anti-beta-Site APP-Cleaving Enzyme 1 (BACE) 抗体

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. 再加上,我们可以发beta-Site APP-Cleaving Enzyme 1 试剂盒 (59)beta-Site APP-Cleaving Enzyme 1 蛋白 (32)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
BACE 23621 P56817
BACE 23821 P56818
BACE 29392 P56819
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Showing 10 out of 282 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 IF, IHC, WB <b>WB Suggested Anti-BACE1 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:62500<br><b>Positive Control: </b>Human Liver 100 μL Log in to see 2至3个工作日
$289.00
详细
Cow 非结合性 WB WB Suggested Anti-Bace1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:1562500 Positive Control: Mouse Heart 100 μL Log in to see 2至3个工作日
$289.00
详细
非结合性 WB Western blot analysis of anti-BACE Antibody (S498) (ABIN392200) in mouse cerebellum tissue lysates (35 µg/lane). BACE (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10至11个工作日
$324.50
详细
非结合性 EIA, IHC (p), WB 0.4 mL Log in to see 6至8个工作日
$390.50
详细
非结合性 EIA, IHC (p), WB 0.4 mL Log in to see 6至8个工作日
$390.50
详细
非结合性 IHC (p), WB The anti-Phospho-BACE-S498 Pab (ABIN389517) is used in Western blot to detect Phospho-BACE-S498 in mouse brain tissue lysate Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10至11个工作日
$324.50
详细
非结合性 IHC (p), WB Western blot analysis of anti-BACE1 Antibody (N-term) (ABIN392201) in mouse heart tissue lysates (35 µg/lane). BACE1(arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human brain tissue reacted with BACE1 antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10至11个工作日
$324.50
详细
非结合性 EIA, WB 0.4 mL Log in to see 6至8个工作日
$390.50
详细
小鼠 非结合性 CyTOF, FACS, IHC, WB Detection of Human BACE-1 by Western Blot. Western blot shows lysates of human brain (Alzheimer's disease hippocampus) tissue. PVDF Membrane was probed with 2 ug/mL of Mouse Anti-Human/Mouse BACE-1 Ectodomain Monoclonal Antibody. This experiment was conducted under reducing conditions. Detection of Human BACE-1 by Western Blot. Western blot shows lysates of human brain (Alzheimer's disease hippocampus) tissue. PVDF Membrane was probed with 2 ug/mL of Mouse Anti-Human/Mouse BACE-1 Ectodomain Monoclonal Antibody. This experiment was conducted under reducing conditions. 100 μg Log in to see 8至9个工作日
$294.00
详细
非结合性 IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti BACE1/ASP2 Polyclonal Antibody, Unconjugated (ABIN725705) at 1:200 followed by conjugation to the secondary antibody and DAB staining L1 rat brain lysates probed with Anti BACE1/ASP2 Polyclonal Antibody, Unconjugated (ABIN725705) at 1:200 overnight at 4 °C. Followed by conjugation to secondary antibody at 1:3000 for 90 min at 37 °C. Predicted band 51kD. Observed band size:51kD. 100 μL Log in to see 3至7个工作日
$307.45
详细

通过反应活性、应用领域、克隆类型和共轭标记 BACE 抗体

特性 应用范围 宿主 克隆类型 标记
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引用最多的anti-beta-Site APP-Cleaving Enzyme 1 抗体

  1. Human Polyclonal BACE Primary Antibody for IF (p), IHC (p) - ABIN725705 : Tian, Guo, Wu, Ma, Zhao: Minocycline Alleviates Sevoflurane-Induced Cognitive Impairment in Aged Rats. in Cellular and molecular neurobiology 2015 (PubMed)
    Show all 4 Pubmed References

  2. Human Monoclonal BACE Primary Antibody for CyTOF, FACS - ABIN4900525 : Cheng, He, Lee, Yao, Li, Shen: High activities of BACE1 in brains with mild cognitive impairment. in The American journal of pathology 2013 (PubMed)
    Show all 3 Pubmed References

  3. Human Monoclonal BACE Primary Antibody for CyTOF, FACS - ABIN4900526 : Ahmed, Holler, Webb, Li, Beckett, Murphy: BACE1 and BACE2 enzymatic activities in Alzheimer's disease. in Journal of neurochemistry 2010 (PubMed)
    Show all 3 Pubmed References

  4. Human Polyclonal BACE Primary Antibody for IHC (p), WB - ABIN392201 : Xie, Guo: PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein. in The Journal of biological chemistry 2005 (PubMed)
    Show all 5 Pubmed References

  5. Human Polyclonal BACE Primary Antibody for WB - ABIN550289 : Vassar, Bennett, Babu-Khan, Kahn, Mendiaz, Denis, Teplow, Ross, Amarante, Loeloff, Luo, Fisher, Fuller, Edenson, Lile, Jarosinski, Biere, Curran, Burgess, Louis, Collins, Treanor, Rogers, Citron: Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. in Science (New York, N.Y.) 1999 (PubMed)
    Show all 3 Pubmed References

