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Bone morphogenetic proteins (e.g., BMP9\; MIM 605120) are members of the transforming growth factor-beta (see TGFB1\; MIM 190180) superfamily and regulate tissue differentiation and maintenance. 再加上，我们可以发GDF15 试剂盒 (81) 和 GDF15 蛋白 (41)和数多这个蛋白质的别的产品。
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Human Polyclonal GDF15 Primary Antibody for IF (p), IHC (p) - ABIN704561
Ruan, Li, Nie, Zhou, Zou: Differential expression of glycoprotein non-metastatic melanoma protein B (GPNMB) involved in trichostatin A-induced apoptosis in gastric cancer. in International journal of clinical and experimental medicine 2015
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Chimpanzee Polyclonal GDF15 Primary Antibody for EIA, WB - ABIN453961
Baek, Eling: Changes in gene expression contribute to cancer prevention by COX inhibitors. in Progress in lipid research 2006
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Human Polyclonal GDF15 Primary Antibody for ELISA, WB - ABIN185465
Wollmann, Goodman, Bhat-Nakshatri, Kishimoto, Goulet, Mehrotra, Morimiya, Badve, Nakshatri: The macrophage inhibitory cytokine integrates AKT/PKB and MAP kinase signaling pathways in breast cancer cells. in Carcinogenesis 2005
PPIX concentrations correlated with both growth differentiation factor (GDF) 15 (p = 0.012) and male gender (p = 0.015).
Data show that growth differentiation factor 15 (GDF15) knockdown significantly inhibited the growth and metastasis of cancer stem-like sphere cells (SCs (显示 TWIST1 抗体)) through AKT (显示 AKT1 抗体)/GSK-3beta (显示 GSK3b 抗体)/beta-catenin (显示 CTNNB1 抗体) pathway suppression.
epithelial restitution was promoted by enhanced NAG-1 expression and subsequent enterocyte locomotion during the early wound-healing process
serum GDF15 may be a useful diagnostic and prognostic biomarker for colorectal cancer.
These findings highlight an important contribution of GDF15 in promoting airway epithelial senescence upon cigarette smoke exposure.
The results of this study, including a robust induction of GDF-15 expression by several external factors known to elevate IOP, and rGDF-15-induced increase in contractility, cell adhesion, and the levels of ECM (显示 MMRN1 抗体) proteins and alphaSMA (显示 ACTA2 抗体) in TM cells
GDF-15 captures distinct aspects of cardiovascular disease development, progression, and prognosis, which are not represented by clinical risk predictors and other biomarkers. The usefulness of GDF-15 to guide management decisions and discover new treatment targets should be further explored.
In stable Coronary Heart Disease, GDF-15 was independently associated with cardiovascular (CV), non-CV, and cancer mortality, as well as with MI and stroke. When also adjusting for other prognostic biomarkers, the associations to all fatal and nonfatal events were maintained except for MI. Information on GDF-15, therefore, might be helpful when assessing the risk of adverse outcomes in patients with stable CHD (显示 CHDH 抗体).
Impaired glucose tolerance is associated with increased GDF-15 levels even in the absence of anemia
GDF15 is a potent mitohormetic signal that safeguards against the onset of obesity and insulin (显示 INS 抗体) resistance.
This is the first study defining the role of Mic-1/Gdf15 in a number of behavioural domains.
both GDF-15 and TGF-beta1 (显示 TGFB1 抗体) counteract chemokine (显示 CCL1 抗体)-induced integrin activation on neutrophils via the ALK-5 (显示 TGFBR1 抗体)/TGF-betaRII heterodimer.
The aim of this study was to identify the role of endogenous Gdf-15 in the MPTP (显示 PTPN2 抗体) (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse model of Parkinson's disease (PD) by comparing Gdf-15 (+/+) and Gdf-15 (-/-) mice.
The results of this study indicated the importance of Gdf-15 in promoting survival of DAergic neurons and regulating the inflammatory response post 6-OHDA lesion.
endogenous Growth/differentiation factor-15 is beneficial for axon regeneration following sciatic nerve crush
repeated cisterna magna administration of human umbilical cord blood-derived mesenchymal stem cells enhanced endogenous adult hippocampal neurogenesis and synaptic activity through a paracrine factor of GDF-15
Levels of GDF-15 mRNA increased 2 h after induction of ventilator-induced lung injury in WT lungs. Non-hematopoietic cells are the main source of GDF-15. GDF-15 is required for platelet-leukocyte interactions during ventilator-induced lung injury.
hNAG-1 appears to be a novel therapeutic target in preventing and treating obesity and insulin (显示 INS 抗体) resistance.
Bone morphogenetic proteins (e.g., BMP9\; MIM 605120) are members of the transforming growth factor-beta (see TGFB1\; MIM 190180) superfamily and regulate tissue differentiation and maintenance. They are synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein.
growth differentiation factor 15
, NSAID (nonsteroidal anti-inflammatory drug)-activated protein 1
, NSAID-activated gene 1 protein
, NSAID-regulated gene 1 protein
, growth/differentiation factor 15
, macrophage inhibitory cytokine 1
, placental TGF-beta
, placental bone morphogenetic protein
, prostate differentiation factor
, macrophage inhibiting cytokine-1