anti-Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) 抗体

The protein encoded by TRPM2 is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. 再加上,我们可以发TRPM2 蛋白 (6)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
TRPM2 7226 O94759
TRPM2 294329  
TRPM2 28240  
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antibodies-online.cn销售最多的anti-TRPM2 抗体

Showing 10 out of 95 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 IHC, WB 100 μL Log in to see 2至3个工作日
$289.00
详细
小鼠 非结合性 ICC, IHC (fro), IF, IHC, WB Staining of rat hippocampus using ABIN259658. TRPM2 is stained red, GFAP is stained green and nuclei staining is blue. Photo courtesy of Dr. Ji-Zhong Bai, The University of Auckland, New Zealand. 0.1 mL Log in to see 7至9个工作日
$408.19
详细
非结合性 IHC (p), WB Anti-TRPM2 antibody, IHC(P) IHC(P): Rat Brain Tissue Anti-TRPM2 antibody, Western blotting Lane 1: Rat Brain Tissue Lysate Lane 2: Mouse Brain Tissue Lysate Lane 3: Mouse Liver Tissue Lysate Lane 4: JURKAT Cell Lysate Lane 5: HELA Cell Lysate Lane 6: A549 Cell Lysate 100 μg Log in to see 4至6个工作日
$200.00
详细
非结合性 ICC, IHC (fro), IF, IP, IHC, WB Western Blot: TRPM2 Antibody  - Samples: Membrane Prep (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) from Jurkat cells. Antibodies: Affinity purified rabbit anti-TRPM2 antibody (lot was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds. Western Blot: TRPM2 Antibody  - Samples: Jurkat Membrane Prep (50, 15, 5 ug). Antibody: Affinity purified rabbit anti-TRPM2 antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes. 100 μL Log in to see 7至9个工作日
$486.94
详细
非结合性 ICC, IF, IP, WB Western Blot: TRPM2 Antibody [ABIN153041] - Membrane Prep (50 ug) from Jurkat cells. Antibody: Affinity purified rabbit anti-TRPM2 antibody used for WB at 2 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes. 100 μL Log in to see 7至9个工作日
$486.94
详细
山羊 非结合性 IHC (p) Brain, cortex, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Pancreas, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 7至9个工作日
$451.00
详细
豚鼠 非结合性 IHC (p), WB Brain, cortex, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Heart, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 7至9个工作日
$676.50
详细
小鼠 非结合性 ICC, IF, WB Detection of TRPM2 in mouse brain membrane lysates using ABIN259771. Immunocytochemistry/Immunofluorescence: TRPM2 Antibody [ABIN2597714] - TRPM2 antibody was tested in Neuro2A cells with DyLight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red). 0.1 mL Log in to see 7至9个工作日
$381.94
详细
非结合性 IHC (p), IHC, WB Western Blot: TRPM2 Antibody [NBP1-33416] - Sample (30 ug of whole cell lysate) A: Hep G2 7. 5% SDS PAGE, antibody diluted at 1:500. Immunohistochemistry-Paraffin: TRPM2 Antibody [NBP1-33416] - Paraffin-embedded MDAMB468 xenograft, using antibody at 1:100 dilution. 100 μL Log in to see 7至9个工作日
$447.56
详细
小鼠 DyLight 550 ICC, IF, IHC, IHC (fro), WB   0.1 mL Log in to see 7至9个工作日
$500.06
详细

通过反应活性、应用领域、克隆类型和共轭标记 TRPM2 抗体

特性 应用范围 宿主 克隆类型 标记
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引用最多的anti-TRPM2 抗体

  1. Mouse (Murine) Polyclonal TRPM2 Primary Antibody for ICC, IHC (fro) - ABIN259658 : Bai, Lipski: Differential expression of TRPM2 and TRPV4 channels and their potential role in oxidative stress-induced cell death in organotypic hippocampal culture. in Neurotoxicology 2010 (PubMed)
    Show all 8 Pubmed References

  2. Human Polyclonal TRPM2 Primary Antibody for ICC, IHC (fro) - ABIN153042 : Partida-Sanchez, Gasser, Fliegert, Siebrands, Dammermann, Shi, Mousseau, Sumoza-Toledo, Bhagat, Walseth, Guse, Lund: Chemotaxis of mouse bone marrow neutrophils and dendritic cells is controlled by adp-ribose, the major product generated by the CD38 enzyme reaction. in Journal of immunology (Baltimore, Md. : 1950) 2007 (PubMed)
    Show all 4 Pubmed References