  6. Cow (Bovine) Polyclonal BACE Primary Antibody for IHC (p) - ABIN2477571 : Rossner, Lange-Dohna, Zeitschel, Perez-Polo: Alzheimer's disease beta-secretase BACE1 is not a neuron-specific enzyme. in Journal of neurochemistry 2005 (PubMed)

  7. Human Monoclonal BACE Primary Antibody for IHC, WB - ABIN4282833 : Prior, Dargusch, Ehren, Chiruta, Schubert: The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice. in Alzheimer's research & therapy 2014 (PubMed)

更多抗beta-Site APP-Cleaving Enzyme 1的相互作用对抗体

Human beta-Site APP-Cleaving Enzyme 1 (BACE) interaction partners

  1. Results indicate that SNX4 (显示 SNX4 抗体)-mediated regulation of the steady-state levels and trafficking of BACE1, as well as the subsequent increase in BACE1-mediated cleavage, may be relevant to Alzheimer's disease progression.

  2. We discuss how the underlying mechanisms can be conceived and develop scenarios how the regulation of ion conductances by BACE1 might shape electric activity in the intact and diseased brain and heart

  3. Study showed that serum deprivation enhances ADAM10 (显示 ADAM10 抗体)/17-mediated cleavage and secretion of enzymatically active BACE1. This could be the result of alterations in the lipid composition of the membrane that lead in disruption of membrane compartmentalization in lipid rafts and non-lipid rafts. At present the significance of BACE1 shedding in the development of Alzheimer's disease is unclear.

  4. Data suggest that trimerization of BACE1 requires transmembrane sequences (TMSs) and cytoplasmic domains, with residues Ala463 and Cys466 buried within trimer interface of the sulfur-rich core of TMSs; BACE1 appears to play role in compartmentalization of intracellular copper by transferring cytosolic copper to intracellular compartments.

  5. SEPT8 (显示 SEPT8 抗体) modulates beta-amyloidogenic processing of APP (显示 APP 抗体) through a mechanism affecting the intracellular sorting and accumulation of BACE1.

  6. the depletion of BIN1 (显示 BIN1 抗体) increases cellular BACE1 levels through impaired endosomal trafficking and reduces BACE1 lysosomal degradation, resulting in increased Ab production. Our findings provide a mechanistic role of BIN1 (显示 BIN1 抗体) in the pathogenesis of Alzheimer disease (AD), as a novel genetic regulator of BACE1 levels and Ab production

  7. in vitro BACE1-activity assays demonstrate that palmitoylation-dependent dimerization of APP (显示 APP 抗体) promotes beta-cleavage of APP (显示 APP 抗体) in lipid-rich detergent resistant cell membranes (DRMs), when compared to total APP (显示 APP 抗体).

  8. The circular RNA ciRS-7 promotes APP (显示 APP 抗体) and BACE1 degradation in an NF-kappaB (显示 NFKB1 抗体)-dependent manner.

  9. rs638405 in BACE1 was not associated with the risk of Alzheimer's disease (AD), rs638405 decreased the risk of apolipoprotein-E (显示 APOE 抗体) epsilon4 (APOE4) positive AD patients, rs638405 also decreased the risk of Asian AD patients. Data of meta-analysis suggested rs638405 in BACE1 was a protective factor of AD.

  10. analysis suggests that some familial Alzheimer's disease mutations in APP (显示 APP 抗体) are amyloidogenic and/or amyloidolytic via selection of alternative BACE1 cleavage sites

Mouse (Murine) beta-Site APP-Cleaving Enzyme 1 (BACE) interaction partners

  1. study demonstrates that SEZ6 and SEZ6L (显示 SEZ6L 抗体) are physiological BACE1 substrates in the murine brain and suggests that sSEZ6 and sSEZ6L levels in CSF (显示 CSF2 抗体) are suitable markers to monitor BACE1 inhibition in mice

  2. Chronic variable stress led to increased Bace1 expression in the hippocampus of young adult mice and the hippocampus, prefrontal cortex and amygdala of aged mice. The increased expression of Bace1 was associated with decreased methylation of several CpGs in the Bace1 promoter region.

  3. Results indicate that SNX4 (显示 SNX4 抗体)-mediated regulation of the steady-state levels and trafficking of BACE1, as well as the subsequent increase in BACE1-mediated cleavage, may be relevant to Alzheimer's disease progression.

  4. In conclusion, glucocorticoid couples mGR (显示 GRHL1 抗体) with Galphas (显示 GNAS 抗体) and triggers cAMP-PKA-CREB (显示 CREB1 抗体) axis dependent on the lipid raft to stimulate BACE1 upregulation and Abeta (显示 APP 抗体) generation.SIGNIFICANCE STATEMENT Patients with Alzheimer's disease (AD) have been growing sharply and stress is considered as the major environment factor of AD.

