Use your antibodies-online credentials, if available.
The protein encoded by EHMT1 is a histone methyltransferase that is part of the E2F6 complex, which represses transcription. 再加上，我们可以发EHMT1 蛋白 (4) 和 EHMT1 试剂盒 (2)和数多这个蛋白质的别的产品。
Showing 10 out of 135 products:
GLP (显示 GOLGA6A 抗体)/G9a (显示 EHMT2 抗体) H3K9 methyltransferase complex is an enzyme counteracting Jmjd1a (显示 KDM3A 抗体)-mediated H3K9 demethylation at the Sry (显示 SRY 抗体) locus in gonadal somatic cells
miR (显示 MLXIP 抗体)-217-mediated, genetic, or pharmacological inactivation of EHMT1/2 was sufficient to promote pathological hypertrophy
EHMT1 Mediates Homeostatic Synaptic Scaling
The stress-induced Brg1 (显示 SMARCA4 抗体)-G9a (显示 EHMT2 抗体)/GLP (显示 GOLGA6A 抗体)-Dnmt3 interactions and sequence of repressive chromatin assembly on Myh6 (显示 MYH6 抗体) promoter illustrates a molecular mechanism by which the heart epigenetically responds to environmental signals.
data provide genetic and pharmacologic evidence that EHMT1 and EHMT2 (显示 EHMT2 抗体) are epigenetic regulators involved in gamma-globin repression and represent a novel therapeutic target for SCD (显示 SCD 抗体).
histone methyltransferase activities of GLP (显示 GOLGA6A 抗体) and G9a (显示 EHMT2 抗体) are stimulated by neighboring nucleosomes that are premethylated at H3K9
Prdm16 (显示 PRDM16 抗体) was required in young mice to suppress the expression of white-fat-selective genes in BAT (显示 BAAT 抗体) through recruitment of the histone methyltransferase Ehmt1.
G9a (显示 EHMT2 抗体) and GLP (显示 GOLGA6A 抗体) have an essential role in normal morphogenesis of the atrioventricular septum through regulation of the size of the atrioventricular cushion.
Reduced Euchromatin histone methyltransferase 1 (显示 DNMT1 抗体) causes developmental delay, hypotonia, and cranial abnormalities associated with increased bone gene expression in Kleefstra syndrome mice.
EHMT1 is an essential BAT (显示 BAAT 抗体)-enriched lysine methyltransferase in the PRDM16 (显示 PRDM16 抗体) transcriptional complex and controls brown adipose cell fate
trr (显示 TXNRD1 抗体) and G9a (显示 EHMT2 抗体) also have common direct targets, including the Drosophila ortholog of Arc (显示 NOL3 抗体) (Arc1 (显示 CDH1 抗体)), a key regulator of synaptic plasticity. Our data highlight the clinical and molecular convergence between the KMT2 and EHMT protein families, which may contribute to a molecular network underlying a larger group of intellectual disability / autism spectrum disorder -related disorders.
missense variants in EHMT1 that lead to protein misfolding and disrupted histone mark binding can lead to Kleefstra Syndrome [case reports]
we find an estrogen receptor (显示 ESR1 抗体)-independent synthetic lethal interaction between a GATA3 (显示 GATA3 抗体) frameshift mutant with an extended C-terminus and the histone methyltransferases G9A (显示 EHMT2 抗体) and GLP (显示 RCBTB1 抗体), indicating perturbed epigenetic regulation
Selective degradation of the mutant EHMT1 mRNA leads to Kleefstra syndrome.
G9a (显示 EHMT2 抗体) and GLP (显示 RCBTB1 抗体) are required for stable maintenance of imprinted DNA methylation (显示 HELLS 抗体) in embryonic stem cells.
the clinical picture we found in Norwegian patients with Kleefstra syndrome is similar to the findings described in the literature. An interesting point is that in the literature >85% of the patients have a deletion of 9q34.3 and the remaining have a mutation in the EHMT1 gene, whereas in this study we found 50% with a deletion, and 50% with a mutation.
Data indicate zinc finger proteins ZNF644 (显示 ZNF644 抗体) and WIZ (显示 ZNF803 抗体) as two core subunits in the histone-lysine N-methyltransferase G9a (显示 EHMT2 抗体)/GLP (显示 RCBTB1 抗体) complex, and interact with the transcription activation domain of G9a (显示 EHMT2 抗体) and GLP (显示 RCBTB1 抗体).
data provide genetic and pharmacologic evidence that EHMT1 and EHMT2 (显示 EHMT2 抗体) are epigenetic regulators involved in gamma-globin (显示 HBG1 抗体) repression and represent a novel therapeutic target for SCD (显示 SCD 抗体).
The expression level of EHMT1 and EHMT2 (显示 EHMT2 抗体) inversely correlates with the type I interferon (显示 IFNA 抗体) responsiveness in chronic myeloid leukemia (显示 BCL11A 抗体) cell lines.
The current knowledge on the mechanisms of action and function of EHMT1, with particular emphasis on their interplay in the regulation of chromatin states and biological processes.
The protein encoded by this gene is a histone methyltransferase that is part of the E2F6 complex, which represses transcription. The encoded protein methylates the Lys-9 position of histone H3, which tags it for transcriptional repression. This protein may be involved in the silencing of MYC- and E2F-responsive genes and therefore could play a role in the G0/G1 cell cycle transition. Defects in this gene are a cause of chromosome 9q subtelomeric deletion syndrome (9q-syndrome). Two transcript variants encoding different isoforms have been found for this gene.
euchromatic histone methyltransferase 1
, histone-lysine N-methyltransferase, H3 lysine-9 specific 5
, euchromatic histone-lysine N-methyltransferase 1
, histone-lysine N-methyltransferase EHMT1
, histone-lysine N-methyltransferase, H3 lysine-9 specific 5-like
, G9a-like protein 1
, lysine N-methyltransferase 1D
, G9a like protein
, H3-K9-HMTase 5
, histone H3-K9 methyltransferase 5