  3. Human Polyclonal TRPM2 Primary Antibody for ICC, IF - ABIN153041 : Moreau, Kirchberger, Swarbrick, Bartlett, Fliegert, Yorgan, Bauche, Harneit, Guse, Potter: Structure-activity relationship of adenosine 5'-diphosphoribose at the transient receptor potential melastatin 2 (TRPM2) channel: rational design of antagonists. in Journal of medicinal chemistry 2013 (PubMed)
    Show all 2 Pubmed References

  4. Polyclonal TRPM2 Primary Antibody for WB - ABIN540252 : Zhang, Chu, Tong, Cheung, Conrad, Masker, Miller: A novel TRPM2 isoform inhibits calcium influx and susceptibility to cell death. in The Journal of biological chemistry 2003 (PubMed)
    Show all 2 Pubmed References

  5. Mouse (Murine) Polyclonal TRPM2 Primary Antibody for ICC, IF - ABIN4362934 : Rah, Kwak, Chung, Kim: ADP-ribose/TRPM2-mediated Ca2+ signaling is essential for cytolytic degranulation and antitumor activity of natural killer cells. in Scientific reports 2015 (PubMed)

更多抗TRPM2的相互作用对抗体

Pig (Porcine) Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) interaction partners

  1. Study determined the sequence of pig TRPC1 and TRPC3-7 channels and found pig TRPC cDNAs resemble their human homologs more than the others .

  2. heteromeric cation channels comprised of the TRPP2 mutant and the TRPC3 (显示 TRPC3 抗体) or TRPC7 protein induce enhanced receptor-activated Ca(2 (显示 CA2 抗体)+) influx that may lead to dysregulated cell growth in ADPKD

Human Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) interaction partners

  1. oxidative stress activated the TRPM2 (显示 CLU 抗体)-CaMKII (显示 CAMK2G 抗体) cascade to further induce intracellular ROS (显示 ROS1 抗体) production, which led to mitochondria fragmentation and loss of mitochondrial membrane potential

  2. The work summarized here shows that TRPM2 (显示 CLU 抗体) channels protect cardiac myocytes from ischaemia-reperfusion injury and tumour cells from doxorubicin toxicity, and demonstrates that the mechanisms involve preservation of mitochondrial bioenergetics and modulation of ROS (显示 ROS1 抗体)

  3. Activation of TRPM2 (显示 CLU 抗体) channels, however, caused intracellular release of not only Ca(2 (显示 CA2 抗体)+) but also of Zn(2+) Intriguingly, elevation of intracellular Zn(2+) faithfully reproduced all of the effects of H2O2, whereas Ca(2 (显示 CA2 抗体)+) showed opposite effects. Interestingly, H2O2 caused increased trafficking of Zn(2+)-enriched lysosomes to the leading edge of migrating cells, presumably to impart polarisation of Zn(2+) location.

  4. neutrophils sense reactive oxygen species via the TRPM2 (显示 CLU 抗体) channel to arrest migration at their target site.

  5. The inhibitory function of oxidant sensing by TRPM2 (显示 CLU 抗体) requires the oxidation of Cys549, which then induces TRMP2 binding to formyl peptide receptor 1 (FPR1 (显示 FPR1 抗体)) and subsequent FPR1 (显示 FPR1 抗体) internalization and signaling inhibition

  6. findings demonstrate the important function of TRPM2 (显示 CLU 抗体) in modulation of cell survival through mitochondrial ROS (显示 ROS1 抗体), and the potential of targeted inhibition of TRPM2 (显示 CLU 抗体) as a therapeutic approach to reduce cellular bioenergetics, tumor growth, and enhance susceptibility to chemotherapeutic agents.

  7. Study demonstrate that PRL (显示 PRL 抗体) is necessary for the survival of (retinal pigment epithelium) RPE (显示 RPE 抗体) under normal and advancing age conditions and, identified SIRT2 (显示 SIRT2 抗体) and TRPM2 (显示 CLU 抗体) as molecular targets for the antioxidant and antiapoptotic actions of PRL (显示 PRL 抗体) in the RPE (显示 RPE 抗体).

  8. TRPM2 (显示 CLU 抗体) has a role in the DNA damage response of T cell leukemia cells in a BCL-2 (显示 BCL2 抗体) dependent manner

  9. Data show that HEK293 cells expressing low levels of receptor potential melastatin 2 (TRPM2) chan (显示 TRPM3 抗体)nel wer (显示 CLU 抗体)e more susceptible to silica nanoparticles (NPs) than those expressing high levels of TRPM2.