  5. study supports the hypothesis that Abeta (显示 APP 抗体) induces microtubule disruption in presynaptic dystrophic neurites that surround plaques, thus impairing axonal transport and leading to accumulation of BACE1 and exacerbation of amyloid pathology in Alzheimer's disease

  6. Here, we demonstrate that Snapin (显示 SNAPIN 抗体)-mediated retrograde transport plays a critical role in removing BACE1 from presynaptic terminals toward the soma, thus reducing synaptic Abeta (显示 APP 抗体) production. Adeno (显示 ADORA2A 抗体)-associated virus-mediated Snapin (显示 SNAPIN 抗体) overexpression in the hippocampus of mutant hAPP mice significantly decreases synaptic Abeta (显示 APP 抗体) levels, attenuates synapse loss, and thus rescues cognitive deficits. Our study uncovers a new pathway...

  7. beta-site APP cleaving enzyme 1 (BACE1) is essential for amyloid beta protein production. We discovered that A673V mutation shifted the BACE1 cleavage site from the Glu (显示 GCG 抗体)(11) to the Asp(1 (显示 BACE2 抗体)) site, resulting in much higher C99 level and C99/C89 ratio.

  8. SEPT8 (显示 SEPT8 抗体) modulates beta-amyloidogenic processing of APP (显示 APP 抗体) through a mechanism affecting the intracellular sorting and accumulation of BACE1.

  9. the depletion of BIN1 (显示 BIN1 抗体) increases cellular BACE1 levels through impaired endosomal trafficking and reduces BACE1 lysosomal degradation, resulting in increased Ab production. Our findings provide a mechanistic role of BIN1 (显示 BIN1 抗体) in the pathogenesis of Alzheimer disease (AD), as a novel genetic regulator of BACE1 levels and Ab production

  10. In an Alzheimer's disease mouse model we show that BACE-1 is upregulated at the blood-brain barrier compared to healthy controls.

Zebrafish beta-Site APP-Cleaving Enzyme 1 (BACE) interaction partners

  1. bace1 mutants display hypomyelination in the peripheral nervous system and supernumerary neuromasts while in bace2 (显示 BACE2 抗体) mutants the shape and migration of melanocytes is affected.

beta-Site APP-Cleaving Enzyme 1 (BACE) 抗原简介

蛋白简介

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with BACE

  • beta-secretase 1 (BACE1) 抗体
  • beta-site APP cleaving enzyme 1 (Bace1) 抗体
  • beta-secretase 1 (Bace1) 抗体
  • beta-site APP-cleaving enzyme 1 (bace1) 抗体
  • beta-site APP-cleaving enzyme 2 L homeolog (bace2.L) 抗体
  • beta-site APP-cleaving enzyme 2 S homeolog (bace2.S) 抗体
  • beta-site APP-cleaving enzyme 2 (bace2) 抗体
  • beta-site APP-cleaving enzyme 2 (BACE2) 抗体
  • ASP2 抗体
  • Bace 抗体
  • BACE1 抗体
  • BACE2 抗体
  • C76936 抗体
  • HSPC104 抗体
  • MGC68482 抗体
  • MGC68881 抗体
  • MGC145931 抗体
  • zgc:77409 抗体

Protein level used designations for BACE

APP beta-secretase , asp 2 , aspartyl protease 2 , beta-secretase 1 , beta-secretase 1 precursor variant 1 , beta-site APP cleaving enzyme 1 , beta-site amyloid beta A4 precursor protein-cleaving enzyme , memapsin-2 , membrane-associated aspartic protease 2 , transmembrane aspartic proteinase Asp2 , ASP2 , beta-site amyloid precursor protein cleaving enzyme 1 , beta-site APP cleaving enzyme , beta secretase 1 , beta-secretase 1 isoform A preproprotein , beta-secretase 1 isoform B preproprotein , beta-secretase 1 isoform C preproprotein , beta-site APP-cleaving enzyme 1 , beta-secretase 1-like , beta-site APP-cleaving enzyme 2 , beta-secretase 2-like

GENE ID SPECIES
23621 Homo sapiens
23821 Mus musculus
29392 Rattus norvegicus
419768 Gallus gallus
489390 Canis lupus familiaris
614333 Bos taurus
697694 Macaca mulatta
779940 Xenopus (Silurana) tropicalis
100071137 Equus caballus
100343442 Oryctolagus cuniculus
100459804 Pongo abelii
380307 Xenopus laevis
398806 Xenopus laevis
100216145 Xenopus (Silurana) tropicalis
100224177 Taeniopygia guttata
451573 Pan troglodytes
100025518 Monodelphis domestica
403005 Danio rerio
100135485 Cavia porcellus
100016587 Monodelphis domestica
100406072 Callithrix jacchus
747819 Pan troglodytes
100602656 Nomascus leucogenys
100511707 Sus scrofa
101119667 Ovis aries
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