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BRSK1 抗体

(BR Serine/threonine Kinase 1 (BRSK1))
Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Ser-573'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV- induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C (By similarity). In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1.
BRSK1 抗体  (AA 426-591) BRSK1 抗体  (AA 426-591) BRSK1 抗体 (AA 426-591) (ABIN7169019)

BRSK1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

BRSK1 抗体  (AA 355-384) BRSK1 抗体  (AA 355-384) BRSK1 抗体 (AA 355-384) (ABIN1881121)

BRSK1 适用: 小鼠 WB 宿主: 兔 Polyclonal RB40234 unconjugated

BRSK1 抗体 by 适用

Find BRSK1 抗体 for a variety of species such as anti-Human BRSK1, anti-Mouse BRSK1, anti-Rat BRSK1. The species listed below are among those available. Click on a link to go to the corresponding products.

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Find BRSK1 抗体 validated for a specific application such as WB, ELISA, IHC, IF (cc). Some of the available applications are listed below. Click on a link to go to the corresponding products.

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Find BRSK1 抗体 with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

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Popular BRSK1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (3)
Cat. No. ABIN7169019
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Application WB
Validations
  • (3)
  • (1)
Cat. No. ABIN1881121
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IF, ICC
Validations
  • (2)
Cat. No. ABIN5066517
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IF, ICC
Validations
  • (2)
Cat. No. ABIN5066519
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IF, ICC
Validations
  • (2)
Cat. No. ABIN5066516
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, ELISA, IF, ICC
Validations
  • (2)
Cat. No. ABIN6256963
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IF, ICC
Validations
  • (2)
Cat. No. ABIN5066528
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IF, ICC
Validations
  • (2)
Cat. No. ABIN5066527
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IF, ICC
Validations
  • (2)
Cat. No. ABIN5066526
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IF, ICC
Validations
  • (2)
Cat. No. ABIN5066530
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p)
Validations
  • (2)
Cat. No. ABIN652432
Quantity 400 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC (p), EIA
Validations
  • (2)
Cat. No. ABIN499499
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Rat
Application ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
Cat. No. ABIN873206
Quantity 100 μL
Datasheet Datasheet
Reactivity Rat
Application ELISA, IHC (p), IHC (fro)
Validations
Cat. No. ABIN885576
Quantity 100 μL
Datasheet Datasheet
Reactivity Rat
Application IF (cc), IF (p)
Validations
Cat. No. ABIN2810445
Quantity 100 μL
Datasheet Datasheet

Latest Publications for our BRSK1 抗体

Zempel, Thies, Mandelkow, Mandelkow: "Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 36, pp. 11938-50, (2010) (PubMed).

Alvarado-Kristensson, Rodríguez, Silió, Valpuesta, Carrera: "SADB phosphorylation of gamma-tubulin regulates centrosome duplication." in: Nature cell biology, Vol. 11, Issue 9, pp. 1081-92, (2009) (PubMed).

Fogarty, Hardie: "C-terminal phosphorylation of LKB1 is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest." in: The Journal of biological chemistry, Vol. 284, Issue 1, pp. 77-84, (2008) (PubMed).

Bright, Carling, Thornton: "Investigating the regulation of brain-specific kinases 1 and 2 by phosphorylation." in: The Journal of biological chemistry, Vol. 283, Issue 22, pp. 14946-54, (2008) (PubMed).

Kishi, Pan, Crump, Sanes: "Mammalian SAD kinases are required for neuronal polarization." in: Science (New York, N.Y.), Vol. 307, Issue 5711, pp. 929-32, (2005) (PubMed).

Lu, Niida, Nakanishi: "Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function." in: The Journal of biological chemistry, Vol. 279, Issue 30, pp. 31164-70, (2004) (PubMed).

Lizcano, Göransson, Toth, Deak, Morrice, Boudeau, Hawley, Udd, Mäkelä, Hardie, Alessi: "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1." in: The EMBO journal, Vol. 23, Issue 4, pp. 833-43, (2004) (PubMed).

Aliases for BRSK1 抗体

BR serine/threonine kinase 1 (BRSK1) 抗体
BR serine/threonine kinase 1 (Brsk1) 抗体
BRSK1 抗体
Gm1100 抗体
hSAD1 抗体
RGD1563268 抗体
SAD-B 抗体
Sad-b 抗体
SADB 抗体
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