Sclerostin (SOST) ELISA试剂盒

Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. 再加上,我们可以发Sclerostin 抗体 (128)Sclerostin 蛋白 (18)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
SOST 50964 Q9BQB4
SOST 74499 Q99P68
SOST 80722 Q99P67

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7.8 pg/mL 31.25-2000 pg/mL Typical standard curve 96 Tests Log in to see 7至10个工作日
¥3,994.38
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小鼠 23.4 pg/mL 93.75-6000 pg/mL Typical standard curve 96 Tests Log in to see 9至12个工作日
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大鼠 32 pg/mL 78-5.000 pg/mL 96 Tests Log in to see 7至10个工作日
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Cow 15.63 pg/mL   96 Tests Log in to see 9至12个工作日
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豚鼠 0.1 ng/mL 0.5-10 ng/mL   96 Tests Log in to see 9至12个工作日
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0.1 ng/mL 0.5-10 ng/mL   96 Tests Log in to see 9至12个工作日
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0.1 ng/mL 0.312-20 ng/mL   96 Tests Log in to see 24至29个工作日
¥4,752.80
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0.1 ng/mL 1.0-25 ng/mL   96 Tests Log in to see 9至12个工作日
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大鼠
0.312-20 ng/mL   96 Tests Log in to see 24至29个工作日
¥4,932.49
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小鼠
0.15-10.0 ng/mL   96 Tests Log in to see 24至29个工作日
¥5,830.93
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引用最多的Sclerostin ELISA试剂盒

  1. Human Sclerostin ELISA Kit for Sandwich ELISA - ABIN457071 : Cidem, Usta, Karacan, Kucuk, Uludag, Gun: Effects of sex steroids on serum sclerostin levels during the menstrual cycle. in Gynecologic and obstetric investigation 2013 (PubMed)
    Show all 5 Pubmed References

  2. Human Sclerostin ELISA Kit for Sandwich ELISA - ABIN415155 : Brabnikova Maresova, Pavelka, Stepan: Acute effects of glucocorticoids on serum markers of osteoclasts, osteoblasts, and osteocytes. in Calcified tissue international 2013 (PubMed)
    Show all 3 Pubmed References

  3. Mouse (Murine) Sclerostin ELISA Kit for Sandwich ELISA - ABIN426039 : Yorgan, Peters, Jeschke, Benisch, Jakob, Amling, Schinke: The Anti-Osteoanabolic Function of Sclerostin Is Blunted in Mice Carrying a High Bone Mass Mutation of Lrp5. in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2015 (PubMed)
    Show all 2 Pubmed References

  4. Rat (Rattus) Sclerostin ELISA Kit for Sandwich ELISA - ABIN416496 : Kim, Lee, Jo, Song, Lim, Park, Bonewald, Kim: Exendin-4 increases bone mineral density in type 2 diabetic OLETF rats potentially through the down-regulation of SOST/sclerostin in osteocytes. in Life sciences 2013 (PubMed)
    Show all 2 Pubmed References

  5. Rat (Rattus) Sclerostin ELISA Kit for Sandwich ELISA - ABIN585201 : Ferreira, Ferrari, Neves, Cavallari, Dominguez, Dos Reis, Graciolli, Oliveira, Liu, Sabbagh, Jorgetti, Schiavi, Moysés: Effects of dietary phosphate on adynamic bone disease in rats with chronic kidney disease--role of sclerostin? in PLoS ONE 2013 (PubMed)

适于 Sclerostin 相互作用对的更多 ELISA 试剂盒

Human Sclerostin (SOST) interaction partners

  1. observed an association between sclerostin levels with fasting insulin (显示 INS ELISA试剂盒) levels and homoeostatic model assessment-insulin (显示 INS ELISA试剂盒) resistance, but there was no clear association with type 2 diabetes risk.

  2. Sclerostin levels in KTR are normal and influenced more by bone turnover than by eGFR (显示 EGFR ELISA试剂盒). Its involvement with other hormones of mineral homeostasis (FGF23 (显示 FGF23 ELISA试剂盒)/Klotho (显示 KL ELISA试剂盒) and Vitamin D) is part of the sophisticated cross-talk between bone and the kidney

  3. In chronic kidney disease, serum levels of the Wnt (显示 WNT2 ELISA试剂盒) inhibitors DKK1 (显示 DKK1 ELISA试剂盒) and sclerostin are unrelated, indicating different sites of origin and/ or different regulatory mechanisms. Sclerostin, as opposed to DKK1 (显示 DKK1 ELISA试剂盒), may qualify as a biomarker of chronic kidney disease-mineral and bone and mineral disorder (CKD-MBD (显示 DPEP1 ELISA试剂盒)), particularly in dialysis patients.