  10. This is expected to provide a basis for inhibiting TRPM2 (显示 CLU 抗体) for the improved treatment of breast cancer, which potentially includes treating breast tumors that are resistant to chemotherapy due to their evasion of apoptosis.

Mouse (Murine) Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2) interaction partners

  1. this study shows that TRPM2 ion channels regulate macrophage polarization and gastric inflammation during Helicobacter pylori infection

  2. Overexpression of TRPM2 channel prevented neutrophil transendothelial migration and vascular injury.

  3. These findings of this study suggest that TRPM2 channels play an essential role in mediating hypoxic-ischemic brain injury in neonatal mice.

  4. TRPM2 regulates phagosomal acidification, and is essential for the bacterial killing function of macrophages.

  5. Lysophosphatidylcholine induces intracellular Ca(2 (显示 CA2 抗体)+) influx and increases phosphorylation of p38 MAPK (显示 MAPK14 抗体) via TRPM2, which in turn activates microglia.

  6. The current study demonstrated that a physiological concentration of adrenaline attenuates insulin (显示 INS 抗体) release via coupling of alpha2A-adrenoceptor to cAMP/TRPM2 signaling.

  7. Trpm2 does not seem to play a major role in myeloid leukemogenesis. Additionally, loss of Trpm2 does not augment the cytotoxicity of standard AML (显示 RUNX1 抗体) chemotherapeutic agents.

  8. TRPM2 channels contribute to visceral nociception in response to noxious stimuli under normal conditions and visceral hypersensitivity in pathological conditions.

  9. Data show that macrophages from young mice showed lower transient receptor potential melastatin 2 (显示 TRPM3 抗体) (TRPM2) expression than those from senescent mice and had lower viability after silica nanoparticles (NPs (显示 NPS 抗体)) exposure than those from senescent ones.

  10. TRPM2 activation is likely to be mediated by ADP-ribose production via PARP (显示 PARP1 抗体) pathway

TRPM2 抗原简介

蛋白简介

The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.

Gene names and symbols associated with TRPM2

  • transient receptor potential cation channel subfamily M member 2 (TRPM2) 抗体
  • transient receptor potential cation channel, subfamily M, member 2 (Trpm2) 抗体
  • transient receptor potential cation channel subfamily C member 6 (TRPC6) 抗体
  • transient receptor potential cation channel, subfamily M, member 2 (trpm2) 抗体
  • transient receptor potential cation channel subfamily C member 7 (TRPC7) 抗体
  • short transient receptor potential channel 7 (LOC100443123) 抗体
  • short transient receptor potential channel 7 (LOC100539776) 抗体
  • transient receptor potential cation channel subfamily M member 2 (trpm2) 抗体
  • transient receptor potential cation channel subfamily M member 2 (Trpm2) 抗体
  • 9830168K16Rik 抗体
  • C79133 抗体
  • EREG1 抗体
  • KNP3 抗体
  • LTRPC2 抗体
  • NUDT9H 抗体
  • NUDT9L1 抗体
  • si:ch73-263b18.1 抗体
  • Trp7 抗体
  • TRPC7 抗体
  • TRPM2 抗体
  • Trpm2-predicted 抗体
  • Trrp7 抗体

Protein level used designations for TRPM2

LTrpC-2 , estrogen-responsive element-associated gene 1 protein , long transient receptor potential channel 2 , transient receptor potential cation channel subfamily M member 2 , transient receptor potential channel 7 , transient receptor potential melastatin family 2 , transient receptor potential cation channel, subfamily M, member 2 , transient receptor potential cation channel, subfamily C, member 7 , transient receptor potential cation channel, subfamily C, member 7-like , short transient receptor potential channel 7-like , transient receptor potential cation channel subfamily M member 2-like , transient receptor protein 7 , transient receptor potential channel subfamily C member 7

GENE ID SPECIES
7226 Homo sapiens
294329 Rattus norvegicus
424835 Gallus gallus
470101 Pan troglodytes
508029 Bos taurus
703611 Macaca mulatta
799412 Danio rerio
100056810 Equus caballus
100083361 Ornithorhynchus anatinus
100124999 Xenopus (Silurana) tropicalis
100341596 Oryctolagus cuniculus
100443123 Pongo abelii
100479298 Ailuropoda melanoleuca
100479364 Ailuropoda melanoleuca
100539776 Meleagris gallopavo
100556895 Anolis carolinensis
28240 Mus musculus
100271727 Sus scrofa
100720314 Cavia porcellus
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