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Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. 再加上，我们可以发BRSK1 蛋白 (6) 和 BRSK1 试剂盒 (4)和数多这个蛋白质的别的产品。
Showing 10 out of 134 products:
Mouse (Murine) Polyclonal BRSK1 Primary Antibody for WB - ABIN1881121
Alvarado-Kristensson, Rodríguez, Silió, Valpuesta, Carrera: SADB phosphorylation of gamma-tubulin regulates centrosome duplication. in Nature cell biology 2009
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Human Polyclonal BRSK1 Primary Antibody for IHC (p), WB - ABIN2477731
Suzuki, Hyodo, Kobayashi, Aida, Urano: Characterization and localization of mRNA encoding the salmon-type gonadotrophin-releasing hormone precursor of the masu salmon. in Journal of molecular endocrinology 1992
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Human Polyclonal BRSK1 Primary Antibody for EIA, WB - ABIN360694
Lu, Niida, Nakanishi: Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function. in The Journal of biological chemistry 2004
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Human Polyclonal BRSK1 Primary Antibody for IHC (p), WB - ABIN652432
Lizcano, Göransson, Toth, Deak, Morrice, Boudeau, Hawley, Udd, Mäkelä, Hardie, Alessi: LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. in The EMBO journal 2004
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Human Polyclonal BRSK1 Primary Antibody for IHC (p), WB - ABIN303016
Zempel, Thies, Mandelkow, Mandelkow: Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2010
These results suggest that frameshift mutations of EGR1 (显示 EGR1 抗体) and BRSK1 might play a role in tumorigenesis through tumor suppressor gene inactivation in colorectal cancer and gastric cancer.
BRSK1 is a novel tumor suppressor in breast cancer which inversely correlated with Jab1 (显示 COPS5 抗体) expression.
Single nucleotide polymorphism in BRSK1 is associated with the length of reproductive lifespan.
acts as checkpoint kinase (显示 ATR 抗体) upon DNA damage induced by UV
protein phosphatase 2C (显示 PDP 抗体) is a likely candidate for catalyzing the dephosphorylation and inactivation of BRSK1/2.
STRADalpha.MO25alpha complexes containing LKB1 (显示 STK11 抗体) variants were equally effective at phosphorylating and activating AMPK (显示 PRKAA1 抗体), BRSK1, and BRSK2 (显示 BRSK2 抗体)
SADB kinase activity controls centrosome homeostasis by regulating phosphorylation of gamma-tubulin (显示 TUBG1 抗体).
Structure and inhibition analysis of the mouse SAD-B C-terminal fragment
At mature pre-synaptic terminals, SAD-B regulates vesicular release probability and synaptic plasticity.
SAD-A (显示 BRSK2 抗体) and SAD-B kinases have multiple, sequential roles in axonal differentiation
The regulation of Wee1 (显示 WEE1 抗体) by SadA (显示 BRSK2 抗体) and SadB kinases is essential for the differentiation of polarized neurons.
results show that SAD-A (显示 BRSK2 抗体) and SAD-B, mammalian orthologs of a kinase needed for presynaptic differentiation in Caenorhabditis elegans, are required for neuronal polarization.
Once activated, LKB1 (显示 STK11 抗体) phosphorylates and thereby activates SAD-A (显示 BRSK2 抗体) and SAD-B kinases, which are also required for neuronal polarization in the cerebral cortex.
Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Ser-573'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV- induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C (By similarity). In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1.
BR serine/threonine kinase 1
, BR serine/threonine-protein kinase 1-like
, BR serine/threonine-protein kinase 1
, SAD1 homolog
, SAD1 kinase
, SadB kinase short isoform
, brain-selective kinase 1
, brain-specific serine/threonine-protein kinase 1
, protein kinase SAD1A
, serine/threonine-protein kinase BRSK1
, serine/threonine-protein kinase SAD-B
, synapses of Amphids Defective homolog 1
, serine/threonine kinase SAD-B
, serine/threonine kinase SADB