  4. Vitamin D receptor (显示 VDR ELISA试剂盒) agonism by paricalcitol causes a moderate increase in serum sclerostin in CKD patients, and this effect is modified by circulating pentosidine levels.

  5. SOST is frequently expressed in skeletal bone- and cartilage-forming tumors. The strong spatial correlation with bone formation and the in vitro expression patterns are in line with the known functions of SOST in nonneoplastic bone, as a feedback inhibitor on osteogenic differentiation.

  6. Intermittent compressive stress regulates Notch (显示 NOTCH1 ELISA试剂盒) receptor and target gene expression via the TGF-beta (显示 TGFB1 ELISA试剂盒) signaling pathway. Notch (显示 NOTCH1 ELISA试剂盒) signaling participates in TGF-beta (显示 TGFB1 ELISA试剂盒)-induced sclerostin expression in periodontal ligament cells.

  7. Dickkopf-1 (显示 DKK1 ELISA试剂盒) and sclerostin were never correlated with each other or with bone turnover markers patients with Paget's disease of bone. Sclerostin was positively correlated with age.

  8. These data suggest that sclerostin plays an important role in the bone remodeling of tooth movement.

  9. Circulating sclerostin and Dickkopf-1 (显示 DKK1 ELISA试剂盒) levels do not change across the menstrual cycle and do not demonstrate any relationship with estradiol in premenopausal women.

  10. SOST is expressed in the aorta and downregulated in human aortic aneurysms and atheros (显示 WNT2 ELISA试剂盒)clerosis, possibly because of epigenetic silencing.

Mouse (Murine) Sclerostin (SOST) interaction partners

  1. In mice, sclerostin deficiency hastened reparative dentinogenesis after pulp injury, suggesting that the inhibition of sclerostin may constitute a promising therapeutic strategy for improving the healing of damaged pulps.

  2. These data suggest that sclerostin plays an important role in the bone remodeling of tooth movement.

  3. Sclerostin inhibits angiotensin II-induced aortic aneurysm and atherosclerosis via wnt (显示 WNT2 ELISA试剂盒) signaling pathway inhibition.

  4. Analysis of SOST expression using large minigenes reveals the MEF2C (显示 MEF2C ELISA试剂盒) binding site in the evolutionarily conserved region (ECR5) enhancer mediates forskolin, but not 1,25-dihydroxyvitamin D3 or TGFbeta1 (显示 TGFB1 ELISA试剂盒) responsiveness.

  5. removal of sclerostin appears to modestly protect the alveolar bone from resorption in this experimental setting

  6. chronic TNFalpha (tumor necrosis factor alpha (显示 TNF ELISA试剂盒))-dependent arthritis, fibroblast-like synoviocytes constitute a major source of sclerostin and that either the lack of sclerostin or its antibody-mediated inhibition leads to an acceleration of rheumatoid arthritis (RA)-like disease.

  7. Data show that the phenotype of Notch (显示 NOTCH1 ELISA试剂盒) activation in osteocytes was prevented in matrix protein 1 (Dmp1 (显示 DMP1 ELISA试剂盒))-Cre;Rosa(Notch (显示 NOTCH1 ELISA试剂盒)) mice hemizygous for the Dmp1 (显示 DMP1 ELISA试剂盒)-sclerostin (SOST) transgene.

  8. Results found that sclerostin enhances adipocyte differentiation in 3T3-L1 cells and reduced TAZ (显示 TAZ ELISA试剂盒)-responsive transcriptional activity and TAZ (显示 TAZ ELISA试剂盒)-responsive gene expression, indicating a role for TAZ (显示 TAZ ELISA试剂盒) as a regulator of adipogenesis by sclerostin.

  9. Our results suggested that sclerostin could be expressed in the liver and sustained successfully at high levels in the blood by using the PhiC31 integrase system, leading to trabecular bone loss.

  10. Sclerostin depletion enhances tibial fracture healing.

Sclerostin (SOST) 抗原简介

Antigen Summary

Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.

Gene names and symbols associated with Sclerostin (SOST) ELISA试剂盒

  • sclerostin (LOC100313724) 抗体
  • sclerostin (SOST) 抗体
  • sclerostin (Sost) 抗体
  • sclerostin-like (LOC100513306) 抗体
  • 5430411E23Rik 抗体
  • CDD 抗体
  • LOC100313724 抗体
  • VBCH 抗体

Protein level used designations for Sclerostin (SOST) ELISA试剂盒

sclerostin , sclerosteosis

GENE ID SPECIES
100313724 Saccoglossus kowalevskii
50964 Homo sapiens
74499 Mus musculus
80722 Rattus norvegicus
490948 Canis lupus familiaris
100730713 Cavia porcellus
282880 Bos taurus
429784 Gallus gallus
101114123 Ovis aries
100513306 Sus scrofa
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