Data of meta-analysis suggested rs638405 in BACE1 was a protective factor of AD.
In this study, we aimed to investigate the association of BACE1 rs490460 with the risk of Schizophrenia in an Iranian population. A significant association was observed between the rs490460 T allele and Schizophrenia ( p = 0.0002, odds ratio 0.69, 95% confidence interval 0.57-0.84).
findings demonstrate that USP8 (显示 USP8 抗体) plays a key role in the trafficking and degradation of BACE1 by deubiquitinating lysine 501.
bace1 mutants display hypomyelination in the peripheral nervous system and supernumerary neuromasts while in bace2 (显示 BACE2 抗体) mutants the shape and migration of melanocytes is affected.
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene.
beta-site APP-cleaving enzyme 1
, beta-secretase 1
, beta-secretase 1 isoform A preproprotein
, beta-secretase 1 isoform B preproprotein
, beta-secretase 1 isoform C preproprotein
, beta-secretase 1-like
, beta-site APP-cleaving enzyme 2
, beta-secretase 2-like
, APP beta-secretase
, asp 2
, aspartyl protease 2
, beta-site amyloid precursor protein cleaving enzyme 1
, membrane-associated aspartic protease 2
, beta-secretase 1 precursor variant 1
, beta-site APP cleaving enzyme 1
, beta-site amyloid beta A4 precursor protein-cleaving enzyme
, transmembrane aspartic proteinase Asp2
, beta-site APP cleaving enzyme
, beta secretase 1