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LAMC2 抗体

(Laminin, gamma 2 (LAMC2))
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 2. The gamma 2 chain, formerly thought to be a truncated version of beta chain (B2t), is highly homologous to the gamma 1 chain\; however, it lacks domain VI, and domains V, IV and III are shorter. It is expressed in several fetal tissues but differently from gamma 1, and is specifically localized to epithelial cells in skin, lung and kidney. The gamma 2 chain together with alpha 3 and beta 3 chains constitute laminin 5 (earlier known as kalinin), which is an integral part of the anchoring filaments that connect epithelial cells to the underlying basement membrane. The epithelium-specific expression of the gamma 2 chain implied its role as an epithelium attachment molecule, and mutations in this gene have been associated with junctional epidermolysis bullosa, a skin disease characterized by blisters due to disruption of the epidermal-dermal junction. Two transcript variants resulting from alternative splicing of the 3' terminal exon, and encoding different isoforms of gamma 2 chain, have been described. The two variants are differentially expressed in embryonic tissues, however, the biological significance of the two forms is not known. Transcript variants utilizing alternative polyA_signal have also been noted in literature. [provided by RefSeq, Aug 2011].
LAMC2 抗体  (AA 416-602) LAMC2 抗体  (AA 416-602) LAMC2 抗体 (AA 416-602) (ABIN7442369)

LAMC2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

LAMC2 抗体  (AA 28-196) LAMC2 抗体  (AA 28-196) LAMC2 抗体 (AA 28-196) (ABIN7434659)

LAMC2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

LAMC2 抗体  (C-Term) LAMC2 抗体  (C-Term) LAMC2 抗体 (C-Term) (ABIN3187887)

LAMC2 适用: 人, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated

LAMC2 抗体 by 适用

Find LAMC2 抗体 for a variety of species such as anti-Human LAMC2, anti-Mouse LAMC2, anti-Rat LAMC2. The species listed below are among those available. Click on a link to go to the corresponding products.

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Find LAMC2 抗体 with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

LAMC2 抗体 by 克隆形成能力

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LAMC2 抗体 by 克隆

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LAMC2 抗体 by 标记

Find LAMC2 抗体 with a specific conjugate such as Biotin, FITC, HRP. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular LAMC2 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (4)
Cat. No. ABIN7442369
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (4)
Cat. No. ABIN7434659
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Rat
Application WB, ELISA, IHC (p)
Validations
  • (4)
Cat. No. ABIN3187887
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (4)
Cat. No. ABIN6143076
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, ELISA
Validations
  • (3)
Cat. No. ABIN7157898
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (3)
Cat. No. ABIN517440
Quantity 50 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IF
Validations
  • (3)
Cat. No. ABIN7259891
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (2)
Cat. No. ABIN7426463
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p)
Validations
  • (2)
Cat. No. ABIN2856930
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC (p)
Validations
  • (3)
Cat. No. ABIN3031592
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
Cat. No. ABIN7185092
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Application WB, IHC, ICC
Validations
  • (2)
Cat. No. ABIN1859607
Quantity 100 μL
Datasheet Datasheet
Reactivity Rat
Application WB, IHC, ICC
Validations
  • (2)
Cat. No. ABIN1980449
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA
Validations
Cat. No. ABIN7157899
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application
Validations
Cat. No. ABIN7157900
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our LAMC2 抗体

Parikh, Puram, Faquin, Richmon, Emerick, Deschler, Varvares, Tirosh, Bernstein, Lin: "Immunohistochemical quantification of partial-EMT in oral cavity squamous cell carcinoma primary tumors is associated with nodal metastasis." in: Oral oncology, Vol. 99, pp. 104458, (2019) (PubMed).

Amin, Janson, Sevéus, Miyazaki, Virtanen, Venge: "Uncoordinated production of Laminin-5 chains in airways epithelium of allergic asthmatics." in: Respiratory research, Vol. 6, pp. 110, (2005) (PubMed).

Aliases for LAMC2 抗体

laminin subunit gamma 2 (LAMC2) 抗体
laminin, gamma 2 (Lamc2) 抗体
laminin subunit gamma 2 (Lamc2) 抗体
AA589349 抗体
B2T 抗体
BM600 抗体
CSF 抗体
EBR2 抗体
EBR2A 抗体
LAMB2T 抗体
LAMC2 抗体
LAMNB2 抗体
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