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F9 encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. 再加上，我们可以发Coagulation Factor IX 试剂盒 (62) 和 Coagulation Factor IX 蛋白 (38)和数多这个蛋白质的别的产品。
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caspase-3 (显示 CASP3 抗体) inhibitors also suppressed the attenuation of cell adhesion and phosphorylation of p38 MAPK (显示 MAPK14 抗体) by EGF (显示 EGF 抗体)-F9. Our data indicated that EGF (显示 EGF 抗体)-F9 activated signals for apoptosis and induced de-adhesion in a caspase-3 (显示 CASP3 抗体) dependent manner.
Data suggest that coagulation factor IX (hFIX) minigene containing beta-globin (hBG) introns could represent a particular interest in stem cell-based gene therapy of hemophilias.
miR (显示 MLXIP 抗体)-128 and miR (显示 MLXIP 抗体)-125 could help to increase the nonsense-mutant F9 levels by repressing nonsense-mediated mRNA decay.
In 293T cells, the addition of 0.5 mM Ca(+2) and 1 mM Mg(+2) resulted in higher recombinant human Factor IX concentration. SK-Hep-1 cell line proved to be very effective in rhFIX production, and it can be used as a novel biotechnological platform for the production of recombinant proteins.
Differentiation studies demonstrated osteogenic (but not chondrogenic or adipogenic) differentiation capability and efficient FIX secretion of the enclosed MSCs in the fibronectin (显示 FN1 抗体)-alginate suspension culture.
Selective disruption of exosite-mediated regulation of factor IX by heparin and antithrombin (显示 SERPINC1 抗体) can be achieved with preserved or enhanced thrombin (显示 F2 抗体) generation capacity.
Describe inhibition of tissue factor:factor VIIa-catalyzed factor IX and factor X activation by TFPI (显示 TFPI 抗体) and TFPI (显示 TFPI 抗体) constructs.
Activatable bioengineered FIX molecules with FVIII (显示 F8 抗体)-independent activity might be a promising tool for improving hemophilia A treatment, especially for patients with inhibitors.
structural features within residues of the 39-loop contribute to the resistance of FIXa (显示 ETFB 抗体) to inhibition by plasma inhibitors ZPI (显示 SERPINA10 抗体) and TFPI (显示 TFPI 抗体).
hnRNP A3 is a major liver nuclear protein binding to age related increase element of the factor IX gene.
functional role of binding of F9 to collagen IV (显示 COL4 抗体) in hemostasis.
FIX and FXI (显示 F11 抗体) deficiency cause similar effects in the carotid artery injury model
findings show coagulation factor IX & complement component C4-binding protein can bind Adenovirus fiber knob domain & provide a bridge for virus uptake through cell surface heparan sulfate proteoglycans & low-density lipoprotein receptor (显示 LDLR 抗体)-related protein (显示 LRP1 抗体)
Mice lacking plasminogen (显示 PLG 抗体) and fIX (Plg (显示 PLG 抗体)(-/-)/fIX-/-) have lower mortality at age 6 months than Plg (显示 PLG 抗体)(-/-)/fIX+/+ mice
important role for Lyn (显示 LYN 抗体) in VWF (显示 VWF 抗体)/GPIb-IX-induced integrin activation mediated via the cGMP signaling pathway independently of TXA2 (显示 TBXA2R 抗体) synthesis and also indicate that Lyn (显示 LYN 抗体) is critically important in GPIb-IX-mediated activation of the cGMP pathway
the heparin-binding exosite of factor IXa is a critical regulator of plasma thrombin (显示 F2 抗体) generation and venous thrombosis
Mg2 (显示 MCOLN1 抗体)+ ions are required to maintain native conformation and in vivo function of factor IX gamma-carboxyglutamic acid domain
This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease.
coagulation factor IX
, coagulation factor 9 (plasma thromboplastic component, Christmas disease, hemophilia B)
, gla domain
, coagulation factor 9
, Coagulation factor IX
, coagulation factor IX-like
, Christmas factor
, F9 p22
, FIX F9
, factor 9
, factor IX F9
, plasma thromboplastic component
, plasma thromboplastin component
, christmas factor
, Coagulation factor IX (plasma thromboplastic component, Christmas disease, hemophilia B)
, coagulation factor IX (plasma thromboplastic component, Christmas disease, hemophilia B)
, factor IX activated protein
, factor IX