anti-Ring Finger Protein 2 (RNF2) 抗体

Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. 再加上,我们可以发RNF2 蛋白 (7)RNF2 试剂盒 (1)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
RNF2 6045 Q99496
RNF2 19821 Q9CQJ4
RNF2 304850 Q4KLY4
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Showing 10 out of 64 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 WB <b>WB Suggested Anti-RNF2 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>Daudi cell lysate 100 μL Log in to see 2至3个工作日
Cow 非结合性 IHC, WB <b>WB Suggested Anti-RNF2 Antibody Titration: </b>1.25ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>HepG2 cell lysate 100 μL Log in to see 2至3个工作日
小鼠 非结合性 WB Western Blot analysis of RNF2 expression in transfected 293T cell line by RNF2 monoclonal antibody (M01), clone 6C2. Lane 1: RNF2 transfected lysate(37.7 KDa). Lane 2: Non-transfected lysate. Western blot analysis of RNF2 over-expressed 293 cell line, cotransfected with RNF2 Validated Chimera RNAi used as specificity and loading control. 0.1 mg Log in to see 8至11个工作日
Hamster 小鼠 非结合性 IP, WB 0.1 mg Log in to see 6至8个工作日
山羊 非结合性 ELISA, WB ABIN184925 staining (0.5 µg/ml) of K562 lysate (RIPA buffer, 35µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. 100 μg Log in to see 6至7个工作日
小鼠 非结合性 WB RNF2 monoclonal antibody (M14), clone 2B4. Western Blot analysis of RNF2 expression in A-549. 0.1 mg Log in to see 8至11个工作日
非结合性 IHC (p), WB Western blot analysis of RING2/RING1B/RNF2 expression in rat brain extract (lane 1), and HELA whole cell lysates (lane 2). RING2/RING1B/RNF2 at 38KD was detected using rabbit anti- RING2/RING1B/RNF2 Antigen Affinity purified polyclonal antibody at0.5 μg/mL. The blot was developed using chemiluminescence (ECL) method RING2/RING1B/RNF2 was detected in paraffin-embedded sections of human mammary cancer tissues using rabbit anti- RING2/RING1B/RNF2 Antigen Affinity purified polyclonal antibody at 1 μg/mL. The immunohistochemical section was developed using SABC method 100 μg Log in to see 4至6个工作日
小鸡 山羊 非结合性 EIA, IF, IHC (p), WB   0.1 mg Log in to see 6至8个工作日
非结合性 IHC, IHC (p), IP, WB Western Blot: RNF2 Antibody [NBP1-49966] - Detection of Human and Mouse RNF2 by Western Blot (h&m) and Immunoprecipitation (h). Samples: Whole cell lysate from K562 (5, 15 and 50 mcg for WB; 1 mg for IP, 20% of IP loaded), 293T (T; 50 mcg), and mouse NIH3T3 (M; 50 mcg) cells. Antibodies: Affinity purified rabbit anti-RNF2 antibody used for WB at 0.1 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 3 mcg/mg lysate. RNF2 was also immunoprecipitated by rabbit anti-RNF2 antibody, which recognizes a downstream epitope. For blotting immunoprecipitated RNF2 was used. Detection: Chemiluminescence with exposure times of 30 seconds (A and B). Immunohistochemistry-Paraffin: RNF2 Antibody [NBP1-49966] - Human prostate carcinoma. Antibody used at a dilution of 1:1,000. 100 μL Log in to see 7至9个工作日
小鼠 非结合性 ChIPSeq, ChIP, ICC, IF, IP, WB Ring1B antibody (mAb) tested by ChIP-chip. ChIP was performed using the ChIP-IT® High Sensitivity Kit (Cat. No. 53040) with chromatin from 4.5 million human embryonic stem cells and 4 µl of antibody. ChIP DNA was amplified by WGA, labeled and hybridized to a human tiling array. The two images show regions of strong binding on chromosomes 2 and 9. 100 μg Log in to see 1至2个工作日

