Tumor Necrosis Factor Receptor Superfamily, Member 11b 蛋白 (TNFRSF11B)

Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. 再加上,我们可以发Tumor Necrosis Factor Receptor Superfamily, Member 11b 抗体 (174)Tumor Necrosis Factor Receptor Superfamily, Member 11b 试剂盒 (88)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
TNFRSF11B 4982 O00300
TNFRSF11B 18383 O08712
TNFRSF11B 25341 O08727
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产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
人细胞 His tag 100 μg Log in to see 20至21个工作日
$250.80
详细
Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,960.83
详细
HEK-293 Cells 小鼠 非结合性 25 μg Log in to see 10至12个工作日
$148.82
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人细胞 猕猴 Fc Tag 100 μg Log in to see 20至21个工作日
$272.80
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Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,960.83
详细
HEK-293 Cells Fc Tag Human Osteoprotegerin, Fc Tag on SDS-PAGE under reducing (R) and no-reducing (NR) conditions. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 92%. 100 μg Log in to see 2至3个工作日
$198.00
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Hi-5 Cells His tag 30 μg Log in to see 15至19个工作日
$407.00
详细
人细胞 小鼠 Fc Tag SDS-PAGE 100 μg Log in to see 20至21个工作日
$272.80
详细
HOST_HEK-293T Cells His-DYKDDDDK-Strep II Tag 25 μg Log in to see 11至12个工作日
$932.86
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小麦胚 GST tag 10 μg Log in to see 11至12个工作日
$414.29
详细

TNFRSF11B 蛋白 by Origin and Source

Origin 在表达 标记
Human , , , , , , , , ,
, , ,
Mouse (Murine) , ,
,
Rat (Rattus)

更多Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B)互动伙伴

Human Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B) interaction partners

  1. We have concluded that low OPG levels may be associated with osteoporosis in ulcerative colitis, but it is not correlated with the c.-223C > T polymorphism in the TNFRSF11B gene.

  2. RANKL (显示 TNFSF11 蛋白)/Osteoprotegerin have roles in bone turnover in Hashimoto Thyroiditis

  3. High OPG expression is associated with colorectal carcinoma.

  4. Data suggest that elevated plasma levels of osteoprotegerin/TNFRSF11B correlate with increased risk of cardiovascular comorbidities in children and adolescents with type 1 diabetes (as compared to healthy control subjects); thus, osteoprotegerin/TNFRSF11B may serve as biomarker of cardiovascular risk in these patients. This study was conducted in Tunisia.

  5. Studies showed that the central hypothalamic-pituitary regulatory system, via it's relative hormones, seems to control OPG/RANKL (显示 TNFSF11 蛋白)/RANK system function, and the pulsatility and circadian rhythmicity of these hormones may induce an oscillatory fluctuation of the OPG/ RANKL (显示 TNFSF11 蛋白) ratio. Also, psycological characteristics may provoke a shift of the OPG/ RANKL (显示 TNFSF11 蛋白) ratio towards an unbalanced or a balanced status. [review]

  6. Formulation and in vitro and in vivo evaluation of a new osteoprotegerin-chitosan gel for bone tissue regeneration

  7. The RANKL/OPG (显示 TNFSF11 蛋白) ratio significantly increased in the presence of bone metastasis with appropriate sensitivity and specificity (73% and 72%, respectively) at a cutoff of >/=0.14 for the detection of bone metastasis. Serum OPG and RANKL/OPG (显示 TNFSF11 蛋白) ratios are promising biomarkers for detecting bone metastasis in breast cancer patients.

  8. Osteoprotegerin facilitates pulmonary arterial hypertension pathogenesis by regulating pulmonary arterial smooth muscle cell proliferation via integrin alphavbeta3 (显示 ITGAV 蛋白)/FAK (显示 PTK2 蛋白)/AKT (显示 AKT1 蛋白) signaling pathway.

  9. Elevated osteoprotegerin concentration is associated with an increased risk of incident cardiovascular disease in the general population

  10. Physical activity does not increase circulating osteoprotegerin level.

Mouse (Murine) Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B) interaction partners

  1. findings demonstrate that mTORC1 activation-stimulated RANKL (显示 TNFSF11 蛋白) expression in B cells is sufficient to induce bone loss and osteoporosis. The study also established a link between mTORC1 and the RANKL/OPG (显示 TNFSF11 蛋白) axis via negative regulation of beta-catenin (显示 CTNNB1 蛋白).

