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Histone methyltransferase that plays an essential role in early development and hematopoiesis. 再加上，我们可以发Myeloid/lymphoid Or Mixed-Lineage Leukemia 1 抗体 (10)和数多这个蛋白质的别的产品。
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Collectively, these data indicated that ATR (显示 ATR ELISA试剂盒) or ATM (显示 ATM ELISA试剂盒) inhibition represent potential therapeutic strategies for the treatment of AML (显示 RUNX1 ELISA试剂盒), especially MLL (显示 MLL ELISA试剂盒)-driven leukemias.
Epigenomic profiling indicates an abnormal H3K79me2 pattern on MLL (显示 MLL ELISA试剂盒)-fusion targeted genes, but the molecular mechanism underlying this epigenetic dependency is not well understood.
NUP98 (显示 NUP98 ELISA试剂盒)-HOXA9 (显示 HOXA9 ELISA试剂盒) interacts with MLL (显示 MLL ELISA试剂盒) via the NUP98 (显示 NUP98 ELISA试剂盒) second FG repeat domain. In the absence of MLL (显示 MLL ELISA试剂盒) (in knockout mice), NUP98 (显示 NUP98 ELISA试剂盒)-HOXA9 (显示 HOXA9 ELISA试剂盒)-induced cell immortalization and leukemogenesis are severely inhibited. MLL (显示 MLL ELISA试剂盒) is important for the recruitment of NUP98 (显示 NUP98 ELISA试剂盒)-HOXA9 (显示 HOXA9 ELISA试剂盒) to the HOXA locus and for NUP98 (显示 NUP98 ELISA试剂盒)-HOXA9 (显示 HOXA9 ELISA试剂盒)-induced HOXA gene expression. MLL (显示 MLL ELISA试剂盒) is crucial for NUP98 (显示 NUP98 ELISA试剂盒)-HOXA9 (显示 HOXA9 ELISA试剂盒) leukemia initiation.
Atg5 (显示 ATG5 ELISA试剂盒)-dependent autophagy contributes to the development of acute myeloid leukemia (显示 BCL11A ELISA试剂盒) in an MLL (显示 MLL ELISA试剂盒)-AF9 (显示 MLLT3 ELISA试剂盒)-driven mouse model.
These results reveal a cooperative transcriptional activation mechanism of AEP (显示 LGMN ELISA试剂盒) and DOT1L (显示 DOT1L ELISA试剂盒) and suggest a molecular rationale for the simultaneous inhibition of the MLL (显示 MLL ELISA试剂盒) fusion-AF4 complex and DOT1L (显示 DOT1L ELISA试剂盒) for more effective treatment of MLL (显示 MLL ELISA试剂盒)-rearranged leukemia.
This study demonstrated that Kmt2a (显示 MLL ELISA试剂盒) regulates synaptic plasticity in striatal neurons and provides an epigenetic drug target for anxiety and dopamine-mediated behaviors.
Inactivation of Kmt2a in Men1-deficient mice accelerated pancreatic islet tumorigenesis and shortened the average life span. Increases in cell proliferation were observed in mouse pancreatic islet tumors upon inactivation of both Kmt2a and Men1.
Data suggest that RAS-homolog enriched in brain protein (Rheb1) promotes MLL-AF9 fusion protein initiated acute myeloid leukemia (AML) progression through target of rapamycin complex 1 (mTORC1) signaling pathway.
HoxBlinc RNA Recruits Set1 (显示 SETD1A ELISA试剂盒)/MLL (显示 MLL ELISA试剂盒) Complexes to Activate Hox (显示 MSH2 ELISA试剂盒) Gene Expression Patterns and Mesoderm Lineage Development.
MLL1 and DOT1L (显示 DOT1L ELISA试剂盒) cooperate with meningioma-1 to induce acute myeloid leukemia (显示 BCL11A ELISA试剂盒).
Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9. Promotes PPP1R15A-induced apoptosis (By similarity).
Mixed-lineage leukemia (also acute lymphocytic leukemia 1 or tritorax Drosophila gene)
, histone-lysine N-methyltransferase MLL
, myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)
, myeloid/lymphoid or mixed-lineage leukemia 1
, histone-lysine N-methyltransferase 2A
, lysine N-methyltransferase 2A
, myeloid/lymphoid or mixed-lineage leukemia protein 1
, trithorax Drosophila
, zinc finger protein HRX