MLL1 产品
(Myeloid/lymphoid Or Mixed-Lineage Leukemia 1 (MLL1))
Categories
Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9. Promotes PPP1R15A-induced apoptosis (By similarity).
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MLL1 抗体
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Recommended MLL1 抗体
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Recommended MLL1 ELISA试剂盒
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ABIN1503539
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Dog
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Reactivity
Monkey
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Synonyms and alternative names related to MLL1
lysine methyltransferase 2A (Kmt2a), lysine (K)-specific methyltransferase 2A (Kmt2a), 6430520K01, ALL-1, All1, Cxxc7, HRX, HTRX1, mKIAA4050, Mll, Mll1Protein level used designations for MLL1
- Mixed-lineage leukemia (also acute lymphocytic leukemia 1 or tritorax Drosophila gene)
- histone-lysine N-methyltransferase MLL
- myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)
- myeloid/lymphoid or mixed-lineage leukemia 1
- histone-lysine N-methyltransferase 2A
- lysine N-methyltransferase 2A
- myeloid/lymphoid or mixed-lineage leukemia protein 1
- trithorax Drosophila
- zinc finger protein HRX
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