Matrix Metallopeptidase 17 (Membrane-inserted) (MMP17) ELISA试剂盒

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as art. 再加上,我们可以发Matrix Metallopeptidase 17 (Membrane-inserted) 抗体 (95)Matrix Metallopeptidase 17 (Membrane-inserted) 蛋白 (5)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
MMP17 23948 Q9R0S3
MMP17 288626  
MMP17 4326 Q9ULZ9
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0.039 ng/mL 0.156-10 ng/mL Typical standard curve 96 Tests Log in to see 15至18个工作日
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小鼠 0.06 ng/mL   96 Tests Log in to see 15至18个工作日
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0.21 ng/mL 0.312-20 ng/mL   96 Tests Log in to see 2至3个工作日
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大鼠 0.094 ng/mL 0.156-10 ng/mL   96 Tests Log in to see 13至16个工作日
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适于 Matrix Metallopeptidase 17 (Membrane-inserted) 相互作用对的更多 ELISA 试剂盒

Mouse (Murine) Matrix Metallopeptidase 17 (Membrane-inserted) (MMP17) interaction partners

  1. while Adam17 (显示 ADAM17 ELISA试剂盒)-deficiency suppresses Ang II (显示 AGT ELISA试剂盒)-induced SMC (显示 DYM ELISA试剂盒) remodeling in vitro, in vivo Adam17 (显示 ADAM17 ELISA试剂盒)-deficiency provides only a transient protective effect against Ang II (显示 AGT ELISA试剂盒)-mediated hypertension and end-organ damage.

  2. Mmp17-mediated osteopontin cleavage regulated vascular SMC maturation via c-JNK during aorta wall development. Mmp17 proteolytic activity regulates vascular SMC phenotype in the arterial vessel wall. Its absence predisposes to thoracic aortic aneurysm.

  3. function and expression of MT4-MMP

  4. MT4-MMP promotes lung metastasis by disturbing the tumour vessel integrity and thereby facilitating tumour cell intravasation

  5. MT1 (显示 MT1 ELISA试剂盒)-MT4-MMP chimaeras do not undergo normal trafficking and are not correctly processed to their fully active forms and, as a consequence, they are unable to activate pro-MMP-2 (显示 MMP2 ELISA试剂盒) at the cell surface.

Human Matrix Metallopeptidase 17 (Membrane-inserted) (MMP17) interaction partners

  1. Three forms of MT4-MMP with molecular masses of 45 kDa, 58 kDa and 69 kDa were detected. Further, we demonstrate that the 58 kDa form is the mature protein in the cell membrane, while the 69 kDa form is its precursor found in intracellular compartments.

  2. Low MT4-MMP expression is associated with erlotinib resistance in breast cancer.

  3. The MT4-MMP is internalized by the clathrin-independent carriers/GPI (显示 GNPDA1 ELISA试剂盒)-enriched early endosomal compartments pathway, a mechanism that differs from that responsible for the internalization of other membrane-type MMP members.

  4. Screening of patients with inherited thoracic aortic aneurysms and dissections identified a missense mutation (R373H) in the MMP17 gene that prevented the expression of the protease in human transfected cells.

  5. A functional link between MT4-MMP and the growth factor receptor (显示 RYK ELISA试剂盒) EGFR (显示 EGFR ELISA试剂盒).

  6. CAV1 (显示 CAV1 ELISA试剂盒) when found in lipid rafts does not allow the metalloproteinase MT4-MMP to localize into the lipid rafts, affecting its expression in the cell and probably its activity which is translated into the metastasis-associated activities of these cells.

  7. It identifies MT4-MMP as a key intrinsic tumor cell determinant that contributes to the elaboration of a permissive microenvironment for metastatic dissemination.

  8. MT4-MMP promotes lung metastasis by disturbing the tumour vessel integrity and thereby facilitating tumour cell intravasation

  9. The data presented here provide a new insight into the characteristics of MT4-MMP and highlight the common and distinct properties of the glycosylphosphatidylinositol-anchored membrane type-matrix metalloproteinases.

  10. Studies suggest a model of hypoxia induced metastasis through expression of HIF-1alpha (显示 HIF1A ELISA试剂盒), and SLUG regulation of MT4-MMP transcription.

Matrix Metallopeptidase 17 (Membrane-inserted) (MMP17) 抗原简介

Antigen Summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene is considered a member of the membrane-type MMP (MT-MMP) subfamily. However, this protein is unique among the MT-MMP's in that it is a GPI-anchored protein rather than a transmembrane protein. The protein activates MMP-2 by cleavage.

Gene names and symbols associated with MMP17

  • matrix metallopeptidase 17 (Mmp17) 抗体
  • matrix metallopeptidase 17 (MMP17) 抗体
  • matrix metallopeptidase 17a (mmp17a) 抗体
  • mmp17 抗体
  • MT4-MMP 抗体
  • MT4MMP 抗体
  • MTMMP4 抗体

Protein level used designations for MMP17

MMP-17 , MT-MMP 4 , matrix metalloproteinase 17 , matrix metalloproteinase-17 , membrane type-4 matrix metalloproteinase , membrane-type matrix metalloproteinase 4 , membrane-type-4 matrix metalloproteinase , MT4MMP , MTMMP4 , matrix metalloproteinase 17 (membrane-inserted) , matrix metallopeptidase 17 (membrane-inserted)

GENE ID SPECIES
23948 Mus musculus
288626 Rattus norvegicus
4326 Homo sapiens
570076 Danio rerio
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