anti-Chromosome 10 Open Reading Frame 2 (C10ORF2) 抗体

C10ORF2 encodes a hexameric DNA helicase which unwinds short stretches of double-stranded DNA in the 5' to 3' direction and, along with mitochondrial single-stranded DNA binding protein and mtDNA polymerase gamma, is thought to play a key role in mtDNA replication. 再加上,我们可以发Chromosome 10 Open Reading Frame 2 蛋白 (9)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
C10ORF2 56652 Q96RR1
C10ORF2 309441  
C10ORF2 226153 Q8CIW5

antibodies-online.cn销售最多的anti-Chromosome 10 Open Reading Frame 2 抗体

Showing 10 out of 55 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 WB 100 μL Log in to see 5至7个工作日
¥20,898.73
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Cow 非结合性 WB <b>WB Suggested Anti-PEO1 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:62500<br><b>Positive Control: </b>Jurkat cell lysate 100 μL Log in to see 5至7个工作日
¥20,898.73
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非结合性 IHC (p), WB C10orf2 Antibody (C-term)  western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the C10orf2 antibody detected the C10orf2 protein (arrow). C10orf2 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of C10orf2 Antibody (C-term) for immunohistochemistry.  Clinical relevance has not been evaluated. 400 μL Log in to see 5至8个工作日
¥2,325.14
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非结合性 EIA, IHC (p), WB C10orf2 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of C10orf2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. C10orf2 Antibody (C-term) western blot analysis in ZR-75-1 cell line lysates (35µg/lane).This demonstrates the C10orf2 antibody detected the C10orf2 protein (arrow). 0.4 mL Log in to see 29至35个工作日
¥4,086.26
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Bat 非结合性 WB 50 μg Log in to see 29至35个工作日
¥5,538.93
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非结合性 WB 50 μg Log in to see 29至35个工作日
¥5,538.93
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非结合性 IF, IHC, WB 100 μL Log in to see 34至38个工作日
¥2,882.69
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非结合性 ELISA, WB 50 μg Log in to see 24至29个工作日
¥4,312.06
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非结合性 ELISA, WB 50 μg Log in to see 24至29个工作日
¥4,312.06
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非结合性 IF (p), IHC (p), WB Paraformaldehyde-fixed, paraffin embedded mouse testis tissue, Antigen retrieval by boiling in sodium citrate buffer(pH6) for 15min, Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes, Blocking buffer (normal goat serum) at 37°C for 20min, Antibody incubation with Rabbit Anti-Twinkle Polyclonal Antibody, Unconjugated  at 1:500 overnight at 4°C, followed by a conjugated secondary and DAB staining 100 μL Log in to see 5至7个工作日
¥2,610.23
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通过反应活性、应用领域、克隆类型和共轭标记 C10ORF2 抗体

特性 应用范围 宿主 克隆类型 标记
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引用最多的anti-Chromosome 10 Open Reading Frame 2 抗体

  1. Cow (Bovine) Polyclonal C10ORF2 Primary Antibody for WB - ABIN2775251 : Farge, Holmlund, Khvorostova, Rofougaran, Hofer, Falkenberg: The N-terminal domain of TWINKLE contributes to single-stranded DNA binding and DNA helicase activities. in Nucleic acids research 2008 (PubMed)
    Show all 3 Pubmed References

更多抗Chromosome 10 Open Reading Frame 2的相互作用对抗体

Human Chromosome 10 Open Reading Frame 2 (C10ORF2) interaction partners

  1. ere we present eight families affected by Perrault syndrome. In five families we identified novel or previously reported variants in HSD17B4 (显示 HSD17B4 抗体), LARS2 (显示 LARS2 抗体), CLPP (显示 CLPP 抗体) and C10orf2

  2. It has been demonstrated that MTERF1 (显示 MTERF 抗体) arrests mitochondrial DNA (mtDNA) replication with distinct polarity whereby MTERF1 (显示 MTERF 抗体) acts as a directional contra-helicase, blocking mtDNA unwinding by the mitochondrial helicase TWINKLE.