  2. RANK/RANKL (显示 TNFSF11 蛋白) signaling is involved in the androgen deprivation therapy-induced acceleration of bone metastasis in castration-insensitive prostate cancer and is inhibited by osteoprotegerin to prevent bone metastasis.

  3. endocortical resorption is driven by reduced OPG (显示 TNFSF11 蛋白) rather than elevated RANKL (显示 TNFSF11 蛋白) expression

  4. Diabetes significantly increased OPG (显示 TNFSF11 蛋白) and the OPG (显示 TNFSF11 蛋白)/TRAIL ratio expression in the aorta, while dyslipidemia was the major determinant of the changes observed in the heart, where it significantly increased OPG (显示 TNFSF11 蛋白) and reduced TRAIL expression, thus increasing cardiac OPG (显示 TNFSF11 蛋白)/TRAIL ratio.

  5. These discoveries strongly suggest that Heparan Sulfate plays an active role in regulating OPG-RANKL (显示 TNFSF11 蛋白) interaction and osteoclastogenesis.

  6. OPG (显示 TNFSF11 蛋白) plays an important role in regulating bone marrow mesenchymal stem cells differentiation and bone marrow adipogenesis.

  7. These data suggested that OPG (显示 TNFSF11 蛋白) played an important role in maintaining the homeostasis of articular cartilage of femoral head.

  8. Data show that p38alpha (显示 MAPK14 蛋白) mitogen-activated protein kinase (显示 MAPK1 蛋白) (MAPK (显示 MAPK1 蛋白)) in paired related homeobox 1 (显示 PRRX1 蛋白) protein (Prx1 (显示 PRDX1 蛋白)+) bone marrow-derived mesenchymal stromal cells acts to preserve the bone by sustaining osteoprotegerin (OPG) production.

  9. OPG (显示 TNFSF11 蛋白) expression in chondrocyte increases bone mass in the proximal metaphysis of tibiae through negative regulation of osteoclast formation.

  10. the generation of Rag2GFP+ regulatory T cells is unaltered in Tnfrsf11b(-/-) mice

Rabbit Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B) interaction partners

  1. The OPG (显示 TNFSF11 蛋白) expression levels decreased while those of RANKL (显示 TNFSF11 蛋白) and RUNX2 (显示 RUNX2 蛋白) increased during orthodontic tooth movement, which suggested that they play a role in the osteogenesis process and the reconstruction of periodontal tissue.

  2. Low-frequency vibration may promote the osteogenic differentiation capability of BMSC probably through regulating the OPG/RANKL (显示 TNFSF11 蛋白) mRNA expression.

Pig (Porcine) Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B) interaction partners

  1. Regional variation of periosteal activity at the mandibular ramus is regulated by differential expression of osteoprotegerin.

蛋白简介Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B)

蛋白简介

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.

Gene names and symbols associated with TNFRSF11B

  • TNF receptor superfamily member 11b (TNFRSF11B)
  • tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) (Tnfrsf11b)
  • TNF receptor superfamily member 11B (Tnfrsf11b)
  • tumor necrosis factor receptor superfamily member 11b S homeolog (tnfrsf11b.S)
  • tumor necrosis factor receptor superfamily, member 11b (TNFRSF11B)
  • ocif 蛋白
  • opg 蛋白
  • tr1 蛋白

Protein level used designations for TNFRSF11B

osteoclastogenesis inhibitory factor , osteoprotegerin , tumor necrosis factor receptor superfamily member 11B , Osteoprotegerin , tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) , tumor necrosis factor receptor superfamily, member 11b , tumor necrosis factor receptor superfamily member 11B-like

GENE ID SPECIES
4982 Homo sapiens
18383 Mus musculus
25341 Rattus norvegicus
464351 Pan troglodytes
523822 Bos taurus
100037695 Ovis aries
444716 Xenopus laevis
482025 Canis lupus familiaris
701850 Macaca mulatta
100399751 Callithrix jacchus
100433420 Pongo abelii
100465761 Ailuropoda melanoleuca
100599407 Nomascus leucogenys
100348133 Oryctolagus cuniculus
100049688 Sus scrofa
100860896 Capra hircus
100065885 Equus caballus
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