通过反应活性、应用领域、克隆类型和共轭标记 RNF2 抗体

特性 应用范围 宿主 克隆类型 标记
Human ,
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Mouse (Murine)
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Rat (Rattus)

引用最多的anti-RNF2 抗体

  1. Human Monoclonal RNF2 Primary Antibody for ChIPSeq, ChIP - ABIN2668629 : Basu, Wilkinson, Colavita, Fennelly, Atchison: YY1 DNA binding and interaction with YAF2 is essential for Polycomb recruitment. in Nucleic acids research 2014 (PubMed)
    Show all 4 Pubmed References

  2. Human Monoclonal RNF2 Primary Antibody for RNAi, ELISA - ABIN562662 : Ohtsubo, Yasunaga, Ohno, Tsumura, Okada, Ishikawa, Shirao, Kikuchi, Nishitani, Kobayashi, Takihara: Polycomb-group complex 1 acts as an E3 ubiquitin ligase for Geminin to sustain hematopoietic stem cell activity. in Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal RNF2 Primary Antibody for IHC, IHC (p) - ABIN4350772 : Holdt, Hoffmann, Sass, Langenberger, Scholz, Krohn, Finstermeier, Stahringer, Wilfert, Beutner, Gielen, Schuler, Gäbel, Bergert, Bechmann, Stadler, Thiery, Teupser: Alu elements in ANRIL non-coding RNA at chromosome 9p21 modulate atherogenic cell functions through trans-regulation of gene networks. in PLoS genetics 2013 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal RNF2 Primary Antibody for ELISA, WB - ABIN268569 : Tuckfield, Clouston, Wilanowski, Zhao, Cunningham, Jane: Binding of the RING polycomb proteins to specific target genes in complex with the grainyhead-like family of developmental transcription factors. in Molecular and cellular biology 2002 (PubMed)


Zebrafish Ring Finger Protein 2 (RNF2) interaction partners

  1. The polycomb group protein (显示 CBX4 抗体) ring1b/rnf2 is specifically required for craniofacial development.

  2. These results reveal that, in the absence of functional Ring1b, fin bud cells fail to execute the pectoral fin developmental program.

Human Ring Finger Protein 2 (RNF2) interaction partners

  1. Study detected RNF2 expression to be overexpressed in esophageal carcinoma cell lines and was associated with the poor prognosis of esophageal carcinoma patients. Data also reflect its important role in the growth of esophageal carcinoma cells by shRNA silencing of RNF2 expression.

  2. overexpression of RNF2, as examined by immunohistochemical analysis, might serve as a novel prognostic biomarker and potential therapeutic target for urothelial carcinoma of the bladder patients.

  3. Our findings support the notion that epigenetic regulators, such as RNF2, directly and functionally control powerful gene networks that are vital in multiple cancer processes.

  4. O-GlcNAc (显示 OGT 抗体) modifies and regulates an essential epigenetic tool, RING1B, which may contribute to human embryonic stem cells pluripotency maintenance and differentiation.

  5. The enzymatic activity of BMI1 (显示 BMI1 抗体) and RING1B were evaluated and compared.

  6. Bmi1 (显示 BMI1 抗体) and possibly RNF2 may be attractive biomarkers of gemcitabine resistance in the context of RRM1 (显示 RRM1 抗体) expression.

  7. combinatorial silencing along with Ezh2 (显示 EZH2 抗体) depleted epigenetically modified H2- and H3-histones and inhibited pancreatic cancer cell growth in vitro and in vivo (xenograft model)

  8. BAP1 deficiency causes increased expression of FoxK2 (显示 FOXK2 抗体) target genes in a Ring1B-Bmi1 (显示 BMI1 抗体)-dependent manner

  9. Authors describe a critical role for the polycomb group protein Ring1b in nonhomologous end-joining (NHEJ)-mediated end-to-end chromosome fusions.