  3. sequencing coding regions of C10orf2 revealed three variants in three different patients, of which two were novel (c.1964G>A/p.G655D; c.204G>A/p.G68G) variants and one was reported (c.1052A>G/p. N351S).

  4. We identified a missense mutation in c10orf2 in an Iranian family with an association to progressive external ophthalmoplegia, myopathy, dysphagia, dysphonia, and behavior change. Early death was also a novel feature in affected family members.

  5. An electron microscopy model of Twinkle reveals a hexameric two-layered ring comprising the zinc-binding domain and RNA polymerase domain in one layer and the RecA-like hexamerization C-terminal domain in another.

  6. Identified compound heterozygous mutations of the C10orf2 gene as the cause of infantile-onset spinocerebellar ataxia with sensorimotor polyneuropathy and myopathy.

  7. The mitochondrial replicative helicase Twinkle inefficiently unwinds well characterized intermolecular and intramolecular G-quadruplex DNA substrates, as well as a unimolecular G4 substrate.

  8. 16-year follow-up of autosomal dominant progressive external ophthalmoplegia (adPEO) due to the p.R357P gene mutation in PEO1; adPEO due to this mutation is a late-onset ocular myopathy beginning with ptosis and progressing slowly; ophthalmoparesis, if present, is mild

  9. Overexpression of Twinkle-helicase protects cardiomyocytes from genotoxic stress caused by reactive oxygen species.

  10. analysis did not reveal disease causing POLG (显示 POLG 抗体) or PEO1 mutations in patients with atypical parkinsonism

Mouse (Murine) Chromosome 10 Open Reading Frame 2 (C10ORF2) interaction partners

  1. study describes findings in a family with late onset parkinsonism and progressive external ophthalmoplegia, with mutation of G1750A in the exon 1 of PEO1 gene

  2. TWINKLE is essential for nascent H-strand synthesis in the D-loop, thus showing that there is no separate DNA helicase responsible for replication of this region.

Chromosome 10 Open Reading Frame 2 (C10ORF2) 抗原简介

蛋白简介

This gene encodes a hexameric DNA helicase which unwinds short stretches of double-stranded DNA in the 5' to 3' direction and, along with mitochondrial single-stranded DNA binding protein and mtDNA polymerase gamma, is thought to play a key role in mtDNA replication. The protein localizes to the mitochondrial matrix and mitochondrial nucleoids. Mutations in this gene cause infantile onset spinocerebellar ataxia (IOSCA) and progressive external ophthalmoplegia (PEO) and are also associated with several mitochondrial depletion syndromes. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with C10ORF2

  • chromosome 10 open reading frame 2 (c10orf2) 抗体
  • chromosome 10 open reading frame 2 (C10orf2) 抗体
  • chromosome 28 open reading frame, human C10orf2 (C28H10orf2) 抗体
  • progressive external ophthalmoplegia 1 (Peo1) 抗体
  • progressive external ophthalmoplegia 1 (PEO1) 抗体
  • progressive external ophthalmoplegia 1 (human) (Peo1) 抗体
  • ATXN8 抗体
  • C6H10orf2 抗体
  • D19Ertd626e 抗体
  • IOSCA 抗体
  • MTDPS7 抗体
  • PEO 抗体
  • PEO1 抗体
  • PEOA3 抗体
  • SANDO 抗体
  • SCA8 抗体
  • Twinl 抗体

Protein level used designations for C10ORF2

uncharacterized protein LOC414487 , twinkle protein, mitochondrial , T7 gp4-like protein with intramitochondrial nucleoid localization , T7 helicase-related protein with intramitochondrial nucleoid localization , T7-like mitochondrial DNA helicase , ataxin 8 , mitochondrial twinkle protein , progressive external ophthalmoplegia 1 protein , progressive external ophthalmoplegia 1 , progressive external ophthalmoplegia 1 homolog , progressive external ophthalmoplegia 1 protein homolog

GENE ID SPECIES
414487 Xenopus laevis
710958 Macaca mulatta
56652 Homo sapiens
486845 Canis lupus familiaris
309441 Rattus norvegicus
425626 Gallus gallus
226153 Mus musculus
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