  10. we identify p63 (显示 RPE65 抗体) as a target of Ring1B to regulate Fak (显示 PTK2 抗体) expression in breast cancer epithelial cells

Mouse (Murine) Ring Finger Protein 2 (RNF2) interaction partners

  1. the ability of RING1B, a core component of PRC1 (显示 PRC1 抗体), to ubiquitinate histone H2A is dispensable for early mouse embryonic development and much of the gene repression activity of PRC1 (显示 PRC1 抗体)

  2. RNF2 associates with AMBRA1 (显示 AMBRA1 抗体) to act as an E3 ligase to ubiquitinate AMBRA1 (显示 AMBRA1 抗体) via K48 linkage.

  3. The polycomb (显示 CBX2 抗体) component Ring1B regulates the timed termination of Fezf2 (显示 FEZF2 抗体) expression and thus subcerebral projection neuron production during mouse neocortical development.

  4. Expansion of hepatic stem/progenitor cells requires Ring1B-mediated epigenetic silencing of Cdkn1a (显示 CDKN1A 抗体) and Cdkn2a (显示 CDKN2A 抗体), demonstrating that Ring1B simultaneously regulates multiple CDKIs in tissue stem/progenitor cells.

  5. Af9 (显示 MLLT3 抗体) mediates site-selective physical and functional recruitment of Rnf2 to the alpha-ENaC (显示 SCNN1A 抗体) promoter to constrain basal alpha-ENaC (显示 SCNN1A 抗体) transcription in collecting duct cells.

  6. Ring1b mediates Meis2 (显示 MEIS2 抗体) promoter and midbrain-specific enhancer association.

  7. Aurora B (显示 AURKC 抗体) and Ring1B co-occupy active promoters in resting lymphocytes.

  8. Fbxl10 (显示 KDM2B 抗体) has a key role in regulating Ring1B recruitment to its target genes and H2AK119 ubiquitylation in embryonic stem cells.

  9. identification of gene-dosage-dependent roles in primordial germ cell development for Ring1 (显示 RING1 抗体) and Rnf2, two central components of the Polycomb (显示 CBX2 抗体) repressive complex 1 (PRC1 (显示 PRC1 抗体))

  10. Ring1b inactivation in differentiated islet beta cells (Ring1b(betaKO)) did not cause derepression, even after multiple rounds of cell division, suggesting a role for Ring1b in the establishment but not the maintenance of repression

RNF2 抗原简介


Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. The protein encoded by this gene is one of the PcG proteins. It has been shown to interact with, and suppress the activity of, transcription factor CP2 (TFCP2/CP2). Studies of the mouse counterpart suggested the involvement of this gene in the specification of anterior-posterior axis, as well as in cell proliferation in early development. This protein was also found to interact with huntingtin interacting protein 2 (HIP2), an ubiquitin-conjugating enzyme, and possess ubiquitin ligase activity.

Gene names and symbols associated with RNF2

  • ring finger protein 2 (rnf2) 抗体
  • ring finger protein 2 (RNF2) 抗体
  • ring finger protein 2 (Rnf2) 抗体
  • ring finger protein 2 L homeolog (rnf2.L) 抗体
  • AI326319 抗体
  • AI450156 抗体
  • AU019207 抗体
  • bap-1 抗体
  • bap1 抗体
  • ding 抗体
  • fa19h05 抗体
  • hipi3 抗体
  • Ring1B 抗体
  • ring2 抗体
  • wu:fa19h05 抗体
  • wz4556 抗体

Protein level used designations for RNF2

E3 ubiquitin-protein ligase RING2 , ring finger protein 1b , wz4566 , RING finger protein 1B , HIP2-interacting protein 3 , RING finger protein BAP-1 , huntingtin-interacting protein 2-interacting protein 3 , protein DinG , RING1b

327035 Danio rerio
424452 Gallus gallus
457581 Pan troglodytes
100174504 Pongo abelii
6045 Homo sapiens
480042 Canis lupus familiaris
540090 Bos taurus
19821 Mus musculus
304850 Rattus norvegicus
100127274 Xenopus laevis
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